Spp1 (secreted phosphoprotein 1) - Rat Genome Database

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Gene: Spp1 (secreted phosphoprotein 1) Rattus norvegicus
Analyze
Symbol: Spp1
Name: secreted phosphoprotein 1
RGD ID: 3752
Description: Predicted to enable extracellular matrix binding activity; integrin binding activity; and small molecule binding activity. Involved in several processes, including negative regulation of collateral sprouting of intact axon in response to injury; positive regulation of bone resorption; and response to macrophage colony-stimulating factor. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and vesicle. Used to study several diseases, including encephalomyelitis; glomerulonephritis; myocarditis; radiculopathy; and renovascular hypertension. Biomarker of autosomal dominant polycystic kidney disease; calcinosis; and glomerulosclerosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1); PARTICIPATES IN diabetic nephropathy pathway; c-Jun N-terminal kinases MAPK signaling pathway; fibroblast growth factor signaling pathway; INTERACTS WITH (R,R)-tramadol; (S)-naringenin; 1,3,5-trinitro-1,3,5-triazinane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bone sialoprotein 1; LOC100359743; OSP; osteopontin; osteopontin-like; Sialoprotein (osteopontin); SPP-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Spp1em1Mcwi   spp1em3Mcwi   Spp1em4Mcwi   Spp1em2Mcwi  
Genetic Models: SS-Spp1em3Mcwi SHRSP-Spp1em2Mcwi SHRSP-Spp1em1Mcwi SS-Spp1em4Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,613,569 - 5,620,695 (-)NCBIGRCr8
mRatBN7.2145,308,885 - 5,315,120 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,308,885 - 5,315,162 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx145,269,750 - 5,275,787 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,569,945 - 6,575,982 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,261,625 - 5,267,707 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0146,673,686 - 6,679,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,673,686 - 6,679,901 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0146,653,086 - 6,658,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1146,422,741 - 6,426,400 (-)NCBI
Celera145,447,814 - 5,453,553 (-)NCBICelera
RH 3.4 Map1484.5RGD
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Original Reference(s)
Spp1Ratacute kidney failure  ISOSpp1 (Mus musculus)6903264 RGD 
Spp1RatAlbuminuria  IEP 6903862 RGD 
Spp1RatAneurysm  ISOSPP1 (Homo sapiens)1581391 RGD 
Spp1RatAngina Pectoris  ISOSPP1 (Homo sapiens)1581390 RGD 
Spp1Ratanti-basement membrane glomerulonephritis  ISOSpp1 (Mus musculus)6903276 RGD 
Spp1Rataortic aneurysm  ISOSPP1 (Homo sapiens)155260284protein:increased expression:aorta (human)RGD 
Spp1Rataortic dissection  ISOSPP1 (Homo sapiens)155260309protein:increased expression:aorta (human)RGD 
Spp1Rataortic dissection  ISOSPP1 (Homo sapiens)155260287protein:increased expression:aorta (human)RGD 
Spp1Ratautosomal dominant polycystic kidney disease  IEP 5131995 RGD 
Spp1Ratbiliary atresia  ISOSPP1 (Homo sapiens)1581370 RGD 
Spp1Ratcalcinosis  IEP 6903869 RGD 
Spp1Ratcalcinosis  ISOSPP1 (Homo sapiens)9068449protein:increased expression:dermis:RGD 
Spp1RatCardiomegaly  ISOSpp1 (Mus musculus)1581339 RGD 
Spp1RatChronic Hepatitis C treatmentISOSPP1 (Homo sapiens)1581374DNA:SNPs:promoter:-443C>T and -1748G>A (human)RGD 
Spp1Ratcoronary artery disease  ISOSPP1 (Homo sapiens)6903271In type 2 diabetic patientsRGD 
Spp1Ratcoronary restenosis  ISOSPP1 (Homo sapiens)1581366 RGD 
Spp1Ratcoronary restenosis  ISOSpp1 (Mus musculus)1581358 RGD 
Spp1RatCystic, Mucinous, and Serous Neoplasms  ISOSPP1 (Homo sapiens)1581360 RGD 
Spp1RatDiabetic Nephropathies  IDA 1581328 RGD 
Spp1Ratdisease of cellular proliferation  ISOSPP1 (Homo sapiens)1581381 RGD 
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Original Reference(s)
Spp1Ratautosomal dominant polycystic kidney disease  ISOSPP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal dominant polycystic kidney diseaseClinVarPMID:17582161 more ...
