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Gene: Clca2 (chloride channel accessory 2) Rattus norvegicus

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Symbol:

Clca2

Name:

chloride channel accessory 2

RGD ID:

1304894

Description:

Predicted to enable intracellularly calcium-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport and proteolysis. Predicted to act upstream of or within chloride transport. Predicted to be located in cell junction; cytosol; and nucleus. Predicted to be active in plasma membrane. Orthologous to human CLCA2 (chloride channel accessory 2); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

calcium-activated chloride channel regulator 2; chloride channel calcium activated 5; chloride channel, calcium activated, family member 2; Clca5; LOC308016

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CLCA2 (chloride channel accessory 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Clca2 (chloride channel accessory 2)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Clca2 (chloride channel accessory 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CLCA2 (chloride channel accessory 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CLCA2 (chloride channel accessory 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Clca2 (chloride channel accessory 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CLCA2 (chloride channel accessory 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CLCA2 (chloride channel accessory 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Clca2 (chloride channel accessory 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CLCA2 (chloride channel accessory 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Clca2 (chloride channel accessory 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	clca1 (chloride channel accessory 1)	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	clca3p	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	clca1.1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	clca4.1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	236,655,419 - 236,682,669 (-)	NCBI		GRCr8
mRatBN7.2	2	233,993,619 - 234,022,691 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	233,995,078 - 234,022,199 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	241,783,941 - 241,811,118 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	239,672,060 - 239,699,210 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	234,541,565 - 234,568,742 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	250,954,423 - 250,981,544 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	250,954,397 - 250,981,623 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	269,482,241 - 269,509,237 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	243,114,775 - 243,142,349 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	225,983,314 - 226,010,397 (-)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Lung Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,5-hexanedione (EXP)

6-propyl-2-thiouracil (EXP)

actinomycin D (ISO)

aflatoxin B1 (ISO)

amitrole (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

beta-damascenone (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

carbendazim (EXP)

carbon nanotube (ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) chloride (ISO)

diarsenic trioxide (ISO)

dioxygen (EXP)

endosulfan (EXP)

ethyl methanesulfonate (ISO)

folic acid (ISO)

fonofos (ISO)

formaldehyde (ISO)

furan (EXP)

gentamycin (EXP)

L-methionine (ISO)

lead diacetate (ISO)

lipopolysaccharide (ISO)

lucanthone (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

nicotine (ISO)

Nutlin-3 (ISO)

paracetamol (EXP,ISO)

parathion (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

terbufos (ISO)

testosterone (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (EXP)

triptonide (ISO)

zaragozic acid A (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chloride transmembrane transport (IEA)

chloride transport (ISO)

proteolysis (IEA)

Cellular Component

cell junction (IEA,ISO)

cytosol (IEA,ISO)

nuclear membrane (IEA,ISO)

nucleoplasm (IEA,ISO)

plasma membrane (IBA,ISO)

Molecular Function

chloride channel activity (ISO)

intracellularly calcium-gated chloride channel activity (IBA)

ligand-gated monoatomic ion channel activity (ISO)

metal ion binding (IEA)

metallopeptidase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15284223	PMID:25212661	PMID:33486586

Genomics

Comparative Map Data

Clca2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	236,655,419 - 236,682,669 (-)	NCBI		GRCr8
mRatBN7.2	2	233,993,619 - 234,022,691 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	233,995,078 - 234,022,199 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	241,783,941 - 241,811,118 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	239,672,060 - 239,699,210 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	234,541,565 - 234,568,742 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	250,954,423 - 250,981,544 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	250,954,397 - 250,981,623 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	269,482,241 - 269,509,237 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	243,114,775 - 243,142,349 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	225,983,314 - 226,010,397 (-)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

CLCA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	86,424,171 - 86,456,553 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	86,424,171 - 86,456,553 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	86,889,854 - 86,922,236 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	86,662,413 - 86,694,829 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	86,601,845 - 86,634,259	NCBI
Celera	1	85,133,768 - 85,166,240 (+)	NCBI		Celera
Cytogenetic Map	1	p22.3	NCBI
HuRef	1	85,000,753 - 85,032,874 (+)	NCBI		HuRef
CHM1_1	1	87,004,629 - 87,037,098 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	86,264,193 - 86,296,574 (+)	NCBI		T2T-CHM13v2.0

Clca2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	144,776,021 - 144,805,204 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	144,776,024 - 144,805,204 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	145,070,260 - 145,099,443 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	145,070,263 - 145,099,443 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	144,733,229 - 144,762,005 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	145,007,651 - 145,036,427 (-)	NCBI		MGSCv36	mm8
Celera	3	151,513,121 - 151,541,898 (-)	NCBI		Celera
Cytogenetic Map	3	H2	NCBI
cM Map	3	69.31	NCBI

