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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:28600
Term: farnesol
Definition: A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1.
Chemical ID: MESH:D005204
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2increases activityEXP 6480464CTDFarnesol results in increased activity of CYP3A2 proteinPMID:15840382
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTDFarnesol results in increased expression of CYP3A4 mRNAPMID:30611723
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTDFarnesol analog inhibits the reaction [Oleic Acid results in decreased expression of CYP3A4 mRNA]PMID:30611723
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