Xdh (xanthine dehydrogenase) - Rat Genome Database

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Gene: Xdh (xanthine dehydrogenase) Mus musculus
Analyze
Symbol: Xdh
Name: xanthine dehydrogenase
RGD ID: 62335
MGI Page MGI
Description: Exhibits oxidoreductase activity, acting on CH or CH2 groups. Involved in several processes, including iron-sulfur cluster assembly; lactation; and purine-containing compound catabolic process. Localizes to cytosol and sarcoplasmic reticulum. Is expressed in several structures, including adrenal gland; genitourinary system; intestine; liver; and lung. Human ortholog(s) of this gene implicated in several diseases, including Lesch-Nyhan syndrome; artery disease (multiple); chronic kidney disease; hyperuricemia; and xanthinuria. Orthologous to human XDH (xanthine dehydrogenase).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: X; xanthine dehydrogenase/oxidase; xanthine oxidase; xanthine oxidoreductase; XO; Xor; Xox; Xox-; Xox-1; Xox1
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391774,190,890 - 74,257,369 (-)NCBIGRCm39mm39
GRCm39 Ensembl1774,190,890 - 74,257,191 (-)Ensembl
GRCm381773,883,895 - 73,950,397 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1773,883,895 - 73,950,196 (-)EnsemblGRCm38mm10GRCm38
MGSCv371774,233,248 - 74,299,522 (-)NCBIGRCm37mm9NCBIm37
MGSCv361773,788,790 - 73,855,081 (-)NCBImm8
Celera1778,175,030 - 78,239,710 (-)NCBICelera
Cytogenetic Map17E2NCBI
cM Map1745.25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IDA,ISO)
Acute Lung Injury  (ISO)
Animal Mammary Neoplasms  (ISO)
Arterial Thrombosis  (ISO)
autistic disorder  (ISO)
Autoinflammation with Infantile Enterocolitis  (ISO)
Brain Injuries  (ISO)
Carbon Monoxide Poisoning  (ISO)
carcinoma  (ISO)
cardiomyopathy  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
cataract  (ISO)
cholestasis  (ISO)
chronic kidney disease  (ISO)
Colonic Neoplasms  (ISO)
congestive heart failure  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (IMP,ISO)
Dwarfism  (ISO)
Eczema  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
Fetal Growth Retardation  (ISO)
gout  (ISO)
heart disease  (ISO)
hepatocellular carcinoma  (ISO)
hydronephrosis  (ISO)
Hyperoxaluria  (ISO)
Hyperoxic Lung Injury  (ISO)
hypertension  (ISO)
hyperuricemia  (IEP,IMP,ISO)
Hypotension  (ISO)
interstitial nephritis  (ISO)
Intestinal Reperfusion Injury  (ISO)
ischemia  (ISO)
kidney failure  (IAGP,IMP)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lesch-Nyhan syndrome  (ISO)
Liver Reperfusion Injury  (ISO)
major depressive disorder  (ISO)
Mammary Neoplasms, Experimental  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Organ Failure  (ISO)
muscular disease  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nerve Degeneration  (ISO)
neutropenia  (ISO)
obesity  (ISO)
pancreatitis  (ISO)
peritonitis  (ISO)
Pneumoperitoneum  (ISO)
portal hypertension  (ISO)
protein-losing enteropathy  (ISO)
pulmonary embolism  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
renal fibrosis  (ISO)
Renal Ischemia  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
Sepsis  (ISO)
Shock  (ISO)
Spinal Cord Injuries  (ISO)
Testis Reperfusion Injury  (ISO)
thrombocytopenia  (ISO)
Transplant Rejection  (ISO)
Urachal Cyst  (ISO)
urinary bladder cancer  (ISO)
Wounds, Penetrating  (ISO)
xanthinuria  (ISO,ISS)
Xanthinuria, Type I  (ISO)
Xanthinuria, Type II  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
(R)-adrenaline  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (ISO)
1-methyl-7H-xanthine  (ISO)
1-methyluric acid  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitroanisole  (ISO)
2-nitrofluorene  (EXP,ISO)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (EXP,ISO)
3-phenylprop-2-enal  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
7H-xanthine  (EXP,ISO)
9H-xanthine  (EXP,ISO)
acetaldehyde  (ISO)
acetic acid  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
allantoin  (ISO)
allopurinol  (EXP,ISO)
alloxan  (ISO)
alloxanthine  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium acetate  (ISO)
ammonium chloride  (ISO)
anthocyanin  (ISO)
apocynin  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
aspartame  (EXP)
avobenzone  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzoyl peroxide  (EXP)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
buspirone  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
Chloramine  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
chlorzoxazone  (ISO)
chromium(6+)  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloartenol  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
D-glucose  (ISO)
