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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1592345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mt2A
Name: metallothionein 2A
Acc ID: CHEBI:18248
Term: iron atom
Definition: An iron group element atom that has atomic number 26.
Chemical ID: MESH:D007501
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mt2Aincreases expressionEXP 6480464CTDIron deficiency results in increased expression of MT2A mRNAPMID:16629162
Mt2Amultiple interactionsEXP 6480464CTD[Zinc co-treated with Iron] results in increased expression of and affects the localization of MT2A protein; Iron results in increased expression of and affects the localization of MT2A proteinPMID:17241390
Mt2Aaffects abundanceISOMT2A (Homo sapiens)6480464CTDMT2A gene SNP affects the abundance of IronPMID:21328412
Mt2Aincreases expressionISOMt2 (Mus musculus)6480464CTDIron deficiency results in increased expression of MT2 mRNAPMID:24089420
Mt2Amultiple interactionsISOMT2A (Homo sapiens)6480464CTD[Deferoxamine results in decreased abundance of Iron] which results in increased expression of MT2A mRNA; [ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of MT2A mRNA; [Hemin results in decreased abundance of Iron] which results in increased expression of MT2A mRNAPMID:12393473
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