SPP1 Human (R,R)-tramadol multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein] and Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein] CTD PMID:33645892 SPP1 Human (R,R)-tramadol increases expression ISO Spp1 (Rattus norvegicus) 6480464 Tramadol results in increased expression of SPP1 protein CTD PMID:33645892 SPP1 Human (S)-naringenin multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 naringenin inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA] CTD PMID:22709785 SPP1 Human (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of SPP1 protein CTD PMID:11425648 SPP1 Human (S)-nicotine multiple interactions EXP 6480464 Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein] CTD PMID:11425648 SPP1 Human 1,2-dimethylhydrazine increases expression ISO Spp1 (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in increased expression of SPP1 mRNA CTD PMID:22206623 SPP1 Human 1,3,5-trinitro-1,3,5-triazinane increases expression ISO Spp1 (Rattus norvegicus) 6480464 cyclonite results in increased expression of SPP1 mRNA CTD PMID:25559034 SPP1 Human 1,4-dichlorobenzene increases expression ISO Spp1 (Mus musculus) 6480464 4-dichlorobenzene results in increased expression of SPP1 mRNA CTD PMID:26975756 SPP1 Human 1-chloro-2,4-dinitrobenzene multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Dinitrochlorobenzene inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Glucose results in increased secretion of SPP1 protein]] more ... CTD PMID:20453393 SPP1 Human 1-fluoro-2,4-dinitrobenzene multiple interactions ISO Spp1 (Mus musculus) 6480464 Trinitrobenzenesulfonic Acid promotes the reaction [SPP1 protein results in increased susceptibility to Dinitrofluorobenzene] CTD PMID:14555839 SPP1 Human 1-fluoro-2,4-dinitrobenzene increases response to substance ISO Spp1 (Mus musculus) 6480464 SPP1 protein results in increased susceptibility to Dinitrofluorobenzene CTD PMID:14555839 SPP1 Human 1-methylphenanthrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of SPP1 mRNA CTD PMID:17690111 SPP1 Human 1-naphthyl isothiocyanate increases expression ISO Spp1 (Rattus norvegicus) 6480464 1-Naphthylisothiocyanate results in increased expression of SPP1 mRNA CTD PMID:18289764 and PMID:23558518 SPP1 Human 1-naphthyl isothiocyanate multiple interactions EXP 6480464 [1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of SPP1 mRNA CTD PMID:27344345 SPP1 Human 1-nitropyrene decreases expression EXP 6480464 1-nitropyrene results in decreased expression of SPP1 mRNA CTD PMID:19428942 SPP1 Human 11-deoxycorticosterone multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [Desoxycorticosterone co-treated with Sodium Chloride more ... CTD PMID:21135038 SPP1 Human 15-deoxy-Delta(12,14)-prostaglandin J2 decreases expression ISO Spp1 (Mus musculus) 6480464 15-deoxy-delta(12 and 14)-prostaglandin J2 results in decreased expression of SPP1 mRNA CTD PMID:12021203 SPP1 Human 17alpha-ethynylestradiol increases expression ISO Spp1 (Mus musculus) 6480464 Ethinyl Estradiol results in increased expression of SPP1 mRNA CTD PMID:17942748 SPP1 Human 17alpha-ethynylestradiol increases expression ISO Spp1 (Rattus norvegicus) 6480464 Ethinyl Estradiol results in increased expression of SPP1 mRNA CTD PMID:17557909 SPP1 Human 17alpha-ethynylestradiol decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Ethinyl Estradiol results in decreased expression of SPP1 mRNA CTD PMID:12655037 and PMID:16140622 SPP1 Human 17alpha-ethynylestradiol multiple interactions ISO Spp1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SPP1 mRNA CTD PMID:17942748 SPP1 Human 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of SPP1 mRNA CTD PMID:20170705 SPP1 Human 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of SPP1 mRNA CTD PMID:20106945 SPP1 Human 17beta-estradiol multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SPP1 mRNA CTD PMID:32741896 SPP1 Human 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of SPP1 mRNA CTD PMID:31646340 SPP1 Human 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of SPP1 mRNA more ... CTD PMID:20226447 more ... SPP1 Human 17beta-estradiol affects expression ISO Spp1 (Rattus norvegicus) 6480464 Estradiol affects the expression of SPP1 mRNA and Estradiol affects the expression of SPP1 protein CTD PMID:19387089 SPP1 Human 17beta-estradiol increases expression ISO Spp1 (Mus musculus) 6480464 Estradiol results in increased expression of SPP1 mRNA CTD PMID:15289156 SPP1 Human 17beta-estradiol affects expression ISO Spp1 (Mus musculus) 6480464 Estradiol affects the expression of SPP1 mRNA CTD PMID:15598610 SPP1 Human 17beta-estradiol 3-benzoate multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SPP1 mRNA CTD PMID:32741896 SPP1 Human 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO Spp1 (Mus musculus) 6480464 Dihydrotestosterone results in increased expression of SPP1 mRNA CTD PMID:17023530 and PMID:17898587 SPP1 Human 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one multiple interactions EXP 6480464 1H-(1 more ... CTD PMID:22543296 SPP1 Human 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one decreases expression EXP 6480464 1H-(1 more ... CTD PMID:22543296 SPP1 Human 2,2',4,4',5,5'-hexachlorobiphenyl increases expression ISO Spp1 (Rattus norvegicus) 6480464 2 more ... CTD PMID:20959002 SPP1 Human 2,2',4,4',5,5'-hexachlorobiphenyl increases expression EXP 6480464 2 more ... CTD PMID:23146750 SPP1 Human 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2 more ... CTD PMID:23146750 and PMID:31173147 SPP1 Human 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO Spp1 (Mus musculus) 6480464 2 more ... CTD PMID:30294300 SPP1 Human 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO Spp1 (Rattus norvegicus) 6480464 2 more ... CTD PMID:27291303 SPP1 Human 2,2',5,5'-tetrachlorobiphenyl increases expression EXP 6480464 2 more ... CTD PMID:36804509 SPP1 Human 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Spp1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SPP1 mRNA CTD PMID:17942748 SPP1 Human 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Spp1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin affects the expression of SPP1 mRNA CTD PMID:34747641 SPP1 Human 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SPP1 mRNA] CTD PMID:30203000 SPP1 Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Spp1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of SPP1 mRNA CTD PMID:33956508 SPP1 Human 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SPP1 mRNA CTD PMID:20106945 more ... SPP1 Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of SPP1 mRNA CTD PMID:11018766 and PMID:21215274 SPP1 Human 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Spp1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in increased expression of SPP1 mRNA CTD PMID:20959002 SPP1 Human 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SPP1 mRNA] CTD PMID:11018766 SPP1 Human 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Spp1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of SPP1 mRNA CTD PMID:21570461 SPP1 Human 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SPP1 mRNA CTD PMID:22298810 and PMID:30203000 SPP1 Human 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Spp1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of SPP1 mRNA CTD PMID:17975115 and PMID:29673856 SPP1 Human 2,3-dimethoxynaphthalene-1,4-dione increases expression EXP 6480464 2 more ... CTD PMID:17547211 SPP1 Human 2,4,6-trinitrobenzenesulfonic acid increases expression ISO Spp1 (Mus musculus) 6480464 Trinitrobenzenesulfonic Acid results in increased expression of SPP1 mRNA CTD PMID:17982090 SPP1 Human 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO Spp1 (Mus musculus) 6480464 Trinitrobenzenesulfonic Acid promotes the reaction [SPP1 protein results in increased susceptibility to Dinitrofluorobenzene] CTD PMID:14555839 SPP1 Human 2,4-D multiple interactions ISO Spp1 (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:37567420 SPP1 Human 2,4-di-tert-butylphenol multiple interactions EXP 6480464 [SAG compound co-treated with 2 and 4-di-tert-butylphenol co-treated with Fibroblast Growth Factor 2 co-treated with Ascorbic Acid co-treated with alpha-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of SPP1 mRNA CTD PMID:36682590 SPP1 Human 2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:26705709 SPP1 Human 2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expression ISO Spp1 (Mus musculus) 6480464 2 more ... CTD PMID:38648751 SPP1 Human 2,6-di-tert-butyl-4-methylphenol increases expression ISO Spp1 (Mus musculus) 6480464 Butylated Hydroxytoluene results in increased expression of SPP1 mRNA CTD PMID:19925653 SPP1 Human 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO Spp1 (Mus musculus) 6480464 [LEP gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of SPP1 protein more ... CTD PMID:19913045 SPP1 Human 2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid multiple interactions EXP 6480464 anacardic acid inhibits the reaction [Tretinoin results in increased expression of SPP1 mRNA] CTD PMID:24819975 SPP1 Human 2-palmitoylglycerol increases expression EXP 6480464 2-palmitoylglycerol results in increased expression of SPP1 mRNA CTD PMID:37199045 SPP1 Human 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Drugs more ... CTD PMID:14738908 and PMID:16452496 SPP1 Human 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression ISO Spp1 (Rattus norvegicus) 6480464 Puromycin Aminonucleoside results in increased expression of SPP1 mRNA and Puromycin Aminonucleoside results in increased expression of SPP1 protein CTD PMID:14738908 and PMID:16452496 SPP1 Human 3,3',4,4',5-pentachlorobiphenyl affects expression EXP 6480464 3 more ... CTD PMID:21703328 SPP1 Human 3,3',4,4',5-pentachlorobiphenyl affects expression ISO Spp1 (Mus musculus) 6480464 3 more ... CTD PMID:37080397 SPP1 Human 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:23146750 SPP1 Human 3,3',4,4',5-pentachlorobiphenyl increases expression ISO Spp1 (Rattus norvegicus) 6480464 3 more ... CTD PMID:20959002 SPP1 Human 3,3',5,5'-tetrabromobisphenol A increases expression ISO Spp1 (Mus musculus) 6480464 tetrabromobisphenol A results in increased expression of SPP1 mRNA CTD PMID:25172293 SPP1 Human 3-aminobenzamide increases expression EXP 6480464 3-aminobenzamide results in increased expression of SPP1 mRNA CTD PMID:15670817 SPP1 Human 3-chloropropane-1,2-diol multiple interactions ISO Spp1 (Mus musculus) 6480464 [alpha-Chlorohydrin co-treated with glycidol] results in increased expression of SPP1 mRNA CTD PMID:33187795 SPP1 Human 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 1-Methyl-3-isobutylxanthine inhibits the reaction [Glucose results in increased secretion of SPP1 protein] CTD PMID:20453393 SPP1 Human 4,4'-diaminodiphenylmethane decreases expression ISO Spp1 (Rattus norvegicus) 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of SPP1 mRNA CTD PMID:18289764 SPP1 Human 4,4'-sulfonyldiphenol increases expression ISO Spp1 (Mus musculus) 6480464 bisphenol S results in increased expression of SPP1 mRNA CTD PMID:30951980 SPP1 Human 4,4'-sulfonyldiphenol decreases expression ISO Spp1 (Mus musculus) 6480464 bisphenol S results in decreased expression of SPP1 mRNA CTD PMID:37611474 SPP1 Human 4-aminophenol decreases expression ISO Spp1 (Rattus norvegicus) 6480464 4-aminophenol results in decreased expression of SPP1 mRNA CTD PMID:23558518 SPP1 Human 5-aza-2'-deoxycytidine increases expression ISO Spp1 (Mus musculus) 6480464 Decitabine results in increased expression of SPP1 mRNA CTD PMID:27915011 SPP1 Human 6-propyl-2-thiouracil decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Propylthiouracil results in decreased expression of SPP1 mRNA CTD PMID:24780913 SPP1 Human 7,12-dimethyltetraphene multiple interactions ISO Spp1 (Mus musculus) 6480464 [9 more ... CTD PMID:27891153 and PMID:32553695 SPP1 Human 7,12-dimethyltetraphene increases expression ISO Spp1 (Rattus norvegicus) 6480464 9 more ... CTD PMID:19480007 SPP1 Human 8-Br-cAMP multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Glucose results in increased secretion of SPP1 protein] more ... CTD PMID:20453393 SPP1 Human 8-Br-cAMP decreases expression EXP 6480464 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of SPP1 mRNA CTD PMID:22079614 SPP1 Human 8-bromo-3',5'-cyclic GMP multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein] more ... CTD PMID:20453393 SPP1 Human 9-cis-retinoic acid decreases expression EXP 6480464 Alitretinoin results in decreased expression of SPP1 mRNA and Alitretinoin results in decreased expression of SPP1 protein CTD PMID:11139446 SPP1 Human 9-cis-retinoic acid increases expression ISO Spp1 (Mus musculus) 6480464 Alitretinoin results in increased expression of SPP1 mRNA CTD PMID:16392701 SPP1 Human 9-cis-retinoic acid decreases expression ISO Spp1 (Mus musculus) 6480464 Alitretinoin results in decreased expression of SPP1 mRNA CTD PMID:16392701 SPP1 Human acetaldehyde increases expression EXP 6480464 Acetaldehyde results in increased expression of SPP1 mRNA and Acetaldehyde results in increased expression of SPP1 protein CTD PMID:18703563 SPP1 Human acetylsalicylic acid affects expression ISO Spp1 (Rattus norvegicus) 6480464 Aspirin affects the expression of SPP1 mRNA CTD PMID:12800193 SPP1 Human acrylic acid multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of SPP1 protein] CTD PMID:27018375 SPP1 Human adefovir increases secretion ISO Spp1 (Rattus norvegicus) 6480464 adefovir results in increased secretion of SPP1 protein CTD PMID:27742868 SPP1 Human adenine multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [Phosphates co-treated with Adenine] results in increased expression