Maoa (monoamine oxidase A) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Maoa (monoamine oxidase A) Rattus norvegicus
Analyze
Symbol: Maoa
Name: monoamine oxidase A
RGD ID: 61898
Description: Enables heterocyclic compound binding activity and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Involved in phenylethylamine metabolic process and serotonin metabolic process. Located in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; Brunner Syndrome; alcohol use disorder; autism spectrum disorder; and panic disorder. Orthologous to human MAOA (monoamine oxidase A); PARTICIPATES IN alkaptonuria pathway; citalopram pharmacodynamics pathway; citalopram pharmacokinetics pathway; INTERACTS WITH (+)-catechin; (5-hydroxyindol-3-yl)acetic acid; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: amine oxidase [flavin-containing] A; Mao; MAO-A; monoamine oxidase; monoamine oxidase type A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X8,615,239 - 8,681,372 (-)NCBIGRCr8
mRatBN7.2X6,032,172 - 6,098,308 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX6,030,795 - 6,099,593 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX6,087,389 - 6,153,584 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X9,563,201 - 9,629,388 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X5,883,319 - 5,949,461 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X6,554,698 - 6,620,722 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX6,554,698 - 6,620,722 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X7,373,101 - 7,439,125 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X17,678,960 - 17,745,908 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X17,731,861 - 17,799,225 (-)NCBI
CeleraX6,522,076 - 6,588,367 (-)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+-)-Carnegine  (ISO)
(-)-Salsoline  (ISO)
(-)-selegiline  (ISO)
(1->4)-beta-D-glucan  (ISO)
(5-hydroxyindol-3-yl)acetaldehyde  (ISO)
(5-hydroxyindol-3-yl)acetic acid  (EXP)
(R)-noradrenaline  (ISO)
(R)-salsolinol  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-Methylenedioxyamphetamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methyl-N'-(phenylmethyl)-3-isoxazolecarbohydrazide  (ISO)
5-methyltryptamine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
almotriptan  (ISO)
alpha-methyltryptamine  (ISO)
alpha-Zearalanol  (ISO)
amitraz  (EXP)
amitriptyline  (EXP)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
antimonite  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
astragaloside IV  (EXP)
atrazine  (EXP,ISO)
befloxatone  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzyl benzoate  (ISO)
benzyl cinnamate  (ISO)
beta-carboline  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbidopa  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chrysene  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clorgyline  (EXP,ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichlorvos  (EXP)
diclofenac  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dizocilpine maleate  (EXP)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
finasteride  (EXP)
flavanone  (ISO)
flavone  (ISO)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycidyl methacrylate  (ISO)
harmaline  (EXP,ISO)
harman  (ISO)
harmine  (EXP,ISO)
Heliotrine  (ISO)
hydralazine  (ISO)
hydrogen sulfide  (ISO)
indol-3-ylacetaldehyde  (ISO)
indometacin  (EXP)
inulin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoflavones  (ISO)
ketorolac tromethamine  (EXP)
kojic acid  (EXP)
kynuramine  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
linezolid  (ISO)
luteolin  (ISO)
melatonin  (EXP)
Metanephrine  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylparaben  (ISO)
mifepristone  (ISO)
mithramycin  (ISO)
moclobemide  (EXP,ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitroprusside  (ISO)
Nonylphenol  (EXP)
ochratoxin A  (EXP)
olanzapine  (EXP)
Paeonol  (EXP)
paracetamol  (EXP,ISO)
parathion-methyl  (EXP)
Pargyline  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phenylpropanolamine  (EXP,ISO)
PhIP  (EXP)
phosphamidon  (EXP)
piperine  (EXP,ISO)
pirinixic acid  (EXP,ISO)
procarbazine  (EXP)
progesterone  (ISO)
propanal  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
risperidone  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP)
sarpogrelate  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
serotonin  (EXP,ISO)
sertraline  (ISO)
simazine  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulindac  (EXP)
tamoxifen  (EXP)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toloxatone  (EXP)
toluene  (EXP)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tryptamine  (ISO)
tyramine  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
yohimbine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Association of MAO A polymorphism and alcoholism in Brazilian females. Guindalini C, etal., Psychiatr Genet. 2005 Jun;15(2):141-4.
4. Paradoxical effects of copper and manganese on brain mitochondrial function. Heron P, etal., Life Sci. 2001 Feb 23;68(14):1575-83.
5. Primary structure of rat monoamine oxidase A deduced from cDNA and its expression in rat tissues. Kuwahara T, etal., Agric Biol Chem 1990 Jan;54(1):253-7.
6. Tyrosine residues near the FAD binding site are critical for FAD binding and for the maintenance of the stable and active conformation of rat monoamine oxidase A. Ma J and Ito A, J Biochem (Tokyo). 2002 Jan;131(1):107-11.
7. Associations between serotonin-related gene polymorphisms and panic disorder. Maron E, etal., Int J Neuropsychopharmacol. 2005 Jun;8(2):261-6. Epub 2005 Jan 26.