DDT  (ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (EXP,ISO)
dextromethorphan  (ISO)
diethylstilbestrol  (EXP,ISO)
diisopropyl fluorophosphate  (ISO)
diosmin  (EXP,ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
erdosteine  (ISO)
ethanol  (ISO)
ethylenediaminetetraacetic acid  (EXP)
flavonoids  (ISO)
fluocinolone acetonide  (EXP)
fluoranthene  (EXP)
formaldehyde  (ISO)
fructose  (ISO)
genistein  (EXP)
glucose  (ISO)
glutathione  (ISO)
glyburide  (EXP)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
hydroxytyrosol  (ISO)
hypoxanthine  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
isotretinoin  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-glutamine  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipoic acid  (ISO)
Lithospermic acid  (ISO)
lupeol  (EXP)
mercaptopurine  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methylisothiazolinone  (ISO)
mitomycin C  (ISO)
monosodium L-glutamate  (EXP)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nicorandil  (EXP,ISO)
nicotine  (ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
palytoxin  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (EXP)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
purine-6-thiol  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (ISO)
rotenone  (ISO)
rutin  (ISO)
SB 203580  (ISO)
Senkirkine  (ISO)
serotonin  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium acetate trihydrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium benzoate  (ISO)
sodium fluoride  (EXP)
sodium nitrate  (EXP)
sodium tungstate  (ISO)
streptozocin  (ISO)
superoxide  (ISO)
taurine  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
toluene  (ISO)
trans-caffeic acid  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
trovafloxacin  (EXP)
tubocurarine  (ISO)
tungsten  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
adenosine catabolic process  (IDA,IMP,ISO)
aging  (ISO)
allantoin biosynthetic process  (IDA,ISO)
allantoin metabolic process  (IDA,IMP,ISO)
AMP catabolic process  (IDA,ISO)
cellular response to interleukin-1  (ISO)
cellular response to tumor necrosis factor  (ISO)
dAMP catabolic process  (IDA)
deoxyadenosine catabolic process  (IDA)
deoxyguanosine catabolic process  (IDA)
deoxyinosine catabolic process  (IDA,IMP,ISO)
dGMP catabolic process  (IDA)
GMP catabolic process  (IDA)
guanine catabolic process  (IDA,ISO)
hypoxanthine catabolic process  (IDA,IMP,ISO)
IMP catabolic process  (IDA,ISO)
inosine catabolic process  (IDA,IMP,ISO)
iron-sulfur cluster assembly  (IDA)
lactation  (IMP)
negative regulation of endothelial cell differentiation  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of vascular endothelial growth factor signaling pathway  (ISO)
negative regulation of vasculogenesis  (ISO)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
regulation of epithelial cell differentiation  (IMP)
response to aluminum ion  (ISO)
response to azide  (ISO)
response to carbon monoxide  (ISO)
response to heat  (ISO)
response to hydrogen peroxide  (ISO)
response to lipopolysaccharide  (ISO)
xanthine catabolic process  (IBA,IDA,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
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Additional References at PubMed
PMID:1590774   PMID:1619276   PMID:3443108   PMID:4207016   PMID:6895582   PMID:7835888   PMID:7864814   PMID:8064675   PMID:8226898   PMID:8537361   PMID:8541302   PMID:8562047  
PMID:8661045   PMID:8661125   PMID:8751373   PMID:8798497   PMID:8920983   PMID:9169125   PMID:10349636   PMID:10753524   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12456835  
PMID:12477932   PMID:12502743   PMID:14681479   PMID:15486091   PMID:15528468   PMID:15857914   PMID:15863459   PMID:15878860   PMID:16141072   PMID:16141073   PMID:16452486   PMID:16537416  
PMID:16632522   PMID:17276354   PMID:17364940   PMID:17597094   PMID:18287332   PMID:18669934   PMID:18767115   PMID:19076165   PMID:19531472   PMID:19800018   PMID:19828843   PMID:20142047  
PMID:21224483   PMID:21267068   PMID:21310927   PMID:21626205   PMID:21677750   PMID:21775420   PMID:21873635   PMID:22095983   PMID:22723833   PMID:23380026   PMID:23426966   PMID:23951137  
PMID:24024171   PMID:24158515   PMID:25044064   PMID:25800347   PMID:25879627   PMID:25999428   PMID:26903297   PMID:26987748   PMID:27433030   PMID:27609225   PMID:27696407   PMID:27914912  
PMID:28539355   PMID:29101234   PMID:29502045   PMID:29895374   PMID:30312761   PMID:30333137   PMID:30336599   PMID:30936145   PMID:30938853   PMID:31659168   PMID:31850710   PMID:32239172  
PMID:32325033  


Genomics

Comparative Map Data
