Anxa1 (annexin A1) - Rat Genome Database
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Gene: Anxa1 (annexin A1) Rattus norvegicus
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Symbol: Anxa1
Name: annexin A1
RGD ID: 2118
Description: Exhibits several functions, including double-stranded DNA helicase activity; nucleic acid binding activity; and phospholipase A2 inhibitor activity. Contributes to single-stranded RNA binding activity. Involved in several processes, including estrous cycle; gland development; and peptide hormone secretion. Localizes to several cellular components, including mast cell granule; mitochondrial membrane; and synaptic membrane. Predicted to colocalize with actin filament. Used to study acute kidney failure; brain ischemia; pleurisy; and uveitis. Biomarker of several diseases, including carcinoma (multiple); cerebral infarction; eye disease (multiple); hyperthyroidism; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in brain ischemia and pancreatic cancer. Orthologous to human ANXA1 (annexin A1); PARTICIPATES IN cyclooxygenase mediated pathway of arachidonic acid metabolism; INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: annexin 1; Annexin 1 (p35) (Lipocortin 1); annexin I; annexin-1; Anx1; calpactin II; calpactin-2; chromobindin-9; lipocortin 1; lipocortin I; p35; phospholipase A2 inhibitory protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21217,861,175 - 217,877,205 (-)NCBI
Rnor_6.0 Ensembl1237,893,966 - 237,910,012 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01237,893,983 - 237,910,002 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01245,192,875 - 245,220,057 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,478,436 - 223,494,455 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11223,642,460 - 223,658,478 (-)NCBI
Celera1215,138,950 - 215,154,969 (-)NCBICelera
Cytogenetic Map1q51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IDA)
Animal Mammary Neoplasms  (ISO)
asthma  (ISO)
Blister  (ISO)
brain ischemia  (IMP,ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cataract  (IEP,ISO)
Cerebral Hemorrhage  (IEP)
cerebral infarction  (IEP)
colitis  (IEP)
contact dermatitis  (ISO)
COVID-19  (ISO)
Craniofacial Abnormalities  (ISO)
Delayed Hypersensitivity  (ISO)
Discoid Lupus Erythematosus  (ISO)
dry eye syndrome  (ISO)
ductal carcinoma in situ  (ISO)
encephalitis  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Neuritis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IEP,ISO)
Hyperalgesia  (IEP,IMP)
hypertension  (IEP,ISO)
hyperthyroidism  (IEP)
hypothyroidism  (IEP)
Inflammation  (IEP)
invasive ductal carcinoma  (ISO)
ischemia  (IEP)
keratosis follicularis  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (IDA)
lung adenocarcinoma  (ISO)
Lymphatic Metastasis  (ISO)
malignant astrocytoma  (ISO)
Mammary Neoplasms, Experimental  (IEP,ISO)
Mouth Neoplasms  (ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (IEP,IMP,ISO)
Ocular Toxoplasmosis  (ISO)
pancreatic cancer  (ISO)
paranasal sinus benign neoplasm  (ISO)
pleurisy  (IDA)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (IEP)
renal cell carcinoma  (IEP)
Rhinosinusitis  (ISO)
seborrheic keratosis  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (IEP,ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (IEP)
stomach disease  (ISO)
transitional cell carcinoma  (IEP)
uveitis  (IDA,IEP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-lariciresinol  (ISO)
(-)-demecolcine  (ISO)
(-)-lariciresinol  (ISO)
(R)-noradrenaline  (ISO)
(S)-nicotine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
9-cis-retinoic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aniline  (EXP)
anthracen-2-amine  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
ATP  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carrageenan  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-penicillamine  (EXP)
DDT  (EXP)
Deoxycorticosterone acetate  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
diethyldithiocarbamic acid  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eurycomanone  (ISO)
fluoxetine  (EXP)
flurbiprofen  (ISO)
fluticasone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
graphite  (ISO)
hexachlorobenzene  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
ibuprofen  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoflavones  (EXP)
isoprenaline  (ISO)
ketoconazole  (EXP)
kojic acid  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
lead(II) chloride  (ISO)
levofloxacin  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
magnesium atom  (EXP)
mercury dibromide  (ISO)
metacetamol  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
miconazole  (EXP)
mifepristone  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel sulfate  (ISO)
nicotine  (EXP)
ochratoxin A  (EXP)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
potassium chloride  (EXP)
potassium dichromate  (EXP)
Propiverine  (EXP)
prostaglandin E2  (ISO)
quercetin  (EXP,ISO)
quinoline  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rofecoxib  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tanespimycin  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton reorganization  (IBA,ISO,ISS)
adaptive immune response  (IEA)
alpha-beta T cell differentiation  (IBA,ISO)
arachidonic acid secretion  (IBA,ISO)
cell surface receptor signaling pathway  (IBA,IDA)
cellular response to glucocorticoid stimulus  (IBA,IDA,ISO)
cellular response to hydrogen peroxide  (IBA,IMP)
cellular response to vascular endothelial growth factor stimulus  (IBA,ISO)
DNA duplex unwinding  (IBA,IDA)
