Rorc (RAR-related orphan receptor C)

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Gene: Rorc (RAR-related orphan receptor C) Rattus norvegicus

Analyze

Symbol:

Rorc

Name:

RAR-related orphan receptor C

RGD ID:

1595785

Description:

Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; oxysterol binding activity; and transcription coactivator binding activity. Involved in circadian rhythm. Predicted to be located in external side of plasma membrane and nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 42. Orthologous to human RORC (RAR related orphan receptor C); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC368158; MGC189525; nuclear receptor ROR-gamma; RAR-related orphan receptor gamma; similar to Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Thymus orphan receptor) (TOR)

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RORC (RAR related orphan receptor C)	RGD	RGD
Mus musculus (house mouse):	Rorc (RAR-related orphan receptor gamma)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Rorc (RAR related orphan receptor C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RORC (RAR related orphan receptor C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RORC (RAR related orphan receptor C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rorc (RAR related orphan receptor C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RORC (RAR related orphan receptor C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RORC (RAR related orphan receptor C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rorc (RAR related orphan receptor C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RORC (RAR related orphan receptor C)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rorc (RAR-related orphan receptor gamma)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rorc (RAR-related orphan receptor C)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	nhr-23	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Hr3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Rorc^em3Mcwi Rorc^em5Mcwi

Genetic Models:

LEW-Rorc^em3Mcwi LEW-Rorc^em5Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	182,009,707 - 182,034,910 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	182,009,286 - 182,034,907 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	2	195,612,471 - 195,636,797 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	195,617,021 - 195,637,630 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
RGSC_v3.4	2	189,345,134 - 189,369,442 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	174,560,165 - 174,584,474 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

advanced sleep phase syndrome (ISO)

Animal Toxoplasmosis (ISO)

bacterial pneumonia (ISO)

Dysbiosis (IEP)

dyschromatosis symmetrica hereditaria (ISO)

Experimental Autoimmune Myocarditis (IEP)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

immunodeficiency 42 (ISO)

Inflammation (ISO)

MHC class II deficiency (ISO)

parathyroid carcinoma (ISO)

severe congenital neutropenia 3 (ISO)

severe congenital neutropenia 5 (ISO)

Sjogren's syndrome (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-Tetrandrine (ISO)

(R)-mevalonic acid (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (ISO)

14-Deoxy-11,12-didehydroandrographolide (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-tert-butylhydroquinone (ISO)

25-hydroxycholesterol (ISO)

3-chloropropane-1,2-diol (EXP)

3-phenoxybenzoic acid (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

alloxan (ISO)

alpha-galactosylceramide (ISO)

arsane (ISO)

arsenic atom (ISO)

azoxystrobin (EXP,ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bifenthrin (ISO)

biochanin A (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

buspirone (EXP)

buta-1,3-diene (ISO)

butanal (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

calciol (ISO)

calcitriol (ISO)

cannabidiol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chloroprene (ISO)

chlorpyrifos (EXP,ISO)

chrysene (ISO)

clofibrate (ISO)

cyclophosphamide (ISO)

cycloprothrin (ISO)

cyclosporin A (ISO)

cyhalothrin (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diclofenac (ISO)

digoxigenin (ISO)

digoxin (ISO)

dihydroouabain (ISO)

endosulfan (EXP,ISO)

epoxiconazole (ISO)

flucloxacillin (ISO)

flutamide (EXP)

fluvalinate (ISO)

folic acid (ISO)

formaldehyde (ISO)

fragrance (ISO)

gentamycin (EXP)

glafenine (EXP)

glyphosate (EXP)

Helveticoside (ISO)

hexaconazole (ISO)

imidacloprid (EXP)

imiquimod (ISO)

indoxyl sulfate (ISO)

lead(0) (ISO)

lead(2+) (ISO)

leflunomide (ISO)

levamisole (ISO)

methamphetamine (EXP)

N-Nitrosopyrrolidine (ISO)

nefazodone (EXP)

nickel atom (ISO)

nimesulide (EXP)

O-methyleugenol (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

phenobarbital (ISO)

pioglitazone (ISO)

pirinixic acid (ISO)

platycodin D (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

prostaglandin D2 (ISO)

prostaglandin E2 (ISO)

rofecoxib (ISO)