8. Association analysis of the functional monoamine oxidase A gene promotor polymorphism in migraine. Marziniak M, etal., J Neural Transm. 2004 May;111(5):603-9.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. The oxidation of adrenaline and noradrenaline by the two forms of monoamine oxidase from human and rat brain. O'Carroll AM, etal., Neurochem Int. 1986;8(4):493-500. doi: 10.1016/0197-0186(86)90182-8.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Interaction between MAOA and FOXP2 in association with autism and verbal communication in a Korean population. Park Y, etal., J Child Neurol. 2014 Dec;29(12):NP207-11. doi: 10.1177/0883073813511301. Epub 2013 Dec 18.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. Substrate-dependent regulation of MAO-A in rat mesangial cells: involvement of dopamine D2-like receptors. Pizzinat N, etal., Am J Physiol Renal Physiol 2003 Jan;284(1):F167-74.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Brain gamma-aminobutyrate aminotransferase (GABA-T) and monoamine oxidase (MAO) in patients with Alzheimer's disease. Sherif F, etal., J Neural Transm Park Dis Dement Sect. 1992;4(3):227-40.
21. Structure of human monoamine oxidase A at 2.2-A resolution: the control of opening the entry for substrates/inhibitors. Son SY, etal., Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5739-44. doi: 10.1073/pnas.0710626105. Epub 2008 Apr 7.
22. A key amino acid responsible for substrate selectivity of monoamine oxidase A and B. Tsugeno Y and Ito A, J Biol Chem. 1997 May 30;272(22):14033-6. doi: 10.1074/jbc.272.22.14033.
Additional References at PubMed
PMID:9520487   PMID:12477932   PMID:12531732   PMID:14651853   PMID:14747710   PMID:15050826   PMID:15526171   PMID:16129825   PMID:16286591   PMID:16421512   PMID:16631124   PMID:17158340  
PMID:17561096   PMID:18092818   PMID:18614015   PMID:19456107   PMID:19883764   PMID:19909795   PMID:20833797   PMID:21341713   PMID:21700703   PMID:21819071   PMID:22225631   PMID:22738191  
PMID:22871113   PMID:23321813   PMID:23581564   PMID:23926250   PMID:25315831   PMID:26122707   PMID:26645625   PMID:26689857   PMID:27503749   PMID:28653655   PMID:28857544   PMID:28948423  
PMID:29227084   PMID:29476059   PMID:29549852   PMID:30167938   PMID:33264068   PMID:34244591   PMID:35563271   PMID:35723772  


Genomics

Comparative Map Data
Maoa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X8,615,239 - 8,681,372 (-)NCBIGRCr8
mRatBN7.2X6,032,172 - 6,098,308 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX6,030,795 - 6,099,593 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX6,087,389 - 6,153,584 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X9,563,201 - 9,629,388 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X5,883,319 - 5,949,461 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X6,554,698 - 6,620,722 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX6,554,698 - 6,620,722 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X7,373,101 - 7,439,125 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X17,678,960 - 17,745,908 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X17,731,861 - 17,799,225 (-)NCBI
CeleraX6,522,076 - 6,588,367 (-)NCBICelera
Cytogenetic MapXq11NCBI
MAOA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X43,655,006 - 43,746,817 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX43,654,907 - 43,746,817 (+)EnsemblGRCh38hg38GRCh38
GRCh37X43,514,254 - 43,606,064 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X43,400,353 - 43,491,012 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X43,271,662 - 43,362,321NCBI
CeleraX47,658,765 - 47,745,839 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX41,244,782 - 41,335,636 (+)NCBIHuRef
CHM1_1X43,547,315 - 43,639,233 (+)NCBICHM1_1
T2T-CHM13v2.0X43,061,181 - 43,153,033 (+)NCBIT2T-CHM13v2.0
Maoa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X16,485,937 - 16,554,051 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX16,485,937 - 16,554,057 (+)EnsemblGRCm39 Ensembl
GRCm38X16,619,698 - 16,687,812 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX16,619,698 - 16,687,818 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X16,196,824 - 16,264,938 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X15,776,657 - 15,844,677 (+)NCBIMGSCv36mm8
CeleraX14,235,521 - 14,303,664 (+)NCBICelera
Cytogenetic MapXA1.2NCBI
cM MapX11.78NCBI
Maoa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555164,493,946 - 4,576,317 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555164,494,133 - 4,576,317 (-)NCBIChiLan1.0ChiLan1.0
MAOA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X45,303,983 - 45,396,951 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X45,307,374 - 45,400,324 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X36,106,680 - 36,197,907 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X43,931,198 - 44,022,199 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX43,931,044 - 44,022,199 (+)Ensemblpanpan1.1panPan2
MAOA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X37,678,933 - 37,744,757 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX37,677,493 - 37,744,757 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX24,906,697 - 24,972,819 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X37,766,823 - 37,832,990 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX37,765,383 - 37,835,465 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X37,808,131 - 37,874,259 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X37,790,918 - 37,857,220 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X37,886,004 - 37,952,154 (+)NCBIUU_Cfam_GSD_1.0
