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Gene: Sik2 (salt-inducible kinase 2) Rattus norvegicus

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Symbol:

Sik2

Name:

salt-inducible kinase 2

RGD ID:

1559698

Description:

Predicted to enable ATP binding activity; magnesium ion binding activity; and protein kinase activity. Predicted to be involved in several processes, including protein autophosphorylation; regulation of insulin receptor signaling pathway; and regulation of primary metabolic process. Predicted to act upstream of or within insulin receptor signaling pathway and protein phosphorylation. Predicted to be active in endoplasmic reticulum membrane and nucleus. Orthologous to human SIK2 (salt inducible kinase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; azoxystrobin; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC315649; RGD1559698; serine/threonine-protein kinase SIK2; similar to salt inducible kinase 2; SNF1-like kinase 2; Snf1lk2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SIK2 (salt inducible kinase 2)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Sik2 (salt inducible kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sik2 (salt inducible kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SIK2 (salt inducible kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SIK2 (salt inducible kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sik2 (salt inducible kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SIK2 (salt inducible kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SIK2 (salt inducible kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sik2 (salt inducible kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SIK2 (salt inducible kinase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sik2 (salt inducible kinase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sik2a (salt-inducible kinase 2a)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	sik2b (salt-inducible kinase 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Sik2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sik2	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)

Allele / Splice:

Sik2^em4Mcwi Sik2^em5Mcwi

Genetic Models:

WKY-Sik2^em5Mcwi WKY-Sik2^em4Mcwi

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	60,121,913 - 60,221,707 (-)	NCBI		GRCr8
mRatBN7.2	8	51,225,543 - 51,325,343 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	51,225,543 - 51,325,415 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	8	55,309,005 - 55,408,608 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	55,308,757 - 55,408,464 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	53,905,730 - 54,005,295 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	54,240,307 - 54,337,976 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	50,772,712 - 50,871,786 (-)	NCBI		Celera
Cytogenetic Map	8	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

ataxia telangiectasia (ISO)

BH4-deficient hyperphenylalaninemia A (ISO)

Carney-Stratakis syndrome (ISO)

chromosome 11 partial duplication syndrome (ISO)

Disease Progression (ISO)

hepatocellular carcinoma (ISO)

intellectual disability (ISO)

Pyruvate Dehydrogenase E2 Deficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

arsane (ISO)

arsenic atom (ISO)

azoxystrobin (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

cadmium dichloride (ISO)

carnosic acid (ISO)

chlorpyrifos (EXP)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

DDE (ISO)

dexamethasone (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

FR900359 (ISO)

fulvestrant (ISO)

gentamycin (EXP)

glyphosate (EXP)

imidacloprid (EXP)

indole-3-methanol (EXP)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (EXP)

phenylmercury acetate (ISO)

piperonyl butoxide (EXP)

pirinixic acid (EXP,ISO)

pregnenolone 16alpha-carbonitrile (EXP)

quercetin (ISO)

rifampicin (ISO)

rotenone (EXP)

SB 431542 (ISO)

sodium arsenite (ISO)

Soman (EXP)

thiabendazole (EXP)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

triphenyl phosphate (EXP,ISO)

valdecoxib (EXP)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

insulin receptor signaling pathway (ISO)

intracellular signal transduction (IBA,IEA,ISO)

negative regulation of glycolytic process (ISO)

negative regulation of lipid biosynthetic process (ISO)

negative regulation of transcription from RNA polymerase II promoter by glucose (ISO)

protein autophosphorylation (ISO)

protein phosphorylation (ISO)

regulation of insulin receptor signaling pathway (ISO)

Cellular Component

cytoplasm (IBA,IEA,ISO)

endoplasmic reticulum membrane (IEA,ISO)

nucleus (IBA,ISO)

Molecular Function

ATP binding (IEA,ISO)

kinase activity (IEA)

magnesium ion binding (IEA,ISO)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein serine kinase activity (IEA,ISO)

protein serine/threonine kinase activity (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12624099	PMID:14976552	PMID:18348280	PMID:22109884	PMID:22588126	PMID:23599336	PMID:34402252	PMID:36414551

