Spp1 (secreted phosphoprotein 1) - Rat Genome Database

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Gene: Spp1 (secreted phosphoprotein 1) Mus musculus
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Symbol: Spp1
Name: secreted phosphoprotein 1
RGD ID: 11340
MGI Page MGI
Description: Enables extracellular matrix binding activity and integrin binding activity. Involved in bone mineralization and calcium ion homeostasis. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; intracellular chloride ion homeostasis; and intracellular monoatomic cation homeostasis. Located in apical part of cell and cytoplasm. Is expressed in several structures, including alimentary system; brain; metanephros; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2AR; 44 kDa bone phosphoprotein; AA960535; AI790405; Ap; Apl-1; B; BNSP; bone sialoprotein 1; Bsp; BSPI; calcium oxalate crystal growth inhibitor protein; early T-lymphocyte activation 1 protein; Eta; ETA-; ETA-1; mi; minopontin; OP; Opn; Opnl; ost; osteopontin; osteopontin-like protein; R; Ric; Sp; Spp-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395104,582,977 - 104,588,919 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5104,582,984 - 104,588,916 (+)EnsemblGRCm39 Ensembl
GRCm385104,435,111 - 104,441,053 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5104,435,118 - 104,441,050 (+)EnsemblGRCm38mm10GRCm38
MGSCv375104,864,137 - 104,870,069 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365104,657,300 - 104,681,345 (+)NCBIMGSCv36mm8
Celera5101,744,286 - 101,750,760 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.68NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
adenocarcinoma  (ISO)
Albuminuria  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
Aneurysm  (ISO)
Angina Pectoris  (ISO)
anti-basement membrane glomerulonephritis  (IEP)
aortic aneurysm  (ISO)
aortic dissection  (ISO)
asbestosis  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
biliary atresia  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
calcinosis  (ISO)
Cardiomegaly  (IDA)
carotid stenosis  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (ISO)
coronary artery disease  (ISO)
coronary restenosis  (IDA,ISO)
Cystic, Mucinous, and Serous Neoplasms  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
encephalomyelitis  (IDA)
Endometrioid Carcinomas  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (IDA)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Experimental Seizures  (ISO)
Fibrosis  (IDA)
focal segmental glomerulosclerosis  (ISO)
Foreign-Body Reaction  (IDA)
glomerulonephritis  (ISO)
glomerulosclerosis  (ISO)
heart disease  (ISO)
heart valve disease  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Inflammation  (IDA)
Kidney Calculi  (IDA,ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Laryngeal Neoplasms  (ISO)
Leukoencephalopathies  (ISO)
liver cirrhosis  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
malaria  (IDA)
melanoma  (ISO)
Mesothelioma  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (IDA,ISO)
Myocardial Reperfusion Injury  (IDA)
myocarditis  (ISO)
Neoplasm Metastasis  (IDA,ISO)
Neovascularization, Pathologic  (IDA)
Nervous System Trauma  (ISO)
Osteolysis  (ISO)
Ovarian Neoplasms  (ISO)
pancreas disease  (ISO)
pancreatic cancer  (ISO)
Pleural Neoplasms  (ISO)
pneumonia  (ISO)
progressive osseous heteroplasia  (ISO)
prostate carcinoma  (ISO)
Prostatic Neoplasms  (IDA)
proteinuria  (ISO)
pulmonary fibrosis  (IEP,ISO)
radiculopathy  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (IAGP)
rheumatoid arthritis  (ISO)
scrapie  (IDA)
Spinal Cord Injuries  (IDA)
Stomach Neoplasms  (IDA)
Thyroid Neoplasms  (ISO)
tuberculosis  (ISO)
uremia  (ISO)
urinary bladder cancer  (ISO)
Urinary Calculi  (ISO)
Vascular System Injuries  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R)-tramadol  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
1,4-dichlorobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-methylphenanthrene  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
11-deoxycorticosterone  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (EXP)
2,4-di-tert-butylphenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-aminobenzamide  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylfuran  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-aminophenol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
9-cis-retinoic acid  (EXP,ISO)
acetaldehyde  (ISO)
acetylsalicylic acid  (ISO)
acrylic acid  (ISO)
adefovir  (ISO)
adenine  (ISO)
aflatoxin B1  (ISO)
agomelatine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (ISO)
allyl alcohol  (ISO)
Allylamine  (ISO)
aluminium atom  (EXP)
aluminium oxide  (EXP,ISO)