S-butyl-DL-homocysteine (S,R)-sulfoximine (EXP)

simvastatin (ISO)

sodium arsenite (EXP,ISO)

strophanthidin (ISO)

sulforaphane (ISO)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

thiabendazole (EXP)

thioacetamide (EXP)

thymoquinone (ISO)

tofacitinib (ISO)

toluene 2,4-diisocyanate (ISO)

trichloroethene (ISO)

triflumizole (ISO)

Triptolide (ISO)

triptonide (ISO)

Tryptanthrine (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adipose tissue development (ISO)

alpha-beta T cell differentiation (ISO)

cell differentiation (ISO)

cellular response to sterol (ISO)

circadian regulation of gene expression (ISO)

circadian rhythm (IEP)

DNA-templated transcription (IEA)

intracellular receptor signaling pathway (IEA)

lymph node development (ISO)

mucosa-associated lymphoid tissue development (ISO)

negative regulation of thymocyte apoptotic process (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

Peyer's patch development (ISO)

positive regulation of circadian rhythm (ISO)

positive regulation of DNA-templated transcription (ISO)

protein phosphorylation (ISO)

regulation of fat cell differentiation (ISO)

regulation of gamma-delta T cell differentiation (ISO)

regulation of glucose metabolic process (ISO)

regulation of steroid metabolic process (ISO)

regulation of transcription by RNA polymerase II (IBA,ISO)

T cell differentiation in thymus (ISO)

T-helper 17 cell differentiation (ISO)

T-helper cell differentiation (ISO)

xenobiotic metabolic process (ISO)

Cellular Component

cellular_component (ND)

external side of plasma membrane (ISO)

nuclear body (ISO)

nucleus (IBA,ISO)

Molecular Function

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (ISO)

DNA-binding transcription repressor activity, RNA polymerase II-specific (ISO)

ligand-activated transcription factor activity (ISO)

molecular_function (ND)

nuclear receptor activity (IBA)

oxysterol binding (IBA,ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,ISO)

sequence-specific double-stranded DNA binding (ISO)

transcription coactivator binding (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulatory T cell activity is partly inhibited in a mouse model of chronic Pseudomonas aeruginosa lung infection.	Ding FM, etal., Exp Lung Res. 2015 Feb;41(1):44-55. doi: 10.3109/01902148.2014.964351. Epub 2014 Nov 14.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Circadian expression of clock genes and clock-controlled genes in the rat retina.	Kamphuis W, etal., Biochem Biophys Res Commun. 2005 Apr 29;330(1):18-26.
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation
7.	Bupi Hewei decoction ameliorates 5-fluorouracil-induced intestinal dysbiosis in rats through T helper 17/T regulatory cell signaling pathway.	Sun Z, etal., J Tradit Chin Med. 2020 Feb;40(1):38-48.
8.	The Treg/Th17 imbalance in Toxoplasma gondii-infected pregnant mice.	Zhang H, etal., Am J Reprod Immunol. 2012 Feb;67(2):112-21. doi: 10.1111/j.1600-0897.2011.01065.x. Epub 2011 Sep 19.
9.	Fibrinogen-like protein-2 causes deterioration in cardiac function in experimental autoimmune myocarditis rats through regulation of programmed death-1 and inflammatory cytokines.	Zheng Z, etal., Immunology. 2018 Feb;153(2):246-252. doi: 10.1111/imm.12837. Epub 2017 Oct 16.

Additional References at PubMed

PMID:12477932	PMID:14691482	PMID:15010863	PMID:15247480	PMID:16148126	PMID:16990136	PMID:17476214	PMID:17666523	PMID:18164222	PMID:18368049	PMID:18792410	PMID:19965867
PMID:20427770	PMID:21628546	PMID:21737317	PMID:21853531	PMID:22753030	PMID:23034280	PMID:23723244	PMID:25470037	PMID:27055905	PMID:27545881	PMID:28093217	PMID:30738851
PMID:32924545	PMID:33834668

Genomics

Comparative Map Data

Rorc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	182,009,707 - 182,034,910 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	182,009,286 - 182,034,907 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	2	195,612,471 - 195,636,797 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	195,617,021 - 195,637,630 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
RGSC_v3.4	2	189,345,134 - 189,369,442 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	174,560,165 - 174,584,474 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