Genomics

Comparative Map Data

Sik2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	60,121,913 - 60,221,707 (-)	NCBI		GRCr8
mRatBN7.2	8	51,225,543 - 51,325,343 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	51,225,543 - 51,325,415 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	8	55,309,005 - 55,408,608 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	55,308,757 - 55,408,464 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	53,905,730 - 54,005,295 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	54,240,307 - 54,337,976 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	50,772,712 - 50,871,786 (-)	NCBI		Celera
Cytogenetic Map	8	q23	NCBI

SIK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	111,602,449 - 111,730,855 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	111,602,449 - 111,730,855 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	111,473,173 - 111,601,579 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	110,978,380 - 111,102,845 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	110,978,379 - 111,102,840	NCBI
Celera	11	108,626,358 - 108,750,800 (+)	NCBI		Celera
Cytogenetic Map	11	q23.1	NCBI
HuRef	11	107,397,365 - 107,521,692 (+)	NCBI		HuRef
CHM1_1	11	111,356,226 - 111,480,689 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	111,612,584 - 111,741,007 (+)	NCBI		T2T-CHM13v2.0

Sik2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	50,800,944 - 50,920,432 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	50,804,101 - 50,920,373 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	50,889,644 - 51,009,132 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	50,892,801 - 51,009,073 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	50,700,906 - 50,817,178 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	50,645,031 - 50,761,303 (-)	NCBI		MGSCv36	mm8
Celera	9	48,179,153 - 48,295,530 (-)	NCBI		Celera
Cytogenetic Map	9	A5.3	NCBI
cM Map	9	27.75	NCBI

Sik2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	13,342,032 - 13,457,563 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	13,342,032 - 13,458,076 (+)	NCBI	ChiLan1.0	ChiLan1.0

SIK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	112,348,699 - 112,477,488 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	113,440,776 - 113,571,851 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	106,484,913 - 106,613,711 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	110,329,237 - 110,453,543 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	110,329,237 - 110,453,543 (+)	Ensembl	panpan1.1		panPan2

SIK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	21,354,127 - 21,479,891 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	21,358,902 - 21,479,841 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	21,276,144 - 21,401,711 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	21,382,313 - 21,503,342 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	5	21,438,206 - 21,563,749 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	21,338,626 - 21,464,410 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	21,387,568 - 21,513,180 (-)	NCBI		UU_Cfam_GSD_1.0