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Spp1Ratacute kidney failure  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11274264 and PMID:20623750
Spp1Ratadenocarcinoma  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20495387 and PMID:21552421
Spp1RatAlcoholic Liver Diseases  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18703563
Spp1Ratallergic contact dermatitis  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14555839
Spp1Ratallergic disease  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21625544
Spp1Ratasbestosis  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16221779 and PMID:21514415
Spp1RatBrain Neoplasms  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16651633
Spp1RatBreast Neoplasms  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18949741 and PMID:22531848
Spp1Ratcalcinosis  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21193197 and PMID:21335463
Spp1Ratcarotid stenosis  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26564003
Spp1RatCerebral Hemorrhage  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:20440599
Spp1RatChemical and Drug Induced Liver Injury  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20623750
Spp1RatDiabetic Cardiomyopathies  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16980342
Spp1RatDrug-Related Side Effects and Adverse Reactions  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15805072
Spp1RatExperimental Liver Neoplasms  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11420682
Spp1RatExperimental Mammary Neoplasms  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:15318939
Spp1RatExperimental Neoplasms  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:21852811
Spp1Ratfocal segmental glomerulosclerosis  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9294829
Spp1Ratheart disease  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23558518
Spp1Ratheart valve disease  ISOSPP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21335463
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Original Reference(s)
Spp1Rat(R,R)-tramadol multiple interactionsEXP 6480464Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein] and Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein]CTDPMID:33645892
Spp1Rat(R,R)-tramadol increases expressionEXP 6480464Tramadol results in increased expression of SPP1 proteinCTDPMID:33645892
Spp1Rat(S)-naringenin multiple interactionsEXP 6480464naringenin inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA]CTDPMID:22709785
Spp1Rat(S)-nicotine increases expressionISOSPP1 (Homo sapiens)6480464Nicotine results in increased expression of SPP1 proteinCTDPMID:11425648
Spp1Rat(S)-nicotine multiple interactionsISOSPP1 (Homo sapiens)6480464Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein]CTDPMID:11425648
Spp1Rat1,2-dimethylhydrazine increases expressionISOSpp1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of SPP1 mRNACTDPMID:22206623
Spp1Rat1,3,5-trinitro-1,3,5-triazinane increases expressionEXP 6480464cyclonite results in increased expression of SPP1 mRNACTDPMID:25559034
Spp1Rat1,4-dichlorobenzene increases expressionISOSpp1 (Mus musculus)64804644-dichlorobenzene results in increased expression of SPP1 mRNACTDPMID:26975756
Spp1Rat1-chloro-2,4-dinitrobenzene multiple interactionsEXP 6480464Dinitrochlorobenzene inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Glucose results in increased secretion of SPP1 protein]] more ...CTDPMID:20453393
Spp1Rat1-fluoro-2,4-dinitrobenzene increases response to substanceISOSpp1 (Mus musculus)6480464SPP1 protein results in increased susceptibility to DinitrofluorobenzeneCTDPMID:14555839
Spp1Rat1-fluoro-2,4-dinitrobenzene multiple interactionsISOSpp1 (Mus musculus)6480464Trinitrobenzenesulfonic Acid promotes the reaction [SPP1 protein results in increased susceptibility to Dinitrofluorobenzene]CTDPMID:14555839
Spp1Rat1-methylphenanthrene multiple interactionsISOSPP1 (Homo sapiens)6480464[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of SPP1 mRNACTDPMID:17690111
Spp1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of SPP1 mRNACTDPMID:18289764 and PMID:23558518