Xdh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391774,190,890 - 74,257,369 (-)NCBIGRCm39mm39
GRCm39 Ensembl1774,190,890 - 74,257,191 (-)Ensembl
GRCm381773,883,895 - 73,950,397 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1773,883,895 - 73,950,196 (-)EnsemblGRCm38mm10GRCm38
MGSCv371774,233,248 - 74,299,522 (-)NCBIGRCm37mm9NCBIm37
MGSCv361773,788,790 - 73,855,081 (-)NCBImm8
Celera1778,175,030 - 78,239,710 (-)NCBICelera
Cytogenetic Map17E2NCBI
cM Map1745.25NCBI
XDH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl231,334,321 - 31,414,742 (-)EnsemblGRCh38hg38GRCh38
GRCh38231,334,320 - 31,414,777 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37231,557,187 - 31,637,608 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36231,410,692 - 31,491,115 (-)NCBINCBI36hg18NCBI36
Build 34231,470,146 - 31,549,264NCBI
Celera231,399,873 - 31,481,045 (-)NCBI
Cytogenetic Map2p23.1NCBI
HuRef231,294,906 - 31,375,846 (-)NCBIHuRef
CHM1_1231,487,808 - 31,568,252 (-)NCBICHM1_1
Xdh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2621,530,463 - 21,592,172 (+)NCBI
Rnor_6.0 Ensembl625,149,235 - 25,211,494 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0625,149,570 - 25,211,273 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0634,996,983 - 35,059,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4621,417,685 - 21,590,015 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1621,420,637 - 21,592,968 (+)NCBI
Celera621,081,179 - 21,143,279 (+)NCBICelera
Cytogenetic Map6q13-q14NCBI
XDH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A31,425,183 - 31,504,455 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A31,425,183 - 31,504,455 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A31,356,011 - 31,435,111 (-)NCBIMhudiblu_PPA_v0panPan3
XDH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11724,900,708 - 24,960,748 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1724,901,447 - 24,971,935 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1724,694,965 - 24,754,929 (-)NCBI
ROS_Cfam_1.01725,464,496 - 25,524,534 (-)NCBI
UMICH_Zoey_3.11724,767,742 - 24,827,816 (-)NCBI
UNSW_CanFamBas_1.01724,830,189 - 24,890,224 (-)NCBI
UU_Cfam_GSD_1.01724,929,639 - 24,989,647 (-)NCBI
Xdh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629269,015,034 - 69,076,787 (-)NCBI
SpeTri2.0NW_0049364931,762,814 - 1,824,501 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XDH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3107,986,528 - 108,080,151 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13107,987,060 - 108,052,043 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23114,732,427 - 114,796,636 (+)NCBISscrofa10.2Sscrofa10.2susScr3
XDH
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11476,084,693 - 76,162,840 (+)NCBI
ChlSab1.1 Ensembl1476,085,368 - 76,163,936 (+)Ensembl
Xdh
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473813,116,317 - 13,180,935 (-)NCBI

Position Markers
X62932  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381773,884,037 - 73,884,159UniSTSGRCm38
MGSCv371774,233,377 - 74,233,499UniSTSGRCm37
Celera1778,175,163 - 78,175,285UniSTS
Cytogenetic Map17E2UniSTS
cM Map1745.3UniSTS
Whitehead/MRC_RH17863.06UniSTS
Xdh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E2UniSTS
cM Map1745.3UniSTS
04.MMHAP91FLB1.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381773,891,279 - 73,891,462UniSTSGRCm38
MGSCv371774,240,619 - 74,240,802UniSTSGRCm37
Celera1778,180,189 - 78,180,372UniSTS
Cytogenetic Map17E2UniSTS
cM Map1745.3UniSTS
Whitehead_YAC17 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4022744774227623Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174063218774632187Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174620000082100000Mouse
1357754Ahl3_mage related hearing loss 3 (mouse)Not determined174989696283897108Mouse
1357532Bmch7_mbone mechanical trait 7 (mouse)Not determined175145143085451617Mouse
4141879Chlq9_mcirculating hormone level QTL 9 (mouse)Not determined175145143085451617Mouse
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175680065690800808Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175680065690800808Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175680065690800808Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175680065690800808Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175680065690800808Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175680065690800808Mouse
4142201Obrq15_mobesity resistance QTL 15 (mouse)Not determined5722744780578347Mouse
4142414Pregq4_mpregnancy QTL 4 (mouse)Not determined175722744793199751Mouse
4141040Hmtb9_mhemostasis and thrombosis rebleeding time 9 (mouse)Not determined5728209491282202Mouse