Sik2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	93,894,634 - 94,013,880 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936612	2,691,524 - 2,810,981 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936612	2,691,729 - 2,810,975 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SIK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	39,368,599 - 39,483,515 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	39,368,555 - 39,483,519 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	44,262,713 - 44,269,792 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SIK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	102,944,171 - 103,070,973 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	102,944,281 - 103,068,823 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	22,907,785 - 23,034,098 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sik2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624784	6,745,595 - 6,895,747 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624784	6,728,504 - 6,900,557 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sik2
354 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	615
Count of miRNA genes:	286
Interacting mature miRNAs:	391
Transcripts:	ENSRNOT00000066893
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30856404	75856404	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	30848154	101699754	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	41866876	86866876	Rat
11556286	Cm81	Cardiac mass QTL 81		0.01	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	30848154	61290444	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	42692684	90165460	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	30848154	101699754	Rat
1582222	Epfw2	Epididymal fat weight QTL 2	3.2	0.0005	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	8	31737729	76737729	Rat
1354627	Despr14	Despair related QTL 14		0.0056	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	7688955	52688955	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	35582032	80582032	Rat
4889938	Bss89	Bone structure and strength QTL 89	3.8		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	8	50095249	82460899	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	30848154	101699754	Rat
1300146	Rf17	Renal function QTL 17	2.9		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	8	28242912	73242912	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	28242912	99525068	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	30848154	82460899	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	27205715	99103503	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	19331152	93965294	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	29502665	70386295	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	30848154	61290444	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	22662330	67662330	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	40713066	82925667	Rat
1359033	Bp273	Blood pressure QTL 273			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	30848154	61290444	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	41866876	75097878	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	35551938	80551938	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	40713066	93965294	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	27205715	99103503	Rat
1331744	Bp217	Blood pressure QTL 217	3.398		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	30848154	58482492	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30848259	105647037	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	27205715	99103503	Rat
631216	Stl9	Serum triglyceride level QTL 9	4.71	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	8	41867010	70386132	Rat
5684973	Bss100	Bone structure and strength QTL 100	4.7		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	8	50095249	82460899	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	16290444	61290444	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	30848154	82460899	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	43296169	98968765	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	30188867	94457446	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	43296169	98968765	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	8736635	53736635	Rat
1331804	Cm30	Cardiac mass QTL 30	3.77443		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	8	28242912	53961020	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	30848154	82460899	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	7670578	52670578	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	43296169	98968765	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	43296169	98968765	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	43296169	98968765	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	43296169	98968765	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	8736635	53736635	Rat
2313086	Bss60	Bone structure and strength QTL 60	4.1	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	8	50095249	82460899	Rat
1558646	Swd5	Spike wave discharge measurement QTL 5	3.45	0.00036	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	8	14906751	59906751	Rat
631648	Stl5	Serum triglyceride level QTL 5	4	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	27205715	54998217	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	46531722	99083736	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	36469535	99083736	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631271	Lecl1	Lens clarity QTL 1		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	8	18984168	84531599	Rat
2303564	Gluco43	Glucose level QTL 43	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	26130187	71130187	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	9712220	53356647	Rat
2303570	Gluco48	Glucose level QTL 48	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	49805831	94805831	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	30848154	82460899	Rat
1354595	Despr4	Despair related QTL 4	2.16	0.0036	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	8	7688955	52688955	Rat
2303572	Insul13	Insulin level QTL 13	2		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	8	26130187	71130187	Rat

Markers in Region

D8Got77

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	51,320,033 - 51,320,329 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	55,403,305 - 55,403,600	NCBI	Rnor6.0
Rnor_5.0	8	54,000,210 - 54,000,505	UniSTS	Rnor5.0
RGSC_v3.4	8	54,332,264 - 54,332,560	RGD	RGSC3.4
RGSC_v3.4	8	54,332,265 - 54,332,560	UniSTS	RGSC3.4
RGSC_v3.1	8	54,351,319 - 54,351,614	RGD
RH 3.4 Map	8	557.8	UniSTS
RH 3.4 Map	8	557.8	RGD
RH 2.0 Map	8	416.1	RGD
Cytogenetic Map	8	q24	UniSTS

RH144517

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	51,295,246 - 51,295,485 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	55,378,567 - 55,378,805	NCBI	Rnor6.0
Rnor_5.0	8	53,975,472 - 53,975,710	UniSTS	Rnor5.0
RGSC_v3.4	8	54,307,093 - 54,307,331	UniSTS	RGSC3.4
Celera	8	50,841,700 - 50,841,938	UniSTS
RH 3.4 Map	8	552.0	UniSTS
Cytogenetic Map	8	q24	UniSTS

AW529971

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	51,231,788 - 51,231,938 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	55,315,016 - 55,315,165	NCBI	Rnor6.0
Rnor_5.0	8	53,911,989 - 53,912,138	UniSTS	Rnor5.0
RGSC_v3.4	8	54,243,616 - 54,243,765	UniSTS	RGSC3.4
Celera	8	50,778,312 - 50,778,461	UniSTS
RH 3.4 Map	8	554.0	UniSTS
Cytogenetic Map	8	q24	UniSTS

