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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1592345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mt2A
Name: metallothionein 2A
Acc ID: CHEBI:49976
Term: zinc dichloride
Definition: A compound of zinc and chloride ions in the ratio 1:2. It exists in four crystalline forms, in each of which the Zn(2+) ions are trigonal planar coordinated to four chloride ions.
Chemical ID: MESH:C016837
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mt2Aincreases expressionEXP 6480464CTDzinc chloride results in increased expression of MT2A mRNA; zinc chloride results in increased expression of MT2A proteinPMID:17637929
Mt2Amultiple interactionsEXP 6480464CTDzinc chloride promotes the reaction [Glucose results in increased expression of MT2A mRNA]PMID:23056475
Mt2Aaffects bindingISOMt2 (Mus musculus)6480464CTDzinc chloride binds to MT2 proteinPMID:16987576
Mt2Aaffects response to substanceISOMt2 (Mus musculus)6480464CTDMT2 affects the susceptibility to zinc chloridePMID:19835899
Mt2Aincreases expressionISOMT2A (Homo sapiens)6480464CTDzinc chloride results in increased expression of MT2A mRNAPMID:16870260 PMID:17234632 PMID:18947441 PMID:20471814 PMID:33645215 PMID:35027733 PMID:9138684
Mt2Aincreases expressionISOMt2 (Mus musculus)6480464CTDzinc chloride results in increased expression of MT2 mRNA; zinc chloride results in increased expression of MT2 proteinPMID:15288509 PMID:17637929 PMID:19835899
Mt2Amultiple interactionsISOMT2A (Homo sapiens)6480464CTD[zinc chloride co-treated with pyrithione zinc] results in increased expression of MT2A mRNA; Dactinomycin inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA]; epigallocatechin gallate inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA]; Grape Seed Proanthocyanidins inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA]; zinc chloride inhibits the reaction [Lipopolysaccharides results in increased expression of MT2A mRNA]PMID:17234632 PMID:20471814 PMID:20801194 PMID:9138684
Mt2Amultiple interactionsISOMt2 (Mus musculus)6480464CTDzinc chloride promotes the reaction [Cadmium Chloride results in increased expression of MT2 mRNA]PMID:16842966
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