RORC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	151,806,071 - 151,831,802 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	151,806,071 - 151,831,845 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	151,778,547 - 151,804,278 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	150,045,171 - 150,070,972 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	148,591,621 - 148,617,421	NCBI
Celera	1	124,893,230 - 124,919,042 (-)	NCBI		Celera
Cytogenetic Map	1	q21.3	NCBI
HuRef	1	123,155,515 - 123,181,337 (-)	NCBI		HuRef
CHM1_1	1	153,173,871 - 153,199,672 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	150,929,559 - 150,955,307 (-)	NCBI		T2T-CHM13v2.0

Rorc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	94,280,101 - 94,305,583 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	94,280,101 - 94,305,583 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	94,372,794 - 94,398,276 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	94,372,794 - 94,398,276 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	94,176,748 - 94,202,161 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	94,458,190 - 94,483,992 (+)	NCBI		MGSCv36	mm8
Celera	3	95,819,177 - 95,843,048 (+)	NCBI		Celera
Cytogenetic Map	3	F2.1	NCBI

Rorc
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955589	590,743 - 616,694 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955589	590,653 - 616,784 (+)	NCBI	ChiLan1.0	ChiLan1.0

RORC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	130,808,705 - 130,834,490 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	130,808,705 - 130,834,490 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	127,164,725 - 127,190,479 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

RORC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	60,821,498 - 60,842,485 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	60,821,981 - 60,842,453 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	60,263,366 - 60,285,188 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	61,838,557 - 61,860,379 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	61,837,962 - 61,860,343 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	60,665,332 - 60,687,158 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	60,751,477 - 60,773,308 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	61,480,593 - 61,502,436 (-)	NCBI		UU_Cfam_GSD_1.0

Rorc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	22,967,256 - 22,990,222 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	1,997,640 - 2,020,649 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936580	1,997,640 - 2,020,649 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RORC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	97,375,136 - 97,400,209 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	97,374,672 - 97,399,017 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	106,397,490 - 106,421,980 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RORC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	11,854,911 - 11,880,221 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	11,855,005 - 11,879,717 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	11,414,109 - 11,440,149 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rorc
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624772	19,477,093 - 19,501,169 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624772	19,478,403 - 19,501,184 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rorc
79 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	245
Count of miRNA genes:	148
Interacting mature miRNAs:	188
Transcripts:	ENSRNOT00000067042
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43154682	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	112456140	212696837	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	112456140	212696837	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	114837527	185876470	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	185876470	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	114837527	211674221	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	114837675	212549332	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	133914684	202447032	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	135552573	202446871	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	136445150	202447032	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	136916935	189599348	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	136916935	213594495	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141194931	223265385	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	141194931	223265385	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	141596551	202447032	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	143157029	210020885	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	143657411	190602963	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	143657411	190602963	Rat
6903312	Bw112	Body weight QTL 112	3.2	0.0013	body mass (VT:0001259)	body weight (CMO:0000012)	2	143657569	184114274	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	144599348	189599348	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	147798556	192798556	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	221167075	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150341585	189039377	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150341684	202446871	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150540301	202447032	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	150540301	202447032	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	152413072	185122374	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	152413072	185122374	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	152413072	185122374	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	152413072	185122374	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	152413072	185122374	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	157142078	192625452	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	157142078	211086598	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	157142209	202446871	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	160564068	205564068	Rat
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	161699179	222436696	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	162765032	207765032	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
1598838	Bp290	Blood pressure QTL 290	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166539266	211539266	Rat
1549833	Bp257	Blood pressure QTL 257		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168354880	185122374	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168358098	223265385	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	168594495	213594495	Rat
61469	Bp16	Blood pressure QTL 16	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	169745596	214745596	Rat
70162	Bp63	Blood pressure QTL 63	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	169745596	214745596	Rat
631522	Bp74	Blood pressure QTL 74		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	172710921	184114403	Rat
2293084	Iddm26	Insulin dependent diabetes mellitus QTL 26	2.9		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	174930955	213594495	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	179335906	224335906	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	179946951	224946951	Rat

