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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:3764
Term: clotrimazole
Definition: A member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group.
Chemical ID: MESH:D003022
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2multiple interactionsEXP 6480464CTDClotrimazole inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline]PMID:19858067
Cyp3a2decreases activityISOCYP3A4 (Homo sapiens)6480464CTDClotrimazole results in decreased activity of CYP3A4 proteinPMID:15135088
Cyp3a2increases activityISOCYP3A4 (Homo sapiens)6480464CTDClotrimazole results in increased activity of CYP3A4 proteinPMID:12065438 PMID:14977870
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTDClotrimazole results in increased expression of CYP3A4 mRNA; Clotrimazole results in increased expression of CYP3A4 proteinPMID:12505310 PMID:12673034 PMID:15466163 PMID:16837568 PMID:17998298 PMID:27507784 PMID:8632764
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTDClotrimazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Clotrimazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP3A4 mRNA]PMID:17998298 PMID:19299527 PMID:27507784
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