Id2 (inhibitor of DNA binding 2) - Rat Genome Database
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Gene: Id2 (inhibitor of DNA binding 2) Rattus norvegicus
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Symbol: Id2
Name: inhibitor of DNA binding 2
RGD ID: 2859
Description: Predicted to have RNA polymerase II activating transcription factor binding activity; ion channel binding activity; and molecular function regulator. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; negative regulation of transcription by RNA polymerase II; and positive regulation of cell population proliferation. Localizes to chromatin; cytosol; and nucleus. Orthologous to human ID2 (inhibitor of DNA binding 2); PARTICIPATES IN hypoxia inducible factor pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Ac2-300; DNA-binding protein inhibitor ID-2; inhibitor of differentiation 2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; inhibitor of DNA binding 2, HLH protein; MGC105494
Orthologs:
Homo sapiens (human) : ID2 (inhibitor of DNA binding 2)  HGNC  Alliance
Mus musculus (house mouse) : Id2 (inhibitor of DNA binding 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Id2 (inhibitor of DNA binding 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ID2 (inhibitor of DNA binding 2)
Canis lupus familiaris (dog) : ID2 (inhibitor of DNA binding 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Id2 (inhibitor of DNA binding 2)
Sus scrofa (pig) : ID2 (inhibitor of DNA binding 2)
Chlorocebus sabaeus (African green monkey) : ID2 (inhibitor of DNA binding 2)
Heterocephalus glaber (naked mole-rat) : Id2 (inhibitor of DNA binding 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0644,360,077 - 44,361,908 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl644,348,501 - 44,363,915 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0653,084,391 - 53,086,222 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4642,781,476 - 42,783,307 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1642,784,059 - 42,786,427 (-)NCBI
Celera641,019,266 - 41,021,097 (-)NCBICelera
Cytogenetic Map6q16NCBI
RH 3.4 Map6240.21RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-aminobenzamide  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
butanal  (ISO)
butyric acid  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
ceric oxide  (ISO)
chloroprene  (EXP,ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
Clofop  (ISO)
clozapine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dichromium trioxide  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enzacamene  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glycine betaine  (EXP)
haloperidol  (EXP)
harmine  (ISO)
hexaconazole  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
iodoacetic acid  (ISO)
irinotecan  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
methimazole  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
methylseleninic acid  (ISO)
mianserin  (ISO)
motexafin gadolinium  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
n-propyl gallate  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
nitroglycerin  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
panaxydol  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
pinosylvin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pomalidomide  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (EXP)
quercetin  (EXP,ISO)
ranitidine  (EXP)
resorcinol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
streptozocin  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-pinosylvin  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISO)
adult locomotory behavior  (ISO)
bundle of His development  (ISO)
cell development  (ISO)
cell differentiation  (IBA)
cell maturation  (ISO)
cell morphogenesis involved in neuron differentiation  (ISO)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to lithium ion  (ISO)
cellular senescence  (ISO,ISS)
circadian regulation of gene expression  (IBA,ISO,ISS)
circadian rhythm  (ISO)
embryonic digestive tract morphogenesis  (ISO,ISS)
endodermal digestive tract morphogenesis  (ISO,ISS)
entrainment of circadian clock  (ISO)
entrainment of circadian clock by photoperiod  (ISO,ISS)
enucleate erythrocyte differentiation  (ISO)
epithelial cell differentiation involved in mammary gland alveolus development  (ISO,ISS)
heart development  (ISO)
leukocyte differentiation  (ISO)
locomotor rhythm  (ISO,ISS)
mammary gland alveolus development  (ISO,ISS)
mammary gland epithelial cell proliferation  (ISO,ISS)
membranous septum morphogenesis  (ISO)
metanephros development  (ISO)
natural killer cell differentiation  (ISO)
negative regulation of B cell differentiation  (ISO)
negative regulation of core promoter binding  (ISO)
negative regulation of DNA binding  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of gene expression  (IMP,ISO,ISS)
negative regulation of muscle cell differentiation  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IDA,ISO)
negative regulation of transcription, DNA-templated  (IEA,ISO)
neuron differentiation  (IEP)
neuron fate commitment  (ISO,ISS)
olfactory bulb development  (ISO)
oligodendrocyte development  (ISO)
Peyer's patch development  (ISO)
positive regulation of astrocyte differentiation  (ISO)
positive regulation of blood pressure  (ISO,ISS)
positive regulation of cell cycle  (IDA)
positive regulation of cell cycle arrest  (ISO,ISS)
positive regulation of cell population proliferation  (IDA)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of gene expression  (ISO,ISS)
positive regulation of macrophage differentiation  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO,ISS)
positive regulation of transcription, DNA-templated  (ISO,ISS)
regulation of circadian rhythm  (ISO,ISS)
regulation of G1/S transition of mitotic cell cycle  (ISO)
regulation of gene expression  (ISO,ISS)
regulation of lipid metabolic process  (ISO,ISS)
regulation of neural precursor cell proliferation  (ISO,ISS)
regulation of neuron differentiation  (ISO,ISS)
thigmotaxis  (ISO)