Markers in Region

RH144654

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	182,024,606 - 182,024,759 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	195,627,323 - 195,627,475	NCBI	Rnor6.0
Rnor_5.0	2	215,106,017 - 215,106,169	UniSTS	Rnor5.0
RGSC_v3.4	2	189,359,964 - 189,360,116	UniSTS	RGSC3.4
Celera	2	174,574,996 - 174,575,148	UniSTS
RH 3.4 Map	2	1199.1	UniSTS
Cytogenetic Map	2	q34	UniSTS

Genetic Models

This gene Rorc is modified in the following models/strains

LEW-Rorc^em3Mcwi

LEW-Rorc^em5Mcwi

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			6		6
Low	3	19	33	23	2	23	4	7	4	27	27	8	4
Below cutoff		12	8	8	11	8	4	4	10	4	10	3	4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_006232926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761339	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC133978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC169105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000067042 ⟹ ENSRNOP00000058884

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	182,014,289 - 182,034,907 (+)	Ensembl
Rnor_6.0 Ensembl	2	195,617,021 - 195,637,630 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000101844 ⟹ ENSRNOP00000079633

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	182,009,286 - 182,034,907 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111824 ⟹ ENSRNOP00000089381

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	182,014,326 - 182,033,606 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000118722 ⟹ ENSRNOP00000086848

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	182,009,617 - 182,034,907 (+)	Ensembl

RefSeq Acc Id:

XM_006232926 ⟹ XP_006232988

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	182,009,715 - 182,034,910 (+)	NCBI
Rnor_6.0	2	195,612,473 - 195,636,797 (+)	NCBI

Sequence:

show sequence

CTCTTCCCTCCTCCCTCCCCTGGGCCCTGCTCCCTGCCCTCCTGGGCAGCCAGGGCAGCAAGGA
CGGCACCAAGGGAGCTACCCCATGGACAGGGCCCCACAGAGACACCACCGAACATCTCGGGAGT