Clca2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	7,728,652 - 7,760,697 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	7,729,032 - 7,760,340 (-)	NCBI	ChiLan1.0	ChiLan1.0

CLCA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	140,503,490 - 140,536,078 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	139,655,368 - 139,691,488 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	118,954,863 - 118,987,264 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	87,808,002 - 87,840,605 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	87,808,205 - 87,840,605 (+)	Ensembl	panpan1.1		panPan2

CLCA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	61,665,120 - 61,705,760 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	61,666,105 - 61,704,746 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	64,379,479 - 64,415,767 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	62,205,308 - 62,244,815 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	62,205,904 - 62,244,664 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	61,738,026 - 61,777,512 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	61,701,435 - 61,740,933 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	62,207,245 - 62,246,736 (-)	NCBI		UU_Cfam_GSD_1.0

Clca2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	96,893,563 - 96,928,155 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936865	202,555 - 237,099 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936865	202,970 - 237,072 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CLCA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	129,670,638 - 129,704,846 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	129,670,634 - 129,704,765 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	142,188,545 - 142,223,419 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CLCA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	46,974,030 - 47,007,723 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	46,975,337 - 47,006,646 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	70,803,176 - 70,835,376 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Clca2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	11,183,711 - 11,212,388 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	11,182,852 - 11,217,222 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	298
Count of miRNA genes:	197
Interacting mature miRNAs:	231
Transcripts:	ENSRNOT00000018435
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170656145	239614549	Rat
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	221088977	243501206	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	202029709	236904960	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	210956252	251712708	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	214404877	251712708	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	203664411	248664411	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	204795005	249795005	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	214404877	251712708	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	214404877	251712708	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	218051934	251712708	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	192287802	237287802	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	192287802	237287802	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	214404877	251712708	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	196140964	251540988	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	214404877	251712708	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	205135267	250135267	Rat

Markers in Region

RH131751

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	233,826,314 - 233,826,525 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	250,785,716 - 250,785,926	NCBI	Rnor6.0
Rnor_5.0	2	269,312,537 - 269,312,747	UniSTS	Rnor5.0
RGSC_v3.4	2	242,944,988 - 242,945,198	UniSTS	RGSC3.4
Celera	2	225,815,879 - 225,816,089	UniSTS
Cytogenetic Map	2	q44	UniSTS

BE199161

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	233,996,311 - 233,996,411 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	250,955,657 - 250,955,756	NCBI	Rnor6.0
Rnor_5.0	2	269,483,497 - 269,483,596	UniSTS	Rnor5.0
RGSC_v3.4	2	243,116,009 - 243,116,108	UniSTS	RGSC3.4
Celera	2	225,984,548 - 225,984,647	UniSTS
Cytogenetic Map	2	q44	UniSTS

RH143389

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	233,999,648 - 233,999,768 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	250,958,994 - 250,959,113	NCBI	Rnor6.0
Rnor_5.0	2	269,486,834 - 269,486,953	UniSTS	Rnor5.0
RGSC_v3.4	2	243,119,346 - 243,119,465	UniSTS	RGSC3.4
Celera	2	225,987,885 - 225,988,004	UniSTS
Cytogenetic Map	2	q44	UniSTS

AI008454

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	233,995,619 - 233,995,774 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	250,954,965 - 250,955,119	NCBI	Rnor6.0
Rnor_5.0	2	269,482,805 - 269,482,959	UniSTS	Rnor5.0
RGSC_v3.4	2	243,115,317 - 243,115,471	UniSTS	RGSC3.4
Celera	2	225,983,856 - 225,984,010	UniSTS
RH 3.4 Map	2	1662.41	UniSTS
Cytogenetic Map	2	q44	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	4	9	41	68	74	43	23	43	6	139	44	28	39	48	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107450	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118528	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000018435 ⟹ ENSRNOP00000018435

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	233,995,078 - 234,022,199 (-)	Ensembl
Rnor_6.0 Ensembl	2	250,954,397 - 250,981,623 (-)	Ensembl

RefSeq Acc Id:

NM_001107450 ⟹ NP_001100920

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	236,655,423 - 236,682,458 (-)	NCBI
mRatBN7.2	2	233,995,077 - 234,022,112 (-)	NCBI
Rnor_6.0	2	250,954,423 - 250,981,544 (-)	NCBI
Rnor_5.0	2	269,482,241 - 269,509,237 (-)	NCBI
RGSC_v3.4	2	243,114,775 - 243,142,349 (-)	RGD
Celera	2	225,983,314 - 226,010,397 (-)	RGD

