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Gene: Sik2 (salt-inducible kinase 2) Rattus norvegicus
Symbol: Sik2
Name: salt-inducible kinase 2
Description: Predicted to have ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including insulin receptor signaling pathway; protein autophosphorylation; and regulation of insulin receptor signaling pathway. Predicted to localize to the cytoplasm and nucleus. Orthologous to human SIK2 (salt inducible kinase 2); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; bisphenol A; gentamycin.
Type: gene
RefSeq Status: MODEL
Also known as: LOC315649; RGD1559698; similar to salt inducible kinase 2; SNF1-like kinase 2; Snf1lk2
Homo sapiens (human) : SIK2 (salt inducible kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Sik2 (salt inducible kinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sik2 (salt inducible kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SIK2 (salt inducible kinase 2)
Canis lupus familiaris (dog) : SIK2 (salt inducible kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sik2 (salt inducible kinase 2)
Sus scrofa (pig) : SIK2 (salt inducible kinase 2)
more info ...
Allele / Splice: Sik2em4Mcwi   Sik2em5Mcwi  
Genetic Models: WKY-Sik2em5Mcwi WKY-Sik2em4Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0855,309,005 - 55,408,608 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0853,905,730 - 54,005,295 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4854,240,307 - 54,337,976 (-)NCBIRGSC3.4rn4RGSC3.4
Celera850,772,712 - 50,871,786 (-)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Sik2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1559698
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.