1301107Scc4_mcolon tumor susceptibility 4 (mouse)Not determined176199358194987271Mouse
11528551Sluc32_msusceptibility to lung cancer 32 (mouse)176199358194987271Mouse
1302017Aliq3_macute lung injury QTL 3 (mouse)Not determined176357811994987271Mouse
1301728Ffal1_mfree fatty acid level 1 (mouse)Not determined176490750994987271Mouse
14928308Manh82_mmandible shape 82 (mouse)176600781494987271Mouse
4142256Nilac12_mnicotine induced locomotor activity 12 (mouse)Not determined176863389194987271Mouse
11039498Ltpr7b_mLeishmania tropica response 7b (mouse)177039377094987271Mouse
11039499Ltpr7a_mLeishmania tropica response 7a (mouse)177039377094987271Mouse
11039500Ltpr7c_mLeishmania tropica response 7c (mouse)177039377094987271Mouse
11039514Ltpr7_mLeishmania tropica response 7 (mouse)177039377094987271Mouse
1357528Nhdlq3_mnon-HDL QTL 3 (mouse)Not determined177308770494987271Mouse
4141195Nilac11_mnicotine induced locomotor activity 11 (mouse)Not determined177308770494987271Mouse
4141697Hbnr3_mHeligmosomoides bakeri nematode resistance 3 (mouse)Not determined7380065693199751Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:154
Count of miRNA genes:140
Interacting mature miRNAs:149
Transcripts:ENSMUST00000024866
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011246381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003952104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC101679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC159187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI323529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC141183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY318674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY322557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT025731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000024866   ⟹   ENSMUSP00000024866
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1773,883,895 - 73,950,182 (-)Ensembl
RefSeq Acc Id: ENSMUST00000232717
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1773,884,310 - 73,886,842 (-)Ensembl
RefSeq Acc Id: ENSMUST00000232783   ⟹   ENSMUSP00000156753
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1773,934,802 - 73,950,115 (-)Ensembl
RefSeq Acc Id: ENSMUST00000232843
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1773,940,930 - 73,950,178 (-)Ensembl
RefSeq Acc Id: ENSMUST00000232957
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1773,943,348 - 73,950,096 (-)Ensembl
RefSeq Acc Id: ENSMUST00000233162
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1773,883,908 - 73,950,145 (-)Ensembl
RefSeq Acc Id: ENSMUST00000233352
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1773,888,979 - 73,895,781 (-)Ensembl
RefSeq Acc Id: ENSMUST00000233392   ⟹   ENSMUSP00000156860
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1773,883,895 - 73,900,407 (-)Ensembl
RefSeq Acc Id: ENSMUST00000233433
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1773,926,610 - 73,948,259 (-)Ensembl
RefSeq Acc Id: ENSMUST00000233449
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1773,935,360 - 73,950,092 (-)Ensembl
RefSeq Acc Id: ENSMUST00000233570
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1773,934,312 - 73,950,138 (-)Ensembl
RefSeq Acc Id: ENSMUST00000233621   ⟹   ENSMUSP00000156944
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1773,883,908 - 73,950,196 (-)Ensembl
RefSeq Acc Id: ENSMUST00000233807
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1773,884,411 - 73,886,750 (-)Ensembl
RefSeq Acc Id: ENSMUST00000233946
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1773,915,740 - 73,918,910 (-)Ensembl
RefSeq Acc Id: NM_011723   ⟹   NP_035853
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391774,190,890 - 74,257,191 (-)NCBI
GRCm381773,883,895 - 73,950,196 (-)NCBI
MGSCv371774,233,248 - 74,299,522 (-)RGD
Celera1778,175,017 - 78,239,724 (-)NCBI
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011246381   ⟹   XP_011244683
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391774,190,890 - 74,223,867 (-)NCBI
GRCm381773,883,906 - 73,916,872 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003952104
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391774,190,928 - 74,257,369 (-)NCBI
GRCm381773,883,906 - 73,950,397 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035853   ⟸   NM_011723
- UniProtKB: Q00519 (UniProtKB/Swiss-Prot),   Q9CVF2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011244683   ⟸   XM_011246381
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000156944   ⟸   ENSMUST00000233621
RefSeq Acc Id: ENSMUSP00000156860   ⟸   ENSMUST00000233392
