KCNK2 (potassium two pore domain channel subfamily K member 2) - Rat Genome Database

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Gene: KCNK2 (potassium two pore domain channel subfamily K member 2) Chlorocebus sabaeus
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Symbol: KCNK2
Name: potassium two pore domain channel subfamily K member 2
RGD ID: 18473845
Description: ENCODES a protein that exhibits potassium channel inhibitor activity (ortholog); INVOLVED IN cardiac ventricle development (ortholog); cellular response to arachidonate (ortholog); cellular response to hypoxia (ortholog); ASSOCIATED WITH brain ischemia (ortholog); congestive heart failure (ortholog); depressive disorder (ortholog); FOUND IN apical plasma membrane (ortholog); astrocyte projection (ortholog); axon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: potassium channel subfamily K member 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12514,341,147 - 14,570,982 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2514,340,123 - 14,487,420 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605514,803,316 - 15,034,481 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12514,341,147 - 14,570,982 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2514,340,123 - 14,487,420 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605514,803,316 - 15,034,481 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
KCNK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381215,005,542 - 215,237,090 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1215,005,775 - 215,237,090 (+)EnsemblGRCh38hg38GRCh38
GRCh371215,178,885 - 215,410,433 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361213,245,508 - 213,477,059 (+)NCBINCBI36Build 36hg18NCBI36
Build 341211,645,030 - 211,797,553NCBI
Celera1188,402,753 - 188,634,228 (+)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1185,853,513 - 186,084,965 (+)NCBIHuRef
CHM1_11216,451,204 - 216,682,774 (+)NCBICHM1_1
T2T-CHM13v2.01214,245,543 - 214,477,417 (+)NCBIT2T-CHM13v2.0
Kcnk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391188,940,127 - 189,134,951 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1188,940,127 - 189,134,470 (-)EnsemblGRCm39 Ensembl
GRCm381189,207,930 - 189,402,782 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1189,207,930 - 189,402,273 (-)EnsemblGRCm38mm10GRCm38
MGSCv371191,031,809 - 191,168,071 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361190,908,721 - 191,044,620 (-)NCBIMGSCv36mm8
Celera1196,121,799 - 196,265,023 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map194.22NCBI
Kcnk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813103,297,387 - 103,494,686 (-)NCBIGRCr8
mRatBN7.213100,766,101 - 100,963,435 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13100,766,113 - 100,963,435 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13103,281,547 - 103,478,878 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013104,670,332 - 104,867,622 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013101,869,487 - 102,066,094 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013107,690,111 - 107,886,476 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13107,690,087 - 107,886,476 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013112,318,467 - 112,512,344 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413105,376,001 - 105,574,238 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113105,665,411 - 105,705,891 (-)NCBI
Celera13100,255,787 - 100,450,992 (-)NCBICelera
Cytogenetic Map13q26NCBI
Kcnk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554062,791,803 - 2,975,322 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554062,793,493 - 2,975,322 (-)NCBIChiLan1.0ChiLan1.0
KCNK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2134,168,640 - 34,322,470 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1134,124,656 - 34,280,444 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01190,576,180 - 190,807,367 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11195,431,036 - 195,660,681 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1195,430,994 - 195,662,840 (+)Ensemblpanpan1.1panPan2
KCNK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1712,893,654 - 13,092,319 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl712,894,149 - 13,090,110 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha712,470,423 - 12,670,630 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0712,747,271 - 12,810,022 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1712,529,565 - 12,729,453 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0712,634,038 - 12,833,989 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0712,759,762 - 12,959,899 (+)NCBIUU_Cfam_GSD_1.0
Kcnk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934461,143,721 - 61,335,855 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366283,154,109 - 3,345,660 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366283,155,261 - 3,284,375 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9128,429,092 - 128,661,639 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19128,429,232 - 128,659,662 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29141,099,533 - 141,161,034 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Kcnk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477119,984,857 - 20,164,021 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477120,040,685 - 20,166,992 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 17 33 33 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000013654   ⟹   ENSCSAP00000011645
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2514,340,123 - 14,487,420 (-)Ensembl
RefSeq Acc Id: XM_007988449   ⟹   XP_007986640
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12514,341,147 - 14,487,570 (-)NCBI
Vero_WHO_p1.0NW_02366605514,803,316 - 14,950,818 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988450   ⟹   XP_007986641
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12514,341,147 - 14,570,982 (-)NCBI
Vero_WHO_p1.0NW_02366605514,803,316 - 15,034,481 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988451   ⟹   XP_007986642
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12514,341,147 - 14,487,570 (-)NCBI
Vero_WHO_p1.0NW_02366605514,803,316 - 14,950,818 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988452   ⟹   XP_007986643
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12514,341,147 - 14,488,226 (-)NCBI
Vero_WHO_p1.0NW_02366605514,803,316 - 14,951,750 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988453   ⟹   XP_007986644
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12514,341,147 - 14,486,793 (-)NCBI
Vero_WHO_p1.0NW_02366605514,803,316 - 14,950,014 (-)NCBI
Sequence:
RefSeq Acc Id: XP_007986641   ⟸   XM_007988450
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007986643   ⟸   XM_007988452
- Peptide Label: isoform X4
RefSeq Acc Id: XP_007986642   ⟸   XM_007988451
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RSQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007986640   ⟸   XM_007988449
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007986644   ⟸   XM_007988453
- Peptide Label: isoform X4
Ensembl Acc Id: ENSCSAP00000011645   ⟸   ENSCSAT00000013654


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015559 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013654.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
InterPro 2pore_dom_K_chnl UniProtKB/TrEMBL
  2pore_dom_K_chnl_TREK UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/TrEMBL
NCBI Gene KCNK2 ENTREZGENE
PANTHER POTASSIUM CHANNEL SUBFAMILY K MEMBER 2 UniProtKB/TrEMBL
  PTHR11003 UniProtKB/TrEMBL
Pfam Ion_trans_2 UniProtKB/TrEMBL
PRINTS 2POREKCHANEL UniProtKB/TrEMBL
  TREKCHANNEL UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A0D9RSQ6 ENTREZGENE, UniProtKB/TrEMBL