PRNP (prion protein) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: PRNP (prion protein) Canis lupus familiaris
Analyze
Symbol: PRNP
Name: prion protein
RGD ID: 12255815
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); aspartic-type endopeptidase inhibitor activity (ortholog); ATP-dependent protein binding (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); amyloid precursor protein metabolic process (ortholog); calcium-mediated signaling using intracellular calcium source (ortholog); PARTICIPATES IN glypican signaling pathway; iron uptake pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Creutzfeldt-Jakob disease (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: major prion protein; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); PrP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12416,845,224 - 16,862,319 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2416,846,207 - 16,859,815 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2416,670,727 - 16,671,500 (-)NCBI
ROS_Cfam_1.02417,263,379 - 17,280,460 (-)NCBI
UMICH_Zoey_3.12416,859,351 - 16,860,124 (-)NCBI
UNSW_CanFamBas_1.02416,965,836 - 16,966,609 (-)NCBI
UU_Cfam_GSD_1.02417,299,279 - 17,300,052 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
amyloid precursor protein metabolic process  (ISO)
calcium-mediated signaling using intracellular calcium source  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to copper ion  (ISO)
cellular response to xenobiotic stimulus  (ISO)
learning or memory  (ISO)
modulation of age-related behavioral decline  (ISO)
negative regulation of activated T cell proliferation  (ISO)
negative regulation of amyloid precursor protein catabolic process  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of calcineurin-NFAT signaling cascade  (ISO)
negative regulation of catalytic activity  (ISO)
negative regulation of dendritic spine maintenance  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of interferon-gamma production  (ISO)
negative regulation of interleukin-17 production  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of long-term synaptic potentiation  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of T cell receptor signaling pathway  (ISO)
neuron projection maintenance  (ISO)
positive regulation of cell death  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein targeting to membrane  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
protein destabilization  (ISO)
protein homooligomerization  (IEA)
regulation of calcium ion import across plasma membrane  (ISO)
regulation of glutamate receptor signaling pathway  (ISO)
regulation of intracellular calcium activated chloride channel activity  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of potassium ion transmembrane transport  (ISO)
regulation of protein localization  (ISO)
response to amyloid-beta  (ISO)
response to cadmium ion  (ISO)
response to copper ion  (ISO)
response to oxidative stress  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:10373359   PMID:16925672   PMID:19522879   PMID:21469747   PMID:23236380   PMID:32532135  


