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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3410
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prnp
Name: prion protein
Acc ID: CHEBI:83267
Term: filipin III
Definition: A macrolide that is the major component of a mixture of four isomeric polyene macrolides isolated from Streptomyces filipinensis.
Chemical ID: MESH:D005372
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prnpdecreases expressionISORGD:111606480464CTDFilipin results in decreased expression of PRNP protein alternative formPMID:11994310
Prnpincreases secretionISORGD:111606480464CTDFilipin results in increased secretion of PRNP proteinPMID:11994310
Prnpincreases secretionISORGD:7373066480464CTDFilipin results in increased secretion of PRNP proteinPMID:11994310
Prnpmultiple interactionsISORGD:111606480464CTD[Copper co-treated with Filipin] results in increased cleavage of PRNP protein; Filipin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]PMID:11994310 PMID:19597535
Prnpmultiple interactionsISORGD:7373066480464CTDFilipin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]PMID:11994310
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