Xdh (xanthine dehydrogenase) - Rat Genome Database

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Gene: Xdh (xanthine dehydrogenase) Ictidomys tridecemlineatus
Analyze
Symbol: Xdh
Name: xanthine dehydrogenase
RGD ID: 12503960
Description: ENCODES a protein that exhibits 2 iron, 2 sulfur cluster binding (ortholog); flavin adenine dinucleotide binding (ortholog); hypoxanthine dehydrogenase activity (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); adenosine catabolic process (ortholog); aging (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytosol (ortholog); extracellular space (ortholog); peroxisome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: xanthine dehydrogenase/oxidase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629269,015,034 - 69,076,787 (-)NCBI
SpeTri2.0NW_0049364931,762,814 - 1,824,501 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
Animal Mammary Neoplasms  (ISO)
Arterial Thrombosis  (ISO)
autistic disorder  (ISO)
Autoinflammation with Infantile Enterocolitis  (ISO)
Brain Injuries  (ISO)
Carbon Monoxide Poisoning  (ISO)
carcinoma  (ISO)
cardiomyopathy  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
cataract  (ISO)
cholestasis  (ISO)
chronic kidney disease  (ISO)
Colonic Neoplasms  (ISO)
congestive heart failure  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
Dwarfism  (ISO)
Eczema  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
Fetal Growth Retardation  (ISO)
gout  (ISO)
heart disease  (ISO)
hepatocellular carcinoma  (ISO)
hydronephrosis  (ISO)
Hyperoxaluria  (ISO)
Hyperoxic Lung Injury  (ISO)
hypertension  (ISO)
hyperuricemia  (ISO)
Hypotension  (ISO)
interstitial nephritis  (ISO)
Intestinal Reperfusion Injury  (ISO)
ischemia  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lesch-Nyhan syndrome  (ISO)
Liver Reperfusion Injury  (ISO)
major depressive disorder  (ISO)
Mammary Neoplasms, Experimental  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Organ Failure  (ISO)
muscular disease  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nerve Degeneration  (ISO)
neutropenia  (ISO)
obesity  (ISO)
pancreatitis  (ISO)
peritonitis  (ISO)
Pneumoperitoneum  (ISO)
portal hypertension  (ISO)
protein-losing enteropathy  (ISO)
pulmonary embolism  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
renal fibrosis  (ISO)
Renal Ischemia  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
Sepsis  (ISO)
Shock  (ISO)
Spinal Cord Injuries  (ISO)
Testis Reperfusion Injury  (ISO)
thrombocytopenia  (ISO)
Transplant Rejection  (ISO)
Urachal Cyst  (ISO)
urinary bladder cancer  (ISO)
Wounds, Penetrating  (ISO)
xanthinuria  (ISO)
Xanthinuria, Type I  (ISO)
Xanthinuria, Type II  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

Genomics

Comparative Map Data
Xdh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629269,015,034 - 69,076,787 (-)NCBI
SpeTri2.0NW_0049364931,762,814 - 1,824,501 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XDH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl231,334,321 - 31,414,742 (-)EnsemblGRCh38hg38GRCh38
GRCh38231,334,320 - 31,414,777 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37231,557,187 - 31,637,608 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36231,410,692 - 31,491,115 (-)NCBINCBI36hg18NCBI36
Build 34231,470,146 - 31,549,264NCBI
Celera231,399,873 - 31,481,045 (-)NCBI
Cytogenetic Map2p23.1NCBI
HuRef231,294,906 - 31,375,846 (-)NCBIHuRef
CHM1_1231,487,808 - 31,568,252 (-)NCBICHM1_1
Xdh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391774,190,890 - 74,257,369 (-)NCBIGRCm39mm39
GRCm39 Ensembl1774,190,890 - 74,257,191 (-)Ensembl
GRCm381773,883,895 - 73,950,397 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1773,883,895 - 73,950,196 (-)EnsemblGRCm38mm10GRCm38
MGSCv371774,233,248 - 74,299,522 (-)NCBIGRCm37mm9NCBIm37
MGSCv361773,788,790 - 73,855,081 (-)NCBImm8
Celera1778,175,030 - 78,239,710 (-)NCBICelera
Cytogenetic Map17E2NCBI
cM Map1745.25NCBI
Xdh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2621,530,463 - 21,592,172 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl621,530,113 - 21,592,268 (+)Ensembl
Rnor_6.0625,149,570 - 25,211,273 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl625,149,235 - 25,211,494 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0634,996,983 - 35,059,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4621,417,685 - 21,590,015 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1621,420,637 - 21,592,968 (+)NCBI
Celera621,081,179 - 21,143,279 (+)NCBICelera
Cytogenetic Map6q13-q14NCBI
XDH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A31,425,183 - 31,504,455 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A31,425,183 - 31,504,455 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A31,356,011 - 31,435,111 (-)NCBIMhudiblu_PPA_v0panPan3
XDH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11724,900,708 - 24,960,748 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1724,901,447 - 24,971,935 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1724,694,965 - 24,754,929 (-)NCBI
ROS_Cfam_1.01725,464,496 - 25,524,534 (-)NCBI
UMICH_Zoey_3.11724,767,742 - 24,827,816 (-)NCBI
UNSW_CanFamBas_1.01724,830,189 - 24,890,224 (-)NCBI
UU_Cfam_GSD_1.01724,929,639 - 24,989,647 (-)NCBI
XDH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3107,986,528 - 108,080,151 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13107,987,060 - 108,052,043 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23114,732,427 - 114,796,636 (+)NCBISscrofa10.2Sscrofa10.2susScr3
XDH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11476,084,693 - 76,162,840 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1476,085,368 - 76,163,936 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604535,902,856 - 35,979,384 (-)NCBIVero_WHO_p1.0
Xdh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473813,116,317 - 13,180,935 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013357425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010001352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_013357425   ⟹   XP_013212879
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629269,015,034 - 69,076,787 (-)NCBI
SpeTri2.0NW_0049364931,762,814 - 1,824,501 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013212879 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3267862 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013212879   ⟸   XM_013357425
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000012152 ENTREZGENE
Ensembl Protein ENSSTOP00000010903 ENTREZGENE
NCBI Gene Xdh ENTREZGENE