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Gene: Rorc (RAR-related orphan receptor gamma) Mus musculus
Symbol: Rorc
Name: RAR-related orphan receptor gamma
Description: Exhibits DNA-binding transcription factor activity; sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; interleukin-17 secretion; and regulation of gene expression. Localizes to external side of plasma membrane and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; sensory organ; and thyroid gland. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human RORC (RAR related orphan receptor C); INTERACTS WITH (+)-Tetrandrine; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Nr1f3; nuclear receptor ROR-gamma; nuclear receptor RZR-gamma; nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; retinoid-related orphan receptor-gamma; RORgamma; Thor; thymus orphan receptor; TOR
Homo sapiens (human) : RORC (RAR related orphan receptor C)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Rorc (RAR-related orphan receptor C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rorc (RAR related orphan receptor C)
Pan paniscus (bonobo/pygmy chimpanzee) : RORC (RAR related orphan receptor C)
Canis lupus familiaris (dog) : RORC (RAR related orphan receptor C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rorc (RAR related orphan receptor C)
Sus scrofa (pig) : RORC (RAR related orphan receptor C)
Chlorocebus sabaeus (African green monkey) : RORC (RAR related orphan receptor C)
Heterocephalus glaber (naked mole-rat) : Rorc (RAR related orphan receptor C)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl394,372,794 - 94,398,276 (+)EnsemblGRCm38mm10GRCm38
GRCm38394,372,794 - 94,398,276 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37394,176,748 - 94,202,161 (+)NCBIGRCm37mm9NCBIm37
MGSCv36394,458,190 - 94,483,992 (+)NCBImm8
Celera395,819,177 - 95,843,048 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Rorc
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317897
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.