Mt2A (metallothionein 2A) - Rat Genome Database

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Gene: Mt2A (metallothionein 2A) Rattus norvegicus
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Symbol: Mt2A
Name: metallothionein 2A
RGD ID: 1592345
Description: Enables cadmium ion binding activity and zinc ion binding activity. Involved in astrocyte activation. Predicted to be located in cytoplasm and nucleus. Biomarker of Alzheimer's disease; kidney failure; median neuropathy; retinitis pigmentosa; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in carotid stenosis and type 2 diabetes mellitus. Orthologous to several human genes including MT2A (metallothionein 2A); INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC689415; metallothionein-2; metallothionein-II; MT-2; MT-II; Mt2; similar to Metallothionein-2 (MT-2) (Metallothionein-II) (MT-II)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Mt2-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,837,934 - 10,838,708 (-)NCBIGRCr8
mRatBN7.21910,832,009 - 10,832,783 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,832,002 - 10,832,784 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,800,149 - 10,800,923 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,567,003 - 11,567,777 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,853,995 - 10,854,769 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,307,966 - 11,308,740 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,307,967 - 11,308,740 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,283,093 - 11,283,867 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,267,811 - 11,268,585 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1910,717,971 - 10,718,745 (-)NCBICelera
Cytogenetic Map19p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-aminonicotinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP)
alexidine  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite ion  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
astemizole  (ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP,ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
barium chloride  (EXP)
benomyl  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[d]isothiazol-3-one  (ISO)
benzoic acid  (ISO)
benzyl cinnamate  (ISO)
beta-naphthoflavone  (ISO)
bifenthrin  (ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A5  (ISO)
bromobenzene  (EXP)
budesonide  (ISO)
buta-1,3-diene  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carmustine  (EXP,ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium trinitrate  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumarin  (EXP)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP,ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
D-gluconic acid  (ISO)
D-glucose  (EXP)
daidzein  (ISO)
DDE  (EXP)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
deoxycholic acid  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dihydroxyacetone  (ISO)
dioxygen  (EXP,ISO)
diphenylcyclopropenone  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diprotium oxide  (ISO)
diquat  (ISO)
disulfiram  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
EUK-134  (EXP)
farnesal  (ISO)
fentin chloride  (EXP)
ferric ammonium citrate  (ISO)
fluorescein 5-isothiocyanate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
gallium nitrate  (ISO)
gefitinib  (ISO)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (EXP)
glutathione  (ISO)
glycerol  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
hemin  (ISO)
hexadecanoic acid  (EXP,ISO)
hydrogen peroxide  (ISO)
hydroquinone  (EXP)
hydroxycitronellal  (ISO)
ifosfamide  (ISO)
indirubin-3'-monoxime  (ISO)
indometacin  (ISO)
iron atom  (EXP,ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
iron(III) nitrilotriacetate  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
kainic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
leupeptin  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP)
LY294002  (EXP,ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mefloquine  (ISO)
melatonin  (EXP)
menadione  (ISO)
mercaptopurine  (EXP)
Mercuric oxide  (ISO)
mercury atom  (EXP,ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
mesoporphyrin IX  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
methyl non-2-ynoate  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
motexafin gadolinium  (ISO)
N(4)-hydroxycytidine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP,ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
naphthalene  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
nitroprusside  (ISO)
ochratoxin A  (EXP,ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (EXP)
organoselenium compound  (ISO)
oxaliplatin  (EXP,ISO)
oxidopamine  (EXP,ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenanthrene  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
promegestone  (ISO)
propiconazole  (ISO)
prothioconazole  (ISO)
Ptaquiloside  (ISO)
purine-6-thiol  (EXP)
quercetin  (EXP,ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
ritodrine  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
serotonin  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
streptozocin  (EXP)
SU6656  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbutaline  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (EXP,ISO)
Tolmetin glucuronide  (ISO)
toluene  (EXP)
topotecan  (EXP)
triadimefon  (ISO)
tributylstannane  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP,ISO)
tyrphostin AG 1478  (ISO)
uranium atom  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vanillin  (ISO)
verteporfin  (ISO)
vincristine  (ISO)
water  (ISO)
Xmu-MP-1  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc molecular entity  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISS)
nucleus  (IBA,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice. Abraham S, etal., Life Sci. 2012 Jan 16;90(3-4):140-6. Epub 2011 Nov 10.
