Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: XDH (xanthine dehydrogenase) Homo sapiens
Analyze
Symbol: XDH
Name: xanthine dehydrogenase
Description: Exhibits several functions, including 2 iron, 2 sulfur cluster binding activity; coenzyme binding activity; and oxidoreductase activity, acting on CH or CH2 groups. Involved in several processes, including negative regulation of cell differentiation; negative regulation of signal transduction; and regulation of cellular protein metabolic process. Localizes to the extracellular space. Implicated in several diseases, including Lesch-Nyhan syndrome; cardiovascular system disease (multiple); chronic kidney disease; hyperuricemia; and xanthinuria.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: XAN1; xanthene dehydrogenase; xanthine dehydrogenase/oxidase; xanthine oxidase; xanthine oxidoreductase; XO; XOR
Orthologs:
Mus musculus (house mouse) : Xdh (xanthine dehydrogenase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Xdh (xanthine dehydrogenase)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : XDH (xanthine dehydrogenase)
Canis lupus familiaris (dog) : XDH (xanthine dehydrogenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xdh (xanthine dehydrogenase)
Sus scrofa (pig) : XDH (xanthine dehydrogenase)
Chlorocebus sabaeus (green monkey) : XDH (xanthine dehydrogenase)
Heterocephalus glaber (naked mole-rat) : Xdh (xanthine dehydrogenase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl231,334,321 - 31,414,742 (-)Ensembl
GRCh38231,334,320 - 31,414,777 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37231,557,188 - 31,637,611 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36231,410,692 - 31,491,115 (-)NCBINCBI36hg18NCBI36
Build 34231,470,146 - 31,549,264NCBI
Celera231,399,873 - 31,481,045 (-)NCBI
Cytogenetic Map2p23.1NCBI
HuRef231,294,906 - 31,375,846 (-)NCBIHuRef
CHM1_1231,487,808 - 31,568,252 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on XDH
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348452
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-31
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.