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Gene: Anxa1 (annexin A1) Rattus norvegicus
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Symbol: Anxa1
Name: annexin A1
Description: Exhibits several functions, including DNA/DNA annealing activity; double-stranded DNA helicase activity; and phospholipase A2 inhibitor activity. Contributes to single-stranded DNA binding activity and single-stranded RNA binding activity. Involved in several processes, including estrous cycle; gland development; and protein transport. Localizes to several cellular components, including the extracellular space; intracellular membrane-bounded organelle; and synaptic membrane. Predicted to colocalize with the actin filament. Used to study acute kidney failure; brain ischemia; pleurisy; and uveitis. Biomarker of several diseases, including carcinoma (multiple); cerebral infarction; eye disease (multiple); hyperthyroidism; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in brain ischemia and pancreatic cancer. Orthologous to human ANXA1 (annexin A1); PARTICIPATES IN cyclooxygenase mediated pathway of arachidonic acid metabolism; INTERACTS WITH (RS)-amphetamine; (S)-nicotine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: annexin 1; Annexin 1 (p35) (Lipocortin 1); annexin I; annexin-1; Anx1; calpactin II; calpactin-2; chromobindin-9; lipocortin 1; lipocortin I; p35; phospholipase A2 inhibitory protein
Orthologs:
Homo sapiens (human) : ANXA1 (annexin A1)  HGNC  Alliance
Mus musculus (house mouse) : Anxa1 (annexin A1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Anxa1 (annexin A1)
Pan paniscus (bonobo/pygmy chimpanzee) : ANXA1 (annexin A1)
Canis lupus familiaris (dog) : ANXA1 (annexin A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Anxa1 (annexin A1)
Sus scrofa (pig) : ANXA1 (annexin A1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01237,893,983 - 237,910,002 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01245,192,875 - 245,220,057 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,478,436 - 223,494,455 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11223,642,460 - 223,658,478 (-)NCBI
Celera1215,138,950 - 215,154,969 (-)NCBICelera
Cytogenetic Map1q51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Anxa1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2118
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.