2. Early effects of surgery on zinc and metallothionein levels in female rats. Brambila E, etal., Biol Trace Elem Res. 1999 Nov;70(2):173-82.
3. Comparison of the NMR solution structure and the x-ray crystal structure of rat metallothionein-2. Braun W, etal., Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10124-8.
4. Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion. Campagne MV, etal., J Neurosci. 2000 Jul 15;20(14):5200-7.
5. Putative psychosis genes in the prefrontal cortex: combined analysis of gene expression microarrays. Choi KH, etal., BMC Psychiatry. 2008 Nov 7;8:87.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Novel -209A/G MT2A polymorphism in old patients with type 2 diabetes and atherosclerosis: relationship with inflammation (IL-6) and zinc. Giacconi R, etal., Biogerontology. 2005 Dec;6(6):407-13.
8. The +838 C/G MT2A polymorphism, metals, and the inflammatory/immune response in carotid artery stenosis in elderly people. Giacconi R, etal., Mol Med. 2007 Jul-Aug;13(7-8):388-95.
9. Gene profiling of skeletal muscle in an amyotrophic lateral sclerosis mouse model. Gonzalez de Aguilar JL, etal., Physiol Genomics. 2008 Jan 17;32(2):207-18. Epub 2007 Nov 13.
10. Gene expression alterations in brain areas of intracerebroventricular streptozotocin treated rat. Grunblatt E, etal., J Alzheimers Dis. 2006 Aug;9(3):261-71.
11. Gene expression profiling of cathepsin D, metallothioneins-1 and -2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis. Hashimoto M, etal., Acta Neuropathol. 2005 Feb;109(2):165-80. Epub 2004 Dec 9.
12. Differential display detects altered gene expression between cataractous and normal human lenses. Kantorow M, etal., Invest Ophthalmol Vis Sci. 1998 Nov;39(12):2344-54.
13. Differential regulation of metallothionein-I and metallothionein-II mRNA expression in the rat brain following traumatic brain injury. Kim EH, etal., Mol Cells. 2004 Dec 31;18(3):326-31.
14. Auricular chondritis caused by metal ear tagging in C57BL/6 mice. Kitagaki M and Hirota M, Vet Pathol. 2007 Jul;44(4):458-66.
15. Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivo. Lanza C, etal., J Neurochem. 2009 Sep;110(5):1674-84. Epub 2009 Jul 8.
16. Expression of antioxidant molecules after peripheral nerve injury and regeneration. Lanza C, etal., J Neurosci Res. 2012 Apr;90(4):842-8. doi: 10.1002/jnr.22778. Epub 2012 Jan 18.
17. Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways. Leung YK, etal., Exp Neurol. 2010 Jan;221(1):98-106. Epub 2009 Oct 15.
18. Brain genomics of intracerebral hemorrhage. Lu A, etal., J Cereb Blood Flow Metab. 2006 Feb;26(2):230-52.
19. Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease. Manso Y, etal., Cell Mol Life Sci. 2012 Nov;69(21):3665-81. doi: 10.1007/s00018-012-1045-y. Epub 2012 Jul 6.
20. Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats. Morales AI, etal., Toxicol Appl Pharmacol. 2006 Jan 1;210(1-2):128-35. Epub 2005 Oct 14.
21. Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury. Pankhurst MW, etal., PLoS One. 2012;7(2):e31185. Epub 2012 Feb 17.
22. Increased expression of tissue inhibitor of metalloproteinases (TIMP-I) and metallothionein in murine lungs after hyperoxic exposure. Piedboeuf B, etal., Am J Respir Cell Mol Biol. 1994 Feb;10(2):123-32.
