RGD Reference Report - Exaggerated liver injury induced by renal ischemia reperfusion in diabetes: effect of exenatide. - Rat Genome Database

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Exaggerated liver injury induced by renal ischemia reperfusion in diabetes: effect of exenatide.

Authors: Vaghasiya, JD  Sheth, NR  Bhalodia, YS  Jivani, NP 
Citation: Vaghasiya JD, etal., Saudi J Gastroenterol. 2010 Jul-Sep;16(3):174-80. doi: 10.4103/1319-3767.65187.
RGD ID: 7247695
Pubmed: PMID:20616412   (View Abstract at PubMed)
PMCID: PMC3003206   (View Article at PubMed Central)
DOI: DOI:10.4103/1319-3767.65187   (Journal Full-text)

BACKGROUND/AIM: This study was designed to investigate the possible effect of exenatide (Glucagon like Peptide-1 receptor agonist) on liver injury (distant organ) induced by renal ischemia reperfusion (IR) in diabetic rats. MATERIALS AND METHODS: In vivo renal IR was performed in both type 2 diabetic and normal rats. Each protocol comprised ischemia for 30 minutes followed by reperfusion for 24 hours and a treatment period of 14 days before induction of ischemia. RESULTS: Lipid peroxidation, xanthine oxidase activity, myeloperoxidase activity and nitric oxide level in liver tissue were significantly increased (P < 0.01, P < 0.001, P < 0.001, P < 0.05, respectively), after IR in diabetic rats compared to normal rats. Antioxidant enzymes like glutathione, superoxide dismutase, catalase and glutathione peroxidase were significantly reduced (P < 0.05, P < 0.05, P < 0.01, P < 0.05, respectively), after IR in diabetic rats compared to normal rats. Exenatide treatment significantly normalized (P < 0.01), these biochemical parameters in treated rats compared to diabetic IR rats. Serum creatinine phosphokinase activity and liver function enzymes were also significantly normalized (P < 0.001, P < 0.001, respectively), after administration of exenatide. CONCLUSION: Exenatide exerted protective effect on exaggerated remote organ (liver) injury induced by renal IR in diabetes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Kidney Reperfusion Injury treatmentISOXdh (Rattus norvegicus)7247695; 7247695associated with Diabetes Mellitus and Type 2RGD 
Kidney Reperfusion Injury treatmentIMP 7247695associated with Diabetes Mellitus and Type 2RGD 

Objects Annotated

Genes (Rattus norvegicus)
Xdh  (xanthine dehydrogenase)

Genes (Mus musculus)
Xdh  (xanthine dehydrogenase)

Genes (Homo sapiens)
XDH  (xanthine dehydrogenase)


Additional Information