endocrine pancreas development  (IBA,IEP)
estrous cycle  (IBA,IEP)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (ISO,ISS)
gliogenesis  (IBA,IEP)
granulocyte chemotaxis  (IBA,ISO,ISS)
hepatocyte differentiation  (IBA,IEP)
inflammatory response  (IBA,ISO,ISS)
innate immune response  (IEA)
insulin secretion  (IBA,IDA)
keratinocyte differentiation  (IBA,ISO)
monocyte chemotaxis  (ISO,ISS)
myoblast migration involved in skeletal muscle regeneration  (IBA,ISO)
negative regulation of exocytosis  (IBA,ISO,ISS)
negative regulation of interleukin-8 production  (ISO)
negative regulation of phospholipase A2 activity  (IBA,IDA)
negative regulation of protein secretion  (IMP)
negative regulation of T-helper 2 cell differentiation  (IBA,ISO,ISS)
neutrophil clearance  (IBA,ISO)
neutrophil homeostasis  (ISO)
peptide cross-linking  (ISO)
phagocytosis  (ISO,ISS)
positive regulation of apoptotic process  (IMP)
positive regulation of cell migration involved in sprouting angiogenesis  (IBA,ISO)
positive regulation of G1/S transition of mitotic cell cycle  (IBA,ISO)
positive regulation of interleukin-2 production  (IBA,ISO,ISS)
positive regulation of neutrophil apoptotic process  (IBA,ISO)
positive regulation of prostaglandin biosynthetic process  (IBA,IMP)
positive regulation of T cell proliferation  (IBA,ISO,ISS)
positive regulation of T-helper 1 cell differentiation  (IBA,ISO,ISS)
positive regulation of vesicle fusion  (IBA,ISO)
positive regulation of wound healing  (IBA,ISO,ISS)
prolactin secretion  (IBA,IMP)
prostate gland development  (IBA,IEP)
regulation of cell population proliferation  (ISO)
regulation of cell shape  (IBA,ISO,ISS)
regulation of hormone secretion  (IBA,ISO,ISS)
regulation of inflammatory response  (IBA,ISO,ISS)
regulation of interleukin-1 production  (IBA,ISO,ISS)
regulation of leukocyte migration  (IBA,ISO,ISS)
response to corticosteroid  (IEP)
response to drug  (IBA,IEP)
response to estradiol  (IBA,IEP)
response to glucocorticoid  (IEP)
response to hormone  (IEP)
response to interleukin-1  (IBA,IEP)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IBA,IEP)
response to X-ray  (IBA,IEP)
signal transduction  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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Additional References at PubMed
PMID:2138016   PMID:2958780   PMID:3013422   PMID:8885232   PMID:10908733   PMID:12475898   PMID:12553880   PMID:12586783   PMID:12595246   PMID:14506282   PMID:14516791   PMID:15187149  
PMID:15226301   PMID:15489334   PMID:17008549   PMID:17218541   PMID:17384087   PMID:18504258   PMID:18767904   PMID:18802107   PMID:19056867   PMID:19095957   PMID:19182904   PMID:19190083  
PMID:19199708   PMID:19625660   PMID:20139728   PMID:21362503   PMID:21423176   PMID:21745559   PMID:21957127   PMID:22056994   PMID:22164217   PMID:22206666   PMID:22664934   PMID:22773844  
PMID:22791338   PMID:23106098   PMID:23144744   PMID:23376485   PMID:23533145   PMID:23580065   PMID:23587191   PMID:24254883   PMID:24939696   PMID:25468996   PMID:25616869   PMID:25664854  
PMID:26063293   PMID:26609771   PMID:26616057   PMID:27584794   PMID:27782092   PMID:28259758   PMID:29213013   PMID:29867124   PMID:30272262   PMID:31132398   PMID:31148248  


Genomics

Comparative Map Data
Anxa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21217,861,175 - 217,877,205 (-)NCBI
Rnor_6.0 Ensembl1237,893,966 - 237,910,012 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01237,893,983 - 237,910,002 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01245,192,875 - 245,220,057 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,478,436 - 223,494,455 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11223,642,460 - 223,658,478 (-)NCBI
Celera1215,138,950 - 215,154,969 (-)NCBICelera
Cytogenetic Map1q51NCBI
ANXA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl973,151,865 - 73,170,393 (+)EnsemblGRCh38hg38GRCh38
GRCh38973,151,865 - 73,170,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37975,766,781 - 75,785,309 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36974,956,601 - 74,975,127 (+)NCBINCBI36hg18NCBI36
Build 34972,996,334 - 73,014,861NCBI
Celera946,339,417 - 46,357,944 (+)NCBI
Cytogenetic Map9q21.13ENTREZGENE
HuRef945,589,147 - 45,607,684 (+)NCBIHuRef
CHM1_1975,913,496 - 75,932,176 (+)NCBICHM1_1
Anxa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391920,350,798 - 20,368,035 (-)NCBIGRCm39mm39
GRCm39 Ensembl1920,350,792 - 20,368,308 (-)Ensembl
GRCm381920,373,434 - 20,390,671 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1920,373,428 - 20,390,944 (-)EnsemblGRCm38mm10GRCm38
MGSCv371920,447,924 - 20,465,161 (-)NCBIGRCm37mm9NCBIm37
MGSCv361920,440,455 - 20,457,696 (-)NCBImm8
Celera1921,098,423 - 21,115,607 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1913.83NCBI
Anxa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555125,686,508 - 5,703,645 (-)NCBIChiLan1.0ChiLan1.0
ANXA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1971,930,148 - 71,948,779 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl971,929,728 - 71,948,779 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0951,647,404 - 51,665,990 (-)NCBIMhudiblu_PPA_v0panPan3
ANXA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl184,744,163 - 84,763,011 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1184,744,159 - 84,763,011 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Anxa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365039,124,314 - 9,142,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANXA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,414,307 - 226,432,287 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,414,200 - 226,431,963 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,989,694 - 253,007,485 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANXA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11284,207,818 - 84,226,438 (+)NCBI