Spp1Rat1-naphthyl isothiocyanate multiple interactionsISOSPP1 (Homo sapiens)6480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of SPP1 mRNACTDPMID:27344345
Spp1Rat1-nitropyrene decreases expressionISOSPP1 (Homo sapiens)64804641-nitropyrene results in decreased expression of SPP1 mRNACTDPMID:19428942
Spp1Rat11-deoxycorticosterone multiple interactionsEXP 6480464[Desoxycorticosterone co-treated with Sodium Chloride more ...CTDPMID:21135038
Spp1Rat15-deoxy-Delta(12,14)-prostaglandin J2 decreases expressionISOSpp1 (Mus musculus)648046415-deoxy-delta(12 and 14)-prostaglandin J2 results in decreased expression of SPP1 mRNACTDPMID:12021203
Spp1Rat17alpha-ethynylestradiol increases expressionISOSpp1 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of SPP1 mRNACTDPMID:17942748
Spp1Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of SPP1 mRNACTDPMID:17557909
Spp1Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of SPP1 mRNACTDPMID:12655037 and PMID:16140622

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Biological Process
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Original Reference(s)
Spp1Ratandrogen catabolic process involved_inISOSPP1 (Homo sapiens)1624291 PMID:26482249RGDPMID:26482249
Spp1Ratandrogen catabolic process involved_inIEAUniProtKB:P10451 and ensembl:ENSP000003785171600115GO_REF:0000107EnsemblGO_REF:0000107
Spp1Ratbiomineral tissue development involved_inIEAUniProtKB-KW:KW-00911600115GO_REF:0000043UniProtGO_REF:0000043
Spp1Ratbone mineralization involved_inISOSpp1 (Mus musculus)1624291MGI:1856651 more ...RGDPMID:12817751
Spp1Ratcalcium ion homeostasis involved_inISOSpp1 (Mus musculus)1624291 PMID:12817751RGDPMID:12817751
Spp1Ratcell adhesion  IMP 70021 RGD 
Spp1Ratcell adhesion involved_inIEAUniProtKB:P10451 and ensembl:ENSP000003785171600115GO_REF:0000107EnsemblGO_REF:0000107
Spp1Ratcell adhesion involved_inIBAPANTHER:PTN000064588 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Spp1Ratcell adhesion involved_inIEAUniProtKB-KW:KW-01301600115GO_REF:0000043UniProtGO_REF:0000043
Spp1Ratcell adhesion involved_inIEAInterPro:IPR002038 and InterPro:IPR0198411600115GO_REF:0000002InterProGO_REF:0000002
Spp1Ratcell adhesion involved_inIEAInterPro:IPR0020381600115GO_REF:0000002InterProGO_REF:0000002
Spp1Ratcell adhesion involved_inISOSPP1 (Homo sapiens)1624291 PMID:25839998RGDPMID:25839998
Spp1Ratcell adhesion  IDA 1581129 RGD 
Spp1Ratcell differentiation  IEP 1581120 RGD 
Spp1Ratcellular response to fluid shear stress acts_upstream_of_or_withinISOSpp1 (Mus musculus)1624291 PMID:24841674RGDPMID:24841674
Spp1Ratcellular response to leukemia inhibitory factor acts_upstream_of_or_withinISOSpp1 (Mus musculus)1624291 PMID:20439489RGDPMID:20439489
Spp1Ratcellular response to testosterone stimulus involved_inISOSPP1 (Homo sapiens)1624291 PMID:26482249RGDPMID:26482249
Spp1Ratcellular response to testosterone stimulus involved_inIEAUniProtKB:P10451 and ensembl:ENSP000003785171600115GO_REF:0000107EnsemblGO_REF:0000107
Spp1Ratcollecting duct development acts_upstream_of_or_withinISOSpp1 (Mus musculus)1624291 PMID:17898038RGDPMID:17898038
Spp1Ratintracellular calcium ion homeostasis acts_upstream_of_or_withinISOSpp1 (Mus musculus)1624291 PMID:17898038RGDPMID:17898038
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Cellular Component
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Object Symbol
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Original Reference(s)
Spp1Ratapical part of cell located_inISOSpp1 (Mus musculus)1624291 PMID:16518820RGDPMID:16518820
Spp1Ratcell projection  IDA 730240 RGD 
Spp1Ratcytoplasm located_inISOSpp1 (Mus musculus)1624291 PMID:16518820RGDPMID:16518820
Spp1Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Spp1Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Spp1Ratextracellular space  TAS 730240 RGD 
Spp1Ratextracellular space  IDA 2301841matrix vesicles - cell derived and extracellular vesicles that are initiation sites of mineralizationRGD 
Spp1Ratextracellular space is_active_inIBAPANTHER:PTN000064588 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Spp1Ratextracellular space located_inIEAUniProtKB-KW:KW-02021600115GO_REF:0000043UniProtGO_REF:0000043