Sequence:

show sequence

TATTGCCTTGGAGAACTTGTAGAGACAGGTTCCAGATAGATCCACCCCAGAGTTTTCAAAGAAG
GCAACTCCTTCATCATGTATATTGTAAGACCTTCTGAGTTCCGAAAGAAGCCATTTGCTTCCAC
ATTGATCAGCTGACTCGAGGTGCCCAGCAGGCTCCCCGTGAGTAACCCAGAGGCTTCACTACAA
GATGATCCTCGGGGGTAACACAGGACCTGTTGGCAGGCTGAAACTCGTGACTCTTCTGTTTGCC
CTAAGTCCAGAACTTGTGTTCCTGGGAGCTGGATTGAAGCTGAAAGAGAATGGTTATGATGGAT
TGCTTGTTGCGATCAATCCTCGGGTACCGGAGGACTTGAAGCTGATCAGAAACATTCAGGAGAT
GATCACCGAAGCTTCCTTTTACCTGTTCAATGCGACCAAGAGAAGGGTGTTTTTCAGAAGTGTA
CAGATTCTAATACCTGCCACTTGGACAGCGCATAATTACAGCAGGGTTAAACAGGAATCCTTTG
ACAAGGCAAATGTCTTAGTGACTGAGCAGAATGGGGTACCCGGGGAAGACCCTTATACCCTACA
ACACAGAGGGTGTGGACAAGAGGGGAAATACATCCATTTCACCCCCAACTTCCTACTCAACGAT
GAGTTAGCAGCAGGATATGGCTCTCGAGGCCGAGTGTTTGTCCACGAGTGGGCCCATCTCCGCT
GGGGTGTGTTTGATGAATATAACAGTGACAAGCCGTTCTACGTGAATGGACGGAATGAGATTCA
AGTCACCAGGTGTTCATCTGACATCACGGGTGTTTTTGTTTGTGAAAAGGGCCTTTGCCCCCAC
GAAGACTGCATCATTAGCAAGCTTTTTAGGGAAGGATGCACATTCCTCTACAACAGCACCCAGA
GTGCAACTGGATCAATAATGTTCATGCAGAGTTTACCTTCTGTGGTTGAATTCTGTAACGAAGG
CACCCACAATCGAGAAGCCCCAAATCTCCAGAACCGAGTGTGCAGCCTCAGAAGCACTTGGGAT
GTGATCACTGGCTCCTCAGACCTGAACCACAGCCTCCCGGTGCTGGGGGTTGAGCTTCCAGCCC
CTCCCTCGTTCTCCCTCTTGCAGGCTGGTGACCGAGTGGTCTGCTTAGTGATTGATGTGTCCAG
GAAGATGGCAGAGGGAGACAGACTCCTCCGGCTACAACAAGCAGCCGAACTGTTCTTGATGCAG
GTCGTTGAAGCTCATACTTTTGTGGGCATTGTCACTTTTGACAGCAAAGGAGAAATCCGAGCCC
CGTTGCAACAAATTAACAGCGACGATGACCGGAAGTTGCTGGTTTCGTACCTGCCGACCACTGT
GTCCACTGAAGCAGAGACCAACATCTGTGCAGGGGTTAAGAAAGGCTTTGAGGTGGTTGAGAAG
CAGAATGGACGAGCGGATGGCTCTGTCATGATATTAGTGACCAGCGGAGCAGATGAACACATCA
CCAACTGCCTGCTCACCGCAATGAGCAGTGGGTCCACCATTCATTCCATGGCCCTGGGCTCCTC
TGCAGCCAGAAGACTGGGGGAATTATCACATGTTACAGGAGGTTTGGAGTTCTTCATTCCAGAT
CCATTTACCTCTAGCCGAATGACTGAAGCCTTCAGTGGAATCTCTTCTGGGGCAGGAGACATTT
TCCAGCAAAGCTTACAGCTTGAAAGCACGTGCGAGACTGTGCAACCCCAGCACCAACTGGCAAA
TACTGTGACTGTGGATAGGGCTGTGGGCAATGACACGTTTTTCCTAGTCATGTGGCAGACCGGT
GGTCCCTCTGAGATTGTATTATTGGACCCTAGTGGAAGAAAATACAACACTGGTGACTTTATCA
TCAATCTGCCCTTTCGGACAGCCAGCCTTAAGATTCCAGGAACTGCTAAGCATGGGCACTGGAC
TTACACGCTGAACAATACCCACCATTCTCCTCAAGCTCTGAAAGTGACTGTGGCCTCCCGTGCC
TCCAGTCTGGCCGTGTCCCCAGCCACCGTGGACGCCTTTGTGGAAAGGGACAGCACCTATTTTC
