1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of KCNK2 mRNA CTD PMID:30723492 14-Deoxy-11,12-didehydroandrographolide decreases expression ISO RGD:1354126 6480464 14-deoxy-11, 12-didehydroandrographolide results in decreased expression of KCNK2 mRNA CTD PMID:22101062 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of KCNK2 mRNA CTD PMID:26865667 17beta-estradiol 3-benzoate increases methylation EXP 6480464 estradiol 3-benzoate results in increased methylation of KCNK2 promoter CTD PMID:27415467 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:732064 6480464 Tetrachlorodibenzodioxin results in increased expression of KCNK2 mRNA CTD PMID:19933214 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:732064 6480464 Tetrachlorodibenzodioxin affects the expression of KCNK2 mRNA CTD PMID:21570461 2,4-diaminotoluene increases expression ISO RGD:732064 6480464 2, 4-diaminotoluene results in increased expression of KCNK2 mRNA CTD PMID:20713471 3-methylcholanthrene increases expression ISO RGD:732064 6480464 Methylcholanthrene results in increased expression of KCNK2 mRNA CTD PMID:20713471 4-hydroxyphenyl retinamide decreases expression ISO RGD:732064 6480464 Fenretinide results in decreased expression of KCNK2 mRNA CTD PMID:28973697 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of KCNK2 mRNA CTD PMID:24780913 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of KCNK2 mRNA CTD PMID:28959563 aflatoxin B1 increases methylation ISO RGD:1354126 6480464 Aflatoxin B1 results in increased methylation of KCNK2 intron CTD PMID:30157460 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of KCNK2 mRNA CTD PMID:16483693 arachidonic acid multiple interactions ISO RGD:1354126 6480464 Arachidonic Acid promotes the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 arsenite(3-) increases methylation ISO RGD:1354126 6480464 arsenite results in increased methylation of KCNK2 promoter CTD PMID:23974009 arsenous acid decreases expression ISO RGD:1354126 6480464 Arsenic Trioxide results in decreased expression of KCNK2 mRNA CTD PMID:26705709 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of KCNK2 mRNA CTD PMID:21839799 benzo[a]pyrene affects methylation ISO RGD:1354126 6480464 Benzo(a)pyrene affects the methylation of KCNK2 intron CTD PMID:30157460 benzo[a]pyrene increases expression ISO RGD:732064 6480464 Benzo(a)pyrene results in increased expression of KCNK2 mRNA CTD PMID:15034205 , PMID:20713471 benzo[e]pyrene affects methylation ISO RGD:1354126 6480464 benzo(e)pyrene affects the methylation of KCNK2 intron CTD PMID:30157460 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of KCNK2 mRNA CTD PMID:25181051 bisphenol A decreases methylation ISO RGD:732064 6480464 bisphenol A results in decreased methylation of KCNK2 promoter CTD PMID:27312807 cadmium atom decreases expression ISO RGD:1354126 6480464 Cadmium results in decreased expression of KCNK2 mRNA CTD PMID:24376830 camptothecin decreases response to substance ISO RGD:1354126 6480464 KCNK2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 clozapine decreases expression ISO RGD:732064 6480464 Clozapine results in decreased expression of KCNK2 mRNA CTD PMID:15542763 copper atom multiple interactions EXP 6480464 [Copper co-treated with Dietary Sucrose] results in increased expression of KCNK2 mRNA CTD PMID:26033743 copper atom multiple interactions ISO RGD:1354126 6480464 [NSC 689534 binds to Copper] which results in decreased expression of KCNK2 mRNA CTD PMID:20971185 copper(0) multiple interactions EXP 6480464 [Copper co-treated with Dietary Sucrose] results in increased expression of KCNK2 mRNA CTD PMID:26033743 copper(0) multiple interactions ISO RGD:1354126 6480464 [NSC 689534 binds to Copper] which results in decreased expression of KCNK2 mRNA CTD PMID:20971185 coumarin increases expression EXP 6480464 coumarin results in increased expression of KCNK2 mRNA CTD PMID:18480146 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of KCNK2 mRNA, Dexamethasone results in increased expression of KCNK2 protein CTD