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Gene: Xdh (xanthine dehydrogenase) Rattus norvegicus
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Symbol: Xdh
Name: xanthine dehydrogenase
Description: Exhibits several functions, including 2 iron, 2 sulfur cluster binding activity; coenzyme binding activity; and oxidoreductase activity. Involved in several processes, including aging; cellular response to cytokine stimulus; and purine nucleobase catabolic process. Localizes to the cytosol and extracellular space. Used to study several diseases, including hypertension; hyperuricemia; interstitial nephritis; kidney failure (multiple); and renal fibrosis. Biomarker of several diseases, including cholestasis; liver disease (multiple); obesity; pancreatitis; and peritonitis. Human ortholog(s) of this gene implicated in several diseases, including Lesch-Nyhan syndrome; cardiovascular system disease (multiple); chronic kidney disease; hyperuricemia; and xanthinuria. Orthologous to human XDH (xanthine dehydrogenase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (R)-adrenaline; 1,4-dithiothreitol; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: xanthine dehydrogenase/oxidase; xanthine oxidase; xanthine oxidoreductase; XOR
Orthologs:
Homo sapiens (human) : XDH (xanthine dehydrogenase)  HGNC  Alliance
Mus musculus (house mouse) : Xdh (xanthine dehydrogenase)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : XDH (xanthine dehydrogenase)
Canis lupus familiaris (dog) : XDH (xanthine dehydrogenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xdh (xanthine dehydrogenase)
Sus scrofa (pig) : XDH (xanthine dehydrogenase)
more info ...
Allele / Splice: Xdhem1Mcwi   Xdhem2Mcwi  
Genetic Models: SS-Xdhem2Mcwi SS-Xdhem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0625,149,570 - 25,211,273 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0634,996,983 - 35,059,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4621,417,685 - 21,590,015 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1621,420,637 - 21,592,968 (+)NCBI
Celera621,081,179 - 21,143,279 (+)NCBICelera
Cytogenetic Map6q13-q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Xdh
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62043
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.