aluminium(0)  (EXP)
aminoglutethimide  (ISO)
ammonium chloride  (ISO)
amphotericin B  (ISO)
amphotericin B methyl ester  (EXP)
Ampullosporin  (ISO)
andrographolide  (EXP)
angiotensin II  (EXP)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracen-2-amine  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
asperentin  (EXP)
astaxanthin  (EXP)
aucubin  (EXP,ISO)
bacitracin  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP,ISO)
berberine  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (EXP)
bleomycin A2  (EXP)
bortezomib  (ISO)
budesonide  (EXP)
Butylparaben  (EXP)
butyric acid  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium carbonate  (EXP)
calcium oxalate  (ISO)
calcium(0)  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbofuran  (ISO)
carbon nanotube  (EXP,ISO)
celecoxib  (ISO)
ceric oxide  (ISO)
CGP 52608  (ISO)
chitosan  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chrysene  (EXP)
cisplatin  (EXP,ISO)
Clofop  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyanuric acid  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl trisulfide  (ISO)
diamminedichloroplatinum  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
disodium selenite  (EXP)
diuron  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
ellagic acid  (EXP)
enalapril  (EXP,ISO)
endosulfan  (ISO)
entinostat  (ISO)
Erionite  (EXP)
esketamine  (ISO)
ethanol  (EXP,ISO)
ethylene glycol  (ISO)
etoposide  (EXP,ISO)
Falecalcitriol  (ISO)
fentanyl  (ISO)
fisetin  (ISO)
flavonoids  (ISO)
flunisolide  (EXP)
fluoranthene  (EXP,ISO)
fluvastatin  (ISO)
folic acid  (EXP)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (ISO)
gadodiamide hydrate  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (ISO)
gallocatechin  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
Ginkgoic acid  (ISO)
glucose  (EXP,ISO)
glycerol 1-phosphate  (ISO)
glycerol 2-phosphate  (EXP,ISO)
glycidol  (EXP)
glyoxylic acid  (ISO)
glyphosate  (ISO)
graphite  (EXP,ISO)
griseofulvin  (EXP)
Hexachloro-1,3-butadiene  (ISO)
hydrogen peroxide  (ISO)
icariin  (EXP,ISO)
imperatorin  (ISO)
indole-3-methanol  (ISO)
inulin  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
isocyanuric acid  (ISO)
isoniazide  (ISO)
isonicotinamide  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
jaspamide  (ISO)
kaempferol  (EXP)
ketamine  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
KT 5823  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
lidocaine  (ISO)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (ISO)
LY 364947  (ISO)
LY294002  (ISO)
magnesium atom  (ISO)
maneb  (EXP)
medroxyprogesterone acetate  (ISO)
melamine  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
mesalamine  (ISO)
metaproterenol  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (EXP)
microcystin-LR  (EXP)
milrinone  (ISO)
mitoxantrone  (ISO)
mometasone furoate  (EXP)
Morroniside  (EXP,ISO)
Muraglitazar  (ISO)
mycophenolic acid  (EXP)
mycotoxin  (EXP)
myo-inositol hexakisphosphate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naproxen  (ISO)
naringin  (EXP,ISO)
natamycin  (EXP)
neoechinulin A  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nicotine  (ISO)
nifedipine  (EXP)
nitric oxide  (EXP)
nitroprusside  (ISO)
nystatin  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
okadaic acid  (EXP)
orciprenaline  (ISO)
oxalic acid  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP,ISO)
PD 0325901  (ISO)
PD123319  (ISO)
pentane-2,3-dione  (ISO)
Pentoxifylline  (ISO)
perfluorobutyric acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphonoformic acid  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phylloquinone  (EXP)
pioglitazone  (ISO)
pirfenidone  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium bromate  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
Ptaquiloside  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rolipram  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
Salidroside  (EXP)
Salinomycin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
sclareol  (EXP)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
selenium atom  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP,ISO)
sterigmatocystin  (EXP)
streptozocin  (ISO)
strontium atom  (ISO)
succimer  (ISO)
sulfaphenazole  (ISO)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sumatriptan  (ISO)
SWINHOLIDE A  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (ISO)
thiourea  (EXP)
titanium atom  (ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (EXP)
topotecan  (ISO)
tramadol  (ISO)
transplatin  (ISO)
tremolite asbestos  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimethyltin  (EXP)
troglitazone  (EXP,ISO)
tubocurarine  (ISO)
