Kcnk2 (potassium two pore domain channel subfamily K member 2) - Rat Genome Database

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Gene: Kcnk2 (potassium two pore domain channel subfamily K member 2) Rattus norvegicus
Analyze
Symbol: Kcnk2
Name: potassium two pore domain channel subfamily K member 2
RGD ID: 621448
Description: Enables outward rectifier potassium channel activity; potassium channel inhibitor activity; and potassium ion leak channel activity. Involved in several processes, including cochlea development; negative regulation of cardiac muscle cell proliferation; and positive regulation of cellular response to hypoxia. Located in several cellular components, including apical plasma membrane; astrocyte projection; and calyx of Held. Used to study transient cerebral ischemia. Biomarker of brain ischemia; congestive heart failure; myocardial infarction; and transient cerebral ischemia. Orthologous to human KCNK2 (potassium two pore domain channel subfamily K member 2); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: arachidonic acid sensitive tandem pore domain potassium channel; ion transport membrane protein; outward rectifying potassium channel protein TREK-1; potassium channel subfamily K member 2; potassium channel, subfamily K, member 2; potassium channel, two pore domain subfamily K, member 2; rTREK1d; stretch-activated potassium channel TREK-1; tandem-pore-domain potassium channel TREK-1; Trek-1; TREK-1 K(+) channel subunit; two pore domain potassium channel TREK-1; two pore potassium channel TPKC1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.213100,766,101 - 100,963,435 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13100,766,113 - 100,963,435 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13103,281,547 - 103,478,878 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.013104,670,332 - 104,867,622 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.013101,869,487 - 102,066,094 (-)NCBIRnor_WKY
Rnor_6.013107,690,111 - 107,886,476 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13107,690,087 - 107,886,476 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013112,318,467 - 112,512,344 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413105,376,001 - 105,574,238 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113105,665,411 - 105,705,891 (-)NCBI
Celera13100,255,787 - 100,450,992 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
camptothecin  (ISO)
CGP 52608  (ISO)
chlorohydrocarbon  (EXP)
clozapine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumarin  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
diltiazem  (ISO)
dioxygen  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fipronil  (EXP)
flufenamic acid  (ISO)
fluoxetine  (EXP,ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
halothane  (ISO)
lipopolysaccharide  (ISO)
mefenamic acid  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (EXP)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (EXP)
Niflumic acid  (ISO)
permethrin  (EXP)
potassium atom  (ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
Tesaglitazar  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. TREK-1, a K+ channel involved in polymodal pain perception. Alloui A, etal., EMBO J. 2006 Jun 7;25(11):2368-76. Epub 2006 May 4.
2. Interaction between the cellular prion (PrPC) and the 2P domain K+ channel TREK-1 protein. Azzalin A, etal., Biochem Biophys Res Commun. 2006 Jul 21;346(1):108-15. Epub 2006 May 24.
3. Axonal transport of TREK and TRAAK potassium channels in rat sciatic nerves. Bearzatto B, etal., Neuroreport. 2000 Apr 7;11(5):927-30.
4. Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline. Benoist D, etal., Prog Biophys Mol Biol. 2014 Aug;115(2-3):162-72. doi: 10.1016/j.pbiomolbio.2014.06.008. Epub 2014 Jul 9.
5. KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Bockenhauer D, etal., Nat Neurosci 2001 May;4(5):486-91.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. Gu W, etal., J Physiol 2002 Mar 15;539(Pt 3):657-68.
9. Distribution and expression of TREK-1, a two-pore-domain potassium channel, in the adult rat CNS. Hervieu GJ, etal., Neuroscience. 2001;103(4):899-919.
10. TREK-1, a K+ channel involved in neuroprotection and general anesthesia. Heurteaux C, etal., EMBO J. 2004 Jul 7;23(13):2684-95. Epub 2004 Jun 3.
11. Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype. Heurteaux C, etal., Nat Neurosci. 2006 Sep;9(9):1134-41. Epub 2006 Aug 13.
12. Developmental expression of two-pore domain K+ channels, TASK-1 and TREK-1, in the rat cochlea. Kanjhan R, etal., Neuroreport. 2004 Mar 1;15(3):437-41.
13. Enhancement of K2P2.1 (TREK1) background currents expressed in Xenopus oocytes by voltage-gated K+ channel beta subunits. Kisselbach J, etal., Life Sci. 2012 Oct 5;91(11-12):377-83. doi: 10.1016/j.lfs.2012.08.011. Epub 2012 Aug 15.
14. Linolenic acid provides multi-cellular protective effects after photothrombotic cerebral ischemia in rats. Liu Y, etal., Neurochem Res. 2014 Sep;39(9):1797-808. doi: 10.1007/s11064-014-1390-3. Epub 2014 Jul 26.