of SPP1 mRNA more ... CTD PMID:28866419 and PMID:30466616 SPP1 Human adenine increases expression ISO Spp1 (Rattus norvegicus) 6480464 Adenine results in increased expression of SPP1 mRNA CTD PMID:28866419 SPP1 Human aflatoxin B1 increases expression ISO Spp1 (Rattus norvegicus) 6480464 Aflatoxin B1 results in increased expression of SPP1 mRNA CTD PMID:22484513 and PMID:25378103 SPP1 Human aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of SPP1 mRNA CTD PMID:27153756 SPP1 Human agomelatine multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 agomelatine inhibits the reaction [Methotrexate results in increased expression of SPP1 protein] CTD PMID:31975554 SPP1 Human aldehydo-D-glucose increases expression ISO Spp1 (Mus musculus) 6480464 Glucose results in increased expression of SPP1 mRNA CTD PMID:17178593 SPP1 Human aldehydo-D-glucose multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]] more ... CTD PMID:38000455 SPP1 Human aldehydo-D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of SPP1 mRNA and Glucose results in decreased expression of SPP1 protein CTD PMID:38000455 SPP1 Human aldehydo-D-glucose multiple interactions ISO Spp1 (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:37567420 SPP1 Human aldehydo-D-glucose decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Glucose results in decreased expression of SPP1 mRNA CTD PMID:32643284 SPP1 Human aldehydo-D-glucose increases secretion ISO Spp1 (Rattus norvegicus) 6480464 Glucose results in increased secretion of SPP1 protein CTD PMID:20453393 SPP1 Human aldehydo-D-glucose increases expression ISO Spp1 (Rattus norvegicus) 6480464 Glucose results in increased expression of SPP1 and Glucose results in increased expression of SPP1 mRNA CTD PMID:12505755 and PMID:20453393 SPP1 Human aldehydo-D-glucose multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 1-Methyl-3-isobutylxanthine inhibits the reaction [Glucose results in increased secretion of SPP1 protein] more ... CTD PMID:20453393 and PMID:32643284 SPP1 Human all-trans-retinoic acid increases expression ISO Spp1 (Rattus norvegicus) 6480464 Tretinoin results in increased expression of SPP1 protein CTD PMID:15389522 SPP1 Human all-trans-retinoic acid multiple interactions ISO Spp1 (Mus musculus) 6480464 [bisphenol A co-treated with Tretinoin] results in decreased expression of SPP1 mRNA and [bisphenol F co-treated with Tretinoin] results in decreased expression of SPP1 mRNA CTD PMID:30951980 SPP1 Human all-trans-retinoic acid increases expression ISO Spp1 (Mus musculus) 6480464 Tretinoin results in increased expression of SPP1 mRNA CTD PMID:16392701 more ... SPP1 Human all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of SPP1 mRNA CTD PMID:15498508 more ... SPP1 Human all-trans-retinoic acid multiple interactions EXP 6480464 [Tretinoin co-treated with arsenic trioxide] results in increased expression of SPP1 mRNA more ... CTD PMID:15894607 and PMID:24819975 SPP1 Human all-trans-retinoic acid decreases expression ISO Spp1 (Mus musculus) 6480464 Tretinoin results in decreased expression of SPP1 mRNA CTD PMID:16392701 and PMID:16604517 SPP1 Human allyl alcohol increases expression ISO Spp1 (Rattus norvegicus) 6480464 allyl alcohol results in increased expression of SPP1 mRNA CTD PMID:23558518 SPP1 Human Allylamine multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Allylamine results in increased expression of SPP1 mRNA] and Hydrogen Peroxide inhibits the reaction [Allylamine results in increased expression of SPP1 mRNA] CTD PMID:15910882 SPP1 Human Allylamine increases expression ISO Spp1 (Rattus norvegicus) 6480464 Allylamine results in increased expression of SPP1 mRNA and Allylamine results in increased expression of SPP1 protein CTD PMID:15910882 and PMID:23558518 SPP1 Human aluminium atom increases expression ISO Spp1 (Mus musculus) 6480464 Aluminum results in increased expression of SPP1 mRNA CTD PMID:37544489 SPP1 Human aluminium oxide increases expression EXP 6480464 Aluminum Oxide results in increased expression of SPP1 mRNA CTD PMID:19464052 SPP1 Human aluminium oxide multiple interactions EXP 6480464 [Aluminum Oxide co-treated with Nanotubes more ... CTD PMID:25216247 SPP1 Human aluminium oxide decreases secretion EXP 6480464 Aluminum Oxide results in decreased secretion of SPP1 protein CTD PMID:25216247 SPP1 Human aluminium oxide multiple interactions ISO Spp1 (Mus musculus) 6480464 [Aluminum Oxide co-treated with Nanotubes more ... CTD PMID:25216247 SPP1 Human aluminium(0) increases expression ISO Spp1 (Mus musculus) 6480464 Aluminum results in increased expression of SPP1 mRNA CTD PMID:37544489 SPP1 Human aminoglutethimide decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Aminoglutethimide results in decreased expression of SPP1 mRNA CTD PMID:23558518 SPP1 Human ammonium chloride affects expression ISO Spp1 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of SPP1 mRNA CTD PMID:16483693 SPP1 Human amphotericin B affects expression ISO Spp1 (Rattus norvegicus) 6480464 Amphotericin B affects the expression of SPP1 mRNA CTD PMID:20623750 SPP1 Human amphotericin B methyl ester increases expression ISO Spp1 (Mus musculus) 6480464 methylamphotericin B results in increased expression of SPP1 mRNA CTD PMID:22863853 SPP1 Human Ampullosporin multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [ampullosporin co-treated with Ketamine] results in increased expression of SPP1 mRNA CTD PMID:16635253 SPP1 Human andrographolide multiple interactions ISO Spp1 (Mus musculus) 6480464 [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SPP1 mRNA CTD PMID:19737545 SPP1 Human angiotensin II increases expression ISO Spp1 (Mus musculus) 155260287 Angiotensin II increases expression of Spp1 protein in vascular smooth muscle cells RGD SPP1 Human aniline increases expression ISO Spp1 (Mus musculus) 6480464 aniline results in increased expression of SPP1 mRNA CTD PMID:22016648 SPP1 Human anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 pyrazolanthrone inhibits the reaction [FGF1 protein results in increased expression of SPP1 mRNA] CTD PMID:15121739 SPP1 Human anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO Spp1 (Mus musculus) 6480464 pyrazolanthrone inhibits the reaction [Ketoglutaric Acids results in increased expression of SPP1 protein] CTD PMID:31051157 SPP1 Human anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [Ketoglutaric Acids results in increased expression of SPP1 protein] CTD PMID:31051157 SPP1 Human anthracen-2-amine increases expression ISO Spp1 (Rattus norvegicus) 6480464 2-anthramine results in increased expression of SPP1 mRNA CTD PMID:31714650 SPP1 Human aristolochic acid A multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [aristolochic acid I co-treated with aristolochic acid II] results in increased expression of SPP1 protein CTD PMID:23912714 SPP1 Human aristolochic acid A decreases expression EXP 6480464 aristolochic acid I results in decreased expression of SPP1 mRNA CTD PMID:33212167 SPP1 Human Aroclor 1254 decreases expression ISO Spp1 (Mus musculus) 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of SPP1 mRNA CTD PMID:23650126 SPP1 Human arsenite(3-) decreases expression ISO Spp1 (Mus musculus) 6480464 arsenite results in decreased expression of SPP1 mRNA CTD PMID:33053406 SPP1 Human arsenite(3-) decreases expression EXP 6480464 arsenite results in decreased expression of SPP1 mRNA CTD PMID:31646340 SPP1 Human arsenite(3-) multiple interactions EXP 6480464 Fulvestrant inhibits the reaction [arsenite results in decreased expression of SPP1 mRNA] CTD PMID:31646340 SPP1 Human arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of SPP1 mRNA CTD PMID:20471514 SPP1 Human arsenous acid decreases expression ISO Spp1 (Mus musculus) 6480464 Arsenic Trioxide results in decreased expression of SPP1 mRNA CTD PMID:35676786 SPP1 Human arsenous acid multiple interactions EXP 6480464 [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of SPP1 mRNA CTD PMID:15894607 SPP1 Human asbestos increases expression EXP 6480464 Asbestos results in increased expression of SPP1 protein CTD PMID:16221779 SPP1 Human asperentin increases expression ISO Spp1 (Mus musculus) 6480464 cladosporin results in increased expression of SPP1 mRNA CTD PMID:19818335 SPP1 Human astaxanthin multiple interactions ISO Spp1 (Mus musculus) 6480464 astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA] CTD PMID:16964424 SPP1 Human aucubin increases expression EXP 6480464 aucubin results in increased expression of SPP1 protein CTD PMID:29408431 SPP1 Human aucubin increases expression ISO Spp1 (Rattus norvegicus) 6480464 aucubin results in increased expression of SPP1 protein CTD PMID:38492842 SPP1 Human aucubin increases expression ISO Spp1 (Mus musculus) 6480464 aucubin results in increased expression of SPP1 mRNA and aucubin results in increased expression of SPP1 protein CTD PMID:38492842 SPP1 Human bacitracin increases expression ISO Spp1 (Rattus norvegicus) 6480464 Bacitracin results in increased expression of SPP1 mRNA CTD PMID:18289764 SPP1 Human benazepril decreases expression ISO Spp1 (Rattus norvegicus) 6480464 benazepril results in decreased expression of SPP1 mRNA CTD PMID:11867951 SPP1 Human benzo[a]pyrene decreases expression ISO Spp1 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of SPP1 mRNA CTD PMID:19770486 SPP1 Human benzo[a]pyrene affects methylation EXP 6480464 Benzo(a)pyrene affects the methylation of SPP1 promoter CTD PMID:27901495 SPP1 Human benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of SPP1 mRNA CTD PMID:16269432 more ... SPP1 Human benzo[a]pyrene multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:18711122 SPP1 Human benzo[a]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:17690111 SPP1 Human benzo[a]pyrene increases expression ISO Spp1 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of SPP1 mRNA CTD PMID:21569818 and PMID:22228805 SPP1 Human benzo[b]fluoranthene multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SPP1 mRNA CTD PMID:18711122 SPP1 Human benzo[b]fluoranthene decreases expression ISO Spp1 (Mus musculus) 6480464 benzo(b)fluoranthene results in decreased expression of SPP1 mRNA CTD PMID:26377693 SPP1 Human benzo[b]fluoranthene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SPP1 mRNA CTD PMID:17690111 SPP1 Human berberine increases expression EXP 6480464 Berberine results in increased expression of SPP1 mRNA and Berberine results in increased expression of SPP1 protein CTD PMID:26478571 SPP1 Human berberine multiple interactions EXP 6480464 CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein] and DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein] CTD PMID:26478571 SPP1 Human beta-naphthoflavone multiple interactions ISO Spp1 (Mus musculus) 6480464 [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SPP1 mRNA CTD PMID:19737545 SPP1 Human beta-naphthoflavone decreases expression EXP 6480464 beta-Naphthoflavone results in decreased expression of SPP1 mRNA CTD PMID:32858204 SPP1 Human bexarotene decreases expression ISO Spp1 (Rattus norvegicus) 6480464 bexarotene results in decreased expression of SPP1 mRNA CTD PMID:16648578 SPP1 Human bezafibrate multiple interactions EXP 6480464 Bezafibrate inhibits the reaction [IL6 protein results in increased expression of SPP1 mRNA] more ... CTD PMID:17360982 SPP1 Human bezafibrate decreases expression EXP 6480464 Bezafibrate results in decreased expression of SPP1 protein CTD PMID:17360982 SPP1 Human bis(2-chloroethyl) sulfide increases expression ISO Spp1 (Mus musculus) 6480464 Mustard Gas results in increased expression of SPP1 mRNA CTD PMID:15674843 and PMID:15674844 SPP1 Human bis(2-chloroethyl) sulfide increases expression EXP 6480464 Mustard Gas results in increased expression of SPP1 mRNA CTD PMID:33491125 SPP1 Human bis(2-chloroethyl) sulfide increases secretion EXP 6480464 Mustard Gas results in increased secretion of SPP1 protein CTD PMID:33491125 SPP1 Human bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of SPP1 mRNA CTD PMID:28412506 and PMID:31163220 SPP1 Human bis(2-ethylhexyl) phthalate decreases expression ISO Spp1 (Mus musculus) 6480464 Diethylhexyl Phthalate results in decreased expression of SPP1 mRNA CTD PMID:28085963 SPP1 Human bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of SPP1 mRNA CTD PMID:20170705 and PMID:30903817 SPP1 Human bisphenol A decreases expression ISO Spp1 (Mus musculus) 6480464 bisphenol A results in decreased expression of SPP1 mRNA CTD PMID:32156529 more ... SPP1 Human bisphenol A decreases methylation EXP 6480464 bisphenol A results in decreased methylation of SPP1 gene CTD PMID:31601247 SPP1 Human bisphenol A increases expression ISO Spp1 (Rattus norvegicus) 6480464 bisphenol A results in increased expression of SPP1 mRNA CTD PMID:31697385 SPP1 Human bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SPP1 mRNA CTD PMID:29718440 SPP1 Human bisphenol A multiple interactions ISO Spp1 (Mus musculus) 6480464 [bisphenol A co-treated with Tretinoin] results in decreased expression of SPP1 mRNA CTD PMID:30951980 SPP1 Human bisphenol A increases expression ISO Spp1 (Mus musculus) 6480464 bisphenol A results in increased expression of SPP1 mRNA CTD PMID:30951980 SPP1 Human bisphenol A affects expression ISO Spp1 (Rattus norvegicus) 6480464 bisphenol A affects the expression of SPP1 mRNA CTD PMID:25181051 SPP1 Human bisphenol A decreases expression ISO Spp1 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of SPP1 mRNA CTD PMID:22504913 more ... SPP1 Human bisphenol F increases expression ISO Spp1 (Mus musculus) 6480464 bisphenol F results in increased expression of SPP1 mRNA CTD PMID:30951980 SPP1 Human bisphenol F multiple interactions ISO Spp1 (Mus musculus) 6480464 [bisphenol