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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:28197
Term: daidzein
Definition: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by an additional hydroxy group at position 4'.
Chemical ID: MESH:C004742
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2increases expressionEXP 6480464CTDdaidzein results in increased expression of CYP3A4 mRNAPMID:31870919
Cyp3a2decreases activityISOCYP3A4 (Homo sapiens)6480464CTDdaidzein results in decreased activity of CYP3A4 proteinPMID:18420780
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