15. Leak K(+) channel mRNAs in dorsal root ganglia: relation to inflammation and spontaneous pain behaviour. Marsh B, etal., Mol Cell Neurosci. 2012 Mar;49(3):375-86. doi: 10.1016/j.mcn.2012.01.002. Epub 2012 Jan 16.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Localization of TREK-1, a two-pore-domain K+ channel in the peripheral vestibular system of mouse and rat. Nicolas MT, etal., Brain Res. 2004 Aug 13;1017(1-2):46-52.
19. [mRNA expression alteration of two-pore potassium channels in the brain of beta-amyloid peptide25-35-induced memory impaired rats]. Pan YP, etal., Yao Xue Xue Bao. 2003 Oct;38(10):721-4.
20. Distribution of two-pore-domain potassium channels in the adult rat vestibular periphery. Popper P, etal., Hear Res. 2008 Dec;246(1-2):1-8. doi: 10.1016/j.heares.2008.09.004. Epub 2008 Sep 20.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels. Rinne S, etal., Pflugers Arch. 2013 Nov 7.
25. Trek-like potassium channels in rat cardiac ventricular myocytes are activated by intracellular ATP. Tan JH, etal., J Membr Biol 2002 Feb 1;185(3):201-7.
26. A TREK-1-like potassium channel in atrial cells inhibited by beta-adrenergic stimulation and activated by volatile anesthetics. Terrenoire C, etal., Circ Res. 2001 Aug 17;89(4):336-42.
27. Activation of K(2)P channel-TREK1 mediates the neuroprotection induced by sevoflurane preconditioning. Tong L, etal., Br J Anaesth. 2014 Jul;113(1):157-67. doi: 10.1093/bja/aet338. Epub 2013 Oct 22.
28. An increased TREK-1-like potassium current in ventricular myocytes during rat cardiac hypertrophy. Wang W, etal., J Cardiovasc Pharmacol. 2013 Apr;61(4):302-10. doi: 10.1097/FJC.0b013e318280c5a9.
29. TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation. Woo DH, etal., Cell. 2012 Sep 28;151(1):25-40. doi: 10.1016/j.cell.2012.09.005.
30. Small RNA interference-mediated gene silencing of TREK-1 potassium channel in cultured astrocytes. Wu X, etal., J Huazhong Univ Sci Technolog Med Sci. 2012 Dec;32(6):849-55. doi: 10.1007/s11596-012-1046-y. Epub 2012 Dec 28.
31. Alterations in the expression of lipid and mechano-gated two-pore domain potassium channel genes in rat brain following chronic cerebral ischemia. Xu X, etal., Brain Res Mol Brain Res. 2004 Jan 5;120(2):205-9.
32. Functional study of TREK-1 potassium channels during rat heart development and cardiac ischemia using RNAi techniques. Yang X, etal., J Cardiovasc Pharmacol. 2014 Aug;64(2):142-50. doi: 10.1097/FJC.0000000000000099.
33. TREK1 activation mediates spinal cord ischemic tolerance induced by isoflurane preconditioning in rats. Yin X, etal., Neurosci Lett. 2012 May 2;515(2):115-20. doi: 10.1016/j.neulet.2012.03.006. Epub 2012 Mar 10.
34. Effects of acute mechanical stretch on the expression of mechanosensitive potassium channel TREK-1 in rat left ventricle. Zhao F, etal., J Huazhong Univ Sci Technolog Med Sci. 2007 Aug;27(4):385-7.
35. Regional differential expression of TREK-1 at left ventricle in myocardial infarction. Zhao LN, etal., Can J Cardiol. 2011 Nov-Dec;27(6):826-33. doi: 10.1016/j.cjca.2011.01.013. Epub 2011 Jun 16.
36. TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices. Zhou M, etal., J Neurosci. 2009 Jul 1;29(26):8551-64. doi: 10.1523/JNEUROSCI.5784-08.2009.