RH134661

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	51,225,843 - 51,226,040 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	55,309,058 - 55,309,254	NCBI	Rnor6.0
Rnor_5.0	8	53,906,031 - 53,906,227	UniSTS	Rnor5.0
RGSC_v3.4	8	54,237,670 - 54,237,866	UniSTS	RGSC3.4
Celera	8	50,772,765 - 50,772,961	UniSTS
RH 3.4 Map	8	551.5	UniSTS
Cytogenetic Map	8	q24	UniSTS

BF409033

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	51,296,635 - 51,296,740 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	55,379,956 - 55,380,060	NCBI	Rnor6.0
Rnor_5.0	8	53,976,861 - 53,976,965	UniSTS	Rnor5.0
RGSC_v3.4	8	54,308,482 - 54,308,586	UniSTS	RGSC3.4
Celera	8	50,843,089 - 50,843,193	UniSTS
RH 3.4 Map	8	551.7	UniSTS
Cytogenetic Map	8	q24	UniSTS

Genetic Models

This gene Sik2 is modified in the following models/strains:

WKY-Sik2^em5Mcwi WKY-Sik2^em4Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427328	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_056984534	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_056984535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_056984536	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_056984537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_056984538	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_056984539	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265450	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001844630	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_348491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_348493	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_348495	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_356286	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	DQ188032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000066893 ⟹ ENSRNOP00000062018

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	51,225,543 - 51,325,415 (-)	Ensembl
Rnor_6.0 Ensembl	8	55,308,757 - 55,408,464 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000091732 ⟹ ENSRNOP00000068754

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	51,225,627 - 51,325,415 (-)	Ensembl
Rnor_6.0 Ensembl	8	55,312,763 - 55,402,711 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119371 ⟹ ENSRNOP00000087049

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	51,225,627 - 51,325,190 (-)	Ensembl

RefSeq Acc Id:

NM_001427328 ⟹ NP_001414257

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	60,121,913 - 60,221,650 (-)	NCBI

RefSeq Acc Id:

XM_056984534 ⟹ XP_056840514

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	60,121,913 - 60,221,706 (-)	NCBI
mRatBN7.2	8	51,225,543 - 51,325,342 (-)	NCBI

RefSeq Acc Id:

XM_056984535 ⟹ XP_056840515

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	60,121,913 - 60,221,707 (-)	NCBI
mRatBN7.2	8	51,225,543 - 51,325,343 (-)	NCBI

RefSeq Acc Id:

XM_056984536 ⟹ XP_056840516

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	60,121,913 - 60,221,707 (-)	NCBI
mRatBN7.2	8	51,225,543 - 51,325,343 (-)	NCBI

RefSeq Acc Id:

XM_056984537 ⟹ XP_056840517

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	60,121,913 - 60,221,498 (-)	NCBI
mRatBN7.2	8	51,225,543 - 51,325,148 (-)	NCBI

RefSeq Acc Id:

XM_056984538 ⟹ XP_056840518

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	60,121,913 - 60,211,132 (-)	NCBI
mRatBN7.2	8	51,225,543 - 51,314,766 (-)	NCBI

RefSeq Acc Id:

XM_056984539 ⟹ XP_056840519

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	60,121,913 - 60,180,478 (-)	NCBI
mRatBN7.2	8	51,225,543 - 51,280,783 (-)	NCBI

RefSeq Acc Id:

XM_063265450 ⟹ XP_063121520

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	60,121,913 - 60,221,707 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001414257	(Get FASTA)	NCBI Sequence Viewer
	XP_056840514	(Get FASTA)	NCBI Sequence Viewer
	XP_056840515	(Get FASTA)	NCBI Sequence Viewer
	XP_056840516	(Get FASTA)	NCBI Sequence Viewer
	XP_056840517	(Get FASTA)	NCBI Sequence Viewer
	XP_056840518	(Get FASTA)	NCBI Sequence Viewer
	XP_056840519	(Get FASTA)	NCBI Sequence Viewer
	XP_063121520	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABA28749	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000062018
	ENSRNOP00000062018.3
	ENSRNOP00000068754
	ENSRNOP00000068754.2
	ENSRNOP00000087049
	ENSRNOP00000087049.1
	ENSRNOP00000109973