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. Mouse model of paraquat-poisoned lungs and its gene expression profile. Tomita M, etal., Toxicology. 2007 Mar 7;231(2-3):200-9. Epub 2006 Dec 15.
26. Serial analysis of gene expression identifies metallothionein-II as major neuroprotective gene in mouse focal cerebral ischemia. Trendelenburg G, etal., J Neurosci. 2002 Jul 15;22(14):5879-88.
27. Metallothionein-III deficiency exacerbates light-induced retinal degeneration. Tsuruma K, etal., Invest Ophthalmol Vis Sci. 2012 Nov 29;53(12):7896-903. doi: 10.1167/iovs.12-10165.
28. Altered expression of metallothionein-I and -II and their receptor megalin in inherited photoreceptor degeneration. Wunderlich KA, etal., Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4809-20. Epub 2010 Mar 31.
29. Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications. Yang L, etal., Am J Physiol Endocrinol Metab. 2008 May;294(5):E987-92. Epub 2008 Mar 18.
Additional References at PubMed
PMID:1942051   PMID:2959527   PMID:3184190   PMID:3653102   PMID:3945804   PMID:6470004   PMID:6853483   PMID:8640230   PMID:11168427   PMID:11792622   PMID:12477932   PMID:16751776  
PMID:18237193   PMID:19004484   PMID:19536566   PMID:19609577   PMID:20109269   PMID:22571646   PMID:22703381   PMID:23012479   PMID:23291980   PMID:23726995   PMID:24489578   PMID:25947372  
PMID:26732138   PMID:27147436   PMID:27173051   PMID:27939232   PMID:33849565  


Genomics

Comparative Map Data
Mt2A
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,837,934 - 10,838,708 (-)NCBIGRCr8
mRatBN7.21910,832,009 - 10,832,783 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,832,002 - 10,832,784 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,800,149 - 10,800,923 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,567,003 - 11,567,777 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,853,995 - 10,854,769 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,307,966 - 11,308,740 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,307,967 - 11,308,740 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,283,093 - 11,283,867 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,267,811 - 11,268,585 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1910,717,971 - 10,718,745 (-)NCBICelera
Cytogenetic Map19p12NCBI
MT2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,608,584 - 56,609,497 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,608,584 - 56,609,497 (+)EnsemblGRCh38hg38GRCh38
GRCh371656,642,496 - 56,643,409 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,200,012 - 55,200,896 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,200,011 - 55,200,892NCBI
Celera1641,139,964 - 41,140,895 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,512,001 - 42,512,932 (+)NCBIHuRef
CHM1_11658,048,948 - 58,049,879 (+)NCBICHM1_1
T2T-CHM13v2.01662,403,549 - 62,404,462 (+)NCBIT2T-CHM13v2.0
Mt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39894,899,246 - 94,900,195 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl894,899,292 - 94,900,196 (+)EnsemblGRCm39 Ensembl
GRCm38894,172,618 - 94,173,567 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,172,664 - 94,173,568 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,696,518 - 96,697,467 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,061,913 - 97,062,691 (+)NCBIMGSCv36mm8
Celera898,504,546 - 98,505,495 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.32NCBI
LOC100986475
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,090,308 - 66,091,276 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,009,207 - 72,010,174 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01636,894,853 - 36,895,826 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,027,016 - 56,028,093 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,007,922 - 56,028,093 (+)Ensemblpanpan1.1panPan2
MT2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,607,926 - 59,608,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,607,927 - 59,626,727 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,241,670 - 56,242,569 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0260,152,672 - 60,153,617 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,152,673 - 60,154,757 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,983,370 - 56,984,269 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,992,082 - 57,992,981 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,885,225 - 58,886,124 (-)NCBIUU_Cfam_GSD_1.0
