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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1592345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mt2A
Name: metallothionein 2A
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mt2Aaffects expressionEXP 6480464CTDCadmium affects the expression of MT2A mRNA; Cadmium affects the expression of MT2A proteinPMID:12140172
Mt2Adecreases expressionEXP 6480464CTDCadmium results in decreased expression of MT2APMID:17948763
Mt2Adecreases response to substanceEXP 6480464CTDMT2A protein results in decreased susceptibility to CadmiumPMID:17443291
Mt2Aincreases expressionEXP 6480464CTDCadmium results in increased expression of MT2 mRNA; Cadmium results in increased expression of MT2A; Cadmium results in increased expression of MT2A mRNA; Cadmium results in increased expression of MT2A proteinPMID:11430474 PMID:11750084 PMID:12854162 PMID:12974610 PMID:15748513 PMID:16226777 PMID:17327699 PMID:17443291 PMID:20238111 PMID:23916567 PMID:25388156 PMID:2771874 PMID:32879253 PMID:7597713 PMID:8845041
Mt2Amultiple interactionsEXP 6480464CTD[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in increased expression of MT2A mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MT2A mRNA; Acetylcysteine inhibits the reaction [[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in increased expression of MT2A mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MT2A mRNA]; Quercetin promotes the reaction [Cadmium results in increased expression of MT2 mRNA]PMID:16226777 PMID:33188856
Mt2Aaffects abundanceISOMT2A (Homo sapiens)6480464CTDMT2A gene SNP affects the abundance of CadmiumPMID:21328412
Mt2Aaffects bindingISOMT2A (Homo sapiens)6480464CTDCadmium binds to MT2A proteinPMID:15698955
Mt2Aaffects bindingISOMt2 (Mus musculus)6480464CTDMT2 protein binds to CadmiumPMID:22001350
Mt2Aaffects expressionISOMT2A (Homo sapiens)6480464CTDCadmium affects the expression of MT2A proteinPMID:28507149
Mt2Aaffects expressionISOMt2 (Mus musculus)6480464CTDCadmium affects the expression of MT2 mRNAPMID:25294218
Mt2Aaffects response to substanceISOMt2 (Mus musculus)6480464CTDMT2 protein affects the susceptibility to CadmiumPMID:7890668
Mt2Aaffects transportISOMT2A (Homo sapiens)6480464CTDMT2A promoter polymorphism affects the transport of CadmiumPMID:25157674
Mt2Adecreases response to substanceISOMT2A (Homo sapiens)6480464CTDMT2A protein results in decreased susceptibility to CadmiumPMID:19433272 PMID:29982767
Mt2Aincreases abundanceISOMT2A (Homo sapiens)6480464CTDMT2A promoter polymorphism results in increased abundance of CadmiumPMID:20303360
Mt2Aincreases expressionISOMT2A (Homo sapiens)6480464CTDCadmium results in increased expression of MT2A mRNA; Cadmium results in increased expression of MT2A proteinPMID:11032763 PMID:12716893 PMID:14568174 PMID:15664440 PMID:15967203 PMID:17409696 PMID:17409708 PMID:17590860 PMID:20801194 PMID:22562489 PMID:24284285 PMID:24376830 PMID:2830259 PMID:28507149
Mt2Aincreases expressionISOMt2 (Mus musculus)6480464CTDCadmium results in increased expression of MT2 mRNAPMID:10605938 PMID:24067728 PMID:24077948 PMID:24496640 PMID:26187450 PMID:8560486 PMID:8917669
Mt2Amultiple interactionsISOMT2A (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MT2A mRNA; [Chromium co-treated with Cadmium co-treated with Lead] results in increased expression of MT2A mRNA; chromium hexavalent ion inhibits the reaction [Cadmium results in increased expression of MT2A mRNA]; EGF protein affects the reaction [Cadmium affects the expression of MT2A protein]; MT2A protein affects the reaction [Cadmium affects the expression of XAF1 protein]; MT2A protein affects the reaction [Cadmium results in increased expression of TP53 protein]; MT2A protein affects the reaction [EGF protein affects the reaction [Cadmium affects the expression of XAF1 protein]]; MT2A protein affects the reaction [EGF protein inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]]; MT2A protein inhibits the reaction [Cadmium results in decreased expression of TP53 protein mutant form]; MT2A protein inhibits the reaction [Cadmium results in decreased expression of XIAP protein]; MT2A protein inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; MT2A protein inhibits the reaction [Cadmium results in increased expression of BAX mRNA]; MT2A protein inhibits the reaction [Cadmium results in increased expression of BBC3 mRNA]; XAF1 protein affects the reaction [Cadmium affects the expression of MT2A protein]PMID:11032763 PMID:12716893 PMID:28507149 PMID:29982767 PMID:31738976 PMID:35301059
Mt2Amultiple interactionsISOMt2 (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MT2 mRNA; [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT2 protein binds to Cadmium]; [MT1 protein co-treated with MT2 protein] inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; [MT1 protein co-treated with MT2 protein] inhibits the reaction [Cadmium results in increased phosphorylation of MAPK9 protein]; [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of MT2 mRNA; MT2A protein inhibits the reaction [Cadmium results in increased cleavage of BAX protein]PMID:16568437 PMID:22001350 PMID:29982767 PMID:31904401 PMID:32645461 PMID:33387572 PMID:33398418 PMID:33483743 PMID:35212737 PMID:36114956 PMID:37325564
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