Cellular Component
chromatin  (IDA)
cytoplasm  (IDA,IEA,ISO)
cytosol  (IDA,ISO)
euchromatin  (ISO)
nucleus  (IBA,IDA,IEA,ISO)
protein-containing complex  (ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1922066   PMID:7864897   PMID:8233567   PMID:9418957   PMID:9892729   PMID:10835421   PMID:12456807   PMID:12477932   PMID:12532109   PMID:12878164   PMID:14627819   PMID:15246553  
PMID:15472070   PMID:15489334   PMID:15569159   PMID:15616565   PMID:15647457   PMID:16304207   PMID:16311606   PMID:16443197   PMID:16481593   PMID:16888283   PMID:17452521   PMID:17604724  
PMID:17681138   PMID:18029094   PMID:18367557   PMID:18437010   PMID:18474814   PMID:18498089   PMID:18523151   PMID:18562627   PMID:19109490   PMID:19217292   PMID:19362560   PMID:19740747  
PMID:20815767   PMID:20861012   PMID:21330551   PMID:21675116   PMID:22041901   PMID:23264561   PMID:23994058   PMID:26187693   PMID:26768262   PMID:27938661   PMID:30143582   PMID:31539631  


Genomics

Candidate Gene Status
Id2 is a candidate Gene for QTL Kiddil2
Id2 is a candidate Gene for QTL Kiddil4
Comparative Map Data
Id2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0644,360,077 - 44,361,908 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl644,348,501 - 44,363,915 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0653,084,391 - 53,086,222 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4642,781,476 - 42,783,307 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1642,784,059 - 42,786,427 (-)NCBI
Celera641,019,266 - 41,021,097 (-)NCBICelera
Cytogenetic Map6q16NCBI
RH 3.4 Map6240.21RGD
ID2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl28,678,845 - 8,684,461 (+)EnsemblGRCh38hg38GRCh38
GRCh3828,682,056 - 8,684,461 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3728,822,113 - 8,824,583 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3628,739,564 - 8,742,034 (+)NCBINCBI36hg18NCBI36
Build 3428,772,710 - 8,775,179NCBI
Celera28,735,903 - 8,738,373 (+)NCBI
Cytogenetic Map2p25.1NCBI
HuRef28,668,297 - 8,670,767 (+)NCBIHuRef
CHM1_128,751,514 - 8,753,984 (+)NCBICHM1_1
Id2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391225,143,798 - 25,146,091 (-)NCBI
GRCm381225,093,799 - 25,096,092 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1225,093,799 - 25,097,140 (-)EnsemblGRCm38mm10GRCm38
MGSCv371225,778,664 - 25,780,957 (-)NCBIGRCm37mm9NCBIm37
MGSCv361225,682,879 - 25,685,148 (-)NCBImm8
Celera1226,550,909 - 26,553,204 (-)NCBICelera
Cytogenetic Map12A1.3NCBI
cM Map128.57NCBI
Id2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955487878,326 - 880,783 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955487878,326 - 880,783 (-)NCBIChiLan1.0ChiLan1.0
ID2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A8,847,776 - 8,850,720 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A8,847,776 - 8,850,720 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A8,681,592 - 8,684,014 (+)NCBIMhudiblu_PPA_v0panPan3
ID2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11054,954,852 - 54,957,116 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Id2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365325,236,175 - 5,238,689 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ID2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3127,500,759 - 127,503,257 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13127,500,759 - 127,503,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23135,801,813 - 135,804,261 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ID2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11498,962,001 - 98,964,486 (-)NCBI
Id2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248462,281,292 - 2,283,596 (-)NCBI

