RGD Reference Report - Early effects of surgery on zinc and metallothionein levels in female rats. - Rat Genome Database

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Early effects of surgery on zinc and metallothionein levels in female rats.

Authors: Brambila, E  Munoz-Sanchez, JL  Albores, A  Waalkes, M 
Citation: Brambila E, etal., Biol Trace Elem Res. 1999 Nov;70(2):173-82.
RGD ID: 6484135
Pubmed: (View Article at PubMed) PMID:10535526
DOI: Full-text: DOI:10.1007/BF02783858

Time-response effects of experimental surgery on zinc (Zn) and metallothionein (MT) homeostasis were investigated in female rats up to 24 h. Hepatic Zn content increased at 20 and 24 h postsurgery, whereas serum Zn levels decreased. Hepatic MT increased significantly by 9 h postsurgery and peaked at up to twofold of control at 12 h after surgery. Following the peak at 12 h, hepatic MT content decreased with time but did not reach control levels at the end of this study. When MT isoforms were evaluated, MT-II levels were elevated to the highest extent by 12 h after surgery, whereas MT-I levels started to decrease after 3 h postsurgery but then increased by 20 h. The early increases in MT content are probably mediated by nonmetallic mediators released during the postsurgical inflammatory process, favoring the plasma/tissue mobilization of Zn. This process might be part of the overall mechanisms occurring in the inflammation.


Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Mt1  (metallothionein 1)
Mt2A  (metallothionein 2A)

Genes (Mus musculus)
Mt1  (metallothionein 1)
Mt2  (metallothionein 2)

Genes (Homo sapiens)
MT1A  (metallothionein 1A)
MT2A  (metallothionein 2A)

Additional Information