F co-treated with Tretinoin] results in decreased expression of SPP1 mRNA CTD PMID:30951980 SPP1 Human bleomycin A2 increases expression ISO Spp1 (Mus musculus) 6480464 Bleomycin results in increased expression of SPP1 mRNA and Bleomycin results in increased expression of SPP1 protein CTD PMID:26345256 and PMID:29175452 SPP1 Human bortezomib decreases expression EXP 6480464 Bortezomib results in decreased expression of SPP1 mRNA CTD PMID:20471514 and PMID:25913414 SPP1 Human budesonide increases expression ISO Spp1 (Mus musculus) 6480464 Budesonide results in increased expression of SPP1 protein CTD PMID:21885873 SPP1 Human Butylparaben multiple interactions ISO Spp1 (Mus musculus) 6480464 NR3C1 protein promotes the reaction [butylparaben results in decreased expression of SPP1 mRNA] and PPARG protein inhibits the reaction [butylparaben results in decreased expression of SPP1 mRNA] CTD PMID:28527915 SPP1 Human Butylparaben decreases expression ISO Spp1 (Mus musculus) 6480464 butylparaben results in decreased expression of SPP1 mRNA CTD PMID:28527915 SPP1 Human butyric acid increases expression ISO Spp1 (Rattus norvegicus) 6480464 Butyric Acid results in increased expression of SPP1 mRNA CTD PMID:12800193 SPP1 Human butyric acid multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA] and Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein] CTD PMID:37414240 SPP1 Human butyric acid multiple interactions EXP 6480464 [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of SPP1 mRNA] CTD PMID:37414240 SPP1 Human C60 fullerene increases expression ISO Spp1 (Rattus norvegicus) 6480464 fullerene C60 results in increased expression of SPP1 mRNA CTD PMID:20471445 SPP1 Human cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of SPP1 mRNA CTD PMID:17547211 SPP1 Human cadmium atom multiple interactions ISO Spp1 (Mus musculus) 6480464 [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of SPP1 mRNA CTD PMID:31904401 SPP1 Human cadmium atom decreases expression EXP 6480464 Cadmium results in decreased expression of SPP1 mRNA CTD PMID:31646340 SPP1 Human cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SPP1 mRNA and Cadmium inhibits the reaction [Fulvestrant results in increased expression of SPP1 mRNA] CTD PMID:29741670 and PMID:31646340 SPP1 Human cadmium atom increases expression ISO Spp1 (Rattus norvegicus) 6480464 Cadmium results in increased expression of SPP1 mRNA and Cadmium results in increased expression of SPP1 protein CTD PMID:17327700 and PMID:25343288 SPP1 Human cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of SPP1 mRNA CTD PMID:17547211 SPP1 Human cadmium dichloride increases export ISO Spp1 (Rattus norvegicus) 6480464 Cadmium Chloride results in increased export of SPP1 protein CTD PMID:29421648 SPP1 Human cadmium dichloride multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Curcumin inhibits the reaction [Cadmium Chloride results in increased export of SPP1 protein] CTD PMID:29421648 SPP1 Human cadmium dichloride increases methylation ISO Spp1 (Rattus norvegicus) 6480464 Cadmium Chloride results in increased methylation of SPP1 promoter CTD PMID:22457795 SPP1 Human cadmium dichloride multiple interactions ISO Spp1 (Mus musculus) 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of SPP1 mRNA and [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of SPP1 mRNA CTD PMID:19840844 and PMID:31904401 SPP1 Human cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of SPP1 mRNA CTD PMID:22019892 SPP1 Human cadmium dichloride multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in decreased expression of SPP1 mRNA] and [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SPP1 mRNA CTD PMID:22019892 and PMID:29741670 SPP1 Human cadmium dichloride increases expression ISO Spp1 (Rattus norvegicus) 6480464 Cadmium Chloride results in increased expression of SPP1 mRNA and Cadmium Chloride results in increased expression of SPP1 protein CTD PMID:17327700 and PMID:26815315 SPP1 Human caffeine decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Caffeine results in decreased expression of SPP1 mRNA CTD PMID:30423288 SPP1 Human caffeine affects phosphorylation EXP 6480464 Caffeine affects the phosphorylation of SPP1 protein CTD PMID:35688186 SPP1 Human calciol multiple interactions EXP 6480464 [Cholecalciferol co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] results in increased expression of SPP1 protein more ... CTD PMID:17692823 and PMID:22940495 SPP1 Human calcitriol multiple interactions ISO Spp1 (Mus musculus) 6480464 Calcitriol promotes the reaction [CREBBP protein binds to SPP1 promoter] more ... CTD PMID:10777672 and PMID:15647825 SPP1 Human calcitriol increases expression EXP 6480464 Calcitriol results in increased expression of SPP1 mRNA CTD PMID:12016462 more ... SPP1 Human calcitriol increases activity ISO Spp1 (Mus musculus) 6480464 Calcitriol results in increased activity of SPP1 promoter CTD PMID:10777672 SPP1 Human calcitriol decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Calcitriol results in decreased expression of SPP1 protein CTD PMID:19092814 SPP1 Human calcitriol multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [glyoxylic acid co-treated with Calcitriol] results in increased expression of SPP1 mRNA CTD PMID:7571189 SPP1 Human calcitriol increases expression ISO Spp1 (Mus musculus) 6480464 Calcitriol results in increased expression of SPP1 mRNA CTD PMID:16889531 SPP1 Human calcitriol multiple interactions EXP 6480464 [Calcitriol co-treated with resveratrol] results in increased expression of SPP1 mRNA CTD PMID:16267019 SPP1 Human calcium atom increases expression ISO Spp1 (Mus musculus) 6480464 Calcium results in increased expression of SPP1 mRNA CTD PMID:12788230 SPP1 Human calcium atom affects expression ISO Spp1 (Rattus norvegicus) 6480464 Calcium affects the expression of SPP1 mRNA CTD PMID:15913539 SPP1 Human calcium atom multiple interactions ISO Spp1 (Mus musculus) 6480464 Foscarnet inhibits the reaction [Calcium results in increased expression of SPP1 mRNA] and Nifedipine inhibits the reaction [Calcium results in increased expression of SPP1 mRNA] CTD PMID:12788230 SPP1 Human calcium carbonate decreases expression ISO Spp1 (Mus musculus) 6480464 Calcium Carbonate results in decreased expression of SPP1 protein CTD PMID:17977878 SPP1 Human calcium oxalate decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Calcium Oxalate results in decreased expression of SPP1 protein CTD PMID:37454925 SPP1 Human calcium oxalate multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of SPP1 protein] more ... CTD PMID:37414240 and PMID:37454925 SPP1 Human calcium(0) increases expression ISO Spp1 (Mus musculus) 6480464 Calcium results in increased expression of SPP1 mRNA CTD PMID:12788230 SPP1 Human calcium(0) affects expression ISO Spp1 (Rattus norvegicus) 6480464 Calcium affects the expression of SPP1 mRNA CTD PMID:15913539 SPP1 Human calcium(0) multiple interactions ISO Spp1 (Mus musculus) 6480464 Foscarnet inhibits the reaction [Calcium results in increased expression of SPP1 mRNA] and Nifedipine inhibits the reaction [Calcium results in increased expression of SPP1 mRNA] CTD PMID:12788230 SPP1 Human cannabidiol increases expression EXP 6480464 Cannabidiol results in increased expression of SPP1 mRNA and Cannabidiol results in increased expression of SPP1 protein CTD PMID:32656944 more ... SPP1 Human capsaicin multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SPP1 protein] more ... CTD PMID:22150557 SPP1 Human capsaicin increases expression ISO Spp1 (Rattus norvegicus) 6480464 Capsaicin results in increased expression of SPP1 protein CTD PMID:22150557 SPP1 Human carbamazepine affects expression EXP 6480464 Carbamazepine affects the expression of SPP1 mRNA CTD PMID:25979313 SPP1 Human carbofuran increases expression ISO Spp1 (Rattus norvegicus) 6480464 Carbofuran results in increased expression of SPP1 mRNA CTD PMID:20211217 SPP1 Human carbon nanotube affects expression ISO Spp1 (Mus musculus) 6480464 Nanotubes and Carbon affects the expression of SPP1 mRNA CTD PMID:23845593 SPP1 Human carbon nanotube multiple interactions ISO Spp1 (Mus musculus) 6480464 [Aluminum Oxide co-treated with Nanotubes more ... CTD PMID:25216247 and PMID:25807359 SPP1 Human carbon nanotube increases secretion EXP 6480464 Nanotubes and Carbon results in increased secretion of SPP1 protein CTD PMID:25216247 SPP1 Human carbon nanotube multiple interactions EXP 6480464 [Aluminum Oxide co-treated with Nanotubes more ... CTD PMID:25216247 SPP1 Human carbon nanotube increases expression ISO Spp1 (Rattus norvegicus) 6480464 Nanotubes more ... CTD PMID:19836432 more ... SPP1 Human carbon nanotube increases secretion ISO Spp1 (Mus musculus) 6480464 Nanotubes and Carbon results in increased secretion of SPP1 protein CTD PMID:25216247 SPP1 Human carbon nanotube increases expression ISO Spp1 (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25216247 more ... SPP1 Human celecoxib multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Celecoxib inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein] CTD PMID:19356721 SPP1 Human ceric oxide decreases expression ISO Spp1 (Rattus norvegicus) 6480464 ceric oxide results in decreased expression of SPP1 mRNA CTD PMID:29463257 SPP1 Human CGP 52608 multiple interactions EXP 6480464 CGP 52608 promotes the reaction [RORA protein binds to SPP1 gene] and CGP 52608 promotes the reaction [RORA protein binds to SPP1 promoter] CTD PMID:28238834 SPP1 Human CGP 52608 increases expression EXP 6480464 CGP 52608 results in increased expression of SPP1 mRNA CTD PMID:28238834 SPP1 Human chitosan increases expression EXP 6480464 Chitosan results in increased expression of SPP1 mRNA CTD PMID:25246786 SPP1 Human chloroprene increases expression ISO Spp1 (Mus musculus) 6480464 Chloroprene results in increased expression of SPP1 mRNA CTD PMID:23125180 SPP1 Human chlorpromazine multiple interactions EXP 6480464 [Chlorpromazine co-treated with Cholic Acids] affects the expression of SPP1 mRNA CTD PMID:27344345 SPP1 Human chlorpyrifos decreases expression ISO Spp1 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of SPP1 mRNA CTD PMID:37019170 SPP1 Human choline multiple interactions ISO Spp1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPP1 mRNA more ... CTD PMID:20938992 and PMID:25712622 SPP1 Human chrysene decreases expression ISO Spp1 (Mus musculus) 6480464 chrysene results in decreased expression of SPP1 mRNA CTD PMID:26377693 SPP1 Human cisplatin increases secretion ISO Spp1 (Rattus norvegicus) 6480464 Cisplatin results in increased secretion of SPP1 protein CTD PMID:28885000 SPP1 Human cisplatin multiple interactions EXP 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of SPP1 mRNA CTD PMID:27392435 SPP1 Human cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of SPP1 mRNA CTD PMID:11099651 SPP1 Human cisplatin affects expression ISO Spp1 (Rattus norvegicus) 6480464 Cisplatin affects the expression of SPP1 mRNA CTD PMID:20623750 SPP1 Human cisplatin increases expression ISO Spp1 (Rattus norvegicus) 6480464 Cisplatin results in increased expression of SPP1 mRNA and Cisplatin results in increased expression of SPP1 protein CTD PMID:11231351 more ... SPP1 Human cisplatin decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Cisplatin results in decreased expression of SPP1 mRNA CTD PMID:22023808 SPP1 Human cisplatin affects expression ISO Spp1 (Mus musculus) 6480464 Cisplatin affects the expression of SPP1 mRNA CTD PMID:21151649 SPP1 Human Clofop multiple interactions EXP 6480464 fenofibric acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA] and PPARA protein affects the reaction [fenofibric acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA]] CTD PMID:17360982 SPP1 Human clozapine decreases expression EXP 6480464 Clozapine results in decreased expression of SPP1 mRNA CTD PMID:17346280 SPP1 Human cobalt atom multiple interactions EXP 6480464 [tungsten carbide co-treated with Cobalt] results in increased expression of SPP1 mRNA CTD PMID:18078969 SPP1 Human cobalt dichloride multiple interactions EXP 6480464 cobaltous chloride affects the reaction [BMP2 protein results in increased expression of SPP1 mRNA] CTD PMID:26054564 SPP1 Human cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of SPP1 mRNA CTD PMID:19376846 SPP1 Human cobalt dichloride increases expression ISO Spp1 (Rattus norvegicus) 6480464 cobaltous chloride deficiency results in increased expression of SPP1 protein more ... CTD PMID:19356721 more ... SPP1 Human cobalt dichloride multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein] more ... CTD PMID:19356721 SPP1 Human copper atom increases expression ISO Spp1 (Rattus norvegicus) 6480464 Copper results in increased expression of SPP1 mRNA CTD PMID:22465980 and PMID:30556269 SPP1 Human copper atom multiple interactions ISO Spp1 (Mus musculus) 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of SPP1 mRNA more ... CTD PMID:15467011 and PMID:16629173 SPP1 Human copper(0) increases expression ISO Spp1 (Rattus norvegicus) 6480464 Copper results in increased expression of SPP1 mRNA CTD PMID:22465980 and PMID:30556269 SPP1 Human copper(0) multiple interactions ISO Spp1 (Mus musculus) 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of SPP1 mRNA more ... CTD PMID:15467011 and PMID:16629173 SPP1 Human copper(II) chloride increases expression EXP 6480464 cupric chloride results in increased expression of SPP1 mRNA CTD PMID:38568856 SPP1 Human copper(II) sulfate increases expression EXP 6480464 Copper Sulfate results in increased expression of SPP1 mRNA CTD PMID:19549813 SPP1 Human corticosterone decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Corticosterone results in decreased expression