RefSeq Acc Id: ENSMUSP00000156753   ⟸   ENSMUST00000232783
RefSeq Acc Id: ENSMUSP00000024866   ⟸   ENSMUST00000024866
Promoters
RGD ID:13676758
Promoter ID:EPDNEW_M22528
Type:initiation region
Name:Xdh_1
Description:Mus musculus xanthine dehydrogenase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381773,950,144 - 73,950,204EPDNEW
RGD ID:6847479
Promoter ID:MM_ACW:23502
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung
Transcripts:XDH.KSEP07,   XDH.MSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361774,235,506 - 74,236,006 (-)MPROMDB
RGD ID:6847481
Promoter ID:MM_ACW:23503
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:XDH.OSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361774,240,391 - 74,240,891 (-)MPROMDB
RGD ID:6828892
Promoter ID:MM_KWN:24181
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_4Hour,   Lung
Transcripts:UC008DNR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361774,258,621 - 74,259,672 (-)MPROMDB
RGD ID:6828890
Promoter ID:MM_KWN:24182
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   Spleen
Transcripts:NM_011723,   UC008DNP.1,   UC008DNQ.1,   UC008DNS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361774,299,076 - 74,300,522 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98973 AgrOrtholog
Ensembl Genes ENSMUSG00000024066 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000024866 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000156753 UniProtKB/TrEMBL
  ENSMUSP00000156860 UniProtKB/TrEMBL
  ENSMUSP00000156944 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000024866 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000232783 UniProtKB/TrEMBL
  ENSMUST00000233392 UniProtKB/TrEMBL
  ENSMUST00000233621 UniProtKB/TrEMBL
Gene3D-CATH 3.10.20.30 UniProtKB/TrEMBL
InterPro 2Fe-2S-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe-2S-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe-2S_ferredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe-2S_ferredoxin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe2S_fd_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Oxase/Xan_DH_a/b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Oxase/Xan_DH_a/b_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Oxase/xanthine_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AldOxase/xan_DH_Mopterin-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AldOxase/xan_DH_Mopterin-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta-grasp_dom_sf UniProtKB/TrEMBL
  CO_DH_flav_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_DH_flav_C_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mopterin_DH_FAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OxRdtase_Mopterin_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Xanthine_DH_Mopterin-bd_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Xanthine_DH_ssu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98973 ENTREZGENE
NCBI Gene 22436 ENTREZGENE
Pfam Ald_Xan_dh_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Xan_dh_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_deh_flav_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_binding_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fer2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fer2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB XDH RGD
PhenoGen Xdh PhenoGen
PIRSF Xanthine_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 2FE2S_FER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2FE2S_FER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_PCMH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MOLYBDOPTERIN_EUK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Ald_Xan_dh_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_deh_flav_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47741 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54292 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54665 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55447 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56176 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs xanthine_xdhA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  xanthine_xdhB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3B2W454_MOUSE UniProtKB/TrEMBL
  A0A3B2WBF8_MOUSE UniProtKB/TrEMBL
  A0A3B2WDA8_MOUSE UniProtKB/TrEMBL
  B2RUJ7_MOUSE UniProtKB/TrEMBL
  Q00519 ENTREZGENE
  Q3TAT6_MOUSE UniProtKB/TrEMBL
  Q3TP30_MOUSE UniProtKB/TrEMBL
  Q3UMS6_MOUSE UniProtKB/TrEMBL
  Q99KV3_MOUSE UniProtKB/TrEMBL
  Q9CVF2 ENTREZGENE, UniProtKB/TrEMBL
  XDH_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary E9QLM9 UniProtKB/Swiss-Prot