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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:4811
Term: epoxiconazole
Definition: A racemate composed of equimolar amounts of (2S,3R)- and (2R,3S)-epoxiconazole. A broad-spectrum fungicide for control of diseases caused by Ascomycetes, Basidiomycetes and Deuteromycetes. Epoxiconazole is moderately toxic to birds, honeybees, earthworms and most aquatic organisms.
Chemical ID: MESH:C109476
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2increases expressionEXP 6480464CTDepoxiconazole results in increased expression of CYP3A2 mRNAPMID:29038839
Cyp3a2multiple interactionsEXP 6480464CTD[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of CYP3A2 mRNA; [cyproconazole co-treated with epoxiconazole] results in increased expression of CYP3A2 mRNAPMID:29038839
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTDepoxiconazole results in increased expression of CYP3A4 mRNA; epoxiconazole results in increased expression of CYP3A4 proteinPMID:29294346
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTD[fluxapyroxad co-treated with epoxiconazole] results in increased expression of CYP3A4 mRNA; [fluxapyroxad co-treated with epoxiconazole] results in increased expression of CYP3A4 proteinPMID:29294346
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