of SPP1 mRNA CTD PMID:30423288 SPP1 Human corticosterone multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Enalapril inhibits the reaction [Corticosterone results in decreased expression of SPP1 mRNA] CTD PMID:30423288 SPP1 Human crocidolite asbestos increases expression EXP 6480464 Asbestos and Crocidolite results in increased expression of SPP1 protein CTD PMID:21570478 SPP1 Human crocidolite asbestos increases expression ISO Spp1 (Mus musculus) 6480464 Asbestos and Crocidolite results in increased expression of SPP1 mRNA CTD PMID:23917077 and PMID:29507420 SPP1 Human Cuprizon decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Cuprizone results in decreased expression of SPP1 mRNA CTD PMID:26577399 SPP1 Human curcumin multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Curcumin inhibits the reaction [Cadmium Chloride results in increased export of SPP1 protein] CTD PMID:29421648 SPP1 Human cyanuric acid multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [cyanuric acid co-treated with melamine] results in increased expression of SPP1 mRNA more ... CTD PMID:21784140 more ... SPP1 Human cyclophosphamide affects response to substance EXP 6480464 SPP1 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 SPP1 Human cyclophosphamide increases expression ISO Spp1 (Rattus norvegicus) 6480464 Cyclophosphamide results in increased expression of SPP1 mRNA CTD PMID:23558518 SPP1 Human cyclophosphamide affects expression ISO Spp1 (Rattus norvegicus) 6480464 Cyclophosphamide affects the expression of SPP1 mRNA CTD PMID:20623750 SPP1 Human cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of SPP1 mRNA CTD PMID:20106945 more ... SPP1 Human cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of SPP1 mRNA CTD PMID:25562108 more ... SPP1 Human cyclosporin A increases expression ISO Spp1 (Rattus norvegicus) 6480464 Cyclosporine results in increased expression of SPP1 mRNA CTD PMID:21865292 and PMID:23558518 SPP1 Human cypermethrin decreases expression ISO Spp1 (Mus musculus) 6480464 cypermethrin results in decreased expression of SPP1 mRNA CTD PMID:29020013 SPP1 Human D-glucose increases expression ISO Spp1 (Mus musculus) 6480464 Glucose results in increased expression of SPP1 mRNA CTD PMID:17178593 SPP1 Human D-glucose multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]] more ... CTD PMID:38000455 SPP1 Human D-glucose multiple interactions ISO Spp1 (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:37567420 SPP1 Human D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of SPP1 mRNA and Glucose results in decreased expression of SPP1 protein CTD PMID:38000455 SPP1 Human D-glucose decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Glucose results in decreased expression of SPP1 mRNA CTD PMID:32643284 SPP1 Human D-glucose increases secretion ISO Spp1 (Rattus norvegicus) 6480464 Glucose results in increased secretion of SPP1 protein CTD PMID:20453393 SPP1 Human D-glucose increases expression ISO Spp1 (Rattus norvegicus) 6480464 Glucose results in increased expression of SPP1 and Glucose results in increased expression of SPP1 mRNA CTD PMID:12505755 and PMID:20453393 SPP1 Human D-glucose multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 1-Methyl-3-isobutylxanthine inhibits the reaction [Glucose results in increased secretion of SPP1 protein] more ... CTD PMID:20453393 and PMID:32643284 SPP1 Human DDE decreases expression EXP 6480464 Dichlorodiphenyl Dichloroethylene results in decreased expression of SPP1 mRNA CTD PMID:38568856 SPP1 Human DDT increases expression EXP 6480464 DDT results in increased expression of SPP1 mRNA CTD PMID:25014179 SPP1 Human DDT decreases expression ISO Spp1 (Rattus norvegicus) 6480464 DDT results in decreased expression of SPP1 mRNA CTD PMID:30207508 SPP1 Human decabromodiphenyl ether multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [Flame Retardants co-treated with pentabromodiphenyl ether co-treated with decabromobiphenyl ether co-treated with hexabromocyclododecane] results in decreased expression of SPP1 mRNA CTD PMID:32207525 SPP1 Human deoxynivalenol decreases phosphorylation ISO Spp1 (Mus musculus) 6480464 deoxynivalenol results in decreased phosphorylation of SPP1 protein CTD PMID:23352502 SPP1 Human deoxynivalenol increases expression EXP 6480464 deoxynivalenol results in increased expression of SPP1 mRNA CTD PMID:27757495 SPP1 Human dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of SPP1 mRNA CTD PMID:19853017 SPP1 Human dexamethasone multiple interactions EXP 6480464 [Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid co-treated with Cholecalciferol] results in increased expression of SPP1 mRNA more ... CTD PMID:22940495 and PMID:36682590 SPP1 Human dexamethasone multiple interactions ISO Spp1 (Mus musculus) 6480464 [Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of SPP1 mRNA more ... CTD PMID:24116280 and PMID:26492236 SPP1 Human dexamethasone decreases expression ISO Spp1 (Mus musculus) 6480464 Dexamethasone results in decreased expression of SPP1 mRNA and Dexamethasone results in decreased expression of SPP1 protein CTD PMID:22733784 and PMID:24116280 SPP1 Human dextran sulfate multiple interactions ISO Spp1 (Mus musculus) 6480464 Qingdai compound inhibits the reaction [Dextran Sulfate results in increased expression of SPP1 mRNA] CTD PMID:32033881 SPP1 Human dextran sulfate decreases expression ISO Spp1 (Mus musculus) 6480464 Dextran Sulfate results in decreased expression of SPP1 protein CTD PMID:35999755 SPP1 Human dextran sulfate increases expression ISO Spp1 (Mus musculus) 6480464 Dextran Sulfate results in increased expression of SPP1 mRNA CTD PMID:32033881 SPP1 Human diallyl trisulfide increases expression EXP 6480464 diallyl trisulfide results in increased expression of SPP1 mRNA CTD PMID:34995734 SPP1 Human diamminedichloroplatinum decreases expression EXP 6480464 transplatin results in decreased expression of SPP1 mRNA CTD PMID:11099651 SPP1 Human diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of SPP1 mRNA CTD PMID:20471514 SPP1 Human diarsenic trioxide decreases expression ISO Spp1 (Mus musculus) 6480464 Arsenic Trioxide results in decreased expression of SPP1 mRNA CTD PMID:35676786 SPP1 Human diarsenic trioxide multiple interactions EXP 6480464 [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of SPP1 mRNA CTD PMID:15894607 SPP1 Human dibenz[a,h]anthracene multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:18711122 SPP1 Human dibenz[a,h]anthracene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:17690111 SPP1 Human dibenzo[a,l]pyrene multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [Benzo(a)pyrene co-treated with dibenzo(a and l)pyrene] affects the expression of SPP1 mRNA CTD PMID:18711122 SPP1 Human dibutyl phthalate increases expression ISO Spp1 (Rattus norvegicus) 6480464 Dibutyl Phthalate results in increased expression of SPP1 mRNA CTD PMID:21266533 SPP1 Human diethylstilbestrol increases expression ISO Spp1 (Mus musculus) 6480464 Diethylstilbestrol results in increased expression of SPP1 mRNA CTD PMID:15289156 SPP1 Human diethylstilbestrol increases expression ISO Spp1 (Rattus norvegicus) 6480464 Diethylstilbestrol results in increased expression of SPP1 mRNA CTD PMID:37077353 SPP1 Human diethylstilbestrol decreases expression EXP 6480464 Diethylstilbestrol results in decreased expression of SPP1 mRNA CTD PMID:36621641 SPP1 Human dioxygen multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Rolipram inhibits the reaction [Oxygen results in increased expression of SPP1 mRNA] and Rolipram inhibits the reaction [Oxygen results in increased expression of SPP1 protein] CTD PMID:18941502 SPP1 Human dioxygen multiple interactions ISO Spp1 (Mus musculus) 6480464 [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of SPP1 mRNA CTD PMID:19640911 SPP1 Human dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of SPP1 mRNA CTD PMID:24236059 SPP1 Human dioxygen increases expression ISO Spp1 (Rattus norvegicus) 6480464 Oxygen results in increased expression of SPP1 mRNA and Oxygen results in increased expression of SPP1 protein CTD PMID:18941502 SPP1 Human dipyridamole multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Dinitrochlorobenzene inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]] more ... CTD PMID:19356721 and PMID:20453393 SPP1 Human disodium selenite multiple interactions ISO Spp1 (Mus musculus) 6480464 [ptaquiloside co-treated with Sodium Selenite] results in decreased expression of SPP1 mRNA CTD PMID:23274088 SPP1 Human diuron decreases expression EXP 6480464 Diuron results in decreased expression of SPP1 mRNA CTD PMID:35967413 SPP1 Human divanadium pentaoxide increases expression ISO Spp1 (Rattus norvegicus) 6480464 vanadium pentoxide results in increased expression of SPP1 mRNA CTD PMID:17134509 SPP1 Human dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 SPP1 Human doxorubicin multiple interactions ISO Spp1 (Mus musculus) 6480464 DMD protein affects the reaction [Doxorubicin results in decreased expression of SPP1 mRNA] CTD PMID:17888722 SPP1 Human doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of SPP1 mRNA CTD PMID:29803840 SPP1 Human doxorubicin increases expression ISO Spp1 (Mus musculus) 6480464 Doxorubicin results in increased expression of SPP1 mRNA CTD PMID:15033991 and PMID:22016648 SPP1 Human doxorubicin decreases expression ISO Spp1 (Mus musculus) 6480464 Doxorubicin results in decreased expression of SPP1 mRNA CTD PMID:17888722 SPP1 Human doxorubicin increases expression ISO Spp1 (Rattus norvegicus) 6480464 Doxorubicin results in increased expression of SPP1 mRNA and Doxorubicin results in increased expression of SPP1 protein CTD PMID:11972865 more ... SPP1 Human elemental selenium decreases expression ISO Spp1 (Mus musculus) 6480464 Selenium results in decreased expression of SPP1 protein CTD PMID:15318939 SPP1 Human enalapril multiple interactions ISO Spp1 (Mus musculus) 6480464 [Enalapril co-treated with paricalcitol] results in decreased expression of SPP1 mRNA CTD PMID:25037058 SPP1 Human enalapril multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Enalapril inhibits the reaction [Corticosterone results in decreased expression of SPP1 mRNA] and Enalapril inhibits the reaction [Ethanol results in decreased expression of SPP1 mRNA] CTD PMID:30423288 and PMID:31887396 SPP1 Human endosulfan increases expression ISO Spp1 (Rattus norvegicus) 6480464 Endosulfan results in increased expression of SPP1 mRNA CTD PMID:29391264 SPP1 Human entinostat increases expression EXP 6480464 entinostat results in increased expression of SPP1 mRNA CTD PMID:26272509 SPP1 Human entinostat multiple interactions EXP 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPP1 mRNA CTD PMID:27188386 SPP1 Human Erionite decreases expression ISO Spp1 (Mus musculus) 6480464 erionite results in decreased expression of SPP1 mRNA CTD PMID:29279043 SPP1 Human esketamine increases expression EXP 6480464 Esketamine results in increased expression of SPP1 mRNA CTD PMID:38219984 SPP1 Human ethanol increases expression ISO Spp1 (Mus musculus) 6480464 Ethanol results in increased expression of SPP1 mRNA and Ethanol results in increased expression of SPP1 protein CTD PMID:18703563 SPP1 Human ethanol decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Ethanol results in decreased expression of SPP1 mRNA CTD PMID:31887396 SPP1 Human ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of SPP1 mRNA CTD PMID:31059573 SPP1 Human ethanol multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Enalapril inhibits the reaction [Ethanol results in decreased expression of SPP1 mRNA] more ... CTD PMID:18703563 more ... SPP1 Human ethanol increases expression ISO Spp1 (Rattus norvegicus) 6480464 Ethanol results in increased expression of SPP1 mRNA and Ethanol results in increased expression of SPP1 protein CTD PMID:18703563 and PMID:33645892 SPP1 Human ethanol multiple interactions ISO Spp1 (Mus musculus) 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of SPP1 mRNA more ... CTD PMID:18703563 and PMID:30517762 SPP1 Human ethanol increases expression EXP 6480464 Ethanol results in increased expression of SPP1 protein CTD PMID:18703563 SPP1 Human ethylene glycol multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA more ... CTD PMID:27018375 more ... SPP1 Human ethylene glycol increases expression ISO Spp1 (Rattus norvegicus) 6480464 Ethylene Glycol results in increased expression of SPP1 mRNA and Ethylene Glycol results in increased expression of SPP1 protein CTD PMID:24145091 more ... SPP1 Human etoposide affects response to substance EXP 6480464 SPP1 protein affects the susceptibility to Etoposide CTD PMID:16217747 SPP1 Human etoposide decreases expression ISO Spp1 (Mus musculus) 6480464 Etoposide results in decreased expression of SPP1 mRNA CTD PMID:25270620 SPP1 Human Falecalcitriol increases expression EXP 6480464 26 more ... CTD PMID:12016462 SPP1 Human fisetin increases expression ISO Spp1 (Rattus norvegicus) 6480464 fisetin results in increased expression of SPP1 mRNA and fisetin results in increased expression of SPP1 protein CTD PMID:37087476 SPP1 Human fisetin multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 ICG 001 inhibits the reaction [fisetin results in increased expression of SPP1 protein] CTD PMID:37087476 SPP1 Human flavonoids multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of SPP1 protein] CTD PMID:27241030 SPP1 Human flunisolide increases expression ISO Spp1 (Mus musculus) 6480464 flunisolide results in increased expression of SPP1 protein CTD PMID:21885873 SPP1 Human fluoranthene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of SPP1 mRNA CTD PMID:17690111 SPP1 Human fluoranthene multiple interactions ISO Spp1 (Mus musculus) 6480464 [1-methylanthracene co-treated with fluoranthene] results in increased expression of SPP1 mRNA CTD PMID:28329830 SPP1 Human fluvastatin multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of SPP1 mRNA] CTD PMID:16452496 SPP1 Human folic acid multiple interactions ISO Spp1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPP1 mRNA and icariin inhibits the reaction [Folic Acid results in increased expression of SPP1 protein] CTD PMID:20938992 and PMID:38272249 SPP1 Human folic acid increases expression ISO Spp1 (Mus musculus) 6480464 Folic Acid results in increased expression of SPP1 protein CTD PMID:38272249 SPP1 Human FR900359 affects phosphorylation EXP 6480464 FR900359 affects the phosphorylation of SPP1 protein CTD PMID:37730182 SPP1 Human fructose multiple interactions ISO Spp1 (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:37567420 SPP1 Human fulvestrant multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 fulvestrant inhibits the reaction [naringin results in increased secretion of SPP1 protein] CTD PMID:23596885 SPP1 Human fulvestrant multiple interactions EXP 6480464 Cadmium inhibits the reaction [Fulvestrant results in increased expression of SPP1 mRNA] more ... CTD PMID:31646340 SPP1 Human fulvestrant increases expression EXP 6480464 Fulvestrant results in increased expression of SPP1 mRNA CTD PMID:31646340 SPP1 Human furan increases expression ISO Spp1 (Rattus norvegicus) 6480464 furan results in increased expression of SPP1 mRNA CTD PMID:26194646 and PMID:27387713 SPP1 Human gadodiamide hydrate increases expression ISO Spp1 (Rattus norvegicus) 6480464 gadodiamide results in increased expression of SPP1 protein CTD PMID:20938346 SPP1 Human gadolinium atom multiple interactions EXP 6480464 [gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of SPP1 mRNA CTD PMID:34878122 SPP1 Human gadolinium trichloride multiple interactions EXP 6480464 [gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of SPP1 mRNA CTD PMID:34878122 SPP1 Human gallocatechin increases expression ISO Spp1 (Rattus norvegicus) 6480464 gallocatechol results in increased expression of SPP1 mRNA CTD PMID:21877759 SPP1 Human gemcitabine increases expression EXP 6480464 Gemcitabine results in increased expression of SPP1 mRNA CTD PMID:17039268 SPP1 Human genistein increases expression ISO Spp1 (Mus musculus) 6480464 Genistein results in increased expression of SPP1 mRNA CTD PMID:15289156 SPP1 Human genistein increases expression ISO Spp1 (Rattus norvegicus) 6480464 Genistein results in increased expression of SPP1 mRNA CTD PMID:21877759 SPP1 Human genistein decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Genistein results in decreased expression of SPP1 mRNA CTD PMID:22504913 SPP1 Human gentamycin affects expression ISO Spp1 (Rattus norvegicus) 6480464 Gentamicins affects the expression of SPP1 mRNA CTD PMID:20623750 SPP1 Human gentamycin multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Sodium Fluoride inhibits the reaction [Gentamicins results in increased expression of SPP1 mRNA] and Sodium Fluoride inhibits the reaction [Gentamicins results in increased expression of SPP1 protein] CTD PMID:26779593 SPP1 Human gentamycin increases expression ISO Spp1 (Rattus norvegicus) 6480464 Gentamicins results in increased expression of SPP1 mRNA and Gentamicins results in increased expression of SPP1 protein CTD PMID:11231351 more ... SPP1 Human Ginkgoic acid multiple interactions EXP 6480464 ginkgolic acid inhibits the reaction [Tretinoin results in increased expression of SPP1 mRNA] CTD PMID:24819975 SPP1 Human glucose increases expression ISO Spp1 (Mus musculus) 6480464 Glucose results in increased expression of SPP1 mRNA CTD PMID:17178593 SPP1 Human glucose decreases expression EXP 6480464 Glucose results in decreased expression of SPP1 mRNA and Glucose results in decreased expression of SPP1 protein CTD PMID:38000455 SPP1 Human glucose multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]] more ... CTD PMID:38000455 SPP1 Human glucose multiple interactions ISO Spp1 (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:37567420 SPP1 Human glucose decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Glucose results in decreased expression of SPP1 mRNA CTD PMID:32643284 SPP1 Human glucose increases secretion ISO Spp1 (Rattus norvegicus) 6480464 Glucose results in increased secretion of SPP1 protein CTD PMID:20453393 SPP1 Human glucose increases expression ISO Spp1 (Rattus norvegicus) 6480464 Glucose results in increased expression of SPP1 and Glucose results in increased expression of SPP1 mRNA CTD PMID:12505755 and PMID:20453393 SPP1 Human glucose multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 1-Methyl-3-isobutylxanthine inhibits the reaction [Glucose results in increased secretion of SPP1 protein] more ... CTD PMID:20453393 and PMID:32643284 SPP1 Human glycerol 1-phosphate multiple interactions EXP 6480464 [SAG compound co-treated with 2 and 4-di-tert-butylphenol co-treated with Fibroblast Growth Factor 2 co-treated with Ascorbic Acid co-treated with alpha-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of SPP1 mRNA CTD PMID:36682590 SPP1 Human glycerol 2-phosphate multiple interactions EXP 6480464 [Cholecalciferol co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] results in increased expression of SPP1 protein more ... CTD PMID:17692823 and PMID:22940495 SPP1 Human glycerol 2-phosphate multiple interactions ISO Spp1 (Mus musculus) 6480464 [Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of SPP1 mRNA more ... CTD PMID:26492236 SPP1 Human glycidol multiple interactions ISO Spp1 (Mus musculus) 6480464 [alpha-Chlorohydrin co-treated with glycidol] results in increased expression of SPP1 mRNA CTD PMID:33187795 SPP1 Human glyoxylic acid multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 2-aminoethyl diphenylborinate inhibits the reaction [glyoxylic acid results in increased expression of SPP1 protein] more ... CTD PMID:37454925 and PMID:7571189 SPP1 Human glyoxylic acid increases expression ISO Spp1 (Rattus norvegicus) 6480464 glyoxylic acid results in increased expression of SPP1 protein CTD PMID:37454925 and PMID:8325891 SPP1 Human glyphosate decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Glyphosate results in decreased expression of SPP1 mRNA CTD PMID:38314887 SPP1 Human graphite decreases expression ISO Spp1 (Mus musculus) 6480464 Graphite results in decreased expression of SPP1 mRNA CTD PMID:27440207 SPP1 Human graphite increases expression ISO Spp1 (Rattus norvegicus) 6480464 Graphite results in increased expression of SPP1 mRNA CTD PMID:29933104 SPP1 Human griseofulvin affects expression ISO Spp1 (Mus musculus) 6480464 Griseofulvin affects the expression of SPP1 mRNA CTD PMID:12735108 SPP1 Human Hexachloro-1,3-butadiene increases expression ISO Spp1 (Rattus norvegicus) 6480464 hexachlorobutadiene results in increased expression of SPP1 protein CTD PMID:21259293 and PMID:23136149 SPP1 Human hydrogen peroxide multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Hydrogen Peroxide inhibits the reaction [Allylamine results in increased expression of SPP1 mRNA] CTD PMID:15910882 SPP1 Human hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of SPP1 mRNA CTD PMID:33491125 SPP1 Human hydrogen peroxide increases secretion EXP 6480464 Hydrogen Peroxide results in increased secretion of SPP1 protein CTD PMID:33491125 SPP1 Human icariin multiple interactions ISO Spp1 (Mus musculus) 6480464 icariin inhibits the reaction [Folic Acid results in increased expression of SPP1 protein] more ... CTD PMID:18295595 and PMID:38272249 SPP1 Human icariin increases expression ISO Spp1 (Rattus norvegicus) 6480464 icariin results in increased expression of SPP1 mRNA CTD PMID:16696327 and PMID:18236786 SPP1 Human icariin increases expression ISO Spp1 (Mus musculus) 6480464 icariin results in increased expression of SPP1 mRNA CTD PMID:18295595 SPP1 Human imperatorin multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 imperatorin analog inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:25727310 SPP1 Human indole-3-methanol affects expression ISO Spp1 (Rattus norvegicus) 6480464 indole-3-carbinol affects the expression of SPP1 mRNA CTD PMID:21396975 SPP1 Human inulin multiple interactions ISO Spp1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SPP1 mRNA CTD PMID:36331819 SPP1 Human iron(2+) sulfate (anhydrous) decreases expression EXP 6480464 ferrous sulfate results in decreased expression of SPP1 mRNA CTD PMID:19428942 SPP1 Human isocyanuric acid multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [cyanuric acid co-treated with melamine] results in increased expression of SPP1 mRNA more ... CTD PMID:21784140 more ... SPP1 Human isoniazide affects expression ISO Spp1 (Rattus norvegicus) 6480464 Isoniazid affects the expression of SPP1 mRNA CTD PMID:20623750 SPP1 Human isoniazide decreases expression EXP 6480464 Isoniazid results in decreased expression of SPP1 mRNA CTD PMID:30008028 SPP1 Human isonicotinamide increases expression EXP 6480464 isonicotinamide results in increased expression of SPP1 mRNA CTD PMID:21745208 SPP1 Human isoprenaline increases expression ISO Spp1 (Mus musculus) 6480464 Isoproterenol results in increased expression of SPP1 mRNA CTD PMID:20003209 SPP1 Human isoprenaline decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Isoproterenol results in decreased expression of SPP1 mRNA CTD PMID:24286936 SPP1 Human isoprenaline increases expression ISO Spp1 (Rattus norvegicus) 6480464 Isoproterenol results in increased expression of SPP1 mRNA CTD PMID:20211217 more ... SPP1 Human isoprenaline decreases expression ISO Spp1 (Mus musculus) 6480464 Isoproterenol results in decreased expression of SPP1 mRNA CTD PMID:21335049 SPP1 Human isotretinoin increases expression EXP 6480464 Isotretinoin results in increased expression of SPP1 mRNA CTD PMID:18769122 SPP1 Human ivermectin decreases expression EXP 6480464 Ivermectin results in decreased expression of SPP1 protein CTD PMID:32959892 SPP1 Human jaspamide decreases expression EXP 6480464 jasplakinolide results in decreased expression of SPP1 protein CTD PMID:19026636 SPP1 Human kaempferol multiple interactions ISO Spp1 (Mus musculus) 6480464 kaempferol inhibits the reaction [APOE affects the expression of SPP1 mRNA] and kaempferol inhibits the reaction [APOE affects the expression of SPP1 protein] CTD PMID:22005275 SPP1 Human ketamine multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [ampullosporin co-treated with Ketamine] results in increased expression of SPP1 mRNA CTD PMID:16635253 SPP1 Human ketoconazole increases expression ISO Spp1 (Rattus norvegicus) 6480464 Ketoconazole results in increased expression of SPP1 mRNA CTD PMID:37077353 SPP1 Human kojic acid increases expression EXP 6480464 kojic acid results in increased expression of SPP1 mRNA CTD PMID:16595896 SPP1 Human KT 5823 multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 KT 5823 inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Glucose results in increased secretion of SPP1 protein]] more ... CTD PMID:20453393 SPP1 Human L-ascorbic acid multiple interactions EXP 6480464 [Cholecalciferol co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] results in increased expression of SPP1 protein more ... CTD PMID:17692823 and PMID:36682590 SPP1 Human L-ascorbic acid multiple interactions ISO Spp1 (Mus musculus) 6480464 [Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of SPP1 mRNA more ... CTD PMID:26492236 SPP1 Human L-ascorbic acid 2-phosphate multiple interactions EXP 6480464 [Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid co-treated with Cholecalciferol] results in increased expression of SPP1 mRNA and PARG mRNA inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid co-treated with Cholecalciferol] results in increased expression of SPP1 mRNA] CTD PMID:22940495 SPP1 Human L-methionine multiple interactions ISO Spp1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPP1 mRNA more ... CTD PMID:20938992 and PMID:25712622 SPP1 Human lead diacetate multiple interactions EXP 6480464 lead acetate results in increased expression of and results in increased secretion of SPP1 protein and NFE2L2 protein affects the reaction [lead acetate results in increased expression of SPP1 mRNA] CTD PMID:27562236 SPP1 Human lead diacetate increases expression ISO Spp1 (Mus musculus) 6480464 lead acetate results in increased expression of SPP1 mRNA CTD PMID:30312686 SPP1 Human lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of SPP1 mRNA CTD PMID:27562236 and PMID:38568856 SPP1 Human lead(0) affects expression EXP 6480464 Lead affects the expression of SPP1 mRNA CTD PMID:28903495 SPP1 Human lead(II) chloride increases expression EXP 6480464 lead chloride results in increased expression of SPP1 mRNA CTD PMID:38447685 SPP1 Human lidocaine increases expression ISO Spp1 (Rattus norvegicus) 6480464 Lidocaine results in increased expression of SPP1 mRNA CTD PMID:35283115 SPP1 Human linalool multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 linalool inhibits the reaction [[Phosphates co-treated with Adenine] results in increased expression of SPP1 mRNA] CTD PMID:30466616 SPP1 Human lipopolysaccharide multiple interactions EXP 6480464 [Aluminum Oxide co-treated with Nanotubes more ... CTD PMID:25216247 and PMID:35877022 SPP1 Human lipopolysaccharide increases expression ISO Spp1 (Mus musculus) 6480464 Lipopolysaccharides results in increased expression of SPP1 mRNA CTD PMID:27339419 SPP1 Human lipopolysaccharide increases secretion EXP 6480464 Lipopolysaccharides results in increased secretion of SPP1 protein CTD PMID:25216247 SPP1 Human losartan multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Losartan