Additional References at PubMed
PMID:11560940   PMID:15123558   PMID:16248991   PMID:17345093   PMID:17556656   PMID:18579077   PMID:19363137   PMID:19429069   PMID:20605797   PMID:21789545   PMID:21822218   PMID:22354168  
PMID:22726831   PMID:22895843   PMID:24402080   PMID:25539776   PMID:25675906   PMID:25778785   PMID:29462125   PMID:29736614   PMID:29980241   PMID:31091801   PMID:31630908   PMID:31959866  
PMID:32439217   PMID:33006141   PMID:36650581  


Genomics

Comparative Map Data
Kcnk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.213100,766,101 - 100,963,435 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13100,766,113 - 100,963,435 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13103,281,547 - 103,478,878 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.013104,670,332 - 104,867,622 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.013101,869,487 - 102,066,094 (-)NCBIRnor_WKY
Rnor_6.013107,690,111 - 107,886,476 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13107,690,087 - 107,886,476 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013112,318,467 - 112,512,344 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413105,376,001 - 105,574,238 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113105,665,411 - 105,705,891 (-)NCBI
Celera13100,255,787 - 100,450,992 (-)NCBICelera
Cytogenetic Map13q26NCBI
KCNK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381215,005,542 - 215,237,090 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1215,005,775 - 215,237,090 (+)EnsemblGRCh38hg38GRCh38
GRCh371215,178,885 - 215,410,433 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361213,245,508 - 213,477,059 (+)NCBINCBI36Build 36hg18NCBI36
Build 341211,645,030 - 211,797,553NCBI
Celera1188,402,753 - 188,634,228 (+)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1185,853,513 - 186,084,965 (+)NCBIHuRef
CHM1_11216,451,204 - 216,682,774 (+)NCBICHM1_1
T2T-CHM13v2.01214,245,543 - 214,477,417 (+)NCBIT2T-CHM13v2.0
Kcnk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391188,940,127 - 189,134,979 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1188,940,127 - 189,134,470 (-)EnsemblGRCm39 Ensembl
GRCm381189,207,930 - 189,402,782 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1189,207,930 - 189,402,273 (-)EnsemblGRCm38mm10GRCm38
MGSCv371191,031,809 - 191,168,071 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361190,908,721 - 191,044,620 (-)NCBIMGSCv36mm8
Celera1196,121,799 - 196,265,023 (-)NCBICelera
Cytogenetic Map1H6NCBI
Kcnk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554062,791,803 - 2,975,322 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554062,793,493 - 2,975,322 (-)NCBIChiLan1.0ChiLan1.0
KCNK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11195,431,036 - 195,660,681 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1195,430,994 - 195,662,840 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01190,576,180 - 190,807,367 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
KCNK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1712,893,654 - 13,092,319 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl712,894,149 - 13,090,110 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha712,470,423 - 12,670,630 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0712,747,271 - 12,810,022 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1712,529,565 - 12,729,453 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0712,634,038 - 12,833,989 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0712,759,762 - 12,959,899 (+)NCBIUU_Cfam_GSD_1.0
Kcnk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934461,143,721 - 61,335,855 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366283,154,109 - 3,345,660 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366283,155,261 - 3,284,375 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9128,429,092 - 128,661,639 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19128,429,232 - 128,659,662 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29141,099,533 - 141,161,034 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12514,341,147 - 14,570,982 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2514,340,123 - 14,487,420 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605514,803,316 - 15,034,481 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477119,984,857 - 20,164,021 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477120,040,685 - 20,166,992 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnk2
1002 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:260
Count of miRNA genes:184
Interacting mature miRNAs:217
Transcripts:ENSRNOT00000003684
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
D13Got97  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213100,787,568 - 100,787,768 (+)MAPPERmRatBN7.2
Rnor_6.013107,711,426 - 107,711,625NCBIRnor6.0
Rnor_5.013112,339,268 - 112,339,467UniSTSRnor5.0
RGSC_v3.413105,397,294 - 105,397,494RGDRGSC3.4
RGSC_v3.413105,397,295 - 105,397,494UniSTSRGSC3.4
RGSC_v3.113105,586,399 - 105,586,598RGD
Celera13100,277,138 - 100,277,337UniSTS
RH 3.4 Map13686.1UniSTS
RH 3.4 Map13686.1RGD
RH 2.0 Map13731.3RGD
Cytogenetic Map13q26UniSTS
RH129439  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213100,766,176 - 100,766,394 (+)MAPPERmRatBN7.2
Rnor_6.013107,690,187 - 107,690,404NCBIRnor6.0
Rnor_5.013112,318,539 - 112,318,756UniSTSRnor5.0
RGSC_v3.413105,376,067 - 105,376,284UniSTSRGSC3.4
Celera13100,255,853 - 100,256,070UniSTS
RH 3.4 Map13686.1UniSTS
Cytogenetic Map13q26UniSTS
RH130296  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213100,766,117 - 100,766,297 (+)MAPPERmRatBN7.2
Rnor_6.013107,690,128 - 107,690,307NCBIRnor6.0
Rnor_5.013112,318,480 - 112,318,659UniSTSRnor5.0
