Prnp (prion protein (Kanno blood group)) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Prnp (prion protein (Kanno blood group)) Chinchilla lanigera
Analyze
Symbol: Prnp
Name: prion protein (Kanno blood group) (Ensembl:prion protein)
RGD ID: 9051825
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); aspartic-type endopeptidase inhibitor activity (ortholog); ATP-dependent protein binding (ortholog); INVOLVED IN amyloid precursor protein metabolic process (ortholog); cellular response to amyloid-beta (ortholog); cellular response to copper ion (ortholog); PARTICIPATES IN glypican signaling pathway; iron uptake pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); autism spectrum disorder (ortholog); Cerebral Amyloidosis with Spongiform Encephalopathy (ortholog); FOUND IN cell surface (ortholog); cytosol (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541515,442,313 - 15,454,644 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541515,442,313 - 15,454,644 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid precursor protein metabolic process  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to copper ion  (ISO)
cellular response to xenobiotic stimulus  (ISO)
learning or memory  (ISO)
negative regulation of activated T cell proliferation  (ISO)
negative regulation of amyloid precursor protein catabolic process  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of calcineurin-NFAT signaling cascade  (ISO)
negative regulation of dendritic spine maintenance  (ISO)
negative regulation of interleukin-17 production  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of long-term synaptic potentiation  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of T cell receptor signaling pathway  (ISO)
negative regulation of type II interferon production  (ISO)
neuron projection maintenance  (ISO)
obsolete calcium-mediated signaling using intracellular calcium source  (ISO)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of glutamate receptor signaling pathway  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein targeting to membrane  (ISO)
protein destabilization  (ISO)
regulation of calcium ion import across plasma membrane  (ISO)
regulation of glutamate receptor signaling pathway  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of potassium ion transmembrane transport  (ISO)
regulation of protein localization  (ISO)
response to amyloid-beta  (ISO)
response to cadmium ion  (ISO)
response to copper ion  (ISO)
response to oxidative stress  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Prnp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541515,442,313 - 15,454,644 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541515,442,313 - 15,454,644 (+)NCBIChiLan1.0ChiLan1.0
PRNP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38204,686,456 - 4,701,588 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl204,686,350 - 4,701,590 (+)EnsemblGRCh38hg38GRCh38
GRCh37204,667,102 - 4,682,234 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36204,614,797 - 4,630,234 (+)NCBINCBI36Build 36hg18NCBI36
Build 34204,615,068 - 4,630,233NCBI
Celera204,736,512 - 4,751,948 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef204,620,194 - 4,635,632 (+)NCBIHuRef
CHM1_1204,667,528 - 4,682,967 (+)NCBICHM1_1
T2T-CHM13v2.0204,725,692 - 4,740,800 (+)NCBIT2T-CHM13v2.0
Prnp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,751,848 - 131,780,356 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2131,751,848 - 131,780,349 (+)EnsemblGRCm39 Ensembl
GRCm382131,909,928 - 131,938,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,909,928 - 131,938,429 (+)EnsemblGRCm38mm10GRCm38
MGSCv372131,735,664 - 131,764,167 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362131,601,398 - 131,629,868 (+)NCBIMGSCv36mm8
Celera2133,143,177 - 133,164,079 (+)NCBICelera
Cytogenetic Map2F2NCBI
cM Map264.07NCBI
Prnp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83139,639,076 - 139,654,420 (+)NCBIGRCr8
mRatBN7.23119,186,073 - 119,201,513 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3119,177,485 - 119,203,937 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3123,090,082 - 123,105,437 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03131,676,802 - 131,692,409 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03129,346,188 - 129,361,543 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03124,515,917 - 124,531,320 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3124,515,978 - 124,531,316 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03131,009,974 - 131,025,370 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43119,676,137 - 119,691,507 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13119,581,709 - 119,597,080 (+)NCBI
Celera3117,986,209 - 118,001,394 (+)NCBICelera
Cytogenetic Map3q36NCBI
PRNP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2215,641,025 - 5,656,375 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1205,637,965 - 5,653,199 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0204,713,616 - 4,728,847 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1204,523,141 - 4,525,522 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl204,523,155 - 4,523,916 (+)Ensemblpanpan1.1panPan2
PRNP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12416,845,224 - 16,862,319 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2416,846,207 - 16,859,815 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2416,670,727 - 16,671,500 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02417,263,379 - 17,280,460 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2417,263,381 - 17,280,378 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12416,859,351 - 16,860,124 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02416,965,836 - 16,966,609 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02417,299,279 - 17,300,052 (-)NCBIUU_Cfam_GSD_1.0
Prnp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640165,673,463 - 165,687,259 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648514,104,831 - 14,118,629 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648514,104,829 - 14,118,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRNP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1713,694,190 - 13,705,124 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11713,694,195 - 13,705,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21714,656,638 - 14,667,625 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRNP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1233,368,020 - 33,384,556 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl233,369,629 - 33,370,366 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607111,150,240 - 11,165,879 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prnp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247415,785,158 - 5,802,162 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247415,785,139 - 5,802,162 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000015752   ⟹   ENSCLAP00000015590
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541515,442,313 - 15,454,644 (+)Ensembl
RefSeq Acc Id: XM_005380818   ⟹   XP_005380875
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541515,442,313 - 15,454,644 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005380875 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000015590
  ENSCLAP00000015590.1
Reference Protein Sequences
RefSeq Acc Id: XP_005380875   ⟸   XM_005380818
- UniProtKB: A0A8C2YQD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000015590   ⟸   ENSCLAT00000015752
Protein Domains
Prion/Doppel protein beta-ribbon


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000010717 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000015752 ENTREZGENE
  ENSCLAT00000015752.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.790.10 UniProtKB/TrEMBL
InterPro Prion UniProtKB/TrEMBL
  Prion/Doppel_b-ribbon_dom_sf UniProtKB/TrEMBL
  Prion/Doppel_prot_b-ribbon_dom UniProtKB/TrEMBL
  Prion_N_dom UniProtKB/TrEMBL
NCBI Gene Prnp ENTREZGENE
PANTHER DOPPEL PRION UniProtKB/TrEMBL
  MAJOR PRION PROTEIN UniProtKB/TrEMBL
Pfam Prion UniProtKB/TrEMBL
  Prion_bPrPp UniProtKB/TrEMBL
PRINTS PRION UniProtKB/TrEMBL
PROSITE PRION_1 UniProtKB/TrEMBL
  PRION_2 UniProtKB/TrEMBL
SMART PRP UniProtKB/TrEMBL
Superfamily-SCOP SSF54098 UniProtKB/TrEMBL
UniProt A0A8C2YQD2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-11-07 Prnp  prion protein (Kanno blood group)  Prnp  prion protein  Symbol and/or name change 5135510 APPROVED