Genomics

Comparative Map Data
PRNP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12416,845,224 - 16,862,319 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2416,846,207 - 16,859,815 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2416,670,727 - 16,671,500 (-)NCBI
ROS_Cfam_1.02417,263,379 - 17,280,460 (-)NCBI
UMICH_Zoey_3.12416,859,351 - 16,860,124 (-)NCBI
UNSW_CanFamBas_1.02416,965,836 - 16,966,609 (-)NCBI
UU_Cfam_GSD_1.02417,299,279 - 17,300,052 (-)NCBI
PRNP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl204,686,350 - 4,701,590 (+)EnsemblGRCh38hg38GRCh38
GRCh38204,686,456 - 4,701,588 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37204,667,102 - 4,682,234 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36204,614,797 - 4,630,234 (+)NCBINCBI36hg18NCBI36
Build 34204,615,068 - 4,630,233NCBI
Celera204,736,512 - 4,751,948 (+)NCBI
Cytogenetic Map20p13NCBI
HuRef204,620,194 - 4,635,632 (+)NCBIHuRef
CHM1_1204,667,528 - 4,682,967 (+)NCBICHM1_1
Prnp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,751,848 - 131,780,356 (+)NCBIGRCm39mm39
GRCm39 Ensembl2131,751,848 - 131,780,349 (+)Ensembl
GRCm382131,909,928 - 131,938,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,909,928 - 131,938,429 (+)EnsemblGRCm38mm10GRCm38
MGSCv372131,735,664 - 131,764,167 (+)NCBIGRCm37mm9NCBIm37
MGSCv362131,601,398 - 131,629,868 (+)NCBImm8
Celera2133,143,177 - 133,164,079 (+)NCBICelera
Cytogenetic Map2F2NCBI
cM Map264.07NCBI
Prnp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23119,186,073 - 119,201,513 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl3124,515,978 - 124,531,316 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03124,515,917 - 124,531,320 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03131,009,974 - 131,025,370 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43119,676,137 - 119,691,507 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13119,581,709 - 119,597,080 (+)NCBI
Celera3117,986,209 - 118,001,394 (+)NCBICelera
Cytogenetic Map3q36NCBI
Prnp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541515,442,313 - 15,454,644 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541515,442,313 - 15,454,644 (+)NCBIChiLan1.0ChiLan1.0
PRNP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1204,523,141 - 4,525,522 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl204,523,155 - 4,523,916 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0204,713,616 - 4,728,847 (+)NCBIMhudiblu_PPA_v0panPan3
LOC101959784
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640165,673,463 - 165,687,259 (-)NCBI
SpeTri2.0NW_00493648514,104,829 - 14,118,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRNP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1713,693,628 - 13,705,318 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11713,694,195 - 13,705,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21714,656,638 - 14,667,625 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103247014
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1233,368,020 - 33,384,556 (-)NCBI
ChlSab1.1 Ensembl233,369,629 - 33,370,366 (-)Ensembl
Vero_WHO_p1.0NW_02366607111,150,240 - 11,165,879 (+)NCBI
Prnp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247415,785,139 - 5,802,162 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 4 12 8 10 6
Low 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001013423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005634691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005634692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022408814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038432821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038432822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038432823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038432824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF113937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF113938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ444487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ444488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF139170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ870766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ870767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX218956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX218957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX218958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX218959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY649551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY649552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY649553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY649554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY649555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY649556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY649557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY649558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY649559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY649560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY649561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY649562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY649563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG018983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000009809   ⟹   ENSCAFP00000009107
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2416,846,207 - 16,859,815 (-)Ensembl
RefSeq Acc Id: NM_001013423   ⟹   NP_001013441
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12416,846,859 - 16,847,632 (-)NCBI
Dog10K_Boxer_Tasha2416,670,727 - 16,671,500 (-)NCBI
ROS_Cfam_1.02417,265,014 - 17,265,787 (-)NCBI
UMICH_Zoey_3.12416,859,351 - 16,860,124 (-)NCBI
UNSW_CanFamBas_1.02416,965,836 - 16,966,609 (-)NCBI
UU_Cfam_GSD_1.02417,299,279 - 17,300,052 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005634691   ⟹   XP_005634748
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12416,845,224 - 16,862,319 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005634692   ⟹   XP_005634749
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12416,845,224 - 16,862,271 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022408814   ⟹   XP_022264522
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12416,845,224 - 16,852,474 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038432821   ⟹   XP_038288749
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02417,263,379 - 17,280,460 (-)NCBI
RefSeq Acc Id: XM_038432822   ⟹   XP_038288750
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02417,263,379 - 17,280,349 (-)NCBI
RefSeq Acc Id: XM_038432823   ⟹   XP_038288751
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02417,263,379 - 17,280,437 (-)NCBI
RefSeq Acc Id: XM_038432824   ⟹   XP_038288752
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02417,263,379 - 17,270,659 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001013441 (Get FASTA)   NCBI Sequence Viewer  
  XP_038288749 (Get FASTA)   NCBI Sequence Viewer  
  XP_038288750 (Get FASTA)   NCBI Sequence Viewer  
  XP_038288751 (Get FASTA)   NCBI Sequence Viewer  
  XP_038288752 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB99743 (Get FASTA)   NCBI Sequence Viewer  
  AAD12061 (Get FASTA)   NCBI Sequence Viewer  
  AAD12062 (Get FASTA)   NCBI Sequence Viewer  
  ABD98455 (Get FASTA)   NCBI Sequence Viewer  
  ABD98456 (Get FASTA)   NCBI Sequence Viewer  
  ABL75506 (Get FASTA)   NCBI Sequence Viewer  
  ACO71290 (Get FASTA)   NCBI Sequence Viewer  
  ACO71291 (Get FASTA)   NCBI Sequence Viewer  
  AGA63676 (Get FASTA)   NCBI Sequence Viewer  
  AGA63677 (Get FASTA)   NCBI Sequence Viewer  
  AGA63678 (Get FASTA)   NCBI Sequence Viewer  
  AGA63679 (Get FASTA)   NCBI Sequence Viewer  
  ATP76280 (Get FASTA)   NCBI Sequence Viewer  
  ATP76281 (Get FASTA)   NCBI Sequence Viewer  
  ATP76282 (Get FASTA)   NCBI Sequence Viewer  
  ATP76283 (Get FASTA)   NCBI Sequence Viewer  
  ATP76284 (Get FASTA)   NCBI Sequence Viewer  
  ATP76285 (Get FASTA)   NCBI Sequence Viewer  
  ATP76286 (Get FASTA)   NCBI Sequence Viewer  
  ATP76287 (Get FASTA)   NCBI Sequence Viewer  
  ATP76288 (Get FASTA)   NCBI Sequence Viewer  
  ATP76289 (Get FASTA)   NCBI Sequence Viewer  
  ATP76290 (Get FASTA)   NCBI Sequence Viewer  
  ATP76291 (Get FASTA)   NCBI Sequence Viewer  
  ATP76292 (Get FASTA)   NCBI Sequence Viewer  
  ATQ64260 (Get FASTA)   NCBI Sequence Viewer  
  O46501 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005634749   ⟸   XM_005634692
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005634748   ⟸   XM_005634691
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001013441   ⟸   NM_001013423
- Peptide Label: precursor
- UniProtKB: O46593 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022264522   ⟸   XM_022408814
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000009107   ⟸   ENSCAFT00000009809
RefSeq Acc Id: XP_038288749   ⟸   XM_038432821
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038288751   ⟸   XM_038432823
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038288750   ⟸   XM_038432822
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038288752   ⟸   XM_038432824
- Peptide Label: isoform X1

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006065 Ensembl
NCBI Gene PRNP ENTREZGENE
UniProt O46501 ENTREZGENE
  O46593 ENTREZGENE
VGNC ID VGNC:45004 ENTREZGENE