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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:79995
Term: GW 3965
Definition: A diarylmethane that has formula C33H31ClF3NO3.
Chemical ID: MESH:C473027
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTDGW 3965 results in increased expression of CYP3A4 mRNAPMID:23732298
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTD[GW 3965 co-treated with NR1H3 protein] results in increased expression of CYP3A4 mRNA; GW 3965 inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]PMID:23732298
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