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Gene: Gpx1 (glutathione peroxidase 1) Rattus norvegicus
Symbol: Gpx1
Name: glutathione peroxidase 1
RGD ID: 2729
Description: Exhibits glutathione peroxidase activity. Involved in several processes, including cellular response to glucose stimulus; hydrogen peroxide catabolic process; and response to estradiol. Localizes to cytosol; mitochondrion; and nucleus. Predicted to colocalize with Lewy body. Used to study several diseases, including cataract; gestational diabetes; hypertension; hyperthyroidism; and hypothyroidism. Biomarker of hyperhomocysteinemia; hypertension; iron deficiency anemia; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); nutritional deficiency disease (multiple); and pseudoxanthoma elasticum. Orthologous to human GPX1 (glutathione peroxidase 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; (+)-taxifolin; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cellular glutathione peroxidase; GPx-1; GSHPx; GSHPx-1
Homo sapiens (human) : GPX1 (glutathione peroxidase 1)  HGNC  Alliance
Mus musculus (house mouse) : Gpx1 (glutathione peroxidase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpx1 (glutathione peroxidase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GPX1 (glutathione peroxidase 1)
Canis lupus familiaris (dog) : GPX1 (glutathione peroxidase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpx1 (glutathione peroxidase 1)
Sus scrofa (pig) : GPX1 (glutathione peroxidase 1)
Chlorocebus sabaeus (African green monkey) : GPX1 (glutathione peroxidase 1)
Heterocephalus glaber (naked mole-rat) : Gpx1 (glutathione peroxidase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.08117,117,430 - 117,118,528 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,117,430 - 117,118,522 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,466,118 - 116,467,216 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,329,847 - 108,330,945 (+)ENTREZGENECelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

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