Spp1Ratextracellular space located_inIEAUniProtKB:P10451 and ensembl:ENSP000003785171600115GO_REF:0000107EnsemblGO_REF:0000107
Spp1Ratextracellular space located_inISOSPP1 (Homo sapiens)1624291 PMID:15516325RGDPMID:15516325
Spp1RatGolgi apparatus located_inISOSPP1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Spp1RatGolgi apparatus located_inIEAUniProtKB:P10451 and ensembl:ENSP000003785171600115GO_REF:0000107EnsemblGO_REF:0000107
Spp1Ratperinuclear region of cytoplasm  IDA 730240 RGD 
Spp1Ratvesicle  IDA 2301841matrix vesicles - cell derived and extracellular vesicles that are initiation sites of mineralizationRGD 
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Molecular Function
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Spp1Ratcell-extracellular matrix signaling pathway  IEA 6907045 KEGGrno:04512
Spp1RatToll-like receptor signaling pathway   IEA 6907045 KEGGrno:04620

Imported Annotations - PID (archival)

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Original Reference(s)
Spp1Ratfibroblast growth factor signaling pathway  ISOSPP1 (Homo sapiens)6484113 PIDPID:200220

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#
Reference Title
Reference Citation
1. Upregulation of osteopontin in Schwann cells of the sciatic nerves of Lewis rats with experimental autoimmune neuritis. Ahn M, etal., Neurosci Lett. 2004 Nov 30;372(1-2):137-41.
2. Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities. Bidder M, etal., J Biol Chem 2002 Nov 15;277(46):44485-96.
3. Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats. Blasi ER, etal., Kidney Int. 2003 May;63(5):1791-800.
4. Expression pattern of osteopontin in endometrial carcinoma: correlation with expression of the adhesion molecule CEACAM1. Briese J, etal., Int J Gynecol Pathol. 2006 Apr;25(2):161-9.
5. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
6. Overexpression of the cytokine osteopontin identifies aggressive laryngeal squamous cell carcinomas and enhances carcinoma cell proliferation and invasiveness. Celetti A, etal., Clin Cancer Res. 2005 Nov 15;11(22):8019-27.
7. The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Chabas D, etal., Science. 2001 Nov 23;294(5547):1731-5.
8. Osteopontin gene haplotypes correlate with multiple sclerosis development and progression. Chiocchetti A, etal., J Neuroimmunol. 2005 Jun;163(1-2):172-8. Epub 2005 Apr 25.
9. Human myeloma cells express the bone regulating gene Runx2/Cbfa1 and produce osteopontin that is involved in angiogenesis in multiple myeloma patients. Colla S, etal., Leukemia. 2005 Dec;19(12):2166-76.
10. Expression and regulation of osteopontin and connective tissue growth factor transcripts in rat anterior pituitary. Ehrchen J, etal., J Endocrinol. 2001 Apr;169(1):87-96.
11. Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: osteopontin localization. Evan AP, etal., Kidney Int. 2005 Jul;68(1):145-54.
12. Prognostic significance of osteopontin expression in human prostate cancer. Forootan SS, etal., Int J Cancer. 2006 May 1;118(9):2255-61.
13. Spinal root avulsion-induced upregulation of osteopontin expression in the adult rat spinal cord. Fu Y, etal., Acta Neuropathol (Berl). 2004 Jan;107(1):8-16. Epub 2003 Sep 26.
14. A polymorphism of the osteopontin gene is related to urinary calcium stones. Gao B, etal., J Urol. 2005 Oct;174(4 Pt 1):1472-6.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Differential regulation of osteopontin expression in the clipped and nonclipped kidney of two-kidney, one-clip hypertensive rats. Gauer S, etal., Am J Hypertens. 2003 Mar;16(3):214-22.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness. Guarino V, etal., J Clin Endocrinol Metab. 2005 Sep;90(9):5270-8. Epub 2005 Jul 5.
19. Nitric oxide-dependent osteopontin expression induces metastatic behavior in HepG2 cells. Guo H, etal., Dig Dis Sci. 2005 Jul;50(7):1288-98.
20. Gene expression profiling of cathepsin D, metallothioneins-1 and -2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis. Hashimoto M, etal., Acta Neuropathol. 2005 Feb;109(2):165-80. Epub 2004 Dec 9.
