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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:3181
Term: bromocriptine
Definition: An indole alkaloid that has formula C32H40BrN5O5.
Chemical ID: MESH:D001971
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2affects bindingISOCYP3A4 (Homo sapiens)6480464CTDBromocriptine binds to CYP3A4 proteinPMID:17198380
Cyp3a2affects metabolic processingISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein affects the metabolism of BromocriptinePMID:15286053
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTDBromocriptine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]PMID:19299527
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