CTCAGCCGGTGATAATTTATGCAAACGTGAGGAAGGGTCTGTACCCCATACTCAATGCCACTGT
GATGGCAACGGTTGAGCCTGAGGCTGGAGACCCTGTTGTGCTGCAACTTTTGGATGAAGGAGCA
GGCGCCGATGTTATAAAAAATGATGGAATTTACTCCAGGTATTTTTTCTCCTTTGCTGTAAGTG
GTAGATATAGCTTGACAGTGCATGTCCGTCACTCTCCCAGCACAAGCACCCTAGCCCACTCTGT
CCCAGGAAACCATGCTATGTATGTACCAGGTTACGTAACCAACGATAATATTCAAATGAATGCT
CCCAAAAGAACAGGCCGCAGACCTGTGAAGGAGCGGTGGGACTTCAGTCGAGTAAGCTCTGGAG
GCTCCTTCTCAGTGCTGGGAGTCCCAGACGGCCCCCACCCTGACGTGTTCCCACCATGCAGAAT
TACGGACCTGGCAGCCATGAACGTAGAAGAGGATGTGACCCTCTCTTGGACGGCACCTGGGGAA
GACTTCGATCAGGGGCAAACCACAAGCTATGAAATAAGAATGAGCAAAAGTCTACAGCGTATTC
GGGATGACTTTGACAATGCCATCTTGGTGAACTCGTCGGGGCTAATTCCTCAGCATGCTGGCAC
CAGGGAGACATTTACATTCTCACCCAAGCTTGTCACCCATGAACTTGAACATGAACCTGATGAA
GAAGCACAAGAAACCTACATAGTGTATGTGGCCCTGAGAGCCATGGATAGAAGCTCCCTCCGGT
CAGCTGTGTCAAACATTGTCCTGGTATCAATGTCTCTCCCCCCAAACTCTGCTCCTGTAGTGAG
CAGAGATGACAGGATACTGAAAGGAGTTTTAACAATAGTAGGTTTGATAACGATTCTTTGCCTT
CTTCTGGTTGTATCACACTGTACTTTAAACAGGAAAAAGAGAGCATCAAGGAAAGAGAATGAAA
CAAAATTTCTATGAGTAGACGTAATACCTTCCTTCTTAGATATGATGACCATAGCCTTTACAGC
CACAAAAATGCCAACAAAATCAAATTAGCCTTAACATTGGGACTTTTACATAGCAGATAGTTGC
CTTCTCCCGCCTTCCTCCCCCCCAAAAAGCCTAACTTTTAATACTCGTTTTAGGGAAAGGGTTT
GAAAACAGTGTAAGGTTCCAATGGAAAAATAATAAAATATATTGCTCAAGGTAATGGCTTGAAA
GGCAAGGACAAAATCAAATGGGAGTCAGGAAAAGCTTGTTTTATTGAAGTTGAGGTCAGGGGAA
GTTCTGTGTACGGAAAAGGATGTTGGGCCTGAGTCAGACAGTGTAACTACCGGTATGAAGCGAA
AGTATTACAGTGATGAATTTCTCTCTCTGCTTATCTGTGCAGAGCAGGGTGAGTGTTTATAACT
GACAACCAAGCTTCTTTATAGACAAGGCCCCGCTACAGGGTTCTTTATACCTTCTCCTTTGGTT
AAACACACTGTGATGACCCACAAGCCACCACTAATGCTCAGGCAGGTCTTTTCTCACCGTGAGA
GGAGACCTTAGAATGCAGTTGTTATCCCTGCTCCTTGGATTCTGATCTACAACAGAGGTCACCT
TAGTTTATTGTTTGTCAGATTTCAGTGCCACTGAAGTAGCTTCCTAAGTTATTGCCTTGGAAGT
AACTGAGTAAAAATGGTCACCACTCCCATGAGGCTTTAAGTAAAGGGTAAAAGACATCATTGTG
AAATAATTTTAATATATACACCATGTAGTTTTATTCTATTGCAAAGAAGAAGTCATGGATGGAA
AGGTGTTTAGAAGCAACTAGCAAATTCTGTCCTGGTTAAATAACAATCTGCAATCCTTGCTTCA
TCGAGGACAGAGAGAAGACAGCAGAGATAATGTGGAAATAAAAACCATCTAATGTTACGTCCTC
CTCTTAAAAATTGTTGTTGAATATTAATATGTCATTTCTAAATTCAAGAACTTAAAATTTTATT
GAATAAATATGTCACAG

hide sequence

RefSeq Acc Id:

