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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:16130
Term: DDT
Definition: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.
Chemical ID: MESH:D003634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2multiple interactionsEXP 6480464CTD[DDT co-treated with Diethylnitrosamine] results in decreased expression of CYP3A2 mRNA; [DDT co-treated with Diethylnitrosamine] results in increased expression of CYP3A2 mRNAPMID:15885732
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTDDDT results in increased expression of CYP3A4 mRNA; DDT results in increased expression of CYP3A4 proteinPMID:15548381 PMID:17035600 PMID:20686338
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTD[DDT co-treated with Dieldrin] results in increased expression of CYP3A4 mRNAPMID:25028461
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