Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: SPP1 (secreted phosphoprotein 1) Homo sapiens
Symbol: SPP1
Name: secreted phosphoprotein 1
Description: Exhibits integrin binding activity. Involved in several processes, including androgen catabolic process; cellular response to testosterone stimulus; and positive regulation of estradiol secretion. Localizes to Golgi apparatus and extracellular space. Implicated in several diseases, including biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); multiple sclerosis; and rheumatoid arthritis. Biomarker of calcinosis; coronary artery disease; kidney failure; progressive osseous heteroplasia; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BNSP; bone sialoprotein 1; bone sialoprotein I; BSPI; early T-lymphocyte activation 1; ETA-1; MGC110940; nephropontin; OPN; osteopontin; osteopontin-C; osteopontin-D; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); secreted phosphoprotein 1 variant 6; secreted phosphoprotein-1 (osteopontin, bone sialoprotein); SPP-1; SPP1/CALPHA1 fusion; urinary stone protein; uropontin
Mus musculus (house mouse) : Spp1 (secreted phosphoprotein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Spp1 (secreted phosphoprotein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spp1 (secreted phosphoprotein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SPP1 (secreted phosphoprotein 1)
Canis lupus familiaris (dog) : SPP1 (secreted phosphoprotein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spp1 (secreted phosphoprotein 1)
Sus scrofa (pig) : SPP1 (secreted phosphoprotein 1)
Chlorocebus sabaeus (African green monkey) : SPP1 (secreted phosphoprotein 1)
Heterocephalus glaber (naked mole-rat) : Spp1 (secreted phosphoprotein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl487,975,650 - 87,983,426 (+)EnsemblGRCh38hg38GRCh38
GRCh38487,975,714 - 87,983,411 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37488,896,802 - 88,904,563 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36489,115,826 - 89,123,587 (+)NCBINCBI36hg18NCBI36
Build 34489,253,980 - 89,261,741NCBI
Celera486,188,727 - 86,196,490 (+)NCBI
Cytogenetic Map4q22.1NCBI
HuRef484,643,231 - 84,650,994 (+)NCBIHuRef
CHM1_1488,873,591 - 88,881,352 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SPP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736066
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.