Prnp (prion protein) - Rat Genome Database

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Gene: Prnp (prion protein) Rattus norvegicus
Analyze
Symbol: Prnp
Name: prion protein
RGD ID: 3410
Description: Enables several functions, including ATP-dependent protein binding activity; lamin binding activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of long-term synaptic potentiation; positive regulation of protein localization to plasma membrane; and response to copper ion. Located in postsynaptic density. Used to study hyperglycemia and scrapie. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; Huntington's disease-like 1; fatal familial insomnia; and kuru. Orthologous to human PRNP (prion protein (Kanno blood group)); PARTICIPATES IN glypican signaling pathway; iron uptake pathway; prion disease pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: major prion protein; Prion protein structural; prion protein, PrP; Prion protein, structural; Prn; PrP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83139,639,076 - 139,654,420 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3139,630,144 - 139,658,436 (+)EnsemblGRCr8
mRatBN7.23119,186,073 - 119,201,513 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3119,177,485 - 119,203,937 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3123,090,082 - 123,105,437 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03131,676,802 - 131,692,409 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03129,346,188 - 129,361,543 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03124,515,917 - 124,531,320 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3124,515,978 - 124,531,316 (+)Ensemblrn6Rnor6.0
Rnor_5.03131,009,974 - 131,025,370 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43119,676,137 - 119,691,507 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3117,986,209 - 118,001,394 (+)NCBICelera
RGSC_v3.13119,581,709 - 119,597,080 (+)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(E)-thiamethoxam  (ISO)
1,2-dichloroethane  (ISO)
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,2,2-trifluoroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
bathocuproine disulfonic acid  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (ISO)
bortezomib  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
Congo Red  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
dichloromethane  (ISO)
diethyldithiocarbamic acid  (EXP)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
edaravone  (EXP)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
ethylenediaminetetraacetic acid  (ISO)
etoposide  (ISO)
fenthion  (ISO)
filipin III  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (ISO)
glutathione  (ISO)
glyphosate  (EXP)
graphene oxide  (ISO)
GW 1929  (ISO)
heparan sulfate  (ISO)
hydrogen peroxide  (ISO)
indoxyl sulfate  (ISO)
inulin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
lead diacetate  (ISO)
lead tetraacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
luzindole  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
mercury dibromide  (ISO)
metam  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitroprusside  (ISO)
nystatin  (ISO)
o-xylene  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
Pyridostigmine bromide  (EXP)
reactive oxygen species  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamibarotene  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thapsigargin  (EXP)
thiamethoxam  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid precursor protein metabolic process  (ISO)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to copper ion  (IEA,ISO)
cellular response to xenobiotic stimulus  (IEA,ISO)
intracellular signal transduction  (IEA,ISO)
learning or memory  (IEA,IMP,ISO)
negative regulation of activated T cell proliferation  (IEA,ISO)
negative regulation of amyloid precursor protein catabolic process  (IEA,ISO)
negative regulation of amyloid-beta formation  (IEA,ISO)
negative regulation of apoptotic process  (IEA,IMP,ISO)
negative regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
negative regulation of dendritic spine maintenance  (IEA,ISO)
negative regulation of interleukin-17 production  (IEA,ISO)
negative regulation of interleukin-2 production  (IEA,ISO)
negative regulation of long-term synaptic potentiation  (IDA)
negative regulation of T cell receptor signaling pathway  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of type II interferon production  (IEA,ISO)
neuron projection maintenance  (IEA,ISO)
positive regulation of calcium-mediated signaling  (IEA,ISO)
positive regulation of glutamate receptor signaling pathway  (IEA,ISO)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of protein localization to plasma membrane  (IEA,IMP,ISO)
positive regulation of protein targeting to membrane  (IEA,ISO)
protein destabilization  (IEA,ISO)
protein homooligomerization  (IEA)
regulation of calcium ion import across plasma membrane  (IEA,ISO)
regulation of glutamate receptor signaling pathway  (IEA,ISO)
regulation of potassium ion transmembrane transport  (IEA,ISO)
regulation of protein localization  (IEA,ISO)
response to amyloid-beta  (IEA,ISO)
response to cadmium ion  (IDA)
response to copper ion  (IDA)
response to oxidative stress  (IEA,ISO)

Cellular Component
cell surface  (IEA,ISO)
cytosol  (IEA,ISO)
dendrite  (IEA,ISO)
endoplasmic reticulum  (IEA,ISO)
Golgi apparatus  (IEA,ISO)
inclusion body  (IEA,ISO)
membrane  (IEA,ISO)
membrane raft  (IEA,ISO,ISS)
mitochondrial outer membrane  (ISO)
nuclear membrane  (IEA,ISO)
plasma membrane  (IEA,ISO)
postsynaptic density  (IDA)
side of membrane  (IEA)
terminal bouton  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interaction between the cellular prion (PrPC) and the 2P domain K+ channel TREK-1 protein. Azzalin A, etal., Biochem Biophys Res Commun. 2006 Jul 21;346(1):108-15. Epub 2006 May 24.