PMID:21069514 dexamethasone multiple interactions EXP 6480464 Fluoxetine inhibits the reaction [Dexamethasone results in increased expression of KCNK2 mRNA], Fluoxetine inhibits the reaction [Dexamethasone results in increased expression of KCNK2 protein] CTD PMID:21069514 diarsenic trioxide decreases expression ISO RGD:1354126 6480464 Arsenic Trioxide results in decreased expression of KCNK2 mRNA CTD PMID:26705709 dibutyl phthalate increases expression ISO RGD:732064 6480464 Dibutyl Phthalate results in increased expression of KCNK2 mRNA CTD PMID:21266533 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of KCNK2 mRNA CTD PMID:21266533 diethylstilbestrol decreases expression EXP 6480464 Diethylstilbestrol results in decreased expression of KCNK2 mRNA CTD PMID:17005392 diltiazem multiple interactions ISO RGD:1354126 6480464 Diltiazem inhibits the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 dioxygen multiple interactions ISO RGD:732064 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of KCNK2 mRNA CTD PMID:30529165 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of KCNK2 mRNA CTD PMID:29391264 ethanol affects splicing ISO RGD:732064 6480464 Ethanol affects the splicing of KCNK2 mRNA CTD PMID:30319688 fipronil decreases expression EXP 6480464 fipronil results in decreased expression of KCNK2 mRNA CTD PMID:23962444 flufenamic acid multiple interactions ISO RGD:1354126 6480464 Flufenamic Acid promotes the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 fluoxetine multiple interactions EXP 6480464 Fluoxetine inhibits the reaction [Dexamethasone results in increased expression of KCNK2 mRNA], Fluoxetine inhibits the reaction [Dexamethasone results in increased expression of KCNK2 protein] CTD PMID:21069514 fluoxetine multiple interactions ISO RGD:732064 6480464 [KCNK2 mRNA co-treated with KCNK10 mRNA] affects the susceptibility to Fluoxetine CTD PMID:23022515 fluoxetine decreases activity ISO RGD:732064 6480464 Fluoxetine results in decreased activity of KCNK2 protein CTD PMID:23022515 fluoxetine affects response to substance ISO RGD:732064 6480464 KCNK2 mRNA affects the susceptibility to Fluoxetine CTD PMID:23022515 fluoxetine decreases expression ISO RGD:732064 6480464 Fluoxetine results in decreased expression of KCNK2 mRNA CTD PMID:23022515 fluoxetine decreases response to substance EXP 6480464 Fluoxetine results in decreased susceptibility to KCNK2 protein CTD PMID:21069514 fluoxetine decreases expression EXP 6480464 Fluoxetine results in decreased expression of KCNK2 mRNA, Fluoxetine results in decreased expression of KCNK2 protein CTD PMID:21069514 furan increases methylation EXP 6480464 furan results in increased methylation of KCNK2 gene CTD PMID:22079235 genistein decreases expression ISO RGD:1354126 6480464 Genistein results in decreased expression of KCNK2 mRNA CTD PMID:26865667 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of KCNK2 mRNA CTD PMID:22061828 halothane multiple interactions ISO RGD:1354126 6480464 Halothane promotes the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 lipopolysaccharide decreases expression ISO RGD:732064 6480464 Lipopolysaccharides results in decreased expression of KCNK2 mRNA CTD PMID:12057914 mefenamic acid multiple interactions ISO RGD:1354126 6480464 Mefenamic Acid promotes the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 methapyrilene affects methylation ISO RGD:1354126 6480464 Methapyrilene affects the methylation of KCNK2 intron CTD PMID:30157460 Niflumic acid multiple interactions ISO RGD:1354126 6480464 Niflumic Acid promotes the reaction [KCNK2 protein results in increased transport of Potassium] CTD PMID:16075240 potassium atom multiple interactions ISO RGD:1354126 6480464 Arachidonic Acid promotes the reaction [KCNK2 protein results in increased transport of Potassium] more ... CTD PMID:16075240 potassium chromate increases expression ISO RGD:1354126 6480464 potassium chromate(VI) results in increased expression of KCNK2 mRNA CTD PMID:22714537 serpentine asbestos decreases methylation ISO