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PMID:2736258   PMID:3167835   PMID:3469201   PMID:8408622   PMID:8889548   PMID:11967208   PMID:12505755   PMID:15121739   PMID:15153550   PMID:15482851   PMID:15489334   PMID:15516325  
PMID:15548430   PMID:15557322   PMID:15865444   PMID:16187297   PMID:16253490   PMID:16502470   PMID:16518820   PMID:16720713   PMID:16753026   PMID:16807234   PMID:16883060   PMID:17546625  
PMID:17643430   PMID:17868879   PMID:17898038   PMID:17973907   PMID:18036861   PMID:18041732   PMID:18158341   PMID:18180311   PMID:18235026   PMID:18378437   PMID:18415800   PMID:18471361  
PMID:18638458   PMID:18703563   PMID:18703867   PMID:18712054   PMID:18728346   PMID:18757743   PMID:19032867   PMID:19076167   PMID:19124839   PMID:19686792   PMID:19723557   PMID:19901966  
PMID:20211246   PMID:20392802   PMID:20396353   PMID:20407481   PMID:20417179   PMID:20439489   PMID:20450731   PMID:20596651   PMID:20626561   PMID:20714131   PMID:20838370   PMID:21264948  
PMID:21283687   PMID:21321126   PMID:21806466   PMID:21940634   PMID:21949681   PMID:22036853   PMID:22049796   PMID:22087764   PMID:22496158   PMID:22552891   PMID:22692550   PMID:22779921  
PMID:22814749   PMID:22847642   PMID:23161527   PMID:23241663   PMID:23376485   PMID:23457612   PMID:23466073   PMID:23467880   PMID:23498805   PMID:23533145   PMID:23788374   PMID:24247243  
PMID:24449951   PMID:24687376   PMID:24841674   PMID:25146847   PMID:25467747   PMID:25839998   PMID:26099282   PMID:26216642   PMID:26482249   PMID:26581507   PMID:27026710   PMID:27089830  
PMID:27262843   PMID:27486809   PMID:27585571   PMID:27659347   PMID:27717860   PMID:27743892   PMID:28270094   PMID:28302392   PMID:28442375   PMID:28978514   PMID:29337251   PMID:29602294  
PMID:30758811   PMID:30893567   PMID:31544532   PMID:31914633   PMID:32061643   PMID:32271401   PMID:32423114   PMID:33645892   PMID:33678127   PMID:33883409   PMID:34510519   PMID:35688947  
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Spp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,613,569 - 5,620,695 (-)NCBIGRCr8
mRatBN7.2145,308,885 - 5,315,120 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,308,885 - 5,315,162 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx145,269,750 - 5,275,787 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,569,945 - 6,575,982 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,261,625 - 5,267,707 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0146,673,686 - 6,679,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,673,686 - 6,679,901 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0146,653,086 - 6,658,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1146,422,741 - 6,426,400 (-)NCBI
Celera145,447,814 - 5,453,553 (-)NCBICelera
RH 3.4 Map1484.5RGD
Cytogenetic Map14p22NCBI
SPP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38487,975,714 - 87,983,411 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl487,975,667 - 87,983,532 (+)EnsemblGRCh38hg38GRCh38
GRCh37488,896,866 - 88,904,563 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36489,115,826 - 89,123,587 (+)NCBINCBI36Build 36hg18NCBI36
Build 34489,253,980 - 89,261,741NCBI
Celera486,188,727 - 86,196,490 (+)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef484,643,231 - 84,650,994 (+)NCBIHuRef
CHM1_1488,873,591 - 88,881,352 (+)NCBICHM1_1
T2T-CHM13v2.0491,302,203 - 91,309,899 (+)NCBIT2T-CHM13v2.0
Spp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395104,582,977 - 104,588,919 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5104,582,984 - 104,588,916 (+)EnsemblGRCm39 Ensembl
GRCm385104,435,111 - 104,441,053 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5104,435,118 - 104,441,050 (+)EnsemblGRCm38mm10GRCm38
MGSCv375104,864,137 - 104,870,069 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365104,657,300 - 104,681,345 (+)NCBIMGSCv36mm8
Celera5101,744,286 - 101,750,760 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.68NCBI
Spp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554741,913,829 - 1,922,016 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554741,914,477 - 1,922,025 (-)NCBIChiLan1.0ChiLan1.0