MT-2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,645,153 - 18,646,033 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1618,645,125 - 18,646,034 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2626,420,815 - 26,421,706 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mt2A
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:91
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000067391
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 11 11 11 1
Medium 3 11 34 27 1 27 1 43 35 40 2
Low 32 12 3 18 3 8 10 31 9 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001137564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC168768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ623001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000067391   ⟹   ENSRNOP00000062585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1910,832,002 - 10,832,784 (-)Ensembl
Rnor_6.0 Ensembl1911,307,967 - 11,308,740 (-)Ensembl
RefSeq Acc Id: NM_001137564   ⟹   NP_001131036
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,837,934 - 10,838,708 (-)NCBI
mRatBN7.21910,832,009 - 10,832,783 (-)NCBI
Rnor_6.01911,307,966 - 11,308,740 (-)NCBI
Rnor_5.01911,283,093 - 11,283,867 (-)NCBI
RGSC_v3.41911,267,811 - 11,268,585 (-)RGD
Celera1910,717,971 - 10,718,745 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001131036 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41640 (Get FASTA)   NCBI Sequence Viewer  
  AAI68768 (Get FASTA)   NCBI Sequence Viewer  
  EDL87351 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062585
  ENSRNOP00000062585.1
  ENSRNOP00055029620
  ENSRNOP00060022644
  ENSRNOP00065003840
  ENSRNOP00065046857
GenBank Protein P04355 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001131036   ⟸   NM_001137564
- UniProtKB: P04355 (UniProtKB/Swiss-Prot),   B6ID08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000062585   ⟸   ENSRNOT00000067391

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04355-F1-model_v2 AlphaFold P04355 1-61 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700957
Promoter ID:EPDNEW_R11473
Type:multiple initiation site
Name:AC128848_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01911,303,008 - 11,303,068EPDNEW
RGD ID:13700950
Promoter ID:EPDNEW_R11474
Type:multiple initiation site
Name:Mt2A_1
Description:metallothionein 2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01911,308,740 - 11,308,800EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592345 AgrOrtholog
BioCyc Gene G2FUF-6476 BioCyc
Ensembl Genes ENSRNOG00000043098 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055021314 UniProtKB/Swiss-Prot
  ENSRNOG00060016415 UniProtKB/Swiss-Prot
  ENSRNOG00065003661 UniProtKB/Swiss-Prot
  ENSRNOG00065033084 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000067391 ENTREZGENE
  ENSRNOT00000067391.2 UniProtKB/Swiss-Prot
  ENSRNOT00055036431 UniProtKB/Swiss-Prot
  ENSRNOT00060028125 UniProtKB/Swiss-Prot
  ENSRNOT00065005311 UniProtKB/Swiss-Prot
  ENSRNOT00065056916 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Metalthion_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_dom_sf_vert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_vert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_vert_metal_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:689415 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 689415 ENTREZGENE
PANTHER METALLOTHIONEIN 1H-LIKE PROTEIN 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23299 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Metallothio UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mt2A PhenoGen
PRINTS MTVERTEBRATE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE METALLOTHIONEIN_VRT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000043098 RatGTEx
  ENSRNOG00055021314 RatGTEx
  ENSRNOG00060016415 RatGTEx
  ENSRNOG00065003661 RatGTEx
  ENSRNOG00065033084 RatGTEx
Superfamily-SCOP SSF57868 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B6ID08 ENTREZGENE, UniProtKB/TrEMBL
  MT2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-08 Mt2A  metallothionein 2A  LOC682651  similar to Metallothionein-2 (MT-2) (Metallothionein-II) (MT-II)  Data merged from RGD:1596641 1643240 APPROVED
2008-03-06 Mt2A  metallothionein 2A  LOC689415  similar to Metallothionein-2 (MT-2) (Metallothionein-II) (MT-II)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC689415  similar to Metallothionein-2 (MT-2) (Metallothionein-II) (MT-II)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC682651  similar to Metallothionein-2 (MT-2) (Metallothionein-II) (MT-II)      Symbol and Name status set to provisional 70820 PROVISIONAL