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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:77260
Term: 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole
Definition: A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
Chemical ID: MESH:D009853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2affects metabolic processingISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein affects the metabolism of OmeprazolePMID:15286053 PMID:15626586
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTDOmeprazole results in increased expression of CYP3A4 mRNA; Omeprazole results in increased expression of CYP3A4 proteinPMID:12235278 PMID:12695340 PMID:15466163 PMID:15802389 PMID:17954527 PMID:19118567 PMID:9744552
Cyp3a2increases metabolic processingISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein results in increased metabolism of OmeprazolePMID:12485723 PMID:17565714 PMID:22634058 PMID:7870052 PMID:8930576
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTD[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA]; Omeprazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Omeprazole results in increased expression of and results in increased activity of CYP3A4 proteinPMID:12695340 PMID:15802389 PMID:17041008 PMID:19299527
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