Clca2 (chloride channel accessory 2) - Rat Genome Database

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Gene: Clca2 (chloride channel accessory 2) Ictidomys tridecemlineatus
Analyze
Symbol: Clca2
Name: chloride channel accessory 2 (Ensembl:calcium-activated chloride channel regulator 2)
RGD ID: 12488991
Description: ENCODES a protein that exhibits chloride channel activity (inferred); intracellularly calcium-gated chloride channel activity (inferred); ligand-gated monoatomic ion channel activity (inferred); INVOLVED IN chloride transport (ortholog); ASSOCIATED WITH genetic disease (ortholog); Lung Neoplasms (ortholog); FOUND IN cell junction (inferred); cytosol (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calcium-activated chloride channel regulator 2; LOC101966788
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505896,893,563 - 96,928,155 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936865202,555 - 237,099 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936865202,970 - 237,072 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Clca2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505896,893,563 - 96,928,155 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936865202,555 - 237,099 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936865202,970 - 237,072 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLCA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38186,424,171 - 86,456,553 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl186,424,171 - 86,456,553 (+)EnsemblGRCh38hg38GRCh38
GRCh37186,889,854 - 86,922,236 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36186,662,413 - 86,694,829 (+)NCBINCBI36Build 36hg18NCBI36
Build 34186,601,845 - 86,634,259NCBI
Celera185,133,768 - 85,166,240 (+)NCBICelera
Cytogenetic Map1p22.3NCBI
HuRef185,000,753 - 85,032,874 (+)NCBIHuRef
CHM1_1187,004,629 - 87,037,098 (+)NCBICHM1_1
T2T-CHM13v2.0186,264,193 - 86,296,574 (+)NCBIT2T-CHM13v2.0
Clca2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393144,776,021 - 144,805,204 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3144,776,024 - 144,805,204 (-)EnsemblGRCm39 Ensembl
GRCm383145,070,260 - 145,099,443 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3145,070,263 - 145,099,443 (-)EnsemblGRCm38mm10GRCm38
MGSCv373144,733,229 - 144,762,005 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363145,007,651 - 145,036,427 (-)NCBIMGSCv36mm8
Celera3151,513,121 - 151,541,898 (-)NCBICelera
Cytogenetic Map3H2NCBI
cM Map369.31NCBI
Clca2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82236,655,419 - 236,682,669 (-)NCBIGRCr8
mRatBN7.22233,993,619 - 234,022,691 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2233,995,078 - 234,022,199 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2241,783,941 - 241,811,118 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02239,672,060 - 239,699,210 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02234,541,565 - 234,568,742 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02250,954,423 - 250,981,544 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2250,954,397 - 250,981,623 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02269,482,241 - 269,509,237 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42243,114,775 - 243,142,349 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2225,983,314 - 226,010,397 (-)NCBICelera
Cytogenetic Map2q44NCBI
Clca2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554237,728,652 - 7,760,697 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554237,729,032 - 7,760,340 (-)NCBIChiLan1.0ChiLan1.0
CLCA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21140,503,490 - 140,536,078 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11139,655,368 - 139,691,488 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,954,863 - 118,987,264 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1187,808,002 - 87,840,605 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl187,808,205 - 87,840,605 (+)Ensemblpanpan1.1panPan2
CLCA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1661,665,120 - 61,705,760 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl661,666,105 - 61,704,746 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha664,379,479 - 64,415,767 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0662,205,308 - 62,244,815 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl662,205,904 - 62,244,664 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1661,738,026 - 61,777,512 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0661,701,435 - 61,740,933 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0662,207,245 - 62,246,736 (-)NCBIUU_Cfam_GSD_1.0
CLCA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4129,670,638 - 129,704,846 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14129,670,634 - 129,704,765 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24142,188,545 - 142,223,419 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLCA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12046,974,030 - 47,007,723 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2046,975,337 - 47,006,646 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603370,803,176 - 70,835,376 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clca2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474211,183,711 - 11,212,388 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474211,182,852 - 11,217,222 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005341301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000001519   ⟹   ENSSTOP00000001359
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936865202,555 - 237,099 (-)Ensembl
RefSeq Acc Id: XM_005341301   ⟹   XP_005341358
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505896,893,563 - 96,928,155 (+)NCBI
SpeTri2.0NW_004936865202,970 - 237,072 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005341358 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000001359.2
GenBank Protein KAG3283531 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005341358   ⟸   XM_005341301
- UniProtKB: I3LYQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000001359   ⟸   ENSSTOT00000001519
Protein Domains
VWFA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000001512 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000001519.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
InterPro CLCA_chordata UniProtKB/TrEMBL
  CLCA_N UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene LOC101966788 ENTREZGENE
PANTHER CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR UniProtKB/TrEMBL
  CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 2 UniProtKB/TrEMBL
Pfam CLCA UniProtKB/TrEMBL
PROSITE VWFA UniProtKB/TrEMBL
SMART VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
UniProt I3LYQ6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 Clca2  chloride channel accessory 2  LOC101966788  calcium-activated chloride channel regulator 2  Symbol and/or name change 5135510 APPROVED