ChlSab1.1 Ensembl1284,207,820 - 84,226,562 (+)Ensembl
Anxa1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624811765,338 - 782,203 (+)NCBI

Position Markers
RH127656  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01237,894,040 - 237,894,245NCBIRnor6.0
Rnor_5.01245,192,932 - 245,193,137UniSTSRnor5.0
RGSC_v3.41223,478,493 - 223,478,698UniSTSRGSC3.4
Celera1215,139,007 - 215,139,212UniSTS
Cytogenetic Map1q51UniSTS
RH129631  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01237,894,024 - 237,894,208NCBIRnor6.0
Rnor_5.01245,192,916 - 245,193,100UniSTSRnor5.0
RGSC_v3.41223,478,477 - 223,478,661UniSTSRGSC3.4
Celera1215,138,991 - 215,139,175UniSTS
RH 3.4 Map3555.4UniSTS
Cytogenetic Map1q51UniSTS
RH94593  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01237,894,035 - 237,894,221NCBIRnor6.0
Rnor_5.01245,192,927 - 245,193,113UniSTSRnor5.0
RGSC_v3.41223,478,488 - 223,478,674UniSTSRGSC3.4
Celera1215,139,002 - 215,139,188UniSTS
Cytogenetic Map1q51UniSTS
RH143668  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01237,909,274 - 237,909,433NCBIRnor6.0
Rnor_5.01245,208,166 - 245,208,325UniSTSRnor5.0
RGSC_v3.41223,493,727 - 223,493,886UniSTSRGSC3.4
Celera1215,154,241 - 215,154,400UniSTS
Cytogenetic Map1q51UniSTS
D1Bda58  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01237,894,046 - 237,894,299NCBIRnor6.0
Rnor_5.01245,192,938 - 245,193,191UniSTSRnor5.0
RGSC_v3.41223,478,499 - 223,478,752UniSTSRGSC3.4
Celera1215,139,013 - 215,139,266UniSTS
Cytogenetic Map1q51UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1233490105264802994Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1217372257244992610Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1236795785281795785Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1193220385238220385Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1236265430281265430Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1215711860260711860Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1156446196274977688Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1236763415258766873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1161321152273792054Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1233663100273792054Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1235850810280850810Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1156446196243311614Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1215828102260828102Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1216324817261324817Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1197963658242963658Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1216213318245529710Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1167394665278228889Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1205603081244401301Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1191825895279986079Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1227107736249206417Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1215711860258765521Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1221901238266901238Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1221901238266901238Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1221901238266901238Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1221901238266901238Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1205195290250195290Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1198446729240017341Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1217054291281795785Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1193968438261264776Rat
634340Hcar5Hepatocarcinoma resistance QTL 58liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1236763415247065599Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1215828102260828102Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1225689973270689973Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1225689973270689973Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1195598053265002735Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1215684498260684498Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1194554354239554354Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1213476630278978026Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1226706329271706329Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1161321256273791893Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1196395041282763074Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1161321256273791893Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1201146802241482368Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1108986301238830534Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1192639698278228889Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169278228889Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1192639698278228889Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1236795785281795785Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1196738546241738546Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1163796316282763074Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1210360774264802828Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1174905700264802994Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1198655722244992610Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1167394665238830534Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1201358068252480016Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1161784422246226103Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1230420627282645769Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1208517798266948272Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1230420627262031693Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1216324817261324817Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1236265430281265430Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1215828102260828102Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1225689973247836969Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1197187728238220385Rat
