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Gene: Serpinc1 (serpin family C member 1) Rattus norvegicus
Symbol: Serpinc1
Name: serpin family C member 1
Description: Exhibits heparin binding activity and serine-type endopeptidase inhibitor activity. Involved in acute inflammatory response to antigenic stimulus; lactation; and response to nutrient. Localizes to the extracellular space. Used to study thrombosis. Biomarker of familial hyperlipidemia; nephrotic syndrome; and ovarian cancer. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (serpin family C member 1); PARTICIPATES IN coagulation cascade pathway; enoxaparin pharmacodynamics pathway; fondaparinux pharmacodynamics pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
Also known as: antithrombin III; antithrombin-III; LOC304917; serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1
Homo sapiens (human) : SERPINC1 (serpin family C member 1)  HGNC  Alliance
Mus musculus (house mouse) : Serpinc1 (serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Serpinc1 (serpin family C member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SERPINC1 (serpin family C member 1)
Canis lupus familiaris (dog) : SERPINC1 (serpin family C member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Serpinc1 (serpin family C member 1)
Sus scrofa (pig) : SERPINC1 (serpin family C member 1)
more info ...
Allele / Splice: Serpinc1em2Mcwi  
Genetic Models: SS.BN-(D13Rat151-D13Rat197)-Serpinc1em2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01378,806,107 - 78,820,375 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1378,805,347 - 78,833,192 (+)Ensembl
Rnor_5.01383,700,761 - 83,715,029 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41376,548,456 - 76,562,724 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11376,562,643 - 76,576,911 (+)NCBI
Celera1373,045,672 - 73,059,940 (+)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Serpinc1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1307404
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.