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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:520985
Term: almotriptan
Definition: An indole compound having a 2-(dimethylamino)ethyl group at the 3-position and a (pyrrolidin-1-ylsulfonyl)methyl group at the 5-position.
Chemical ID: MESH:C409045
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2decreases methylationISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein results in decreased methylation of almotriptanPMID:12642466
Cyp3a2increases hydroxylationISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein results in increased hydroxylation of almotriptanPMID:12642466
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