TGCTGGCTGCAAAGAAGACCCACACCTCACAAATCGAAGTGATCCCTTGCAAGATCTGTGGGGA
CAAGTCATCTGGCATCCACTACGGGGTTATCACCTGTGAGGGGTGCAAGGGCTTCTTCCGCCGC
AGCCAGCAGTGCAATGTGGCCTACTCCTGCACCCGTCAGCAGAACTGCCCCATTGACCGAACCA
GCCGCAACCGATGCCAGCACTGCCGCCTGCAGAAGTGCCTGGCTCTGGGCATGTCCAGAGATGC
TGTCAAGTTCGGCCGAATGTCCAAGAAGCAGAGGGACAGTCTGCATGCAGAGGTGCAGAAACAA
CTGCAACAGCAGCAGCAACGGGAACAAGTAGCCAAGACTCCTCCAGCTGGGAGCCATGGAGCAG
ACACACTCACATACACTTTAGGGGTCCCAGATGGGCAGCTACCACTGGGCGCCTCACCTGACCT
GCCCGAGGCCTCTGCTTGTCCCCCTGGCCTCCTGAGAGCCTCAGGCTCTGGCCCACCATATTCC
AATACCTTGGCCAAAACAGAGGTCCAAGGGGCCTCCTGCCACCTTGAGTATAGCCCAGAGCGAG
GCAAAGCTGAAGGCAGAGACAGCATCTATAGCACTGACGGCCAGCTTACTCTTGGAAGACGTGG
ACTTCAGCTTGGGGAACCAGAACAGGGCTCAGACAGCCACTGCAGTCCCAGTTTCTGCAGTGCC
CCAGAGGCACCATATGCCTCTCTGACAGACATAGAGTACCTGGTACAGAATGTCTGCAAGTCCT
ACCGAGAGACGTGCCAGCTACGCCTGGAGGACCTTCTACGGCAGCGCACCAACCTCTTCTCACG
GGAGGAGGTGACCAGCTACCAGAGGAAGTCAATGTGGGAGATGTGGGAGCGCTGTGCCCACCAC
CTCACTGAGGCCATTCAGTACGTGGTGGAGTTCGCCAAGCGGCTCTCAGGCTTCATGGAGCTGT
GCCAGAATGATCAGATCATACTACTGAAAGCAGGAGCAATGGAAGTCGTCCTCGTCAGAATGTG
CCGGGCCTACAATGCCAACAACCACACAGTCTTTTTTGAAGGCAAATACGGTGGTGTGGAGCTG
TTCCGAGCCTTGGGCTGCAGCGAGCTCATCAGCTCCATATTCGACTTTTCCCACTTCCTCAGCG
CCCTGTGTTTTTCTGAGGATGAGATTGCCCTCTACACGGCCTTGGTTCTCATCAATGCCAACCG
TCCTGGGCTCCAAGAAAAGAGGAGAGTGGAGCATCTGCAATACAATTTGGAGCTGGCCTTTCAT
CATCATCTCTGCAAGACTCATCGACAAGGCCTCCTAGCCAAGCTGCCACCCAAGGGGAAGCTCC
GGAGCCTGTGCAGCCAACATGTGGAAAAGCTACAGGACTTCCAGCACCTCCACCCCATCGTGGT
CCAAGCCGCCTTCCCTCCACTCTATAAGGAACTCTTCAGCACTGACATTGAGTCCTCTGAGGGG
CTGTCAAAGTGACCCGGAGGAAGGACAACTTTCTACTTCCTTCAGCCCTCTGACCGTCTCCCTG
GACTCCACTCACCAGCCTTTCCCTCTCTGCACTCTGTGAAGGGTGATCTCCCTAGGAGTCAAAT
ACTAAGACTGGTTTCTGCCCCTAGGCTTGCCCGGTAGTGCCACAGCAGCAAGCGATGGAGAAAA
GGCTTGTCATGTTTGATTTCCCATAAGTTCCACCCTGGCTCTGGAAGCTGTGGGATAGATGGGA
TATAGGATGACCGAGTCAAACAAACAAAAAGCCAGAAAGACAAACATCGGGGATAAATCCAAGT
ACCTGGGATGAGAGAACTCAAACCTAGGCTCAGAAGCTAATAACAGACCTTTCAATACCTCACT
GTATTTCTCCACAGGCTCCTCCTGGGGGAGATGGATCTAGCTCAGAGACTGGTGGCAAGCACCC
AGAAGGACCTGTATATAACAAGAATATGGATTCTTGAGA