inhibits the reaction [glyoxylic acid results in increased expression of SPP1 protein] CTD PMID:37454925 SPP1 Human LY 364947 decreases phosphorylation EXP 155260309 LY364947 decreases phosphorylation of SPP1 protein in aortic smooth muscle cells RGD SPP1 Human LY294002 multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein] CTD PMID:19356721 SPP1 Human magnesium atom increases expression EXP 6480464 Magnesium results in increased expression of SPP1 protein CTD PMID:10397942 SPP1 Human maneb multiple interactions ISO Spp1 (Mus musculus) 6480464 [Maneb co-treated with Paraquat] results in decreased expression of SPP1 mRNA CTD PMID:36117858 SPP1 Human medroxyprogesterone acetate increases expression EXP 6480464 Medroxyprogesterone Acetate results in increased expression of SPP1 mRNA CTD PMID:20843944 SPP1 Human melamine multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [cyanuric acid co-treated with melamine] results in increased expression of SPP1 mRNA more ... CTD PMID:21784140 more ... SPP1 Human melatonin multiple interactions EXP 6480464 Melatonin inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA] and Melatonin inhibits the reaction [Glucose results in decreased expression of SPP1 protein] CTD PMID:38000455 SPP1 Human mercury atom increases expression EXP 6480464 Mercury results in increased expression of SPP1 mRNA CTD PMID:17547211 SPP1 Human mercury dibromide increases expression EXP 6480464 mercuric bromide results in increased expression of SPP1 mRNA CTD PMID:26272509 SPP1 Human mercury dibromide multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPP1 mRNA CTD PMID:27188386 SPP1 Human mercury dichloride multiple interactions ISO Spp1 (Mus musculus) 6480464 [Trichloroethylene co-treated with Mercuric Chloride] results in increased expression of SPP1 protein CTD PMID:21084432 SPP1 Human mercury dichloride multiple interactions EXP 6480464 [NOG protein co-treated with Mercuric Chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPP1 mRNA CTD PMID:27188386 SPP1 Human mercury dichloride increases expression EXP 6480464 Mercuric Chloride results in increased expression of SPP1 mRNA CTD PMID:26272509 SPP1 Human mercury dichloride increases expression ISO Spp1 (Rattus norvegicus) 6480464 Mercuric Chloride results in increased expression of SPP1 mRNA and Mercuric Chloride results in increased expression of SPP1 protein CTD PMID:11274264 SPP1 Human mercury(0) increases expression EXP 6480464 Mercury results in increased expression of SPP1 mRNA CTD PMID:17547211 SPP1 Human mesalamine multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Mesalamine inhibits the reaction [Thioacetamide results in increased expression of SPP1 protein] CTD PMID:29738702 SPP1 Human metaproterenol increases expression ISO Spp1 (Rattus norvegicus) 6480464 Metaproterenol results in increased expression of SPP1 mRNA CTD PMID:23558518 SPP1 Human methapyrilene increases expression ISO Spp1 (Rattus norvegicus) 6480464 Methapyrilene results in increased expression of SPP1 mRNA CTD PMID:23558518 SPP1 Human methotrexate increases expression ISO Spp1 (Rattus norvegicus) 6480464 Methotrexate results in increased expression of SPP1 protein CTD PMID:31975554 SPP1 Human methotrexate multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 agomelatine inhibits the reaction [Methotrexate results in increased expression of SPP1 protein] CTD PMID:31975554 SPP1 Human methylmercury chloride increases expression ISO Spp1 (Rattus norvegicus) 6480464 methylmercuric chloride results in increased expression of SPP1 protein CTD PMID:28526320 SPP1 Human methylmercury chloride multiple interactions EXP 6480464 [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPP1 mRNA CTD PMID:27188386 SPP1 Human methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of SPP1 mRNA CTD PMID:23179753 more ... SPP1 Human methylparaben decreases expression ISO Spp1 (Mus musculus) 6480464 methylparaben results in decreased expression of SPP1 mRNA CTD PMID:28527915 SPP1 Human microcystin-LR increases expression ISO Spp1 (Mus musculus) 6480464 cyanoginosin LR results in increased expression of SPP1 mRNA CTD PMID:37342990 SPP1 Human milrinone increases expression ISO Spp1 (Rattus norvegicus) 6480464 Milrinone results in increased expression of SPP1 mRNA CTD PMID:22936366 SPP1 Human mitoxantrone increases expression ISO Spp1 (Rattus norvegicus) 6480464 Mitoxantrone results in increased expression of SPP1 mRNA CTD PMID:23558518 SPP1 Human mometasone furoate increases expression ISO Spp1 (Mus musculus) 6480464 Mometasone Furoate results in increased expression of SPP1 protein CTD PMID:21885873 SPP1 Human Morroniside affects expression ISO Spp1 (Mus musculus) 6480464 morroniside affects the expression of SPP1 protein CTD PMID:35848187 SPP1 Human Morroniside multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 morroniside inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA] CTD PMID:32643284 SPP1 Human Muraglitazar decreases expression ISO Spp1 (Rattus norvegicus) 6480464 muraglitazar results in decreased expression of SPP1 mRNA CTD PMID:21515302 SPP1 Human mycophenolic acid increases expression ISO Spp1 (Mus musculus) 6480464 Mycophenolic Acid results in increased expression of SPP1 mRNA CTD PMID:19818335 SPP1 Human mycotoxin increases expression ISO Spp1 (Mus musculus) 6480464 Mycotoxins results in increased expression of SPP1 mRNA CTD PMID:19818335 SPP1 Human myo-inositol hexakisphosphate multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]] more ... CTD PMID:38000455 SPP1 Human N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine multiple interactions ISO Spp1 (Mus musculus) 6480464 [zinc chloride co-treated with N more ... CTD PMID:19913120 SPP1 Human N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Glucose results in increased secretion of SPP1 protein]] more ... CTD PMID:20453393 SPP1 Human N-acetyl-L-cysteine multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Allylamine results in increased expression of SPP1 mRNA] and Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein] CTD PMID:15910882 and PMID:19356721 SPP1 Human N-ethyl-N-nitrosourea increases expression ISO Spp1 (Rattus norvegicus) 6480464 Ethylnitrosourea results in increased expression of SPP1 mRNA CTD PMID:15954086 SPP1 Human N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO Spp1 (Mus musculus) 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of SPP1 mRNA more ... CTD PMID:19840844 SPP1 Human N-methyl-N-nitrosourea decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Methylnitrosourea results in decreased expression of SPP1 mRNA CTD PMID:16525678 SPP1 Human N-nitrosodiethylamine increases expression ISO Spp1 (Rattus norvegicus) 6480464 Diethylnitrosamine results in increased expression of SPP1 mRNA CTD PMID:19638242 SPP1 Human N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of SPP1 mRNA CTD PMID:17547211 SPP1 Human naproxen multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SPP1 protein] and Naproxen inhibits the reaction [Capsaicin results in increased expression of SPP1 protein] CTD PMID:22150557 SPP1 Human naringin increases expression EXP 6480464 naringin results in increased expression of SPP1 mRNA and naringin results in increased expression of SPP1 protein CTD PMID:18495116 and PMID:24915843 SPP1 Human naringin increases expression ISO Spp1 (Mus musculus) 6480464 naringin results in increased expression of SPP1 mRNA and naringin results in increased expression of SPP1 protein CTD PMID:18495116 SPP1 Human naringin increases secretion ISO Spp1 (Rattus norvegicus) 6480464 naringin results in increased secretion of SPP1 protein CTD PMID:23596885 SPP1 Human naringin multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 fulvestrant inhibits the reaction [naringin results in increased secretion of SPP1 protein] CTD PMID:23596885 SPP1 Human natamycin increases expression ISO Spp1 (Mus musculus) 6480464 Natamycin results in increased expression of SPP1 mRNA CTD PMID:22863853 SPP1 Human neoechinulin A increases expression ISO Spp1 (Mus musculus) 6480464 neoechinulin A results in increased expression of SPP1 mRNA CTD PMID:19818335 SPP1 Human nickel atom increases expression ISO Spp1 (Mus musculus) 6480464 Nickel results in increased expression of SPP1 mRNA CTD PMID:12540486 SPP1 Human nickel atom increases expression EXP 6480464 Nickel results in increased expression of SPP1 mRNA CTD PMID:24768652 and PMID:25583101 SPP1 Human nickel dichloride increases expression EXP 6480464 nickel chloride results in increased expression of SPP1 mRNA CTD PMID:17547211 SPP1 Human nickel sulfate increases expression ISO Spp1 (Mus musculus) 6480464 nickel sulfate results in increased expression of SPP1 mRNA CTD PMID:16100012 SPP1 Human nicotine increases expression EXP 6480464 Nicotine results in increased expression of SPP1 protein CTD PMID:11425648 SPP1 Human nicotine multiple interactions EXP 6480464 Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein] CTD PMID:11425648 SPP1 Human nifedipine multiple interactions ISO Spp1 (Mus musculus) 6480464 Nifedipine inhibits the reaction [Calcium results in increased expression of SPP1 mRNA] and Nifedipine inhibits the reaction [Phosphates results in increased expression of SPP1 mRNA] CTD PMID:12788230 SPP1 Human nitric oxide decreases expression ISO Spp1 (Mus musculus) 6480464 Nitric Oxide deficiency results in decreased expression of SPP1 mRNA CTD PMID:15878706 SPP1 Human nitroprusside multiple interactions EXP 6480464 1H-(1 more ... CTD PMID:22543296 SPP1 Human nitroprusside increases expression EXP 6480464 Nitroprusside results in increased expression of SPP1 mRNA CTD PMID:22543296 SPP1 Human nystatin increases expression ISO Spp1 (Mus musculus) 6480464 Nystatin results in increased expression of SPP1 mRNA CTD PMID:22863853 SPP1 Human O-methyleugenol increases expression EXP 6480464 methyleugenol results in increased expression of SPP1 mRNA CTD PMID:32234424 SPP1 Human ochratoxin A increases expression ISO Spp1 (Rattus norvegicus) 6480464 ochratoxin A results in increased expression of SPP1 mRNA and ochratoxin A results in increased expression of SPP1 protein CTD PMID:18308701 and PMID:30449730 SPP1 Human ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of SPP1 mRNA CTD PMID:30008028 SPP1 Human okadaic acid multiple interactions ISO Spp1 (Mus musculus) 6480464 [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of SPP1 mRNA CTD PMID:19840844 SPP1 Human orciprenaline increases expression ISO Spp1 (Rattus norvegicus) 6480464 Metaproterenol results in increased expression of SPP1 mRNA CTD PMID:23558518 SPP1 Human oxalic acid multiple interactions EXP 6480464 [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of SPP1 mRNA] more ... CTD PMID:24145091 and PMID:37414240 SPP1 Human oxalic acid increases expression EXP 6480464 Oxalic Acid results in increased expression of SPP1 mRNA CTD PMID:24145091 and PMID:37414240 SPP1 Human oxaliplatin multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of SPP1 mRNA CTD PMID:25729387 SPP1 Human oxaliplatin increases expression ISO Spp1 (Rattus norvegicus) 6480464 oxaliplatin results in increased expression of SPP1 mRNA CTD PMID:25729387 SPP1 Human oxidopamine decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Oxidopamine results in decreased expression of SPP1 protein CTD PMID:24486959 SPP1 Human ozone increases expression EXP 6480464 Ozone results in increased expression of SPP1 mRNA CTD PMID:31476115 SPP1 Human ozone multiple interactions EXP 6480464 [Air Pollutants results in increased abundance of Ozone] which results in increased expression of SPP1 mRNA CTD PMID:26035830 SPP1 Human ozone increases expression ISO Spp1 (Mus musculus) 6480464 Ozone results in increased expression of SPP1 mRNA CTD PMID:12763052 more ... SPP1 Human ozone increases expression ISO Spp1 (Rattus norvegicus) 6480464 Ozone results in increased expression of SPP1 and Ozone results in increased expression of SPP1 mRNA CTD PMID:16716893 and PMID:24103449 SPP1 Human ozone multiple interactions ISO Spp1 (Mus musculus) 6480464 3-(4-t-butylphenyl)-N-(2 more ... CTD PMID:19555225 more ... SPP1 Human p-chloromercuribenzoic acid increases expression EXP 6480464 p-Chloromercuribenzoic Acid results in increased expression of SPP1 mRNA CTD PMID:26272509 SPP1 Human p-chloromercuribenzoic acid multiple interactions EXP 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPP1 mRNA CTD PMID:27188386 SPP1 Human panobinostat multiple interactions EXP 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPP1 mRNA CTD PMID:27188386 SPP1 Human panobinostat increases expression EXP 6480464 panobinostat results in increased expression of SPP1 mRNA CTD PMID:26272509 SPP1 Human paracetamol decreases response to substance ISO Spp1 (Mus musculus) 6480464 SPP1 gene mutant form results in decreased susceptibility to Acetaminophen CTD PMID:16485898 SPP1 Human paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of SPP1 mRNA CTD PMID:29067470 SPP1 Human paracetamol affects expression ISO Spp1 (Mus musculus) 6480464 Acetaminophen affects the expression of SPP1 mRNA CTD PMID:17562736 SPP1 Human paracetamol increases expression ISO Spp1 (Mus musculus) 6480464 Acetaminophen results in increased expression of SPP1 protein CTD PMID:17439248 SPP1 Human paraquat increases expression ISO Spp1 (Mus musculus) 6480464 Paraquat results in increased expression of SPP1 mRNA and Paraquat results in increased expression of SPP1 protein CTD PMID:26345256 SPP1 Human paraquat multiple interactions ISO Spp1 (Mus musculus) 6480464 [Maneb co-treated with Paraquat] results in decreased expression of SPP1 mRNA CTD PMID:36117858 SPP1 Human paraquat increases expression EXP 6480464 Paraquat results in increased expression of