Tungsten carbide  (ISO)
uranium atom  (EXP,ISO)
urethane  (EXP,ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (EXP,ISO)
vitamin D  (EXP)
vitamin K  (ISO)
vorinostat  (ISO)
warfarin  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc oxide  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aorta morphology  (IAGP)
abnormal blood cell morphology/development  (IAGP)
abnormal blood flow velocity  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal blood vessel physiology  (IAGP)
abnormal body weight  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal chemokine level  (IAGP)
abnormal dentin morphology  (IAGP)
abnormal hematopoietic system physiology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal long bone metaphysis morphology  (IAGP)
abnormal macrophage chemotaxis  (IAGP)
abnormal macrophage morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal physical strength  (IAGP)
abnormal physiological neovascularization  (IAGP)
abnormal response to cardiac infarction  (IAGP)
abnormal response to infection  (IAGP)
abnormal striatum morphology  (IAGP)
abnormal substantia nigra morphology  (IAGP)
abnormal susceptibility to infection  (IAGP)
abnormal tooth root development  (IAGP)
abnormal urine nucleoside level  (IAGP)
abnormal vascular wound healing  (IAGP)
abnormal vasodilation  (IAGP)
abnormal wound healing  (IAGP)
aneurysm  (IAGP)
anophthalmia  (IEA)
atherosclerotic lesions  (IAGP)
calcified aortic valve cusp  (IAGP)
calcified artery  (IAGP)
crystalluria  (IAGP)
decreased acute inflammation  (IAGP)
decreased body weight  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone resorption  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased dendritic cell number  (IAGP)
decreased fibroblast chemotaxis  (IAGP)
decreased granulocyte number  (IAGP)
decreased heart weight  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-12 secretion  (IAGP)
decreased lean body mass  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased macrophage cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased sensitivity to induced cell death  (IAGP)
decreased susceptibility to atherosclerosis  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
decreased susceptibility to dopaminergic neuron neurotoxicity  (IAGP)
decreased susceptibility to experimental autoimmune uveoretinitis  (IAGP)
decreased susceptibility to Herpesvirales infection  (IAGP)
decreased susceptibility to induced aneurysm formation  (IAGP)
decreased susceptibility to type IV hypersensitivity reaction  (IAGP)
decreased systemic arterial blood pressure  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased T cell number  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
decreased urine chloride ion level  (IAGP)
decreased urine sodium level  (IAGP)
delayed wound healing  (IAGP)
dilated kidney collecting duct  (IAGP)
dilated renal tubule  (IAGP)
enlarged spleen  (IAGP)
granulomatous inflammation  (IAGP)
hyporesponsive to tactile stimuli  (IAGP)
impaired macrophage chemotaxis  (IAGP)
improved glucose tolerance  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-single stranded DNA antibody level  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased bone marrow cell number  (IAGP)
increased bone mineral density  (IAGP)
increased bone mineral density of lumbar vertebrae  (IAGP)
increased bone mineral density of presacral vertebrae  (IAGP)
increased bone trabecula number  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased heart rate  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased IgA level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased IgG2b level  (IAGP)
increased IgG3 level  (IAGP)
increased IgM level  (IAGP)
increased insulin sensitivity  (IAGP)
increased interleukin-10 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased lung weight  (IAGP)
increased lymphocyte cell number  (IAGP)
increased macrophage cell number  (IAGP)
increased neuron number  (IAGP)
increased osteoclast cell number  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased regulatory T cell number  (IAGP)
increased respiratory quotient  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to injury  (IAGP)
increased T cell number  (IAGP)
increased trabecular bone thickness  (IAGP)
increased urine phosphate level  (IAGP)
increased urine uric acid level  (IAGP)
internal hemorrhage  (IAGP)
kidney inflammation  (IAGP)
lung cyst  (IAGP)
lymph node hyperplasia  (IAGP)
nephrocalcinosis  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
renal fibrosis  (IAGP)
renal tubular necrosis  (IAGP)
References

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Additional References at PubMed
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