Ensembl Acc Id:

ENSRNOP00000062018 ⟸ ENSRNOT00000066893

Ensembl Acc Id:

ENSRNOP00000068754 ⟸ ENSRNOT00000091732

Ensembl Acc Id:

ENSRNOP00000087049 ⟸ ENSRNOT00000119371

RefSeq Acc Id:	XP_056840516 ⟸ XM_056984536
- Peptide Label:	isoform X4
- UniProtKB:	Q3LRT3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_056840515 ⟸ XM_056984535
- Peptide Label:	isoform X2
- UniProtKB:	Q3LRT3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_056840514 ⟸ XM_056984534
- Peptide Label:	isoform X1
- UniProtKB:	Q3LRT3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_056840517 ⟸ XM_056984537
- Peptide Label:	isoform X5
- UniProtKB:	A6J4G6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_056840518 ⟸ XM_056984538
- Peptide Label:	isoform X6
- UniProtKB:	A6J4G6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_056840519 ⟸ XM_056984539
- Peptide Label:	isoform X7
- UniProtKB:	A6J4G6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063121520 ⟸ XM_063265450
- Peptide Label:	isoform X3
- UniProtKB:	Q3LRT3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001414257 ⟸ NM_001427328
- UniProtKB:	Q3LRT3 (UniProtKB/TrEMBL)

Protein Domains

Protein kinase UBA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-E9PSK5-F1-model_v2	AlphaFold	E9PSK5	1-920	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695961

Promoter ID:

EPDNEW_R6483

Type:

multiple initiation site

Name:

Sik2_1

Description:

salt-inducible kinase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	55,408,524 - 55,408,584	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1559698	AgrOrtholog
BioCyc Gene	G2FUF-30535	BioCyc
Ensembl Genes	ENSRNOG00000043498	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000066893	ENTREZGENE
	ENSRNOT00000066893.4	UniProtKB/TrEMBL
	ENSRNOT00000091732	ENTREZGENE
	ENSRNOT00000091732.2	UniProtKB/TrEMBL
	ENSRNOT00000119371	ENTREZGENE
	ENSRNOT00000119371.1	UniProtKB/TrEMBL
	ENSRNOT00000143737	ENTREZGENE
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser/Thr_prot_kinase_AS	UniProtKB/TrEMBL
	Ser/thre_prot_kinase_SNF1-like	UniProtKB/TrEMBL
	SIK	UniProtKB/TrEMBL
	UBA/transl_elong_EF1B_N_euk	UniProtKB/TrEMBL
NCBI Gene	315649	ENTREZGENE
PANTHER	MAP/MICROTUBULE AFFINITY-REGULATING KINASE	UniProtKB/TrEMBL
	NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PhenoGen	Sik2	PhenoGen
PIRSF	Ser/Thr_PK_SNF1-like	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
	UBA	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000043498	RatGTEx
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
UniProt	A0A0G2JTL2_RAT	UniProtKB/TrEMBL
	A0A8I6A543_RAT	UniProtKB/TrEMBL
	A6J4G6	ENTREZGENE, UniProtKB/TrEMBL
	E9PSK5_RAT	UniProtKB/TrEMBL
	Q3LRT3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-02	Sik2	salt-inducible kinase 2	Snf1lk2	SNF1-like kinase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Snf1lk2	SNF1-like kinase 2	Snf1lk2_predicted	SNF1-like kinase 2 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Snf1lk2_predicted	SNF1-like kinase 2 (predicted)	RGD1559698_predicted	similar to salt inducible kinase 2 (predicted)	Symbol and Name updated	1299863	APPROVED
2006-03-07	RGD1559698_predicted	similar to salt inducible kinase 2 (predicted)	LOC315649	similar to salt inducible kinase 2	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC315649	similar to salt inducible kinase 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD