Dnajc5 (DnaJ heat shock protein family (Hsp40) member C5) - Rat Genome Database

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Gene: Dnajc5 (DnaJ heat shock protein family (Hsp40) member C5) Rattus norvegicus
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Symbol: Dnajc5
Name: DnaJ heat shock protein family (Hsp40) member C5
RGD ID: 620516
Description: Enables ATP-dependent protein binding activity. Predicted to be involved in chaperone-mediated protein folding and regulation of synaptic vesicle cycle. Predicted to act upstream of or within negative regulation of neuron apoptotic process. Located in terminal bouton. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 4. Orthologous to human DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Csp; cysteine string protein; DnaJ (Hsp40) homolog, subfamily C, member 5; dnaJ homolog subfamily C member 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23168,621,905 - 168,656,570 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,621,969 - 168,655,935 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3173,002,718 - 173,032,873 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03181,961,813 - 181,991,968 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03178,623,311 - 178,653,609 (+)NCBIRnor_WKY
Rnor_6.03177,012,714 - 177,047,787 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3177,013,604 - 177,043,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,723,449 - 180,758,075 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,655,557 - 170,685,855 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,561,592 - 170,591,891 (+)NCBI
Celera3163,934,331 - 163,964,588 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rdj2, a J protein family member, interacts with cellular prion PrP(C). Beck KE, etal., Biochem Biophys Res Commun. 2006 Aug 4;346(3):866-71. Epub 2006 Jun 6.
2. Cysteine string protein, a DnaJ family member, is present on diverse secretory vesicles. Braun JE and Scheller RH, Neuropharmacology 1995 Nov;34(11):1361-9.
3. Phosphorylation-dependent interaction of the synaptic vesicle proteins cysteine string protein and synaptotagmin I. Evans GJ and Morgan A, Biochem J 2002 Jun 1;364(Pt 2):343-7.
4. Cysteine-string protein in inner hair cells of the organ of Corti: synaptic expression and upregulation at the onset of hearing. Eybalin M, etal., Eur J Neurosci 2002 May;15(9):1409-20.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. The nucleotide and deduced amino acid sequence of a rat cysteine string protein. Mastrogiacomo A and Gundersen CB, Brain Res Mol Brain Res 1995 Jan;28(1):12-8.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Cysteine string protein (CSP) inhibition of N-type calcium channels is blocked by mutant huntingtin. Miller LC, etal., J Biol Chem 2003 Dec 26;278(52):53072-81. Epub 2003 Oct 21.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Rab-alphaGDI activity is regulated by a Hsp90 chaperone complex. Sakisaka T, etal., EMBO J 2002 Nov 15;21(22):6125-35.
16. Oligomerization characteristics of cysteine string protein. Swayne LA, etal., Biochem Biophys Res Commun 2003 Jan 24;300(4):921-6.
17. A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein. Tobaben S, etal., J Biol Chem 2003 Oct 3;278(40):38376-83. Epub 2003 Jul 23.
18. A trimeric protein complex functions as a synaptic chaperone machine. Tobaben S, etal., Neuron. 2001 Sep 27;31(6):987-99.
19. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
20. Induction of cysteine string protein after chronic antidepressant treatment in rat frontal cortex. Yamada M, etal., Neurosci Lett 2001 Apr 6;301(3):183-6.
Additional References at PubMed
PMID:12783986   PMID:15926915   PMID:15972823   PMID:16269331   PMID:16396499   PMID:16407767   PMID:17113038   PMID:17897319   PMID:18596047   PMID:19282376   PMID:19946888   PMID:20833797  
PMID:21151134   PMID:21820099   PMID:22500637   PMID:22666389   PMID:22871113   PMID:23376485   PMID:23942053   PMID:24956274  


