Gene: CLCA2 (chloride channel accessory 2) Homo sapiens
Symbol: CLCA2
Name: chloride channel accessory 2
Description: This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CACC; CaCC-3; CACC3; calcium-activated chloride channel family member 2; calcium-activated chloride channel protein 3; calcium-activated chloride channel regulator 2; calcium-activated chloride channel-2; chloride channel regulator 2; chloride channel, calcium activated, family member 2; CLCA family member 2, chloride channel regulator; CLCRG2; FLJ97885; hCaCC-3; hCLCA2; OTTHUMP00000011911
Mus musculus (house mouse) : Clca2 (chloride channel accessory 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Clca2 (chloride channel accessory 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clca2 (chloride channel accessory 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CLCA2 (chloride channel accessory 2)
Canis lupus familiaris (dog) : CLCA2 (chloride channel accessory 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38186,424,086 - 86,456,558 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37186,889,769 - 86,922,241 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36186,662,413 - 86,694,829 (+)NCBINCBI36hg18NCBI36
Build 34186,601,845 - 86,634,259NCBI
Celera185,133,768 - 85,166,240 (+)NCBI
Cytogenetic Map1p22.3NCBI
HuRef185,000,753 - 85,032,874 (+)NCBIHuRef
CHM1_1187,004,629 - 87,037,098 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CLCA2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1312594
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2018-03-13
Status: ACTIVE