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Gene: Spp1 (secreted phosphoprotein 1) Mus musculus
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Symbol: Spp1
Name: secreted phosphoprotein 1
Description: Exhibits extracellular matrix binding activity. Involved in several processes, including cellular response to fluid shear stress; cellular response to leukemia inhibitory factor; and neutrophil chemotaxis. Localizes to the apical part of cell and cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); multiple sclerosis; and rheumatoid arthritis. Is expressed in several structures, including alimentary system; limb cartilage condensation; metanephros; reproductive system; and skeleton. Orthologous to human SPP1 (secreted phosphoprotein 1); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; diabetic nephropathy pathway; fibroblast growth factor signaling pathway; INTERACTS WITH 1,4-dichlorobenzene; 1-fluoro-2,4-dinitrobenzene; 15-deoxy-Delta(12,14)-prostaglandin J2.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2AR; 44 kDa bone phosphoprotein; AA960535; AI790405; Apl-1; BNSP; bone sialoprotein 1; Bsp; BSPI; calcium oxalate crystal growth inhibitor protein; early T-lymphocyte activation 1 protein; Eta; ETA-1; minopontin; OP; Opn; Opnl; osteopontin; osteopontin-like protein; Ric; Spp-1
Orthologs:
Homo sapiens (human) : SPP1 (secreted phosphoprotein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Spp1 (secreted phosphoprotein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spp1 (secreted phosphoprotein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SPP1 (secreted phosphoprotein 1)
Canis lupus familiaris (dog) : SPP1 (secreted phosphoprotein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spp1 (secreted phosphoprotein 1)
Sus scrofa (pig) : SPP1 (secreted phosphoprotein 1)
Chlorocebus sabaeus (green monkey) : SPP1 (secreted phosphoprotein 1)
Heterocephalus glaber (naked mole-rat) : Spp1 (secreted phosphoprotein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl5104,435,118 - 104,441,050 (+)Ensembl
GRCm385104,435,111 - 104,441,053 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375104,864,137 - 104,870,069 (+)NCBIGRCm37mm9NCBIm37
MGSCv365104,657,300 - 104,681,345 (+)NCBImm8
Celera5101,744,279 - 101,750,763 (+)NCBICelera
Cytogenetic Map5 E5NCBI
cM Map550.68NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Spp1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11340
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.