SPP1 mRNA CTD PMID:34681664 and PMID:35182771 SPP1 Human paraquat increases expression ISO Spp1 (Rattus norvegicus) 6480464 Paraquat results in increased expression of SPP1 mRNA CTD PMID:32680482 SPP1 Human paricalcitol increases expression ISO Spp1 (Mus musculus) 6480464 paricalcitol results in increased expression of SPP1 mRNA CTD PMID:25037058 SPP1 Human paricalcitol multiple interactions ISO Spp1 (Mus musculus) 6480464 [Enalapril co-treated with paricalcitol] results in decreased expression of SPP1 mRNA CTD PMID:25037058 SPP1 Human paricalcitol multiple interactions EXP 6480464 [Phosphorus co-treated with paricalcitol] results in increased expression of SPP1 mRNA CTD PMID:17715259 SPP1 Human PD 0325901 multiple interactions EXP 6480464 [mirdametinib co-treated with (+)-JQ1 compound] results in decreased expression of SPP1 mRNA CTD PMID:25119042 SPP1 Human PD123319 multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA] and PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:11115077 SPP1 Human pentane-2,3-dione increases expression ISO Spp1 (Rattus norvegicus) 6480464 2 and 3-pentanedione results in increased expression of SPP1 mRNA CTD PMID:25710175 SPP1 Human Pentoxifylline decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Pentoxifylline results in decreased expression of SPP1 mRNA CTD PMID:14993492 SPP1 Human perfluorobutyric acid affects expression EXP 6480464 perfluorobutyric acid affects the expression of SPP1 mRNA CTD PMID:36251517 SPP1 Human perfluorooctane-1-sulfonic acid increases expression ISO Spp1 (Rattus norvegicus) 6480464 perfluorooctane sulfonic acid results in increased expression of SPP1 mRNA CTD PMID:22237054 SPP1 Human perfluorooctane-1-sulfonic acid multiple interactions ISO Spp1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SPP1 mRNA CTD PMID:36331819 SPP1 Human perfluorooctane-1-sulfonic acid affects expression EXP 6480464 perfluorooctane sulfonic acid affects the expression of SPP1 mRNA CTD PMID:30738844 SPP1 Human perfluorooctanoic acid affects expression EXP 6480464 perfluorooctanoic acid affects the expression of SPP1 mRNA CTD PMID:36251517 SPP1 Human phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of SPP1 mRNA CTD PMID:19084549 SPP1 Human phenylephrine increases expression ISO Spp1 (Rattus norvegicus) 6480464 Phenylephrine results in increased expression of SPP1 protein CTD PMID:10406839 SPP1 Human phenylmercury acetate increases expression EXP 6480464 Phenylmercuric Acetate results in increased expression of SPP1 mRNA CTD PMID:26272509 SPP1 Human phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPP1 mRNA CTD PMID:27188386 SPP1 Human phorbol 13-acetate 12-myristate multiple interactions EXP 6480464 [FOS protein co-treated with JUN protein] inhibits the reaction [pirinixic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 protein]] more ... CTD PMID:11426586 more ... SPP1 Human phorbol 13-acetate 12-myristate multiple interactions ISO Spp1 (Mus musculus) 6480464 [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SPP1 mRNA and [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of SPP1 mRNA CTD PMID:19840844 and PMID:31904401 SPP1 Human phorbol 13-acetate 12-myristate increases expression EXP 6480464 Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA and Tetradecanoylphorbol Acetate results in increased expression of SPP1 protein CTD PMID:11426586 more ... SPP1 Human phosphonoformic acid multiple interactions ISO Spp1 (Mus musculus) 6480464 Foscarnet inhibits the reaction [Calcium results in increased expression of SPP1 mRNA] more ... CTD PMID:12788230 more ... SPP1 Human phosphorus atom multiple interactions EXP 6480464 [Phosphorus co-treated with paricalcitol] results in increased expression of SPP1 mRNA CTD PMID:17715259 SPP1 Human phosphorus(.) multiple interactions EXP 6480464 [Phosphorus co-treated with paricalcitol] results in increased expression of SPP1 mRNA CTD PMID:17715259 SPP1 Human phylloquinone multiple interactions ISO Spp1 (Mus musculus) 6480464 [Warfarin co-treated with Vitamin K 1] results in increased expression of SPP1 mRNA CTD PMID:23990204 SPP1 Human pioglitazone multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 pioglitazone inhibits the reaction [Streptozocin results in increased expression of SPP1 mRNA] and pioglitazone inhibits the reaction [Streptozocin results in increased expression of SPP1 protein] CTD PMID:16979161 SPP1 Human pirfenidone multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 pirfenidone inhibits the reaction [Adenine results in increased expression of SPP1 mRNA] CTD PMID:28866419 SPP1 Human pirinixic acid multiple interactions EXP 6480464 [FOS protein co-treated with JUN protein] inhibits the reaction [pirinixic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 protein]] more ... CTD PMID:17360982 SPP1 Human piroxicam decreases expression EXP 6480464 Piroxicam results in decreased expression of SPP1 mRNA CTD PMID:21858171 SPP1 Human potassium bromate increases expression ISO Spp1 (Rattus norvegicus) 6480464 potassium bromate results in increased expression of SPP1 mRNA and potassium bromate results in increased expression of SPP1 protein CTD PMID:23588252 and PMID:23811332 SPP1 Human potassium bromate increases expression EXP 6480464 potassium bromate results in increased expression of SPP1 mRNA CTD PMID:30008028 SPP1 Human progesterone multiple interactions EXP 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of SPP1 mRNA and [Progesterone co-treated with Estradiol] results in increased expression of SPP1 mRNA CTD PMID:20226447 and PMID:20660070 SPP1 Human protein kinase inhibitor multiple interactions EXP 6480464 Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SPP1 mRNA] CTD PMID:28003376 SPP1 Human Ptaquiloside multiple interactions ISO Spp1 (Mus musculus) 6480464 [ptaquiloside co-treated with Sodium Selenite] results in decreased expression of SPP1 mRNA CTD PMID:23274088 SPP1 Human pyrrolidine dithiocarbamate decreases expression ISO Spp1 (Rattus norvegicus) 6480464 pyrrolidine dithiocarbamic acid results in decreased expression of SPP1 CTD PMID:21076490 SPP1 Human quartz increases expression ISO Spp1 (Rattus norvegicus) 6480464 Quartz results in increased expression of SPP1 mRNA CTD PMID:19836432 and PMID:32976597 SPP1 Human quartz multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Tobacco Smoke Pollution promotes the reaction [Quartz results in increased expression of SPP1 mRNA] CTD PMID:32976597 SPP1 Human quercetin multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of SPP1 mRNA] more ... CTD PMID:23223575 and PMID:26053266 SPP1 Human quercetin multiple interactions ISO Spp1 (Mus musculus) 6480464 Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SPP1 mRNA] CTD PMID:25712622 SPP1 Human quercetin increases expression EXP 6480464 Quercetin results in increased expression of SPP1 mRNA and Quercetin results in increased expression of SPP1 protein CTD PMID:16996034 more ... SPP1 Human quercetin increases expression ISO Spp1 (Rattus norvegicus) 6480464 Quercetin results in increased expression of SPP1 mRNA CTD PMID:26053266 SPP1 Human quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of SPP1 mRNA CTD PMID:20596804 SPP1 Human raloxifene affects expression EXP 6480464 Raloxifene Hydrochloride affects the expression of SPP1 mRNA CTD PMID:14699072 SPP1 Human resveratrol multiple interactions EXP 6480464 [Calcitriol co-treated with resveratrol] results in increased expression of SPP1 mRNA and resveratrol inhibits the reaction [Oxalic Acid results in increased expression of SPP1 mRNA] CTD PMID:16267019 and PMID:24145091 SPP1 Human resveratrol decreases expression ISO Spp1 (Rattus norvegicus) 6480464 resveratrol results in decreased expression of SPP1 protein CTD PMID:24145091 SPP1 Human resveratrol multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SPP1 mRNA] CTD PMID:11018766 SPP1 Human resveratrol increases expression ISO Spp1 (Mus musculus) 6480464 resveratrol results in increased expression of SPP1 CTD PMID:19656070 SPP1 Human resveratrol increases expression EXP 6480464 resveratrol results in increased expression of SPP1 mRNA CTD PMID:16267019 and PMID:21745208 SPP1 Human rolipram multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Rolipram inhibits the reaction [Oxygen results in increased expression of SPP1 mRNA] and Rolipram inhibits the reaction [Oxygen results in increased expression of SPP1 protein] CTD PMID:18941502 SPP1 Human rotenone increases expression ISO Spp1 (Mus musculus) 6480464 Rotenone results in increased expression of SPP1 mRNA CTD PMID:22016648 SPP1 Human rotenone increases expression ISO Spp1 (Rattus norvegicus) 6480464 Rotenone results in increased expression of SPP1 mRNA CTD PMID:27900601 SPP1 Human S-butyl-DL-homocysteine (S,R)-sulfoximine decreases expression ISO Spp1 (Mus musculus) 6480464 Buthionine Sulfoximine results in decreased expression of SPP1 mRNA CTD PMID:15707499 and PMID:15878706 SPP1 Human Salidroside increases expression ISO Spp1 (Mus musculus) 6480464 rhodioloside results in increased expression of SPP1 mRNA CTD PMID:24055767 SPP1 Human Salinomycin decreases expression EXP 6480464 salinomycin results in decreased expression of SPP1 mRNA CTD PMID:19682730 SPP1 Human SB 203580 multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein] CTD PMID:19356721 SPP1 Human SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 SPP1 Human sclareol increases expression ISO Spp1 (Mus musculus) 6480464 sclareol results in increased expression of SPP1 mRNA and sclareol results in increased expression of SPP1 protein CTD PMID:33423118 SPP1 Human Se-methyl-L-selenocysteine decreases expression ISO Spp1 (Mus musculus) 6480464 selenomethylselenocysteine results in decreased expression of SPP1 protein CTD PMID:15318939 SPP1 Human Se-methylselenocysteine decreases expression ISO Spp1 (Mus musculus) 6480464 selenomethylselenocysteine results in decreased expression of SPP1 protein CTD PMID:15318939 SPP1 Human selenium atom decreases expression ISO Spp1 (Mus musculus) 6480464 Selenium results in decreased expression of SPP1 protein CTD PMID:15318939 SPP1 Human serpentine asbestos increases expression ISO Spp1 (Mus musculus) 6480464 Asbestos and Serpentine results in increased expression of SPP1 mRNA CTD PMID:16251409 more ... SPP1 Human serpentine asbestos decreases response to substance ISO Spp1 (Mus musculus) 6480464 SPP1 gene mutant form results in decreased susceptibility to Asbestos and Serpentine CTD PMID:21514415 SPP1 Human serpentine asbestos multiple interactions ISO Spp1 (Mus musculus) 6480464 SPP1 gene mutant form inhibits the reaction [Asbestos more ... CTD PMID:21514415 SPP1 Human silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of SPP1 mRNA CTD PMID:19428942 SPP1 Human silicon dioxide increases expression ISO Spp1 (Rattus norvegicus) 6480464 Silicon Dioxide results in increased expression of SPP1 mRNA CTD PMID:22431001 and PMID:34779285 SPP1 Human silicon dioxide increases expression ISO Spp1 (Mus musculus) 6480464 Silicon Dioxide results in increased expression of SPP1 mRNA and Silicon Dioxide results in increased expression of SPP1 protein CTD PMID:26345256 more ... SPP1 Human silicon dioxide multiple interactions ISO Spp1 (Mus musculus) 6480464 Estrogens inhibits the reaction [Silicon Dioxide results in increased expression of SPP1 protein] CTD PMID:26955063 SPP1 Human silver atom increases expression EXP 6480464 Silver results in increased expression of SPP1 mRNA CTD PMID:28959546 SPP1 Human silver atom increases secretion ISO Spp1 (Mus musculus) 6480464 Silver results in increased secretion of SPP1 protein CTD PMID:25458489 SPP1 Human silver(0) increases expression EXP 6480464 Silver results in increased expression of SPP1 mRNA CTD PMID:28959546 SPP1 Human silver(0) increases secretion ISO Spp1 (Mus musculus) 6480464 Silver results in increased secretion of SPP1 protein CTD PMID:25458489 SPP1 Human simvastatin decreases expression EXP 6480464 Simvastatin results in decreased expression of SPP1 mRNA CTD PMID:21109955 SPP1 Human simvastatin increases expression ISO Spp1 (Mus musculus) 6480464 Simvastatin results in increased expression of SPP1 protein CTD PMID:12914771 more ... SPP1 Human simvastatin decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Simvastatin results in decreased expression of SPP1 CTD PMID:21076490 SPP1 Human sirolimus multiple interactions ISO Spp1 (Mus musculus) 6480464 Sirolimus inhibits the reaction [Ketoglutaric Acids results in increased expression of SPP1 protein] CTD PMID:31051157 SPP1 Human sirolimus multiple interactions EXP 6480464 Sirolimus inhibits the reaction [Ketoglutaric Acids results in increased expression of SPP1 protein] CTD PMID:31051157 SPP1 Human sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of SPP1 mRNA and sodium arsenite results in increased expression of SPP1 protein CTD PMID:25493608 more ... SPP1 Human sodium arsenite decreases expression ISO Spp1 (Mus musculus) 6480464 sodium arsenite results in decreased expression of SPP1 mRNA CTD PMID:28206643 and PMID:32068019 SPP1 Human sodium arsenite increases expression ISO Spp1 (Mus musculus) 6480464 sodium arsenite results in increased expression of SPP1 mRNA CTD PMID:20179202 SPP1 Human sodium chloride increases expression ISO Spp1 (Rattus norvegicus) 6480464 Sodium Chloride results in increased expression of SPP1 mRNA CTD PMID:37992803 SPP1 Human sodium dichromate increases expression ISO Spp1 (Rattus norvegicus) 6480464 sodium bichromate results in increased expression of SPP1 mRNA CTD PMID:25993096 SPP1 Human sodium fluoride increases expression ISO Spp1 (Rattus norvegicus) 6480464 Sodium Fluoride results in increased expression of SPP1 protein CTD PMID:23933529 SPP1 Human sodium fluoride increases