SPP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2385,977,678 - 85,985,354 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1486,240,086 - 86,247,760 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0480,263,711 - 80,271,466 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1490,988,200 - 90,995,935 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl490,988,200 - 90,995,935 (+)Ensemblpanpan1.1panPan2
SPP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13211,354,070 - 11,362,325 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3211,353,953 - 11,362,069 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3230,592,131 - 30,600,371 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03211,406,381 - 11,414,630 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3211,406,395 - 11,414,631 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13211,490,535 - 11,498,773 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03211,316,506 - 11,324,744 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03228,630,350 - 28,638,599 (-)NCBIUU_Cfam_GSD_1.0
Spp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052851,729,610 - 1,736,282 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936905148,945 - 156,079 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936905148,956 - 156,023 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8131,077,786 - 131,085,340 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18131,077,786 - 131,085,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,307,933 - 140,315,453 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8qNCBI
SPP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1736,337,165 - 36,344,927 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl736,338,386 - 36,344,407 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603715,089,529 - 15,097,556 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248724,505,522 - 4,513,742 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248724,505,796 - 4,513,247 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Spp1
73 total Variants

Predicted Target Of
Summary Value
Count of predictions:400
Count of miRNA genes:226
Interacting mature miRNAs:264
Transcripts:ENSRNOT00000067875
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 11 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1438130749088978Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat

1 to 10 of 11 rows
RH94678  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,309,008 - 5,309,173 (+)MAPPERmRatBN7.2
Rnor_6.0146,673,810 - 6,673,974NCBIRnor6.0
Rnor_5.0146,653,210 - 6,653,374UniSTSRnor5.0
Celera145,447,938 - 5,448,102UniSTS
RH 3.4 Map1484.5UniSTS
Cytogenetic Map14p22UniSTS
RH129494  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,309,016 - 5,309,234 (+)MAPPERmRatBN7.2
Rnor_6.0146,673,818 - 6,674,035NCBIRnor6.0
Rnor_5.0146,653,218 - 6,653,435UniSTSRnor5.0
Celera145,447,946 - 5,448,163UniSTS
Cytogenetic Map14p22UniSTS
RH136964  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,308,890 - 5,309,100 (+)MAPPERmRatBN7.2
Rnor_6.0146,673,692 - 6,673,901NCBIRnor6.0
Rnor_5.0146,653,092 - 6,653,301UniSTSRnor5.0
Celera145,447,820 - 5,448,029UniSTS
RH 3.4 Map1488.1UniSTS
Cytogenetic Map14p22UniSTS
PMC316977P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,309,424 - 5,309,769 (+)MAPPERmRatBN7.2
Rnor_6.0146,674,226 - 6,674,570NCBIRnor6.0
Rnor_5.0146,653,626 - 6,653,970UniSTSRnor5.0
Celera145,448,354 - 5,448,698UniSTS
Cytogenetic Map14p22UniSTS
UniSTS:280407  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,310,624 - 5,312,028 (+)MAPPERmRatBN7.2
Rnor_6.0146,675,426 - 6,676,829NCBIRnor6.0
Rnor_5.0146,654,826 - 6,656,229UniSTSRnor5.0
RGSC_v3.4146,423,677 - 6,425,080UniSTSRGSC3.4
Celera145,449,554 - 5,450,957UniSTS
Cytogenetic Map14p22UniSTS


This gene Spp1 is modified in the following models/strains:
SS-Spp1em3Mcwi     SHRSP-Spp1em2Mcwi     SHRSP-Spp1em1Mcwi     SS-Spp1em4Mcwi    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 24 59 6 217 96 93 45 60 31



Ensembl Acc Id: ENSRNOT00000067875   ⟹   ENSRNOP00000062358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl145,308,885 - 5,315,162 (-)Ensembl