XM_039102133 ⟹ XP_038958061

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	236,655,419 - 236,682,669 (-)	NCBI
mRatBN7.2	2	233,993,619 - 234,022,691 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100920	(Get FASTA)	NCBI Sequence Viewer
	XP_038958061	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL82390	(Get FASTA)	NCBI Sequence Viewer
	EDL82391	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000018435.4

RefSeq Acc Id:

NP_001100920 ⟸ NM_001107450

- UniProtKB:

D3ZVT7 (UniProtKB/TrEMBL), A6HWA4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MILGGNTGPVGRLKLVTLLFALSPELVFLGAGLKLKENGYDGLLVAINPRVPEDLKLIRNIQEM
ITEASFYLFNATKRRVFFRSVQILIPATWTAHNYSRVKQESFDKANVLVTEQNGVPGEDPYTLQ
HRGCGQEGKYIHFTPNFLLNDELAAGYGSRGRVFVHEWAHLRWGVFDEYNSDKPFYVNGRNEIQ
VTRCSSDITGVFVCEKGLCPHEDCIISKLFREGCTFLYNSTQSATGSIMFMQSLPSVVEFCNEG
THNREAPNLQNRVCSLRSTWDVITGSSDLNHSLPVLGVELPAPPSFSLLQAGDRVVCLVIDVSR
KMAEGDRLLRLQQAAELFLMQVVEAHTFVGIVTFDSKGEIRAPLQQINSDDDRKLLVSYLPTTV
STEAETNICAGVKKGFEVVEKQNGRADGSVMILVTSGADEHITNCLLTAMSSGSTIHSMALGSS
AARRLGELSHVTGGLEFFIPDPFTSSRMTEAFSGISSGAGDIFQQSLQLESTCETVQPQHQLAN
TVTVDRAVGNDTFFLVMWQTGGPSEIVLLDPSGRKYNTGDFIINLPFRTASLKIPGTAKHGHWT
YTLNNTHHSPQALKVTVASRASSLAVSPATVDAFVERDSTYFPQPVIIYANVRKGLYPILNATV
MATVEPEAGDPVVLQLLDEGAGADVIKNDGIYSRYFFSFAVSGRYSLTVHVRHSPSTSTLAHSV
PGNHAMYVPGYVTNDNIQMNAPKRTGRRPVKERWDFSRVSSGGSFSVLGVPDGPHPDVFPPCRI
TDLAAMNVEEDVTLSWTAPGEDFDQGQTTSYEIRMSKSLQRIRDDFDNAILVNSSGLIPQHAGT
RETFTFSPKLVTHELEHEPDEEAQETYIVYVALRAMDRSSLRSAVSNIVLVSMSLPPNSAPVVS
RDDRILKGVLTIVGLITILCLLLVVSHCTLNRKKRASRKENETKFL

hide sequence

Ensembl Acc Id:

ENSRNOP00000018435 ⟸ ENSRNOT00000018435

RefSeq Acc Id:	XP_038958061 ⟸ XM_039102133
- Peptide Label:	isoform X1

Protein Domains

VWFA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZVT7-F1-model_v2	AlphaFold	D3ZVT7	1-942	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304894	AgrOrtholog
BioCyc Gene	G2FUF-50931	BioCyc
Ensembl Genes	ENSRNOG00000013771	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000018435.6	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.410	UniProtKB/TrEMBL
InterPro	CaCC_prot	UniProtKB/TrEMBL
	Cl_channel_Ca	UniProtKB/TrEMBL
	CLCR	UniProtKB/TrEMBL
	VWF_A	UniProtKB/TrEMBL
	vWFA_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:308016	UniProtKB/TrEMBL
NCBI Gene	308016	ENTREZGENE
PANTHER	CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR	UniProtKB/TrEMBL
	CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 2	UniProtKB/TrEMBL
Pfam	CLCA_N	UniProtKB/TrEMBL
	VWA_2	UniProtKB/TrEMBL
PhenoGen	Clca2	PhenoGen
PROSITE	VWFA	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000013771	RatGTEx
SMART	VWA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53300	UniProtKB/TrEMBL
UniProt	A6HWA4	ENTREZGENE, UniProtKB/TrEMBL
	A6HWA5_RAT	UniProtKB/TrEMBL
	D3ZVT7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-11-11	Clca2	chloride channel accessory 2	Clca5	chloride channel calcium activated 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-03	Clca5	chloride channel calcium activated 5	Clca2_predicted	chloride channel, calcium activated, family member 2 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Clca2_predicted	chloride channel, calcium activated, family member 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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