Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: PRNP (prion protein) Homo sapiens
Symbol: PRNP
Name: prion protein
Description: Exhibits several functions, including amyloid-beta binding activity; cuprous ion binding activity; and type 5 metabotropic glutamate receptor binding activity. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; cellular response to amyloid-beta; and protein destabilization. Localizes to several cellular components, including membrane raft; mitochondrial outer membrane; and nuclear membrane. Colocalizes with dendrite. Implicated in Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; Huntington's disease-like 1; fatal familial insomnia; and kuru.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alternative prion protein; AltPrP; ASCR; CD230; CD230 antigen; CJD; GSS; KURU; major prion protein; MGC26679; p27-30; prion; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); prion protein PrP; prion-related protein; PRIP; PrP; PrP27-30; PrP33-35C; PrPc
Mus musculus (house mouse) : Prnp (prion protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prnp (prion protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prnp (prion protein)
Pan paniscus (bonobo/pygmy chimpanzee) : PRNP (prion protein)
Canis lupus familiaris (dog) : PRNP (prion protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prnp (prion protein)
Sus scrofa (pig) : PRNP (prion protein)
Chlorocebus sabaeus (African green monkey) : PRNP (prion protein)
Heterocephalus glaber (naked mole-rat) : Prnp (prion protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl204,686,350 - 4,701,590 (+)EnsemblGRCh38hg38GRCh38
GRCh38204,686,456 - 4,701,588 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37204,666,797 - 4,682,235 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36204,614,797 - 4,630,234 (+)NCBINCBI36hg18NCBI36
Build 34204,615,068 - 4,630,233NCBI
Celera204,736,512 - 4,751,948 (+)NCBI
Cytogenetic Map20p13NCBI
HuRef204,620,194 - 4,635,632 (+)NCBIHuRef
CHM1_1204,667,528 - 4,682,967 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PRNP
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737306
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-04-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.