RGD:1354126 6480464 Asbestos, Serpentine results in decreased methylation of KCNK2 gene CTD PMID:29523930 sodium arsenite increases expression ISO RGD:1354126 6480464 sodium arsenite results in increased expression of KCNK2 mRNA CTD PMID:22714537 Soman decreases expression EXP 6480464 Soman results in decreased expression of KCNK2 mRNA CTD PMID:19281266 Tesaglitazar increases expression EXP 6480464 tesaglitazar results in increased expression of KCNK2 mRNA CTD PMID:21515302 trichloroethene increases methylation EXP 6480464 Trichloroethylene results in increased methylation of KCNK2 gene CTD PMID:27618143 valproic acid affects expression ISO RGD:732064 6480464 Valproic Acid affects the expression of KCNK2 mRNA CTD PMID:17292431
Biological Process cardiac ventricle development IEP 9831164 RGD cellular response to hypoxia IEP 9831164 RGD cochlea development IEP 2316534 RGD G protein-coupled receptor signaling pathway ISO RGD:732064 1624291 (MGI:MGI:2153583, PMID:11560940) RGD MGI:MGI:2153583 , PMID:11560940 memory IEP 9831144 RGD negative regulation of cardiac muscle cell proliferation IMP 9831164 RGD negative regulation of DNA biosynthetic process IMP 9831181 RGD positive regulation of cell death IMP 9831164 RGD positive regulation of cellular response to hypoxia IMP 9831164 RGD potassium ion transmembrane transport IDA 9831115 RGD potassium ion transmembrane transport IBA FB:FBgn0017561 more ... 13792537 PMID:21873635 GO_Central potassium ion transmembrane transport IEA GO:0015271 1600115 GO_REF:0000108 GOC GO_REF:0000108 potassium ion transmembrane transport IDA 9831119 PMID:19571146 UniProt potassium ion transmembrane transport IDA 633144 PMID:11319556 UniProt potassium ion transport ISO RGD:732064 1624291 (MGI:MGI:2153583, PMID:11560940) RGD MGI:MGI:2153583 , PMID:11560940 regulation of membrane potential ISO RGD:732064 1624291 MGI:MGI:1346013 more ... RGD MGI:MGI:5424322 , PMID:22354168 response to axon injury IEP 9831168 RGD response to mechanical stimulus IEP 9831147 RGD stabilization of membrane potential IBA PANTHER:PTN000108561 , ZFIN:ZDB-GENE-100405-2 13792537 PMID:21873635 GO_Central Cellular Component apical plasma membrane IDA 9831118 RGD astrocyte projection IDA 9831122 RGD axon IDA 9831168 RGD axon terminus IDA 9831146 RGD calyx of Held IDA 9831118 RGD cell surface IDA 9831115 RGD endoplasmic reticulum IDA 8661627 PMID:24196565 UniProt endoplasmic reticulum membrane IEA UniProtKB-SubCell:SL-0097 1600115 GO_REF:0000044 UniProt GO_REF:0000044 integral component of plasma membrane IMP 9831119 PMID:19571146 UniProt integral component of plasma membrane IBA MGI:MGI:109322 more ... 13792537 PMID:21873635 GO_Central neuron projection IDA 9831123 RGD neuronal cell body IDA 9831119 RGD nucleus IDA 2316534 RGD plasma membrane ISO RGD:732064 1624291 (MGI:MGI:5424322, PMID:22354168) RGD MGI:MGI:5424322 , PMID:22354168 plasma membrane IDA 8661627 PMID:24196565 UniProt plasma membrane IDA 9831117 RGD voltage-gated potassium channel complex ISO RGD:732064 1624291 (MGI:MGI:2153583, PMID:11560940) RGD MGI:MGI:2153583 , PMID:11560940 Molecular Function outward rectifier potassium channel activity IDA 633144 PMID:11319556 UniProt outward rectifier potassium channel activity IBA PANTHER:PTN000108905 , RGD:621448 13792537 PMID:21873635 GO_Central outward rectifier potassium channel activity IDA 8661627 PMID:24196565 UniProt potassium channel inhibitor activity IDA 8661627 PMID:24196565 UniProt potassium ion leak channel activity IDA 633144 PMID:11319556 UniProt potassium ion leak channel activity IBA FB:FBgn0017561 more ... 13792537 PMID:21873635 GO_Central potassium ion leak channel activity IDA 9831119 PMID:19571146 UniProt protein binding ISO RGD:732064 1624291 UniProtKB:D3YVF0 more ... RGD MGI:MGI:3703490 more ... protein binding IPI UniProtKB:P50150 8655530 PMID:23021213 IntAct protein binding IPI RGD:3410 9831180 RGD voltage-gated potassium channel activity ISO RGD:732064 1624291 (MGI:MGI:2153583, PMID:11560940) RGD MGI:MGI:2153583 , PMID:11560940
Gene-Chemical Interaction Annotations
