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Gene: Spp1 (secreted phosphoprotein 1) Mus musculus
Symbol: Spp1
Name: secreted phosphoprotein 1
Description: Exhibits extracellular matrix binding activity. Involved in several processes, including cellular response to fluid shear stress; cellular response to leukemia inhibitory factor; and neutrophil chemotaxis. Localizes to the apical part of cell and cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); multiple sclerosis; and rheumatoid arthritis. Is expressed in several structures, including alimentary system; limb cartilage condensation; metanephros; reproductive system; and skeleton. Orthologous to human SPP1 (secreted phosphoprotein 1); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; diabetic nephropathy pathway; fibroblast growth factor signaling pathway; INTERACTS WITH 1,4-dichlorobenzene; 1-fluoro-2,4-dinitrobenzene; 15-deoxy-Delta(12,14)-prostaglandin J2.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2AR; 44 kDa bone phosphoprotein; AA960535; AI790405; Apl-1; BNSP; bone sialoprotein 1; Bsp; BSPI; calcium oxalate crystal growth inhibitor protein; early T-lymphocyte activation 1 protein; Eta; ETA-1; minopontin; OP; Opn; Opnl; osteopontin; osteopontin-like protein; Ric; Spp-1
Homo sapiens (human) : SPP1 (secreted phosphoprotein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Spp1 (secreted phosphoprotein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spp1 (secreted phosphoprotein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SPP1 (secreted phosphoprotein 1)
Canis lupus familiaris (dog) : SPP1 (secreted phosphoprotein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spp1 (secreted phosphoprotein 1)
Sus scrofa (pig) : SPP1 (secreted phosphoprotein 1)
Chlorocebus sabaeus (green monkey) : SPP1 (secreted phosphoprotein 1)
Heterocephalus glaber (naked mole-rat) : Spp1 (secreted phosphoprotein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl5104,435,118 - 104,441,050 (+)Ensembl
GRCm385104,435,111 - 104,441,053 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375104,864,137 - 104,870,069 (+)NCBIGRCm37mm9NCBIm37
MGSCv365104,657,300 - 104,681,345 (+)NCBImm8
Celera5101,744,279 - 101,750,763 (+)NCBICelera
Cytogenetic Map5 E5NCBI
cM Map550.68NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Spp1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11340
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.