2. Alzheimer's disease brain-derived amyloid-ß-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein. Barry AE, etal., J Neurosci. 2011 May 18;31(20):7259-63. doi: 10.1523/JNEUROSCI.6500-10.2011.
3. Rdj2, a J protein family member, interacts with cellular prion PrP(C). Beck KE, etal., Biochem Biophys Res Commun. 2006 Aug 4;346(3):866-71. Epub 2006 Jun 6.
4. Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease. Bogdan AR, etal., Trends Biochem Sci. 2016 Mar;41(3):274-86. doi: 10.1016/j.tibs.2015.11.012. Epub 2015 Dec 23.
5. The interaction between prion protein and laminin modulates memory consolidation. Coitinho AS, etal., Eur J Neurosci. 2006 Dec;24(11):3255-64.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Creutzfeldt-Jacob disease associated with the PRNP codon 200Lys mutation: an analysis of 45 families. Goldfarb LG, etal., Eur J Epidemiol. 1991 Sep;7(5):477-86.
9. Cloning of rat "prion-related protein" cDNA. Liao YC, etal., Lab Invest 1987 Oct;57(4):370-4.
10. The membrane environment of endogenous cellular prion protein in primary rat cerebellar neurons. Loberto N, etal., J Neurochem. 2005 Nov;95(3):771-83.
11. A novel vector for transgenesis in the rat CNS. Lopez TP, etal., Acta Neuropathol Commun. 2017 Nov 21;5(1):84. doi: 10.1186/s40478-017-0484-y.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Doppel-induced apoptosis and counteraction by cellular prion protein in neuroblastoma and astrocytes. Qin K, etal., Neuroscience. 2006 Sep 1;141(3):1375-88. Epub 2006 Jun 12.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Prion protein-mediated toxicity of amyloid-ß oligomers requires lipid rafts and the transmembrane LRP1. Rushworth JV, etal., J Biol Chem. 2013 Mar 29;288(13):8935-51. doi: 10.1074/jbc.M112.400358. Epub 2013 Feb 5.
22. Identification of a promoter region in the rat prion protein gene. Saeki K, etal., Biochem Biophys Res Commun 1996 Feb 6;219(1):47-52.
23. Three-exon structure of the gene encoding the rat prion protein and its expression in tissues. Saeki K, etal., Virus Genes 1996;12(1):15-20.
24. Molecular modulation of expression of prion protein by heat shock. Shyu WC, etal., Mol Neurobiol 2002 Aug;26(1):1-12.
25. Cellular prion protein localizes to the nucleus of endocrine and neuronal cells and interacts with structural chromatin components. Strom A, etal., Eur J Cell Biol. 2011 May;90(5):414-9. doi: 10.1016/j.ejcb.2010.11.015. Epub 2011 Jan 28.
26. Pronounced cytosolic aggregation of cellular prion protein in pancreatic beta-cells in response to hyperglycemia. Strom A, etal., Lab Invest. 2006 Dec 4;.
27. Alzheimer amyloid-ß oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Um JW, etal., Nat Neurosci. 2012 Sep;15(9):1227-35. doi: 10.1038/nn.3178. Epub 2012 Jul 22.
28. Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein. Um JW, etal., Neuron. 2013 Sep 4;79(5):887-902. doi: 10.1016/j.neuron.2013.06.036.
29. Induction of cellular prion protein gene expression by copper in neurons. Varela-Nallar L, etal., Am J Physiol Cell Physiol. 2006 Jan;290(1):C271-81. Epub 2005 Sep 7.
30. Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein. Wopfner F, etal., J Mol Biol 1999 Jun 25;289(5):1163-78.
