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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:5063
Term: fipronil
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fipronil.
Chemical ID: MESH:C082360
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2increases expressionEXP 6480464CTDfipronil results in increased expression of CYP3A2 mRNAPMID:23962444
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTDfipronil results in increased expression of CYP3A4 mRNAPMID:17084830 PMID:27091632
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTD[fipronil co-treated with DEET] results in increased expression of CYP3A4 mRNA; fipronil promotes the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; fipronil results in increased expression of and results in increased activity of CYP3A4 proteinPMID:17084830 PMID:27091632
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