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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:4932
Term: eupatilin
Definition: A trimethoxyflavone that is flavone substituted by hydroxy groups at C-5 and C-7 and methoxy groups at C-6, C-3' and C-4' respectively. Isolated from Citrus reticulata and Salvia tomentosa, it exhibits anti-inflammatory, anti-ulcer and antineoplastic activities.
Chemical ID: MESH:C045325
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2increases activityISOCYP3A4 (Homo sapiens)6480464CTDeupatilin results in increased activity of CYP3A4 proteinPMID:31756459
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTD[[eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of MidazolamPMID:31756459
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