GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp3a2 | decreases activity | EXP | | 6480464 | CTD | Chenodeoxycholic Acid results in decreased activity of CYP3A2 protein | PMID:8889968 | Cyp3a2 | multiple interactions | EXP | | 6480464 | CTD | [CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] results in increased abundance of Chenodeoxycholic Acid; Chenodeoxycholic Acid inhibits the reaction [Calcitriol results in increased expression of CYP3A2 mRNA] | PMID:20006981 PMID:34461081 | Cyp3a2 | decreases expression | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | Chenodeoxycholic Acid results in decreased expression of CYP3A4 mRNA | PMID:27174168 | Cyp3a2 | increases hydroxylation | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | CYP3A4 protein results in increased hydroxylation of Chenodeoxycholic Acid | PMID:36473578 | Cyp3a2 | multiple interactions | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | [Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CYP3A4 mRNA; [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CYP3A4 mRNA; [CYP3A4 protein results in increased hydroxylation of Chenodeoxycholic Acid] which results in increased abundance of muricholic acid; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of CYP3A4 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine] results in decreased expression of CYP3A4 mRNA; [nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CYP3A4 mRNA; Chenodeoxycholic Acid promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] | PMID:19299527 PMID:32152650 PMID:33819548 PMID:36473578 | |
Go Back to source page | Continue to Ontology report |