expression ISO Spp1 (Mus musculus) 6480464 Sodium Fluoride results in increased expression of SPP1 mRNA and Sodium Fluoride results in increased expression of SPP1 protein CTD PMID:35218729 SPP1 Human sodium fluoride multiple interactions ISO Spp1 (Mus musculus) 6480464 BMP2 protein affects the reaction [Sodium Fluoride results in increased expression of SPP1 mRNA] more ... CTD PMID:35218729 SPP1 Human sodium fluoride multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Sodium Fluoride inhibits the reaction [Gentamicins results in increased expression of SPP1 mRNA] and Sodium Fluoride inhibits the reaction [Gentamicins results in increased expression of SPP1 protein] CTD PMID:26779593 SPP1 Human sodium fluoride decreases expression ISO Spp1 (Mus musculus) 6480464 Sodium Fluoride results in decreased expression of SPP1 mRNA CTD PMID:27862939 SPP1 Human sterigmatocystin increases expression ISO Spp1 (Mus musculus) 6480464 Sterigmatocystin results in increased expression of SPP1 mRNA CTD PMID:19818335 SPP1 Human streptozocin multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 pioglitazone inhibits the reaction [Streptozocin results in increased expression of SPP1 mRNA] more ... CTD PMID:16684804 and PMID:16979161 SPP1 Human streptozocin increases expression ISO Spp1 (Rattus norvegicus) 6480464 Streptozocin results in increased expression of SPP1 mRNA and Streptozocin results in increased expression of SPP1 protein CTD PMID:16684804 more ... SPP1 Human strontium atom increases expression EXP 6480464 Strontium results in increased expression of SPP1 protein CTD PMID:16886220 SPP1 Human succimer multiple interactions EXP 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SPP1 mRNA CTD PMID:26378955 SPP1 Human sulfaphenazole multiple interactions EXP 6480464 [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of SPP1 mRNA] and Sulfaphenazole inhibits the reaction [Oxalic Acid results in increased expression of SPP1 mRNA] CTD PMID:37414240 SPP1 Human sulfasalazine increases expression ISO Spp1 (Mus musculus) 6480464 Sulfasalazine results in increased expression of SPP1 mRNA CTD PMID:22016648 SPP1 Human sulforaphane increases expression EXP 6480464 sulforaphane results in increased expression of SPP1 mRNA CTD PMID:26833863 and PMID:27562236 SPP1 Human sumatriptan multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SPP1 protein] and Sumatriptan promotes the reaction [Capsaicin results in increased expression of SPP1 protein] CTD PMID:22150557 SPP1 Human SWINHOLIDE A increases expression EXP 6480464 swinholide A results in increased expression of SPP1 protein CTD PMID:19026636 SPP1 Human SWINHOLIDE A multiple interactions EXP 6480464 swinholide A affects the reaction [EEF1A1 protein binds to SPP1 5' UTR] CTD PMID:19026636 SPP1 Human tacrolimus hydrate increases expression ISO Spp1 (Rattus norvegicus) 6480464 Tacrolimus results in increased expression of SPP1 mRNA CTD PMID:12472797 and PMID:21865292 SPP1 Human tamibarotene increases expression EXP 6480464 tamibarotene results in increased expression of SPP1 mRNA CTD PMID:15498508 SPP1 Human tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of SPP1 mRNA CTD PMID:14699072 SPP1 Human tamoxifen increases expression EXP 6480464 Tamoxifen results in increased expression of SPP1 mRNA CTD PMID:19155303 SPP1 Human Tanshinone I multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 tanshinone inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein] CTD PMID:19356721 SPP1 Human telmisartan increases expression ISO Spp1 (Rattus norvegicus) 329956421 telmisartan increases expression of mRNA in mandible of WKY rats with periodontal disease RGD SPP1 Human temozolomide decreases expression EXP 6480464 Temozolomide results in decreased expression of SPP1 mRNA CTD PMID:31758290 SPP1 Human Tesaglitazar decreases expression ISO Spp1 (Rattus norvegicus) 6480464 tesaglitazar results in decreased expression of SPP1 mRNA CTD PMID:21515302 SPP1 Human testosterone multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SPP1 mRNA CTD PMID:32741896 SPP1 Human tetrachloromethane affects expression ISO Spp1 (Mus musculus) 6480464 Carbon Tetrachloride affects the expression of SPP1 mRNA CTD PMID:17484886 SPP1 Human tetrachloromethane decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Carbon Tetrachloride results in decreased expression of SPP1 mRNA CTD PMID:23558518 SPP1 Human tetrachloromethane increases expression ISO Spp1 (Rattus norvegicus) 6480464 Carbon Tetrachloride results in increased expression of SPP1 protein CTD PMID:15548383 SPP1 Human tetrachloromethane affects response to substance ISO Spp1 (Mus musculus) 6480464 SPP1 protein affects the susceptibility to Carbon Tetrachloride CTD PMID:16221502 SPP1 Human tetrachloromethane increases expression ISO Spp1 (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of SPP1 mRNA and Carbon Tetrachloride results in increased expression of SPP1 protein CTD PMID:15070743 more ... SPP1 Human tetrachloromethane multiple interactions ISO Spp1 (Mus musculus) 6480464 2-cyano-3 more ... CTD PMID:15070743 more ... SPP1 Human tetracycline increases expression ISO Spp1 (Mus musculus) 6480464 Tetracycline results in increased expression of SPP1 mRNA CTD PMID:16917069 SPP1 Human tetrathiomolybdate(2-) decreases expression EXP 6480464 tetrathiomolybdate results in decreased expression of SPP1 mRNA CTD PMID:37290678 SPP1 Human thioacetamide multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 halofuginone inhibits the reaction [Thioacetamide results in increased expression of SPP1 mRNA] and Mesalamine inhibits the reaction [Thioacetamide results in increased expression of SPP1 protein] CTD PMID:17180598 and PMID:29738702 SPP1 Human thioacetamide increases expression ISO Spp1 (Rattus norvegicus) 6480464 Thioacetamide results in increased expression of SPP1 mRNA and Thioacetamide results in increased expression of SPP1 protein CTD PMID:12531686 more ... SPP1 Human thiourea multiple interactions ISO Spp1 (Mus musculus) 6480464 Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide and E coli O55-B5 results in increased expression of SPP1 mRNA]] CTD PMID:10868913 SPP1 Human titanium atom increases expression ISO Spp1 (Rattus norvegicus) 6480464 Titanium results in increased expression of SPP1 mRNA CTD PMID:15914587 SPP1 Human titanium dioxide increases expression ISO Spp1 (Mus musculus) 6480464 titanium dioxide results in increased expression of SPP1 mRNA CTD PMID:19464567 more ... SPP1 Human titanium dioxide increases expression ISO Spp1 (Rattus norvegicus) 6480464 titanium dioxide results in increased expression of SPP1 mRNA CTD PMID:30012374 SPP1 Human titanium dioxide decreases expression ISO Spp1 (Mus musculus) 6480464 titanium dioxide results in decreased expression of SPP1 mRNA CTD PMID:29264374 SPP1 Human TMC-120A increases expression ISO Spp1 (Mus musculus) 6480464 TMC 120A results in increased expression of SPP1 mRNA CTD PMID:19818335 SPP1 Human topotecan multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of SPP1 mRNA CTD PMID:25729387 SPP1 Human topotecan affects response to substance EXP 6480464 SPP1 protein affects the susceptibility to Topotecan CTD PMID:16217747 SPP1 Human topotecan increases expression ISO Spp1 (Rattus norvegicus) 6480464 Topotecan results in increased expression of SPP1 mRNA CTD PMID:25729387 SPP1 Human tramadol multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein] and Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein] CTD PMID:33645892 SPP1 Human tramadol increases expression ISO Spp1 (Rattus norvegicus) 6480464 Tramadol results in increased expression of SPP1 protein CTD PMID:33645892 SPP1 Human transplatin decreases expression EXP 6480464 transplatin results in decreased expression of SPP1 mRNA CTD PMID:11099651 SPP1 Human tremolite asbestos increases expression ISO Spp1 (Mus musculus) 6480464 tremolite results in increased expression of SPP1 mRNA CTD PMID:29279043 SPP1 Human trichloroethene multiple interactions ISO Spp1 (Mus musculus) 6480464 [Trichloroethylene co-treated with Mercuric Chloride] results in increased expression of SPP1 protein CTD PMID:21084432 SPP1 Human trichloroethene increases expression ISO Spp1 (Rattus norvegicus) 6480464 Trichloroethylene results in increased expression of SPP1 mRNA CTD PMID:33387578 SPP1 Human trichloroethene decreases expression ISO Spp1 (Mus musculus) 6480464 Trichloroethylene results in decreased expression of SPP1 mRNA CTD PMID:25026505 SPP1 Human trichloroethene increases expression ISO Spp1 (Mus musculus) 6480464 Trichloroethylene results in increased expression of SPP1 protein CTD PMID:21084432 SPP1 Human trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of SPP1 mRNA CTD PMID:24935251 and PMID:26272509 SPP1 Human trichostatin A multiple interactions EXP 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPP1 mRNA CTD PMID:27188386 SPP1 Human triclosan affects expression EXP 6480464 Triclosan affects the expression of SPP1 mRNA CTD PMID:34681664 SPP1 Human trimethyltin increases expression ISO Spp1 (Mus musculus) 6480464 trimethyltin results in increased expression of SPP1 mRNA CTD PMID:24002884 SPP1 Human troglitazone multiple interactions EXP 6480464 PPARG protein affects the reaction [troglitazone results in decreased expression of SPP1 mRNA] and troglitazone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA] CTD PMID:11426586 SPP1 Human troglitazone increases expression EXP 6480464 troglitazone results in increased expression of SPP1 mRNA CTD PMID:25572481 SPP1 Human troglitazone decreases expression ISO Spp1 (Rattus norvegicus) 6480464 troglitazone results in decreased expression of SPP1 mRNA CTD PMID:21515302 SPP1 Human troglitazone decreases expression ISO Spp1 (Mus musculus) 6480464 troglitazone results in decreased expression of SPP1 mRNA CTD PMID:19122273 SPP1 Human troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of SPP1 mRNA CTD PMID:11426586 SPP1 Human tubocurarine multiple interactions EXP 6480464 Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein] CTD PMID:11425648 SPP1 Human Tungsten carbide multiple interactions EXP 6480464 [tungsten carbide co-treated with Cobalt] results in increased expression of SPP1 mRNA CTD PMID:18078969 SPP1 Human uranium atom decreases secretion EXP 6480464 Uranium results in decreased secretion of SPP1 protein CTD PMID:21324525 SPP1 Human uranium atom decreases expression ISO Spp1 (Mus musculus) 6480464 Uranium results in decreased expression of SPP1 mRNA CTD PMID:31120128 SPP1 Human urethane increases expression ISO Spp1 (Mus musculus) 6480464 Urethane results in increased expression of SPP1 mRNA CTD PMID:16289808 SPP1 Human urethane decreases expression EXP 6480464 Urethane results in decreased expression of SPP1 mRNA CTD PMID:28818685 SPP1 Human valproic acid affects expression ISO Spp1 (Mus musculus) 6480464 Valproic Acid affects the expression of SPP1 mRNA CTD PMID:17292431 SPP1 Human valproic acid multiple interactions EXP 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPP1 mRNA CTD PMID:27188386 SPP1 Human valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of SPP1 mRNA CTD PMID:23179753 more ... SPP1 Human valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of SPP1 mRNA CTD PMID:25979313 SPP1 Human valsartan multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA] and Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:11115077 SPP1 Human vanadyl sulfate multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of SPP1 mRNA] CTD PMID:16684804 SPP1 Human vancomycin increases expression ISO Spp1 (Mus musculus) 6480464 Vancomycin results in increased expression of SPP1 mRNA CTD PMID:18930951 SPP1 Human vancomycin increases expression ISO Spp1 (Rattus norvegicus) 6480464 Vancomycin results in increased expression of SPP1 mRNA CTD PMID:18289764 SPP1 Human vitamin D increases activity ISO Spp1 (Mus musculus) 6480464 Vitamin D analog results in increased activity of SPP1 promoter CTD PMID:10777672 SPP1 Human vitamin K multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [Warfarin co-treated with Vitamin K] results in increased expression of SPP1 mRNA CTD PMID:23117658 SPP1 Human vorinostat increases expression EXP 6480464 vorinostat results in increased expression of SPP1 mRNA CTD PMID:26272509 SPP1 Human warfarin multiple interactions ISO Spp1 (Mus musculus) 6480464 [Warfarin co-treated with Vitamin K 1] results in increased expression of SPP1 mRNA CTD PMID:23990204 SPP1 Human warfarin multiple interactions ISO Spp1 (Rattus norvegicus) 6480464 [Quercetin co-treated with Warfarin] results in increased expression of SPP1 mRNA and [Warfarin co-treated with Vitamin K] results in increased expression of SPP1 mRNA CTD PMID:23117658 and PMID:23223575 SPP1 Human zinc atom multiple interactions EXP 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of SPP1 mRNA CTD PMID:16979875 SPP1 Human zinc atom increases expression ISO Spp1 (Mus musculus) 6480464 Zinc deficiency results in increased expression of SPP1 mRNA CTD PMID:20857495 SPP1 Human zinc dichloride decreases expression EXP 6480464 zinc chloride results in decreased expression of SPP1 mRNA CTD PMID:19428942 SPP1 Human zinc dichloride multiple interactions ISO Spp1 (Mus musculus) 6480464 [zinc chloride co-treated with N more ... CTD PMID:10777672 and PMID:19913120 SPP1 Human zinc oxide decreases expression ISO Spp1 (Rattus norvegicus) 6480464 Zinc Oxide results in decreased expression of SPP1 protein CTD PMID:33205376 SPP1 Human zinc(0) multiple interactions EXP 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of SPP1 mRNA CTD PMID:16979875 SPP1 Human zinc(0) increases expression ISO Spp1 (Mus musculus) 6480464 Zinc deficiency results in increased expression of SPP1 mRNA CTD PMID:20857495
