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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:6456
Term: lidocaine
Definition: The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Chemical ID: MESH:D008012
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2affects metabolic processingISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein affects the metabolism of LidocainePMID:15447735
Cyp3a2decreases ethylationISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein results in decreased ethylation of LidocainePMID:15887009
Cyp3a2decreases methylationISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein results in decreased methylation of LidocainePMID:15383492
Cyp3a2increases metabolic processingISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein results in increased metabolism of LidocainePMID:18846481
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTDRifampin promotes the reaction [CYP3A4 protein results in increased metabolism of Lidocaine]PMID:9298257
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