hide sequence

RefSeq Acc Id:

XM_017591313 ⟹ XP_017446802

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	182,009,707 - 182,034,910 (+)	NCBI
Rnor_6.0	2	195,612,471 - 195,636,797 (+)	NCBI

Sequence:

show sequence

CCCTCTTCCCTCCTCCCTCCCCTGGGCCCTGCTCCCTGCCCTCCTGGGCAGCCAGGGCAGCAAG
GACGGCACCAAGGGAGCTACCCCATGGACAGGGCCCCACAGAGACACCACCGAACATCTCGGGA
GTTGCTGGCTGCAAAGAAGACCCACACCTCACAAATCGAAGTGATCCCTTGCAAGATCTGTGGG
GACAAGTCATCTGGCATCCACTACGGGGTTATCACCTGTGAGGGGTGCAAGGGCTTCTTCCGCC
GCAGCCAGCAGTGCAATGTGGCCTACTCCTGCACCCGTCAGCAGAACTGCCCCATTGACCGAAC
CAGCCGCAACCGATGCCAGCACTGCCGCCTGCAGAAGTGCCTGGCTCTGGGCATGTCCAGAGAT
GCTGTCAAGTTCGGCCGAATGTCCAAGAAGCAGAGGGACAGTCTGCATGCAGAGGTGCAGAAAC
AACTGCAACAGCAGCAGCAACGGGAACAAGTAGCCAAGACTCCTCCAGCTGGGAGCCATGGAGC
AGACACACTCACATACACTTTAGGGGTCCCAGATGGGCAGCTACCACTGGGCGCCTCACCTGAC
CTGCCCGAGGCCTCTGCTTGTCCCCCTGGCCTCCTGAGAGCCTCAGGCTCTGGCCCACCATATT
CCAATACCTTGGCCAAAACAGAGGTCCAAGGGGCCTCCTGCCACCTTGAGTATAGCCCAGAGCG
AGGCAAAGCTGAAGGCAGAGACAGCATCTATAGCACTGACGGCCAGCTTACTCTTGGAAGACGT
GGACTTCAGCTTGGGGAACCAGAACAGGGCTCAGACAGCCACTGCAGTCCCAGTTTCTGCAGTG
CCCCAGAGGCACCATATGCCTCTCTGACAGACATAGAGTACCTGGTACAGAATGTCTGCAAGTC
CTACCGAGAGACGTGCCAGCTACGCCTGGAGGACCTTCTACGGCAGCGCACCAACCTCTTCTCA
CGGGAGGAGGTGACCAGCTACCAGAGGAAGTCAATGTGGGAGATGTGGGAGCGCTGTGCCCACC
ACCTCACTGAGGCCATTCAGTACGTGGTGGAGTTCGCCAAGCGGCTCTCAGGCTTCATGGAGCT
GTGCCAGAATGATCAGATCATACTACTGAAAGCAGGAGCAATGGAAGTCGTCCTCGTCAGAATG
TGCCGGGCCTACAATGCCAACAACCACACAGTCTTTTTTGAAGGCAAATACGGTGGTGTGGAGC
TGTTCCGAGCCTTGGACCGTCCTGGGCTCCAAGAAAAGAGGAGAGTGGAGCATCTGCAATACAA
TTTGGAGCTGGCCTTTCATCATCATCTCTGCAAGACTCATCGACAAGGCCTCCTAGCCAAGCTG
CCACCCAAGGGGAAGCTCCGGAGCCTGTGCAGCCAACATGTGGAAAAGCTACAGGACTTCCAGC
ACCTCCACCCCATCGTGGTCCAAGCCGCCTTCCCTCCACTCTATAAGGAACTCTTCAGCACTGA
CATTGAGTCCTCTGAGGGGCTGTCAAAGTGACCCGGAGGAAGGACAACTTTCTACTTCCTTCAG
CCCTCTGACCGTCTCCCTGGACTCCACTCACCAGCCTTTCCCTCTCTGCACTCTGTGAAGGGTG
ATCTCCCTAGGAGTCAAATACTAAGACTGGTTTCTGCCCCTAGGCTTGCCCGGTAGTGCCACAG
CAGCAAGCGATGGAGAAAAGGCTTGTCATGTTTGATTTCCCATAAGTTCCACCCTGGCTCTGGA
AGCTGTGGGATAGATGGGATATAGGATGACCGAGTCAAACAAACAAAAAGCCAGAAAGACAAAC
ATCGGGGATAAATCCAAGTACCTGGGATGAGAGAACTCAAACCTAGGCTCAGAAGCTAATAACA
GACCTTTCAATACCTCACTGTATTTCTCCACAGGCTCCTCCTGGGGGAGATGGATCTAGCTCAG
AGACTGGTGGCAAGCACCCAGAAGGACCTGTATATAACAAGAATATGGATTCTTGAGA

hide sequence

RefSeq Acc Id:

XM_039103783 ⟹ XP_038959711

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	182,016,584 - 182,034,910 (+)	NCBI

RefSeq Acc Id:

XM_039103784 ⟹ XP_038959712

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	182,009,708 - 182,034,910 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_006232988	(Get FASTA)	NCBI Sequence Viewer
	XP_017446802	(Get FASTA)	NCBI Sequence Viewer
	XP_038959711	(Get FASTA)	NCBI Sequence Viewer
	XP_038959712	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI69105	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_006232988 ⟸ XM_006232926
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GEH3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVA YSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQR EQVAKTPPAGSHGADTLTYTLGVPDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTE VQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRRGLQLGEPEQGSDSHCSPSFCSAPEAPYAS LTDIEYLVQNVCKSYRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQY VVEFAKRLSGFMELCQNDQIILLKAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCS ELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTH RQGLLAKLPPKGKLRSLCSQHVEKLQDFQHLHPIVVQAAFPPLYKELFSTDIESSEGLSK hide sequence

RefSeq Acc Id:

XP_017446802 ⟸ XM_017591313

- Peptide Label:

isoform X2

- Sequence:

show sequence

MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVA
YSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQR
EQVAKTPPAGSHGADTLTYTLGVPDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTE
VQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRRGLQLGEPEQGSDSHCSPSFCSAPEAPYAS
LTDIEYLVQNVCKSYRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQY
VVEFAKRLSGFMELCQNDQIILLKAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALDRP
GLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQDFQHLHPIVVQ
AAFPPLYKELFSTDIESSEGLSK

hide sequence

RefSeq Acc Id:

ENSRNOP00000058884 ⟸ ENSRNOT00000067042

RefSeq Acc Id:	XP_038959712 ⟸ XM_039103784
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038959711 ⟸ XM_039103783
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSRNOP00000086848 ⟸ ENSRNOT00000118722

RefSeq Acc Id:

ENSRNOP00000089381 ⟸ ENSRNOT00000111824

RefSeq Acc Id:

ENSRNOP00000079633 ⟸ ENSRNOT00000101844

Protein Domains

NR LBD Nuclear receptor

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2QC01-F1-model_v2	AlphaFold	A0A0G2QC01	1-487	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1595785	AgrOrtholog
BioCyc Gene	G2FUF-52167	BioCyc
Ensembl Genes	ENSRNOG00000020836	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000058884.3	UniProtKB/TrEMBL
	ENSRNOP00000079633.1	UniProtKB/TrEMBL
	ENSRNOP00000086848	ENTREZGENE
	ENSRNOP00000086848.1	UniProtKB/TrEMBL
	ENSRNOP00000089381.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000067042.4	UniProtKB/TrEMBL
	ENSRNOT00000101844.1	UniProtKB/TrEMBL
	ENSRNOT00000111824.1	UniProtKB/TrEMBL
	ENSRNOT00000118722	ENTREZGENE
	ENSRNOT00000118722.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.565.10	UniProtKB/TrEMBL
	3.30.50.10	UniProtKB/TrEMBL
InterPro	NHR_like_domain	UniProtKB/TrEMBL
	NR_DBD_ROR	UniProtKB/TrEMBL
	Nucl_hrmn_rcpt_lig-bd_core	UniProtKB/TrEMBL
	Nuclear_hrmn_rcpt	UniProtKB/TrEMBL
	ROR_rcpt	UniProtKB/TrEMBL
	Znf_hrmn_rcpt	UniProtKB/TrEMBL
	Znf_NHR/GATA	UniProtKB/TrEMBL
NCBI Gene	368158	ENTREZGENE
PANTHER	NUCLEAR HORMONE RECEPTOR HR3-RELATED	UniProtKB/TrEMBL
	NUCLEAR RECEPTOR ROR-GAMMA	UniProtKB/TrEMBL
Pfam	Hormone_recep	UniProtKB/TrEMBL
	zf-C4	UniProtKB/TrEMBL
PhenoGen	Rorc	PhenoGen
PRINTS	RORNUCRECPTR	UniProtKB/TrEMBL
	STRDHORMONER	UniProtKB/TrEMBL
	STROIDFINGER	UniProtKB/TrEMBL
PROSITE	NR_LBD	UniProtKB/TrEMBL
	NUCLEAR_REC_DBD_1	UniProtKB/TrEMBL
	NUCLEAR_REC_DBD_2	UniProtKB/TrEMBL
SMART	HOLI	UniProtKB/TrEMBL
	ZnF_C4	UniProtKB/TrEMBL
Superfamily-SCOP	Glucocorticoid receptor-like (DNA-binding domain)	UniProtKB/TrEMBL
	Str_ncl_receptor	UniProtKB/TrEMBL
UniProt	A0A0G2QC01_RAT	UniProtKB/TrEMBL
	A0A8I5ZN69_RAT	UniProtKB/TrEMBL
	A0A8I6A746_RAT	UniProtKB/TrEMBL
	A0A8I6GEH3	ENTREZGENE, UniProtKB/TrEMBL
	B5DFL4_RAT	UniProtKB/TrEMBL
UniProt Secondary	F1LNV3	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-11	Rorc	RAR-related orphan receptor C	Rorc	RAR-related orphan receptor c	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Rorc	RAR-related orphan receptor c	LOC368158	similar to Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Thymus orphan receptor) (TOR)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC368158	similar to Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Thymus orphan receptor) (TOR)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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