LOC101959784 (prion protein) - Rat Genome Database

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Gene: LOC101959784 (prion protein) Ictidomys tridecemlineatus
Analyze
Symbol: LOC101959784
Name: prion protein
RGD ID: 12676483
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); aspartic-type endopeptidase inhibitor activity (ortholog); ATP-dependent protein binding (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); amyloid precursor protein metabolic process (ortholog); calcium-mediated signaling using intracellular calcium source (ortholog); PARTICIPATES IN glypican signaling pathway; iron uptake pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Creutzfeldt-Jakob disease (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: prion protein PrP; Prnp
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640165,673,463 - 165,687,259 (-)NCBI
SpeTri2.0NW_00493648514,104,829 - 14,118,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
amyloid precursor protein metabolic process  (ISO)
calcium-mediated signaling using intracellular calcium source  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to copper ion  (ISO)
cellular response to xenobiotic stimulus  (ISO)
learning or memory  (ISO)
modulation of age-related behavioral decline  (ISO)
negative regulation of activated T cell proliferation  (ISO)
negative regulation of amyloid precursor protein catabolic process  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of calcineurin-NFAT signaling cascade  (ISO)
negative regulation of catalytic activity  (ISO)
negative regulation of dendritic spine maintenance  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of interferon-gamma production  (ISO)
negative regulation of interleukin-17 production  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of long-term synaptic potentiation  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of T cell receptor signaling pathway  (ISO)
neuron projection maintenance  (ISO)
positive regulation of cell death  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein targeting to membrane  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
protein destabilization  (ISO)
regulation of calcium ion import across plasma membrane  (ISO)
regulation of glutamate receptor signaling pathway  (ISO)
regulation of intracellular calcium activated chloride channel activity  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of potassium ion transmembrane transport  (ISO)
regulation of protein localization  (ISO)
response to amyloid-beta  (ISO)
response to cadmium ion  (ISO)
response to copper ion  (ISO)
response to oxidative stress  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:17199895  


Genomics

Comparative Map Data
LOC101959784
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640165,673,463 - 165,687,259 (-)NCBI
SpeTri2.0NW_00493648514,104,829 - 14,118,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRNP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl204,686,350 - 4,701,590 (+)EnsemblGRCh38hg38GRCh38
GRCh38204,686,456 - 4,701,588 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37204,667,102 - 4,682,234 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36204,614,797 - 4,630,234 (+)NCBINCBI36hg18NCBI36
Build 34204,615,068 - 4,630,233NCBI
Celera204,736,512 - 4,751,948 (+)NCBI
Cytogenetic Map20p13NCBI
HuRef204,620,194 - 4,635,632 (+)NCBIHuRef
CHM1_1204,667,528 - 4,682,967 (+)NCBICHM1_1
Prnp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,751,848 - 131,780,356 (+)NCBIGRCm39mm39
GRCm39 Ensembl2131,751,848 - 131,780,349 (+)Ensembl
GRCm382131,909,928 - 131,938,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,909,928 - 131,938,429 (+)EnsemblGRCm38mm10GRCm38
MGSCv372131,735,664 - 131,764,167 (+)NCBIGRCm37mm9NCBIm37
MGSCv362131,601,398 - 131,629,868 (+)NCBImm8
Celera2133,143,177 - 133,164,079 (+)NCBICelera
Cytogenetic Map2F2NCBI
cM Map264.07NCBI
Prnp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23119,186,073 - 119,201,513 (+)NCBI
Rnor_6.0 Ensembl3124,515,978 - 124,531,316 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03124,515,917 - 124,531,320 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03131,009,974 - 131,025,370 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43119,676,137 - 119,691,507 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13119,581,709 - 119,597,080 (+)NCBI
Celera3117,986,209 - 118,001,394 (+)NCBICelera
Cytogenetic Map3q36NCBI
Prnp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541515,442,313 - 15,454,644 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541515,442,313 - 15,454,644 (+)NCBIChiLan1.0ChiLan1.0
PRNP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1204,523,141 - 4,525,522 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl204,523,155 - 4,523,916 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0204,713,616 - 4,728,847 (+)NCBIMhudiblu_PPA_v0panPan3
PRNP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12416,845,224 - 16,862,319 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2416,846,207 - 16,859,815 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2416,670,727 - 16,671,500 (-)NCBI
ROS_Cfam_1.02417,263,379 - 17,280,460 (-)NCBI
UMICH_Zoey_3.12416,859,351 - 16,860,124 (-)NCBI
UNSW_CanFamBas_1.02416,965,836 - 16,966,609 (-)NCBI
UU_Cfam_GSD_1.02417,299,279 - 17,300,052 (-)NCBI
PRNP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1713,693,628 - 13,705,318 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11713,694,195 - 13,705,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21714,656,638 - 14,667,625 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103247014
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1233,368,020 - 33,384,556 (-)NCBI
ChlSab1.1 Ensembl233,369,629 - 33,370,366 (-)Ensembl
Vero_WHO_p1.0NW_02366607111,150,240 - 11,165,879 (+)NCBI
Prnp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247415,785,139 - 5,802,162 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005320503   ⟹   XP_005320560
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640165,673,463 - 165,687,259 (-)NCBI
SpeTri2.0NW_00493648514,104,829 - 14,118,614 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040274357   ⟹   XP_040130291
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640165,673,463 - 165,687,259 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005320560 (Get FASTA)   NCBI Sequence Viewer  
  XP_040130291 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAL59563 (Get FASTA)   NCBI Sequence Viewer  
  KAG3262888 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005320560   ⟸   XM_005320503
- UniProtKB: A2BDI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040130291   ⟸   XM_040274357

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000015372 ENTREZGENE
Ensembl Protein ENSSTOP00000013768 ENTREZGENE
NCBI Gene Prnp ENTREZGENE
UniProt A2BDI4 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 LOC101959784  prion protein  Prnp  prion protein  Symbol and/or name change 5135510 APPROVED