GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mt2A | affects expression | EXP | | 6480464 | CTD | Zinc affects the expression of MT2A mRNA | PMID:14690761 | Mt2A | increases expression | EXP | | 6480464 | CTD | Zinc deficiency results in increased expression of MT2A; Zinc deficiency results in increased expression of MT2A mRNA; Zinc results in increased expression of MT2A mRNA | PMID:12672911 PMID:17241390 PMID:20128680 PMID:26967026 PMID:2771874 | Mt2A | multiple interactions | EXP | | 6480464 | CTD | [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased expression of MT2A mRNA; [Zinc co-treated with Iron] results in increased expression of and affects the localization of MT2A protein; SLC30A1 protein promotes the reaction [[MT1 protein co-treated with MT2 protein] inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]]; Zinc deficiency inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MT2A mRNA]; Zinc inhibits the reaction [Cadmium Chloride results in increased expression of MT2A]; Zinc results in increased expression of and affects the localization of MT2A protein | PMID:15041749 PMID:17241390 PMID:20096345 PMID:31542844 | Mt2A | affects binding | ISO | MT2A (Homo sapiens) | 6480464 | CTD | Zinc binds to MT2A protein | PMID:15698955 PMID:17224279 | Mt2A | affects binding | ISO | Mt2 (Mus musculus) | 6480464 | CTD | Zinc binds to MT2 protein | PMID:16987576 | Mt2A | affects expression | ISO | MT2A (Homo sapiens) | 6480464 | CTD | Zinc affects the expression of MT2A protein | PMID:28507149 | Mt2A | affects transport | ISO | Mt2 (Mus musculus) | 6480464 | CTD | MT2 protein affects the transport of Zinc | PMID:23274088 | Mt2A | increases expression | ISO | MT2A (Homo sapiens) | 6480464 | CTD | Zinc results in increased expression of MT2A mRNA | PMID:11127411 PMID:11168427 PMID:12716893 PMID:14568174 PMID:1502195 PMID:15226459 PMID:16870260 PMID:17363595 PMID:17409696 PMID:17409708 PMID:17590860 PMID:19097988 PMID:2173694 PMID:2830259 PMID:28507149 | Mt2A | increases expression | ISO | Mt2 (Mus musculus) | 6480464 | CTD | Zinc results in increased expression of MT2 mRNA | PMID:10605938 PMID:11525245 PMID:14617770 PMID:8560486 PMID:8917669 | Mt2A | multiple interactions | ISO | MT2A (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Zinc results in increased expression of MT2A mRNA]; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT2A mRNA; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of MT2A mRNA; [PCI 5002 co-treated with Zinc] results in increased expression of MT2A mRNA; [Zinc Sulfate results in increased abundance of Zinc] which results in increased expression of MT2A mRNA; CEBPA protein inhibits the reaction [Zinc results in increased expression of MT2A mRNA]; CEBPA protein promotes the reaction [MTF1 protein promotes the reaction [Zinc results in increased expression of MT2A mRNA]]; chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT2A mRNA]; MTF1 protein affects the reaction [[Zinc Sulfate results in increased abundance of Zinc] which results in increased expression of MT2A mRNA]; MTF1 protein promotes the reaction [Zinc results in increased expression of MT2A mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of MT2A mRNA]; Zinc deficiency inhibits the reaction [ochratoxin A results in increased expression of MT2A mRNA]; Zinc promotes the reaction [IL1A protein results in increased expression of MT2A mRNA]; Zinc promotes the reaction [IL1B protein results in increased expression of MT2A mRNA]; Zinc promotes the reaction [MTF1 protein binds to MT2A enhancer]; Zinc promotes the reaction [MTF1 protein binds to MT2A promoter]; Zinc promotes the reaction [ochratoxin A results in increased expression of MT2A mRNA] | PMID:12716893 PMID:1459136 PMID:1502195 PMID:15389791 PMID:16460681 PMID:17363595 PMID:18593933 PMID:19097988 PMID:19720134 PMID:23391613 PMID:32661532 | Mt2A | multiple interactions | ISO | Mt2 (Mus musculus) | 6480464 | CTD | [MT1 protein co-treated with MT2 protein] inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]; [MT1 protein co-treated with MT2 protein] promotes the reaction [SLC30A1 protein inhibits the reaction [SLC30A1 gene mutant form results in increased susceptibility to Zinc]]; [MT2 protein affects the susceptibility to 3,4,5,3',4'-pentachlorobiphenyl] which results in decreased abundance of Zinc; cerous chloride promotes the reaction [Zinc binds to MT2 protein]; MT2 gene mutant form inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc] | PMID:14617770 PMID:15041749 PMID:16204935 PMID:26770886 | | ||||||||||||||||||||||
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