Additional References at PubMed
PMID:7909925   PMID:9837873   PMID:10037495   PMID:11739375   PMID:11756421   PMID:11900542   PMID:12093733   PMID:12212939   PMID:12477932   PMID:12500977   PMID:12663673   PMID:12911750  
PMID:12927782   PMID:12970341   PMID:14660659   PMID:14741357   PMID:15208260   PMID:15229281   PMID:15262264   PMID:15489334   PMID:15670783   PMID:15753097   PMID:15891070   PMID:15911347  
PMID:16004966   PMID:16139509   PMID:16254249   PMID:16286452   PMID:17405933   PMID:17556367   PMID:17573534   PMID:17854776   PMID:18025469   PMID:18419754   PMID:18436646   PMID:19056867  
PMID:19204296   PMID:19242475   PMID:19278656   PMID:19327369   PMID:19381258   PMID:19457127   PMID:19493159   PMID:19503793   PMID:19581412   PMID:19805070   PMID:19850936   PMID:19927125  
PMID:20145049   PMID:20345906   PMID:20445063   PMID:20564047   PMID:21041683   PMID:21441913   PMID:21478263   PMID:21559407   PMID:21920025   PMID:22102467   PMID:22116041   PMID:22362149  
PMID:22449963   PMID:22854022   PMID:23376485   PMID:23892077   PMID:24225951   PMID:24386462   PMID:24554723   PMID:24780399   PMID:24859148   PMID:25058115   PMID:25931508   PMID:26149502  
PMID:26946358   PMID:28081197   PMID:32788217   PMID:37819170  


Genomics

Comparative Map Data
Prnp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83139,639,076 - 139,654,420 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3139,630,144 - 139,658,436 (+)EnsemblGRCr8
mRatBN7.23119,186,073 - 119,201,513 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3119,177,485 - 119,203,937 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3123,090,082 - 123,105,437 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03131,676,802 - 131,692,409 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03129,346,188 - 129,361,543 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03124,515,917 - 124,531,320 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3124,515,978 - 124,531,316 (+)Ensemblrn6Rnor6.0
Rnor_5.03131,009,974 - 131,025,370 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43119,676,137 - 119,691,507 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3117,986,209 - 118,001,394 (+)NCBICelera
RGSC_v3.13119,581,709 - 119,597,080 (+)NCBI
Cytogenetic Map3q36NCBI
PRNP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38204,686,456 - 4,701,588 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl204,685,730 - 4,701,590 (+)Ensemblhg38GRCh38
GRCh37204,667,102 - 4,682,234 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36204,614,797 - 4,630,234 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34204,615,068 - 4,630,233NCBI
Celera204,736,512 - 4,751,948 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef204,620,194 - 4,635,632 (+)NCBIHuRef
CHM1_1204,667,528 - 4,682,967 (+)NCBICHM1_1
T2T-CHM13v2.0204,725,692 - 4,740,800 (+)NCBIT2T-CHM13v2.0
Prnp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,751,848 - 131,780,356 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2131,751,848 - 131,780,349 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382131,909,928 - 131,938,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,909,928 - 131,938,429 (+)Ensemblmm10GRCm38
MGSCv372131,735,664 - 131,764,167 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362131,601,398 - 131,629,868 (+)NCBIMGSCv36mm8
Celera2133,143,177 - 133,164,079 (+)NCBICelera
Cytogenetic Map2F2NCBI
cM Map264.07NCBI
Prnp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541515,442,313 - 15,454,644 (+)Ensembl
ChiLan1.0NW_00495541515,442,313 - 15,454,644 (+)NCBIChiLan1.0ChiLan1.0
PRNP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2215,641,025 - 5,656,375 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1205,637,965 - 5,653,199 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0204,713,616 - 4,728,847 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1204,523,141 - 4,525,522 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl204,523,155 - 4,523,916 (+)EnsemblpanPan2panpan1.1
