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Gene: Spp1 (secreted phosphoprotein 1) Rattus norvegicus
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Symbol: Spp1
Name: secreted phosphoprotein 1
Description: Predicted to have extracellular matrix binding activity and integrin binding activity. Involved in several processes, including negative regulation of collateral sprouting of intact axon in response to injury; osteoblast differentiation; and positive regulation of bone resorption. Localizes to several cellular components, including the extracellular space; perinuclear region of cytoplasm; and vesicle. Used to study several diseases, including encephalomyelitis; myocarditis; radiculopathy; renovascular hypertension; and visual epilepsy. Biomarker of autosomal dominant polycystic kidney disease; calcinosis; and glomerulosclerosis. Human ortholog(s) of this gene implicated in several diseases, including biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); multiple sclerosis; and rheumatoid arthritis. Orthologous to human SPP1 (secreted phosphoprotein 1); PARTICIPATES IN diabetic nephropathy pathway; c-Jun N-terminal kinases MAPK signaling pathway; fibroblast growth factor signaling pathway; INTERACTS WITH (S)-naringenin; 1,3,5-trinitro-1,3,5-triazinane; 1-chloro-2,4-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bone sialoprotein 1; LOC100359743; OSP; osteopontin; osteopontin-like; Sialoprotein (osteopontin); SPP-1
Orthologs:
Homo sapiens (human) : SPP1 (secreted phosphoprotein 1)  HGNC  Alliance
Mus musculus (house mouse) : Spp1 (secreted phosphoprotein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spp1 (secreted phosphoprotein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SPP1 (secreted phosphoprotein 1)
Canis lupus familiaris (dog) : SPP1 (secreted phosphoprotein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spp1 (secreted phosphoprotein 1)
Sus scrofa (pig) : SPP1 (secreted phosphoprotein 1)
more info ...
Allele / Splice: Spp1em1Mcwi   spp1em3Mcwi   Spp1em4Mcwi   Spp1em2Mcwi  
Genetic Models: SS-Spp1em3Mcwi SHRSP-Spp1em2Mcwi SHRSP-Spp1em1Mcwi SS-Spp1em4Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0146,673,686 - 6,679,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,673,686 - 6,679,901 (-)Ensembl
Rnor_5.0146,653,086 - 6,658,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1146,422,741 - 6,426,400 (-)NCBI
Celera145,447,814 - 5,453,553 (-)NCBICelera
Cytogenetic Map14p22NCBI
RH 3.4 Map1484.5RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Spp1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3752
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.