Rnor_6.0 Ensembl146,673,686 - 6,679,901 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000075989   ⟹   ENSRNOP00000068511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl145,308,890 - 5,315,139 (-)Ensembl
Rnor_6.0 Ensembl146,673,746 - 6,679,878 (-)Ensembl
RefSeq Acc Id: NM_012881   ⟹   NP_037013
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,613,569 - 5,619,804 (-)NCBI
mRatBN7.2145,308,885 - 5,315,120 (-)NCBI
Rnor_6.0146,673,686 - 6,679,921 (-)NCBI
Rnor_5.0146,653,086 - 6,658,937 (-)NCBI
Celera145,447,814 - 5,453,553 (-)RGD
Sequence:
RefSeq Acc Id: XM_008769996   ⟹   XP_008768218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,613,569 - 5,619,801 (-)NCBI
mRatBN7.2145,308,885 - 5,315,117 (-)NCBI
Rnor_6.0146,673,686 - 6,679,965 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272870   ⟹   XP_063128940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,613,569 - 5,620,695 (-)NCBI
RefSeq Acc Id: NP_037013   ⟸   NM_012881
- Peptide Label: precursor
- UniProtKB: P08721 (UniProtKB/Swiss-Prot),   A6K5R7 (UniProtKB/TrEMBL),   P97827 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768218   ⟸   XM_008769996
- Peptide Label: isoform X1
- UniProtKB: P08721 (UniProtKB/Swiss-Prot),   A6K5R7 (UniProtKB/TrEMBL),   P97827 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062358   ⟸   ENSRNOT00000067875
Ensembl Acc Id: ENSRNOP00000068511   ⟸   ENSRNOT00000075989
RefSeq Acc Id: XP_063128940   ⟸   XM_063272870
- Peptide Label: isoform X1
- UniProtKB: P08721 (UniProtKB/Swiss-Prot),   A6K5R7 (UniProtKB/TrEMBL),   P97827 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-P08721-F1-model_v2 AlphaFold P08721 1-317 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699171
Promoter ID:EPDNEW_R9696
Type:multiple initiation site
Name:Spp1_1
Description:secreted phosphoprotein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0146,679,910 - 6,679,970EPDNEW


1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-16513 BioCyc
Ensembl Genes ENSRNOG00000043451 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000067875 ENTREZGENE
  ENSRNOT00000067875.5 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110677 IMAGE-MGC_LOAD
InterPro Osteopontin UniProtKB/Swiss-Prot
  Osteopontin_CS UniProtKB/Swiss-Prot
KEGG Report rno:25353 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93552 IMAGE-MGC_LOAD
NCBI Gene 25353 ENTREZGENE
PANTHER OSTEOPONTIN UniProtKB/Swiss-Prot
  PTHR10607 UniProtKB/Swiss-Prot
Pfam Osteopontin UniProtKB/Swiss-Prot
PhenoGen Spp1 PhenoGen
PRINTS OSTEOPONTIN UniProtKB/Swiss-Prot
PROSITE OSTEOPONTIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000043451 RatGTEx
SMART OSTEO UniProtKB/Swiss-Prot
TIGR TC216845
UniProt A0A8L2QZH3_RAT UniProtKB/TrEMBL
  A6K5R7 ENTREZGENE, UniProtKB/TrEMBL
  A6K5S2_RAT UniProtKB/TrEMBL
  OSTP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P97827 ENTREZGENE, UniProtKB/TrEMBL
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Spp1  secreted phosphoprotein 1  LOC100359743  osteopontin-like  Data merged from RGD:2323497 737654 PROVISIONAL
2010-05-06 LOC100359743  osteopontin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Spp1  secreted phosphoprotein 1      Name updated 70584 APPROVED

Note Type Note Reference
gene_cellular_localization intracellular form colocalizes with CD44 730240
gene_expression expressed in osteoclasts 730240
gene_expression expressed in osteosarcoma cell line ROS 17/2.8 70021
gene_expression expressed in normal kidney cells and expressed at a lower level in Kirsten sarcoma virus-transformed kidney cells 729935
gene_expression expressed in vibrissa dermal papilla (hair follicle cells) but not detected in cultured skin fibroblasts 1299048
gene_function extracellular matrix protein that binds cells 70021
gene_process may serve to aggregate dermal papilla cells and may protect dermal papilla cells from cytokine- or hypoxia-induced apoptosis 1299048
gene_protein 317 amino acid protein; may be both O- and N-glycosylated 70021
gene_transcript alternative transcript produced in kidney cells which is not expressed in osteosarcoma cells 729935