Position Markers
AI255428  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0644,360,061 - 44,360,202NCBIRnor6.0
Rnor_5.0653,084,375 - 53,084,516UniSTSRnor5.0
RGSC_v3.4642,781,460 - 42,781,601UniSTSRGSC3.4
Celera641,019,250 - 41,019,391UniSTS
Cytogenetic Map6q16UniSTS
RH94852  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0644,360,100 - 44,360,214NCBIRnor6.0
Rnor_5.0653,084,414 - 53,084,528UniSTSRnor5.0
RGSC_v3.4642,781,499 - 42,781,613UniSTSRGSC3.4
Celera641,019,289 - 41,019,403UniSTS
Cytogenetic Map6q16UniSTS
RH 3.4 Map6240.21UniSTS
PMC133998P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0644,361,150 - 44,361,844NCBIRnor6.0
Rnor_5.0653,085,464 - 53,086,158UniSTSRnor5.0
RGSC_v3.4642,782,549 - 42,783,243UniSTSRGSC3.4
Celera641,020,339 - 41,021,033UniSTS
Cytogenetic Map6q16UniSTS
PMC305683P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0644,361,150 - 44,361,844NCBIRnor6.0
Rnor_5.0653,085,464 - 53,086,158UniSTSRnor5.0
RGSC_v3.4642,782,549 - 42,783,243UniSTSRGSC3.4
Celera641,020,339 - 41,021,033UniSTS
Cytogenetic Map6q16UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6144570292Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6175623393Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112039346120393Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)6112039375023446Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)62537030111715717Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)6616172276002731Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6616172276002731Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)percentage of deaths in a study population during a period of time (CMO:0001024)67009971115379601Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)71017386255173862Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)61312295857516539Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61681010761810107Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61681010761810107Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)61941788764417887Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62151530265784818Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat
8693632Alc27Alcohol consumption QTL 272.20.791drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)63425776653855198Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63436743680490628Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63499565675623393Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63626028860606186Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63626028884763275Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63760898075023446Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63810630883106308Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63819641260606431Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64167904686679046Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64167904686679046Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64167904686679046Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:485
Count of miRNA genes:251
Interacting mature miRNAs:301
Transcripts:ENSRNOT00000009491
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 38 57 41 19 41 74 35 34 11
Low 5 8 11 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009491   ⟹   ENSRNOP00000009491
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl644,360,077 - 44,361,908 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085925   ⟹   ENSRNOP00000070000
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl644,348,501 - 44,363,915 (-)Ensembl
RefSeq Acc Id: NM_013060   ⟹   NP_037192
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0644,360,077 - 44,361,908 (-)NCBI
Rnor_5.0653,084,391 - 53,086,222 (-)NCBI
RGSC_v3.4642,781,476 - 42,783,307 (-)RGD
Celera641,019,266 - 41,021,097 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037192 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86391 (Get FASTA)   NCBI Sequence Viewer  
  AAP86283 (Get FASTA)   NCBI Sequence Viewer  
  BAA01634 (Get FASTA)   NCBI Sequence Viewer  
  EDM03197 (Get FASTA)   NCBI Sequence Viewer  
  P41137 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037192   ⟸   NM_013060
- UniProtKB: P41137 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009491   ⟸   ENSRNOT00000009491
RefSeq Acc Id: ENSRNOP00000070000   ⟸   ENSRNOT00000085925
Protein Domains
bHLH

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694526
Promoter ID:EPDNEW_R5049
Type:single initiation site
Name:Id2_1
Description:inhibitor of DNA binding 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0644,361,925 - 44,361,985EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2859 AgrOrtholog
Ensembl Genes ENSRNOG00000007237 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000009491 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000070000 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009491 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000085925 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7303450 IMAGE-MGC_LOAD
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-bd_prot-inh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25587 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105494 IMAGE-MGC_LOAD
NCBI Gene 25587 ENTREZGENE
PANTHER PTHR11723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Id2 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204649
UniGene Rn.3272 ENTREZGENE
UniProt ID2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q7TPI4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-19 Id2  inhibitor of DNA binding 2  Id2  inhibitor of DNA binding 2, HLH protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-15 Id2  inhibitor of DNA binding 2, HLH protein  Id2  inhibitor of DNA binding 2, dominant negative helix-loop-helix protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Id2  inhibitor of DNA binding 2, dominant negative helix-loop-helix protein  Id2  inhibitor of DNA binding 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Id2  inhibitor of DNA binding 2    Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein  Name updated 1299863 APPROVED
2002-06-10 Id2  Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may be involved in the early stage of neural differentiation 729182
gene_process overexpression promotes smooth muscle cell (SMC) proliferation 619536
gene_process inhibits p21 expression in smooth muscle cells 619536