RGSC_v3.413105,376,008 - 105,376,187UniSTSRGSC3.4
Celera13100,255,794 - 100,255,973UniSTS
RH 3.4 Map13687.1UniSTS
Cytogenetic Map13q26UniSTS
RH144239  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213100,908,968 - 100,909,102 (+)MAPPERmRatBN7.2
Rnor_6.013107,832,259 - 107,832,392NCBIRnor6.0
Rnor_5.013112,458,148 - 112,458,281UniSTSRnor5.0
RGSC_v3.413105,518,375 - 105,518,508UniSTSRGSC3.4
Celera13100,397,007 - 100,397,140UniSTS
RH 3.4 Map13701.2UniSTS
Cytogenetic Map13q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 60 2
Low 3 38 22 6 8 6 7 9 14 20 37 9 7
Below cutoff 24 24 5 24 1 2 15 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003684   ⟹   ENSRNOP00000003684
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13100,766,113 - 100,907,381 (-)Ensembl
Rnor_6.0 Ensembl13107,690,087 - 107,831,014 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077282   ⟹   ENSRNOP00000068842
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13100,767,911 - 100,963,435 (-)Ensembl
Rnor_6.0 Ensembl13107,691,921 - 107,886,476 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103519   ⟹   ENSRNOP00000077148
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13100,767,911 - 100,908,274 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107139   ⟹   ENSRNOP00000087071
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13100,767,911 - 100,907,559 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111587   ⟹   ENSRNOP00000091791
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13100,767,911 - 100,963,435 (-)Ensembl
RefSeq Acc Id: NM_172041   ⟹   NP_742038
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213100,767,911 - 100,963,435 (-)NCBI
Rnor_6.013107,691,921 - 107,886,476 (-)NCBI
Rnor_5.013112,318,467 - 112,512,344 (-)NCBI
RGSC_v3.413105,376,001 - 105,574,238 (-)RGD
Celera13100,257,587 - 100,450,992 (-)NCBI
Sequence:
RefSeq Acc Id: NM_172042   ⟹   NP_742039
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213100,766,111 - 100,907,381 (-)NCBI
Rnor_6.013107,690,121 - 107,830,671 (-)NCBI
Rnor_5.013112,318,467 - 112,512,344 (-)NCBI
RGSC_v3.413105,376,001 - 105,574,238 (-)RGD
Celera13100,255,787 - 100,395,419 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250433   ⟹   XP_006250495
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213100,766,101 - 100,908,494 (-)NCBI
Rnor_6.013107,690,111 - 107,831,808 (-)NCBI
Rnor_5.013112,318,467 - 112,512,344 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250434   ⟹   XP_006250496
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.213100,766,105 - 100,907,654 (-)NCBI
Rnor_6.013107,690,111 - 107,831,485 (-)NCBI
Rnor_5.013112,318,467 - 112,512,344 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_742039   ⟸   NM_172042
- Peptide Label: isoform 2
- UniProtKB: Q5DNW5 (UniProtKB/Swiss-Prot),   Q920B6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_742038   ⟸   NM_172041
- Peptide Label: isoform 1
- UniProtKB: Q920B6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006250495   ⟸   XM_006250433
- Peptide Label: isoform X1
- UniProtKB: Q920B6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006250496   ⟸   XM_006250434
- Peptide Label: isoform X2
- UniProtKB: Q920B6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068842   ⟸   ENSRNOT00000077282
RefSeq Acc Id: ENSRNOP00000003684   ⟸   ENSRNOT00000003684
RefSeq Acc Id: ENSRNOP00000077148   ⟸   ENSRNOT00000103519
RefSeq Acc Id: ENSRNOP00000087071   ⟸   ENSRNOT00000107139
RefSeq Acc Id: ENSRNOP00000091791   ⟸   ENSRNOT00000111587
Protein Domains
Ion_trans_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q920B6-F1-model_v2 AlphaFold Q920B6 1-426 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621448 AgrOrtholog
BioCyc Gene G2FUF-16903 BioCyc
Ensembl Genes ENSRNOG00000002653 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003684 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000068842 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000077148 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000087071 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000091791.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003684 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000077282 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000103519 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000107139 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000111587.1 UniProtKB/TrEMBL
InterPro 2pore_dom_K_chnl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2pore_dom_K_chnl_TREK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170899 UniProtKB/Swiss-Prot
NCBI Gene 170899 ENTREZGENE
PANTHER PTHR11003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ion_trans_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnk2 PhenoGen
PRINTS 2POREKCHANEL UniProtKB/Swiss-Prot
  TREKCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AFV9_RAT UniProtKB/TrEMBL
  KCNK2_RAT UniProtKB/Swiss-Prot
  Q5DNW5 ENTREZGENE
  Q920B6 ENTREZGENE
UniProt Secondary A3QR52 UniProtKB/Swiss-Prot
  Q3MMY3 UniProtKB/Swiss-Prot
  Q5DNW4 UniProtKB/Swiss-Prot
  Q5DNW5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnk2  potassium two pore domain channel subfamily K member 2  Kcnk2  potassium channel, two pore domain subfamily K, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnk2  potassium channel, two pore domain subfamily K, member 2  Kcnk2  potassium channel, subfamily K, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Kcnk2  potassium channel, subfamily K, member 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kcnk2  potassium channel, subfamily K, member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the tandem pore family 633143
gene_regulation channel activated directly by ATP 633143