Maoa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X29,974,871 - 30,047,257 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365029,815,319 - 9,888,026 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365029,816,443 - 9,888,002 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAOA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X38,930,452 - 39,006,220 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X43,132,736 - 43,208,694 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAOA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X40,834,158 - 40,920,404 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX40,834,159 - 40,920,444 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660766,054,881 - 6,139,601 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Maoa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476211,743,712 - 11,822,377 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476211,743,833 - 11,820,529 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Maoa
75 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:150
Count of miRNA genes:132
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000066674
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat

Markers in Region
DXGot196  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X6,091,260 - 6,091,463 (+)MAPPERmRatBN7.2
Rnor_6.0X6,613,673 - 6,613,875NCBIRnor6.0
Rnor_5.0X7,432,076 - 7,432,278UniSTSRnor5.0
RGSC_v3.4X17,738,859 - 17,739,061UniSTSRGSC3.4
CeleraX6,580,720 - 6,580,922UniSTS
Cytogenetic MapXq12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000066674   ⟹   ENSRNOP00000063784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX6,030,795 - 6,098,317 (-)Ensembl
Rnor_6.0 EnsemblX6,554,698 - 6,620,722 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097866   ⟹   ENSRNOP00000097595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX6,030,795 - 6,099,593 (-)Ensembl
RefSeq Acc Id: NM_033653   ⟹   NP_387502
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X8,615,239 - 8,681,372 (-)NCBI
mRatBN7.2X6,032,172 - 6,098,308 (-)NCBI
Rnor_6.0X6,554,698 - 6,620,722 (-)NCBI
Rnor_5.0X7,373,101 - 7,439,125 (-)NCBI
RGSC_v3.4X17,678,960 - 17,745,908 (-)RGD
CeleraX6,522,076 - 6,588,367 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_387502 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66508 (Get FASTA)   NCBI Sequence Viewer  
  BAA00592 (Get FASTA)   NCBI Sequence Viewer  
  EDL97663 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063784.2
  ENSRNOP00000097595.1
GenBank Protein P21396 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_387502   ⟸   NM_033653
- UniProtKB: Q63817 (UniProtKB/Swiss-Prot),   P21396 (UniProtKB/Swiss-Prot),   A6JZX2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063784   ⟸   ENSRNOT00000066674
Ensembl Acc Id: ENSRNOP00000097595   ⟸   ENSRNOT00000097866
Protein Domains
Amine oxidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21396-F1-model_v2 AlphaFold P21396 1-526 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701705
Promoter ID:EPDNEW_R12228
Type:multiple initiation site
Name:Maoa_1
Description:monoamine oxidase A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X6,620,727 - 6,620,787EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61898 AgrOrtholog
BioCyc Gene G2FUF-3112 BioCyc
BioCyc Pathway PWY-0 [putrescine degradation III] BioCyc
  PWY-6307 [L-tryptophan degradation X (mammalian, via tryptamine)] BioCyc
  PWY-6313 [serotonin degradation] BioCyc
  PWY-6318 [L-phenylalanine degradation IV (mammalian, via side chain)] BioCyc
  PWY-6342 [noradrenaline and adrenaline degradation] BioCyc
  PWY-6399 [melatonin degradation II] BioCyc
  PWY6666-2 [dopamine degradation] BioCyc
BioCyc Pathway Image PWY-0 BioCyc
  PWY-6307 BioCyc
  PWY-6313 BioCyc
  PWY-6318 BioCyc
  PWY-6342 BioCyc
  PWY-6399 BioCyc
  PWY6666-2 BioCyc
Ensembl Genes ENSRNOG00000002848 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066674.3 UniProtKB/TrEMBL
  ENSRNOT00000097866.1 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.660.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanine Nucleotide Dissociation Inhibitor, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127176 IMAGE-MGC_LOAD
InterPro Amino_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_amine_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_MAO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29253 UniProtKB/TrEMBL
MGC_CLONE MGC:188076 IMAGE-MGC_LOAD
NCBI Gene 29253 ENTREZGENE
PANTHER AMINE OXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMINE OXIDASE [FLAVIN-CONTAINING] A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Amino_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MAOA RGD
PhenoGen Maoa PhenoGen
PRINTS AMINEOXDASEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002848 RatGTEx
Superfamily-SCOP FAD-linked reductases, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AT92_RAT UniProtKB/TrEMBL
  A6JZX2 ENTREZGENE, UniProtKB/TrEMBL
  AOFA_RAT UniProtKB/Swiss-Prot
  B2GV33_RAT UniProtKB/TrEMBL
  G3V9Z3_RAT UniProtKB/TrEMBL
  P21396 ENTREZGENE
  Q63817 ENTREZGENE
UniProt Secondary Q63817 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Maoa  monoamine oxidase A       Name updated 70584 APPROVED
2001-06-12 Mao  Monoamine oxidase      Symbol and Name withdrawn 62408 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_protein 526 amino acid residues 61656