Genomics

Comparative Map Data
Dnajc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23168,621,905 - 168,656,570 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,621,969 - 168,655,935 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3173,002,718 - 173,032,873 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03181,961,813 - 181,991,968 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03178,623,311 - 178,653,609 (+)NCBIRnor_WKY
Rnor_6.03177,012,714 - 177,047,787 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3177,013,604 - 177,043,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,723,449 - 180,758,075 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,655,557 - 170,685,855 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,561,592 - 170,591,891 (+)NCBI
Celera3163,934,331 - 163,964,588 (-)NCBICelera
Cytogenetic Map3q43NCBI
DNAJC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,895,126 - 63,936,011 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2063,895,126 - 63,936,031 (+)EnsemblGRCh38hg38GRCh38
GRCh372062,526,479 - 62,567,364 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,996,962 - 62,035,839 (+)NCBINCBI36Build 36hg18NCBI36
Build 342061,996,961 - 62,035,838NCBI
Celera2059,210,381 - 59,249,259 (+)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2059,258,875 - 59,300,772 (+)NCBIHuRef
CHM1_12062,427,271 - 62,467,998 (+)NCBICHM1_1
T2T-CHM13v2.02065,714,973 - 65,755,860 (+)NCBIT2T-CHM13v2.0
Dnajc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392181,162,141 - 181,194,679 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2181,162,278 - 181,196,926 (+)EnsemblGRCm39 Ensembl
GRCm382181,518,858 - 181,552,886 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,520,485 - 181,555,133 (+)EnsemblGRCm38mm10GRCm38
MGSCv372181,255,210 - 181,286,954 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362181,449,912 - 181,481,656 (+)NCBIMGSCv36mm8
Celera2185,601,949 - 185,633,720 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.63NCBI
Dnajc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528317,891 - 366,293 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955528317,891 - 366,299 (-)NCBIChiLan1.0ChiLan1.0
DNAJC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12061,848,236 - 61,856,265 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2061,848,236 - 61,856,265 (+)Ensemblpanpan1.1panPan2
DNAJC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.02448,520,496 - 48,548,620 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2448,514,370 - 48,545,332 (+)EnsemblROS_Cfam_1.0 Ensembl
Dnajc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,630,910 - 195,685,765 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651411,131,074 - 11,139,446 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493651411,131,666 - 11,139,404 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNAJC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,754,802 - 62,780,468 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11762,754,630 - 62,780,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DNAJC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12303,195 - 310,618 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2307,988 - 310,475 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605047,836,851 - 47,872,106 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnajc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474129,515,298 - 29,562,617 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474129,515,338 - 29,562,619 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnajc5
61 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:46
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000020581
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 8 11 74 35 38 11 8
Low 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020581   ⟹   ENSRNOP00000020581
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,621,969 - 168,652,678 (+)Ensembl
Rnor_6.0 Ensembl3177,013,604 - 177,043,902 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086046   ⟹   ENSRNOP00000070142
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3177,040,707 - 177,043,381 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102827   ⟹   ENSRNOP00000078729
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,621,986 - 168,655,935 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111615   ⟹   ENSRNOP00000088442
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,621,986 - 168,655,649 (+)Ensembl
RefSeq Acc Id: NM_024161   ⟹   NP_077075
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,622,380 - 168,652,680 (+)NCBI
Rnor_6.03177,013,604 - 177,043,902 (+)NCBI
Rnor_5.03180,723,449 - 180,758,075 (+)NCBI
RGSC_v3.43170,655,557 - 170,685,855 (+)RGD
Celera3163,934,331 - 163,964,588 (-)RGD
Sequence:
RefSeq Acc Id: XM_008762544   ⟹   XP_008760766
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,621,920 - 168,656,570 (+)NCBI
Rnor_6.03177,012,718 - 177,047,787 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762545   ⟹   XP_008760767
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,621,916 - 168,656,570 (+)NCBI
Rnor_6.03177,012,717 - 177,047,787 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005501987
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,621,905 - 168,656,570 (+)NCBI
RefSeq Acc Id: XR_352967
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,621,920 - 168,656,570 (+)NCBI
Rnor_6.03177,012,718 - 177,047,787 (+)NCBI
Rnor_5.03180,723,449 - 180,758,075 (+)NCBI
Sequence:
RefSeq Acc Id: XR_352968
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,621,914 - 168,656,570 (+)NCBI
Rnor_6.03177,012,714 - 177,047,787 (+)NCBI
Rnor_5.03180,723,449 - 180,758,075 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_077075   ⟸   NM_024161
- UniProtKB: P60905 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008760766   ⟸   XM_008762544
- Peptide Label: isoform X1
- UniProtKB: P60905 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008760767   ⟸   XM_008762545
- Peptide Label: isoform X1
- UniProtKB: P60905 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020581   ⟸   ENSRNOT00000020581
RefSeq Acc Id: ENSRNOP00000070142   ⟸   ENSRNOT00000086046
RefSeq Acc Id: ENSRNOP00000088442   ⟸   ENSRNOT00000111615
RefSeq Acc Id: ENSRNOP00000078729   ⟸   ENSRNOT00000102827
Protein Domains
J

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P60905-F1-model_v2 AlphaFold P60905 1-198 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620516 AgrOrtholog
BioCyc Gene G2FUF-46274 BioCyc
Ensembl Genes ENSRNOG00000015202 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020581 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000078729.1 UniProtKB/TrEMBL
  ENSRNOP00000088442.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020581 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000102827 ENTREZGENE
  ENSRNOT00000102827.1 UniProtKB/TrEMBL
  ENSRNOT00000111615.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DnaJ_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DnaJ_domain_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  J_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79130 UniProtKB/Swiss-Prot
NCBI Gene 79130 ENTREZGENE
Pfam DnaJ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dnajc5 PhenoGen
PRINTS JDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DNAJ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNAJ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DnaJ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46565 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JX56_RAT UniProtKB/TrEMBL
  A0A8I6A9F3_RAT UniProtKB/TrEMBL
  DNJC5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P54101 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Dnajc5  DnaJ heat shock protein family (Hsp40) member C5  Dnajc5  DnaJ (Hsp40) homolog, subfamily C, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Dnajc5  DnaJ (Hsp40) homolog, subfamily C, member 5    cysteine string protein  Name updated 1299863 APPROVED
2004-09-10 Dnajc5  cysteine string protein  Csp    Symbol and Name updated 1299863 APPROVED
2002-08-07 Csp  cysteine string protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction forms homo-oligomers with itself 632545
gene_physical_interaction forms a complex with Hsp90 and Hsc70 in synaptic membranes 632546