8693618Alc25Alcohol consumption QTL 2530.28drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1227509470249252048Rat
8693661Alc34Alcohol consumption QTL 342.20.611drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1227509470249252048Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1202571665264802994Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1122614824262664716Rat
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1227509470255131140Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1144634295241482368Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1125875758262433692Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1210652654255652654Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221901238266901238Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1202571665264802994Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1222492538267492538Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210990171255990171Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1194872362239872362Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:26
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000023664
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 3 43 42 26 19 26 8 10 9 35 31 11 8
Low 15 15 15 1 65 9
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023664   ⟹   ENSRNOP00000023664
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1237,893,966 - 237,910,012 (-)Ensembl
RefSeq Acc Id: NM_012904   ⟹   NP_037036
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21217,861,175 - 217,877,194 (-)NCBI
Rnor_6.01237,893,983 - 237,910,002 (-)NCBI
Rnor_5.01245,192,875 - 245,220,057 (-)NCBI
RGSC_v3.41223,478,436 - 223,494,455 (-)RGD
Celera1215,138,950 - 215,154,969 (-)RGD
Sequence:
RefSeq Acc Id: XM_008760295   ⟹   XP_008758517
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01237,893,983 - 237,908,095 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101605   ⟹   XP_038957533
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21217,861,175 - 217,877,205 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_037036   ⟸   NM_012904
- UniProtKB: P07150 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008758517   ⟸   XM_008760295
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000023664   ⟸   ENSRNOT00000023664
RefSeq Acc Id: XP_038957533   ⟸   XM_039101605
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690811
Promoter ID:EPDNEW_R1336
Type:multiple initiation site
Name:Anxa1_1
Description:annexin A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01237,910,017 - 237,910,077EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2118 AgrOrtholog
Ensembl Genes ENSRNOG00000017469 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000023664 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023664 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.220.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598112 IMAGE-MGC_LOAD
InterPro Annexin UniProtKB/Swiss-Prot
  Annexin_repeat UniProtKB/Swiss-Prot
  Annexin_repeat_CS UniProtKB/Swiss-Prot
  Annexin_sf UniProtKB/Swiss-Prot
  ANX1 UniProtKB/Swiss-Prot
KEGG Report rno:25380 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72548 IMAGE-MGC_LOAD
NCBI Gene 25380 ENTREZGENE
PANTHER PTHR10502:SF17 UniProtKB/Swiss-Prot
Pfam Annexin UniProtKB/Swiss-Prot
PhenoGen Anxa1 PhenoGen
PRINTS ANNEXIN UniProtKB/Swiss-Prot
  ANNEXINI UniProtKB/Swiss-Prot
PROSITE ANNEXIN UniProtKB/Swiss-Prot
  ANNEXIN_2 UniProtKB/Swiss-Prot
SMART ANX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47874 UniProtKB/Swiss-Prot
UniProt ANXA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q64664 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Anxa1  annexin A1    annexin 1  Name updated 1299863 APPROVED
2002-11-06 Anxa1  annexin 1  Anx1  Annexin 1 (p35) (Lipocortin 1)  Symbol and Name updated 625702 APPROVED
2002-06-10 Anx1  Annexin 1 (p35) (Lipocortin 1)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes in insulin-containing vesicles 628365
gene_domains contain several putative calcium binding domains 632207
gene_expression expressed in blood cells, fibroblast-like synoviocytes, adrenal chromaffin cells, anterior pituitary cells, and pancreatic-beta cells 628365
gene_pathway insulin secretion 628365
gene_process plays a role in the regulation of glucose-induced insulin secretion via the protein phosphorylation process and is involoved in exocytosis, membrane trafficking, endocytosis, and anti-inflammation 628365
gene_process may inhibit phospholipase A2 632207
gene_process may play a role in regulation of inflammatory response 632208
gene_process mediates insulin release in pancreatic islets and is independent of extracellular Ca2+ 628365
gene_product member of the annexin superfamily; 37 kDa 628365
gene_product member of a family of calcium dependent phospholipid binding proteins that inhibit phospholipase A2 632207