PRNP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12416,845,224 - 16,862,319 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2416,846,207 - 16,859,815 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2416,670,727 - 16,671,500 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02417,263,379 - 17,280,460 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2417,263,381 - 17,280,378 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12416,859,351 - 16,860,124 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02416,965,836 - 16,966,609 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02417,299,279 - 17,300,052 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prnp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640165,673,463 - 165,687,259 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648514,104,831 - 14,118,629 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648514,104,829 - 14,118,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRNP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1713,694,190 - 13,705,124 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11713,694,195 - 13,705,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21714,656,638 - 14,667,625 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRNP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1233,368,020 - 33,384,556 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl233,369,629 - 33,370,366 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607111,150,240 - 11,165,879 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prnp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247415,785,158 - 5,802,162 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247415,785,139 - 5,802,162 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Prnp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15111,647,621 - 111,662,784 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prnp
80 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:391
Count of miRNA genes:233
Interacting mature miRNAs:278
Transcripts:ENSRNOT00000028881
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3136091420155634702Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
PMC125625P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23119,199,522 - 119,200,287 (+)MAPPERmRatBN7.2
Rnor_6.03124,529,330 - 124,530,094NCBIRnor6.0
Rnor_5.03131,023,380 - 131,024,144UniSTSRnor5.0
RGSC_v3.43119,689,521 - 119,690,285UniSTSRGSC3.4
Celera3117,999,408 - 118,000,172UniSTS
Cytogenetic Map3q36UniSTS
PMC136859P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23119,199,810 - 119,200,285 (+)MAPPERmRatBN7.2
Rnor_6.03124,529,618 - 124,530,092NCBIRnor6.0
Rnor_5.03131,023,668 - 131,024,142UniSTSRnor5.0
RGSC_v3.43119,689,809 - 119,690,283UniSTSRGSC3.4
Celera3117,999,696 - 118,000,170UniSTS
Cytogenetic Map3q36UniSTS
RH129872  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23119,201,126 - 119,201,327 (+)MAPPERmRatBN7.2
Rnor_6.03124,530,934 - 124,531,134NCBIRnor6.0
Rnor_5.03131,024,984 - 131,025,184UniSTSRnor5.0
RGSC_v3.43119,691,125 - 119,691,325UniSTSRGSC3.4
Celera3118,001,012 - 118,001,212UniSTS
RH 3.4 Map31003.9UniSTS
Cytogenetic Map3q36UniSTS
RH140731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23119,200,591 - 119,200,729 (+)MAPPERmRatBN7.2
Rnor_6.03124,530,399 - 124,530,536NCBIRnor6.0
Rnor_5.03131,024,449 - 131,024,586UniSTSRnor5.0
RGSC_v3.43119,690,590 - 119,690,727UniSTSRGSC3.4
Celera3118,000,477 - 118,000,614UniSTS
RH 3.4 Map31003.8UniSTS
Cytogenetic Map3q36UniSTS
Prnp  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23119,200,553 - 119,200,783 (+)MAPPERmRatBN7.2
Rnor_6.03124,530,361 - 124,530,590NCBIRnor6.0
Rnor_5.03131,024,411 - 131,024,640UniSTSRnor5.0
RGSC_v3.43119,690,552 - 119,690,781UniSTSRGSC3.4
Celera3118,000,439 - 118,000,668UniSTS
Cytogenetic Map3q36UniSTS
Prnp  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83139,652,429 - 139,652,722 (+)Marker Load Pipeline
mRatBN7.23119,199,522 - 119,199,814 (+)MAPPERmRatBN7.2
Rnor_6.03124,529,330 - 124,529,621NCBIRnor6.0
Rnor_5.03131,023,380 - 131,023,671UniSTSRnor5.0
Celera3117,999,408 - 117,999,699UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028881   ⟹   ENSRNOP00000028881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3139,642,133 - 139,654,419 (+)Ensembl
Rnor_6.0 Ensembl3124,515,978 - 124,531,316 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094429   ⟹   ENSRNOP00000081843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3139,630,144 - 139,656,266 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098238   ⟹   ENSRNOP00000089546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3139,638,834 - 139,658,436 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104185   ⟹   ENSRNOP00000093351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3139,639,048 - 139,654,195 (+)Ensembl
mRatBN7.2 Ensembl3119,186,177 - 119,201,327 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106614   ⟹   ENSRNOP00000093957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3139,638,492 - 139,657,503 (+)Ensembl
