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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2decreases activityEXP 6480464CTDsulforaphane results in decreased activity of CYP3A2 proteinPMID:22664424
Cyp3a2increases expressionEXP 6480464CTDsulforaphane results in increased expression of CYP3A2 proteinPMID:18823965
Cyp3a2multiple interactionsEXP 6480464CTDsulforaphane results in decreased expression of and results in decreased activity of CYP3A2 proteinPMID:15906351
Cyp3a2decreases expressionISOCYP3A4 (Homo sapiens)6480464CTDsulforaphane results in decreased expression of CYP3A4 mRNAPMID:20442190 PMID:26775663
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTDsulforaphane inhibits the reaction [ginkgolide B results in increased expression of CYP3A4 mRNA]; sulforaphane inhibits the reaction [Rifampin results in increased expression of CYP3A4]PMID:23153560 PMID:26775663
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