Gene: Spp1 (secreted phosphoprotein 1) Rattus norvegicus
Symbol: Spp1
Name: secreted phosphoprotein 1
Description: ENCODES a protein that exhibits extracellular matrix binding (ortholog); INVOLVED IN cell adhesion; cell differentiation; inflammatory response; PARTICIPATES IN diabetic nephropathy pathway; c-Jun N-terminal kinases MAPK signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH albuminuria; Calcinosis; diabetes mellitus, experimental; FOUND IN cell projection; extracellular space; perinuclear region of cytoplasm; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-naringenin; 1,3,5-trinitro-1,3,5-triazinane
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bone sialoprotein 1; LOC100359743; OSP; osteopontin; osteopontin-like; Sialoprotein (osteopontin); SPP-1
Homo sapiens (human) : SPP1 (secreted phosphoprotein 1)  HGNC  Alliance
Mus musculus (house mouse) : Spp1 (secreted phosphoprotein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spp1 (secreted phosphoprotein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SPP1 (secreted phosphoprotein 1)
Canis lupus familiaris (dog) : SPP1 (secreted phosphoprotein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spp1 (secreted phosphoprotein 1)
more info ...
Allele / Splice: Spp1em1Mcwi   spp1em3Mcwi   Spp1em4Mcwi  
Genetic Models: SS-Spp1em3Mcwi SHRSP-Spp1em1Mcwi SS-Spp1em4Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0146,673,686 - 6,679,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0146,653,086 - 6,658,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1146,422,741 - 6,426,400 (-)NCBI
Celera145,447,814 - 5,453,553 (-)NCBICelera
Cytogenetic Map14p22NCBI
RH 3.4 Map1484.5RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Spp1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3752
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2018-03-13
Status: ACTIVE