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Gene: Xdh (xanthine dehydrogenase) Rattus norvegicus
Symbol: Xdh
Name: xanthine dehydrogenase
RGD ID: 62043
Description: Exhibits several functions, including 2 iron, 2 sulfur cluster binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on CH or CH2 groups. Involved in several processes, including cellular response to cytokine stimulus; purine nucleobase catabolic process; and response to aluminum ion. Localizes to cytosol and extracellular space. Used to study several diseases, including hypertension; hyperuricemia; interstitial nephritis; kidney failure (multiple); and renal fibrosis. Biomarker of several diseases, including cholestasis; liver disease (multiple); obesity; pancreatitis; and peritonitis. Human ortholog(s) of this gene implicated in several diseases, including Lesch-Nyhan syndrome; artery disease (multiple); chronic kidney disease; hyperuricemia; and xanthinuria. Orthologous to human XDH (xanthine dehydrogenase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (R)-adrenaline; (R)-lipoic acid; (S)-nicotine.
Type: protein-coding
Also known as: xanthine dehydrogenase/oxidase; xanthine oxidase; xanthine oxidoreductase; XOR
Homo sapiens (human) : XDH (xanthine dehydrogenase)  HGNC  Alliance
Mus musculus (house mouse) : Xdh (xanthine dehydrogenase)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : XDH (xanthine dehydrogenase)
Canis lupus familiaris (dog) : XDH (xanthine dehydrogenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xdh (xanthine dehydrogenase)
Sus scrofa (pig) : XDH (xanthine dehydrogenase)
Chlorocebus sabaeus (African green monkey) : XDH (xanthine dehydrogenase)
Heterocephalus glaber (naked mole-rat) : Xdh (xanthine dehydrogenase)
more info ...
Allele / Splice: Xdhem1Mcwi   Xdhem2Mcwi  
Genetic Models: SS-Xdhem2Mcwi SS-Xdhem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0625,149,570 - 25,211,273 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl625,149,235 - 25,211,494 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0634,996,983 - 35,059,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4621,417,685 - 21,590,015 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1621,420,637 - 21,592,968 (+)NCBI
Celera621,081,179 - 21,143,279 (+)NCBICelera
Cytogenetic Map6q13-q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Xdh
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62043
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.