RGD Reference Report - Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus.

General

Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus.
Authors:	Yan, X Sano, M Lu, L Wang, W Zhang, Q Zhang, R Wang, L Chen, Q Fukuda, K Shen, W
Citation:	Yan X, etal., Cardiovasc Diabetol. 2010 Oct 29;9:70.
RGD ID:	6903271
Pubmed:	PMID:21034455 (View Abstract at PubMed)
PMCID:	PMC2988001 (View Article at PubMed Central)
DOI:	DOI:10.1186/1475-2840-9-70 (Journal Full-text)
BACKGROUND: The aim of the present cross-sectional study was to assess possible associations between osteopontin (OPN), and thrombin-cleaved (N-half) OPN, and nephropathy and coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). METHODS: Plasma levels of OPN, N-half OPN, and high-sensitivity C-reactive protein (hsCRP) were determined in 301 diabetic patients with (n = 226) or without (n = 75) angiographically documented CAD (luminal diameter narrowing >50%), as well as in 75 non-diabetic controls with normal angiography. The estimated glomerular filtration rate (eGFR) was calculated in all patients. RESULTS: Plasma levels of OPN and hsCRP were significantly higher in patients with T2DM compared with controls. In addition, there was a higher occurrence of moderate renal insufficiency and lower eGFR in patients with T2DM (all P < 0.01). T2DM patients in whom OPN levels were greater than the median value had higher serum creatinine levels, a greater prevalence of mild or moderate renal insufficiency, a higher incidence of CAD, and lower eGFR (all P < 0.05) than T2DM patients in whom OPN levels were the same as or lower than the median value. However, there were no differences in these parameters when patients were stratified according to plasma N-half OPN levels. Furthermore, there was a significant correlation between OPN, but not N-half OPN, and the severity of nephropathy and CAD in diabetes. After adjustment for potential confounders and treatments, multiple linear regression analysis demonstrated an independent association between OPN, but not N-half OPN, and eGFR. Multivariate logistic regression revealed that higher OPN levels conferred a fourfold greater risk of renal insufficiency and CAD in patients with T2DM. CONCLUSIONS: The results of the present study demonstrate that there is an independent association between plasma levels of OPN, but not N-half OPN, and the presence and severity of nephropathy and CAD in diabetes.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
coronary artery disease		IEP		6903271	In type 2 diabetic patients	RGD
coronary artery disease		ISO	SPP1 (Homo sapiens)	6903271; 6903271	In type 2 diabetic patients	RGD
kidney failure		IEP		6903271	In type 2 diabetic patients	RGD
kidney failure		ISO	SPP1 (Homo sapiens)	6903271; 6903271	In type 2 diabetic patients	RGD

Objects Annotated

Genes (Rattus norvegicus)

Spp1 (secreted phosphoprotein 1)

Genes (Mus musculus)

Spp1 (secreted phosphoprotein 1)

Genes (Homo sapiens)

SPP1 (secreted phosphoprotein 1)

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Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus.