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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:80706
Term: Aflatoxin G1
Definition: A coumarin that has formula C17H12O7.
Chemical ID: MESH:C027955
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2affects metabolic processingISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein affects the metabolism of aflatoxin G1PMID:2271712 PMID:2655891
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTDaflatoxin G1 results in increased expression of CYP3A4 mRNAPMID:21641981
Cyp3a2increases response to substanceISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein results in increased susceptibility to aflatoxin G1PMID:11189750
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTDaflatoxin G1 promotes the reaction [NR1I2 protein binds to CYP3A4 promoter]PMID:21641981
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