mRatBN7.2 Ensembl3119,186,081 - 119,203,937 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113525   ⟹   ENSRNOP00000085462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3139,639,367 - 139,656,592 (+)Ensembl
mRatBN7.2 Ensembl3119,177,485 - 119,201,510 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117610   ⟹   ENSRNOP00000096232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3139,630,269 - 139,656,892 (+)Ensembl
mRatBN7.2 Ensembl3119,186,081 - 119,203,937 (+)Ensembl
RefSeq Acc Id: NM_001395658   ⟹   NP_001382587
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83139,639,076 - 139,654,420 (+)NCBI
mRatBN7.23119,186,166 - 119,201,513 (+)NCBI
RefSeq Acc Id: NM_012631   ⟹   NP_036763
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83139,639,078 - 139,654,416 (+)NCBI
mRatBN7.23119,186,168 - 119,201,509 (+)NCBI
Rnor_6.03124,515,978 - 124,531,316 (+)NCBI
Rnor_5.03131,009,974 - 131,025,370 (+)NCBI
RGSC_v3.43119,676,137 - 119,691,507 (+)RGD
Celera3117,986,209 - 118,001,394 (+)RGD
Sequence:
RefSeq Acc Id: XM_063283102   ⟹   XP_063139172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83139,643,046 - 139,654,420 (+)NCBI
RefSeq Acc Id: NP_036763   ⟸   NM_012631
- Peptide Label: precursor
- UniProtKB: Q549H6 (UniProtKB/Swiss-Prot),   P13852 (UniProtKB/Swiss-Prot),   A6HQE9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028881   ⟸   ENSRNOT00000028881
Ensembl Acc Id: ENSRNOP00000093957   ⟸   ENSRNOT00000106614
Ensembl Acc Id: ENSRNOP00000096232   ⟸   ENSRNOT00000117610
Ensembl Acc Id: ENSRNOP00000085462   ⟸   ENSRNOT00000113525
Ensembl Acc Id: ENSRNOP00000093351   ⟸   ENSRNOT00000104185
RefSeq Acc Id: NP_001382587   ⟸   NM_001395658
- Peptide Label: precursor
- UniProtKB: P13852 (UniProtKB/Swiss-Prot),   Q549H6 (UniProtKB/Swiss-Prot),   A6HQE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139172   ⟸   XM_063283102
- Peptide Label: isoform X1
- UniProtKB: Q549H6 (UniProtKB/Swiss-Prot),   P13852 (UniProtKB/Swiss-Prot),   A6HQE9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089546   ⟸   ENSRNOT00000098238
Ensembl Acc Id: ENSRNOP00000081843   ⟸   ENSRNOT00000094429
Protein Domains
Prion/Doppel protein beta-ribbon

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13852-F1-model_v2 AlphaFold P13852 1-254 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692451
Promoter ID:EPDNEW_R2976
Type:multiple initiation site
Name:Prnp_1
Description:prion protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03124,515,986 - 124,516,046EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3410 AgrOrtholog
BioCyc Gene G2FUF-47793 BioCyc
Ensembl Genes ENSRNOG00000021259 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000098238 ENTREZGENE
  ENSRNOT00000104185.1 UniProtKB/Swiss-Prot
  ENSRNOT00000106614 ENTREZGENE
  ENSRNOT00000106614.1 UniProtKB/Swiss-Prot
  ENSRNOT00000113525.1 UniProtKB/Swiss-Prot
  ENSRNOT00000117610.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.790.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7099864 IMAGE-MGC_LOAD
InterPro Prion UniProtKB/Swiss-Prot
  Prion/Doppel_b-ribbon_dom_sf UniProtKB/Swiss-Prot
  Prion/Doppel_prot_b-ribbon_dom UniProtKB/Swiss-Prot
  Prion_copper_b_octapeptide UniProtKB/Swiss-Prot
  Prion_N_dom UniProtKB/Swiss-Prot
KEGG Report rno:24686 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91417 IMAGE-MGC_LOAD
NCBI Gene 24686 ENTREZGENE
PANTHER DOPPEL PRION UniProtKB/Swiss-Prot
  MAJOR PRION PROTEIN UniProtKB/Swiss-Prot
Pfam Prion UniProtKB/Swiss-Prot
  Prion_bPrPp UniProtKB/Swiss-Prot
  Prion_octapep UniProtKB/Swiss-Prot
PhenoGen Prnp PhenoGen
PRINTS PRION UniProtKB/Swiss-Prot
PROSITE PRION_1 UniProtKB/Swiss-Prot
  PRION_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021259 RatGTEx
SMART PRP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54098 UniProtKB/Swiss-Prot
UniProt A6HQE9 ENTREZGENE, UniProtKB/TrEMBL
  P13852 ENTREZGENE, UniProtKB/Swiss-Prot
  Q549H6 ENTREZGENE
UniProt Secondary Q549H6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Prnp  prion protein    Prion protein, structural  Name updated 629478 APPROVED
2002-06-10 Prnp  Prion protein, structural      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization attached to plasma membrane by glycoinositol phospholipid (GPI) anchor 729621
gene_homology flexible region of structured segment (121-231 aa) conserved within 27 mammalian and 9 avian species 729621